Figure 4 Expression profiles of SBF and MBF targets. (a) The expression patterns of SBF and MBF targets are indicated (red-green colour scale). Cell-cycle data is from Spellman et al, sporulation data is from Chu et al. The stages of the cell cycle are indicated as follows: M/G1; yellow, G1; green, S; blue, S/G2; red, G2/M; orange. Yellow boxes indicate the presence of consensus binding sites in the intergenic sequences upstream of each ORF (right panel), and the median percentile rank in immunoprecipitations of the upstream sequences is indicated (blue-yellow colour scale) as in Figure 3. For each set of targets, the top panel contains cell-cycle regulated genes, the bottom panel contains genes that were members of divergently transcribed pairs in which the other member was cell-cycle regulated, and the middle panel contains the remainder of the non-cell cycle regulated genes. (b) Average expression profiles of the cell-cycle regulated targets of SBF and MBF, computed by averaging the log2 (Cy5/Cy3) ratios. Note the specific induction of MBF targets during sporulation.