Alignment table
Needleman Wunsch alignment of:
- S. cerevisiae gene ira2 (YOL081W)
- Human neurofibromin (NF1) gene. GenBank: M89914
(Yeast sequence on top).
BLAST P-value: 1.0e-28
Percent Similarity (|+|): 45.3 Percent Identity (|): 21.1
1 MSQPTKNKKKEHGTDSKSSRMTRTLVNHIL..FERILPILPVESNLSTYS 48
...|.. .||. || || ||| ..| | |
1 ................MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKV 34
49 EVEEYSSFISCRSVLINVTVSRDANAMVEGTLELIESLLQGHEIISDKGS 98
..|. |..||| ||| .|| |.|. | . |.. |||| |.
35 STEHN......KECLIN..ISKYKFSLVISGLTTILKNVNNMRIFGEAAE 76
99 SDVIESILIILRLLSDALEYNWQNQESLHYNDISTHVEHDQEQKYRPKLN 148
.||. | |||| |...|. | .|.||. || .. ..|
77 KNLYLSQLIILDTLEKCLAG..QPKDTMRL..........DETMLVKQLL 114
149 SILPDYSSTHSNGNKHFFHQSKPQALIPELASKLLESCAKLKFNTRTLQI 198
. |..| | .|||.| .| |.| || || |
115 PEICHFLHTCREGNQH.......AAELRNSASGVLFS............. 144
199 LQNMISHVHGNILTTLSSSILPRHKSYLTRHNHPSHCKMIDSTLGHILRF 248
| .| |..| |.| .| | | ||
145 .......LSCNNFNAVFSRISTR...............LQELTV...... 166
249 VAASNPSEYFEFIRKSVQVPVTQTHTHSHSHSHSLPSSVYNSIVPHFDLF 298
|| | |..||||
167 ....................................CSEDNVDVHDIELL 180
299 SFIYLSKHNFKKYLELIKNLSVTLRKTIYHCLLLHYSAKAIMFWIMARPA 348
|| |. .|||.|. ..|... |.| | ||| .||| || . |.
181 QYINVDCAKLKRLLK.ETAFKFKALKKVAQLAVINSLEKAFWNWVENYPD 229
349 EYYELFNLLKDNNNEHSKSLNTLNHTLFEEIH.....STFNVNSMITTNQ 393
|| .||.| ..| .| ...| .| ..| |... ..|.| || . |
230 EFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPE 279
394 NAHQGSSSPSSSSPSSPPSSSSSDNNNQNIIAKSLSRQLSHHQSYIQQQS 443
|| |... ..|| |..|| .||.|.|. |.|
280 IIQDISKDV...........VDENNMNKKLFLDSLRKALAGHGG...... 312
444 ERKLHSSWTTNSQSSTSLSSSTSNSTTTDFSTHTQPGEYDPSLPDTPTMS 493
|. |||.. .||. |.. || .||..|. . .|| ...|.
313 .....SRQLTESAAIACVKLCKA.STYINWEDNSVIFLLVQSM..VVDLK 354
494 NITISASSLLSQTPTPTTQLQQRLNSAAAAAAAAASPSNSTPTGYTAEQQ 543
|| |.||. ||... |. | | .. ... || |. . .. .|.
355 NLLFNPSKPFSRGSQPA...DVDLMIDCLVSCFRISPHNNQHFKICLAQN 401
544 SRASYDAHKTGHTGKDYDEHFLSVTRLDNVLELYTHFDDTEVLPHTSVLK 593
|...| ||| |..|..||. .|.|.
402 SPSTF..............HYVLVNSLHRIIT.............NSALD 424
594 FLTTLTMF...DIDLFNELNATSFKYIPDCTMHRP.........KERTSS 631
||..|. . .||| | |..| | |.||. |.| |||..|
425 WWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTS 474
632 FNNTAHETGSEKTSGIKHITQGLKKLTSLPSSTKKTVKFVKMLLRNLNGN 681
|. ....|| | |.|.|.| || ||. .. |||| | . .
475 LKFKEKPTDLE.TRSYKYLLLSMVKLIHADP.........KLLLCNPRKQ 514
682 QAVSDVALLDTMRALLSFFTMTSAVFLVDRNLPSVLFAKRLIPIMGTNLS 731
.| .|.. | | ||| |.. . . |.| .|..||. ..| .| | .
