Additional features of the TMA Deconvoluter
Note: manual operation is recommended only for
users who are familiar with the TMA-Deconvoluter.
While automatic operation of the TMA Deconvoluter for this system
is sufficient for many users, it is possible to run the TMA
Deconvoluter manually for increased flexibility. When automatic
operation is selected (by choosing one of the two output options and
then clicking "Run Deconvoluter", the following is performed:
- The raw scoring workbooks are deconvoluted and outputted
to a new worksheet in the TMA Deconvoluter, based on the output option
- The scores in each output worksheet is converted to new
scores, based on the output option.
- Each worksheet is output to a text file and saved.
Manual operation entails running each of these steps separately,
and the user may choose not to run all of these steps. This added
flexibility is helpful -- for example, the user may choose to:
- keep the scores unchanged, skipping step 2
- not output any files, skipping step 3
- perform other data manipulations following deconvolution
in step 1 prior to outputting to files.
To perform manual operations, select the "Run deconvoluter manually"
option, as shown below:
In this state, the Deconvoluter will, by default, output in a
format ready for K-M (or other) analysis. To output in cluster-ready
format, check the corresponding option, as shown above. You will
notice that this checkbox option is now enabled while the Deconvoluter
is in manual mode.
Proceed as you would for normal operation in running the
Deconvoluter. You will notice, however, that clicking on "Run
Deconvoluter" will run only the Deconvolution step. To execute the
other steps, click on one of the manual operation buttons, as shown below:
These operations can be performed in any order (after deconvolution),
but the user should know what (s)he is doing to the data.
- Convert Score -- Using the Score Conversion
Utility, the scores are converted based on user settings.
- Transpose -- transpose the data by swapping the x
and y-axis. Note: Because fo Excel's 256-column limit, it is
highly inadvisable to perform transposition on a data set that
contains more than 250 cases.
- Output files -- output the data from the output
worksheets in the TMA-Deconvoluter to text tab-delimited files.
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