Table I: Periodicity Scores of selected genes
|
RANK |
GENE | PERIODICITY SCORE |
MAX FOLD CHANGE |
AVG. FOLD CHANGE |
|
1 |
STK15 |
58.8 |
16 |
10 |
|
2 |
PLK |
56.0 |
11 |
8.6 |
|
7 |
CENPE |
42.6 |
11 |
6.8 |
|
17 |
CKS2 |
35.1 |
11 |
5.5 |
|
25 |
CCNA2 |
31.2 |
5.9 |
4.5 |
|
43 |
CDC6 |
25.3 |
3.8 |
3.0 |
|
50 |
CCNB1 |
24.3 |
7.3 |
4.1 |
|
54 |
E2F1 |
23.0 |
4.9 |
3.9 |
|
95 |
PCNA |
16.9 |
3.4 |
2.7 |
|
105 |
CIT |
16.2 |
7.0 |
4.0 |
|
135 |
GOLGIN-67 |
13.6 |
4.8 |
3.1 |
|
182 |
ORC 1 |
11.2 |
3.7 |
2.2 |
|
355 |
PRIM1 |
7.26 |
2.6 |
2.1 |
|
499 |
VCL |
5.80 |
3.4 |
2.7 |
|
607 |
BRCA1 |
5.17 |
2.5 |
2.1 |
|
618 |
CCNE2 |
7.18 |
3.1 |
2.5 |
|
1127 |
PSEN1 |
3.65 |
2.1 |
1.8 |
|
1333 |
CDC42 |
3.29 |
2.3 |
2.0 |
|
1334 |
CUTOFF |
3.286 |
----- |
----- |
|
1358 |
ZNF162 |
3.25 |
1.9 |
1.8 |
|
1780 |
YY1 |
2.75 |
3 |
2.3 |
Sample periodicity scores for representative
cell cycle regulated genes. The
cutoff for a cell cycle regulated gene was established by balancing the false
positive and false negative rates.
We used a cutoff that gave an estimated 0.15 – 0.75% false
positive rate and 6.5% false negative rate resulting in 1333 clones. The maximum fold change is the maximum
amplitude observed in any of the five synchronizations. The average fold change is the average
amplitude across all five synchronizations.