515 GPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPD 564
732 VGQDWNSKINNSLMVCLKKNSTTFVQLQLIFFSSAIQFDHELLLARLSID 781
.. | ..|.. ||.|| |. |. ||| .. |.| |||||.|
565 APVETFWEISSQMLFYICKKLTSH...QMLSSTEILKWLREILICR.... 607
782 TMANNLNMQKLCLYTEGFRIFFDIPSKKELRKAIAVKISKFFKTLFSIIA 831
.| ||. | | | | |||| .
608 .........................NKFLLKNKQADRSSCHFLLFYGVGC 632
832 DILLQEFPYFDEQITDIVASILDGTIINEYGTKKHFKGSSPSLCSTTRSR 881
|| ..
633 DI..............................................PS 636
882 SGSTSQSSMTPVSPLGLDTDICPMNTLSLVGSSTSRNSDNVNSLNSSPKN 931
||.||| ||. |. | ..|.| ..|..|| .|| .
637 SGNTSQMSMD..............HEELLRTPGASLRKGKGNSSMDSAAG 672
932 LSSDPYLSHLVAPRARHALGGPSSIIRNKIPTTLTSPPGTEKSSPVQRPQ 981
||.| ||| ...| || | . ||||
673 CSGTPPICRQAQTKLEVAL............YMFLWNPDTE......... 701
982 TESISATPMAITNSTPLSSAAFGIRSPLQKIRTRRYSDESLGKFMKSTNN 1031
|. |||. .||..| ||||.||.| || .||.. |.
702 .....AVLVAMSCFRHLCEEA.DIRCGVDEV........SVHNLLPNYNT 737
1032 YIQEHLIPKDLNEATLQDARRIMINIFSIFKRPNSYFIIPHNINSNLQWV 1081
||| |.. |..| . .||||
738 FMEFASVSNMMSTGRAALQKRVM........................... 760
1082 SQDFRNIMKPIFVAIVSPDVDLQNTAQSFMDTLLSNVITYGESDENISIE 1131
.|||.| |..| . .|||| ..| |.
761 .....ALLRRIEHPTAGNTEAWEDTHAKWEQA.................. 787
1132 GYHLLCSYTVTLFAMGLFDLKINNEKRQILLDITVKFMKVRSHLAGIAEA 1181
| | |.. . |||||. . |. || .
788 ..........TKLILNYPKAKMEDGQAAESLHKTI..............V 813
1182 SHHMEYISDSEKLTFPLIMGTVGRALFVSLYSSQQKIEKTLKIAYTEYLS 1231
.|||..|||||.|.|. . | || |. |||||
814 KRRMSHVSGGGSIDLSDTDSLQEW..................INMTGFLC 845
1232 AINFHERNIDDADKTWVHNIEFVEAMCHDNYTTSGSIAFQRRTRNNILRF 1281
|| |||.||.|....| |
846 AL................................GGVCLQQRSNSGLATY 863
1282 ATIPNAILLDSMRMIYKKWHTYTHSKSLEKQERNDFRNFAGILASLSGIL 1331
.. .|| . .|| |||.| |.
864 SPPMGPVSERKGSMI.........................SVMSSEGNAD 888
1332 FINKKILQEMYPYLLDTVSELKKNIDSFISKQCQWLNYPDLLTRENSRDI 1381
.|||| |...|| . ..| || .|.| |||
889 TPVSKFMDRLLSLMVCNHEKV..................GLQIRTNVKDL 920
1382 LSVELHPLSFNLLFNNLRLKLKELACSDLSIPENESSYVLLEQIIKMLRT 1431
||||| | | ||||.|| .|..| || | .|.. ||||.| |||.
921 VGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKN 970
1432 ILGRDDDNYVMMLFSTEIVDLIDLLTDEIKKIPAYCPKYLKAIIQMTKMF 1481
|||...|. | ..| .|| |. || |.. .. |. ..|..|.
