Androgen-induced Transcriptional Programs

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Due to the limitations of printed figures (in terms of size and resolution), these supplemental figures are offered as an alternative. They are meant to fully represent the data produced by these analyses, including full genelists with names and annotations. These figure supplements are presented in PDF format, which allows the viewer to zoom-in as necessary.

	Supplementary Figure 1: Hierarchical cluster analysis and list of representative androgen-regulated genes measured in microarray analysis of LNCaP cells treated with 1 nM R1881. Contains the complete image with all gene names and dendrogram trees.

	Supplementary Figure 2: Gene expression changes in LNCaP treated with R1881 1 nM and with dihydrotestosterone (DHT) 10 nM, DHT 100 nM, and DHT 1000 nM. Note the apparent increase in gene expression with successively higher doses of DHT. On the far right are two experiments in which LNCaP cells were deprived of androgen for 48 and 72 hrs that display reciprocal expression patterns.

	Supplementary Figure 3: Hierarchical clustering analysis of expression patterns of androgen-responsive genes in 4 prostate cancer cell lines and sublines. Contains the complete image with all gene names and dendrogram trees.

	Supplementary Figure 4: Cluster of genes whose relative abundance changed by more than 2-6 fold in at least 2 of the prostate cancer cell lines' arrays.

	Supplementary Figure 5: Androgen responsive genes in LNCaP cells that likely represent secreted and membrane-bound proteins.