Supplemental Figure 6. An AC lung tumor exhibits morphological heterogeneity and tumor progression. The primary tumor from patient 319 (top, tumor grade 2) shows glandular differentiation with few areas of solid growth (indicated by arrows). The two intrapulmonary metatases from the same patient, MT1 (middle) and MT2 (bottom), both tumor grade 3, show poor tumor differentiation and solid growth. MT2 has large nuclei and clear cell de-differentiation.