971 LLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHA.IQIKTKLCQLV 1019
1482 SALQHSEVNLGVKNHFHVKNKWLRQITDWFQVSIAREYDFENLSKPLKEM 1531
..| . |||. ..|..||| | ||||. .. ... | .||
1020 EVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAAD........DDV 1061
1532 DLVKRDMDILYIDTAIEASTAIAYLTRHTFLEIPPAASDPELSRSRSVIF 1581
. |.|||| ||..|. .|||. |..|.|.|| .|| ||
1062 KCLTRDLDQASMEAVVSLLAGLPLQ........PEEGDGVELMEAKSQLF 1103
1582 GFYFNILMKGLEKSSDRDNYPV.......FLRHKMSVLNDNVILSLTNLS 1624
||.|||. ||.||| || .. |.|||. |.. .||.|.||
1104 LKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLASLRHCTVLAMSNLL 1153
1625 NTNVDASLQFTLPMGYSGNRNIRNAFLEVFINIV...TNYRTYTAKTDLG 1671
|.|||.|| .|.||| | ..|..|||||..|| ||| |..... |
1154 NANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLAD 1203
1672 KLEAADKFLRYTIEHPQLSSFG..AAVCPASDIDAYAAGLINAFETRNAT 1719
||| .|| ||.||. |.|.|.|| |..| .||. ||.||
1204 RFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
1720 HIVVAQLIKNEIEKSSRPTDILRRNSCATRSLSMLARSKGNEYLIRTLQP 1769
. || .||..||| ... .||| || |.| |.| | |..|| | |||
1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDP 1303
1770 LLKKIIQNRDF....FEIE..KLKPEDSDAERQIELFVKYMNELLESISN 1813
||| || ..|| |||| ||.|.|| .|.| ||| . |.||..| .
1304 LLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNLL.QMTEKFFHAIIS 1352
1814 SVSYFPPPLFYICQNIYK.....................VACEKFPDHAI 1842
| | |||.| ||| ||. |.|||||||.|
1353 SSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSI 1402
1843 IAAGSFVFLRFFCPALVSPDSENIIDISHLSE.KRTFISLAKVIQNIANG 1891
|.|| |||||| |||||| ...||| .. . .|.| |.||||.|||
1403 GAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANH 1452
1892 SENFSRWPALCSQKDFLKECSDRIFRFLAELCRTDRTIDIQVRTDPTPIA 1941
|.| . | . .||||. | ||| ||... .| .||. .
1453 VL.FTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPT......SDAVNHS 1495
1942 FDYQFLHSFVYLYGLEVRRNVLNEAKHDDGDIDGDDFYKTTFLLIDDVLG 1991
|.| ..| |. | ||.| . |.. .|| | ... | .| |..|||
1496 LSFISDGNVLALHRL.LWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLA 1544
1992 QLGQPKMEFSNEIPIYIREHMD.DYPELYEFMNRHAFRNIETSTA...YS 2037
||.|. ..|| |. || . ..| |||.||..|| |. .| .|
1545 YLGPPE...HKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLS 1591
2038 PSVHESTSSEGIPIITLTMSNFSDRHVDIDTVAYKFLQIYARIWTTKHCL 2087
|.|||..| ||| .. ..|.. ||| | | |..| .. ..|.... |
1592 IFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEI 1641
2088 IIDCTEFDEGGLDMRKFISLVMGLLPEVAPKNCIGCYYFNVNETFMDNYG 2137
||| |. |.|. . .||| |.||||.| .|. |.|.||.| .|| ||.
1642 VVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCN.SWVREYT 1690
2138 KCLDKDNVYVSSKIPHYFINSNSDEGLMKSVG.....ITGQGLKVLQDIR 2182
|| || |..| | .. || ||.| | . || |.|..| | ||||
1691 KYHER..LLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLK 1738
2183 VSLHDITLYDEKRNRFTPVSLKIGDIYFQVLHETPRQYKIRDMGTLFDVK 2232
| |.|.| ... |.||||||.. .|| ..| . || | |.|
1739 VFHNALKLAHKD....TKVSIKVGSTAVQV..TSAERTKVLGQSVF.... 1778
2233 FNDVYEISRIFEVHVSSITGVAAEFTVTF.QDERRLIFSSPKYLEIVKMF 2281
||||| | | || | . ..|||||| .|| .|.| ..| .||. |
1779 LNDIYYASEIEEICLVD....ENQFTLTIANQGTPLTFMHQECEAIVQSI 1824
2282 YYAQIRLESEYEMDNNSSTSSPNSNNKDKQQKERTKLLCHLLLVSLIGLF 2331
.. ..||| | ||| .... |.| .| . || |.||.|
1825 IHIRTRWE..........LSQPDSIPQHTKIRPK.DVPGTLLNIALLNLG 1863
2332 DESKKMKNSSYNLIAATEASFGLNFGSHFHRSPEVYVPEDTTTFLGVIGK 2381
.....||...||||.| ...|.|.||||| ..|||||.|.| ||. |||
1864 SSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISK 1913
2382 SLAESNPELTAYMFIYVLEALKNNVI..PHVYIPHTICGLSYWIPNLYQH 2429
.||..||.|| || .|.||... | .||||.. .. || ||. ||.|
1914 TLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVR.FCKH 1962
2430 VYLADDEEGPENISHIFRILIRLSVRETDFKAVYMQYVWLLLLDDGRLTD 2479
|||. .|.|. || || |.|.|.|| | . . || | | . | |
1963 ....NDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLD 2008
2480 IIVDEVINH....ALERDSENRDWKKTISLLTV...LPTTEVANNIIQKI 2522
||||..|. |||. ..| ...|.| .. |....| ..|.. |
2009 VVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKII 2058
2523 LAKIRSFLPSLKLEAMTQSWSELTILVKISIHVFFETSLLVQMYLPEILF 2572
.. | |.|. . | |.||.||.|. | | ||.|| |. .|| ||
2059 DKTCLSPTPTLEQHLM...WDDIAILARYMLMLSFNNSLDVAAHLPYLFH 2105
2573 IVSLLIDVGPRELRSSLHQLLMNVCHSLAINSAL..PQDHRNNLDEISDI 2620
||.|||..|| .||.| |.|||||.|||.. |.| .|| |. | .
2106 VVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTE 2155
2621 FAHQKVKFMFGFSEDKGRIL.........QIFSASSFASK...FNILDFF 2658
|. .|. ||||||. || | . ||||||... |. || .
2156 FSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETV 2205
2659 INNILLLME.YSSTYEANVWKTRYKKYVLESVFTSNSFLSARSIMIVGIM 2707
.|.|| ||| | ..... | ..|.... .| |. | ||.|||.|.|
2206 TEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCI 2255
2708 GKSYITEGLCKA...MLIETMKVIAEPKITDEHLFLAISHIFTYSKIVEG 2754
||. |..| .|. || ..|. . ... | | .| . ||...|| .
2256 SKR.VSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPL 2304
2755 LDPNLDLMKHLFWFSTLFLESRHPIIFEGALLFVSNCIRRL......... 2795
||.| .| | |||... .|| .. ||.|| ||.. || |
2305 LNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDK 2354
2796 .....YMA..................QFENESETSLISTLLKG....... 2815
||| .||.| | .||| ||||
2355 SPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPA 2404
2816 .....RKFAHTFLSKIENLSGIVWNEDNFTHILIFIINKGLSNPFIKSTA 2860
|| ||||. ||. ... . | | | .| .|||.. ....
2405 IVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCS 2454
2861 FDFLKMMF..........RNSYFEHQINQK...............SDHYL 2885
|. | || .|.| || |.. || ||
2455 LKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYL 2504
2886 CYMFLLY.........................FVLNCNQFEELLGDV... 2907
. | || . . ||.||||.
2505 AATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAP 2554
2908 ...DFEGEMVNIENKNTIPKILLE....WLSSDNENAN...ITLYQGAIL 2947
||||||.. .... ||.. .| ||||..|||| |.| ||.||
2555 KRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVL 2604
2948 FKCSVTDEPSRFRFAL.................IIRHLLTKKPICALRFY 2980
|. .| .||. | | || ..|.. .|. |.|
2605 LDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVF 2654
2981 SVIRN....EIRKISAFEQNSDCVPLAFDILNLLVTHSESNS......LE 3020
.|||| .|..| .| ||.| | |||. || |.|| . ||
2655 PVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQ 2704
3021 KLHEESIERLT...KRGLSIVTSSGIFAKNSDMMIP..LDVKPEDIYERK 3065
.| ||| ||. .|. |.. .|||.| | ||. |.. .||. | .
2705 SFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEES 2754
3066 RIM......TMILSRMSCSA.............................. 3079
| . | |.||..|
2755 LLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPT 2804