ORF Gene Copies/cell t1/2 (min) mRNAs/hr Txn Rate %tile Rank Ribosomal? RAP1 Target? RAP1 ORF %tile Rnk Promoter1 Promoter2 P1 RAP1 %tile Rnk P2 RAP1 %tile Rnk . ORF CNTL Val P1 CNTL %tile Rnk P2 CNTL %tile Rnk Desc YNL145W MFA2 36 5 282.7 1 0.067054358 iYNL146W 0.332552172 0.011843377 0.174347406 "MFA2 -- mating -- Mating pheromone a-factor, nearly identical to a-factor encoded by MFA1, exported from the cell by Ste6p" YGL189C RPS26A 76.1 14 208.4 0.9998 1 1 0.885964513 iYGL189C 0.983275148 0.645182082 0.610620496 "RPS26A -- protein synthesis -- Ribosomal protein S26 (rat S26), nearly identical to Rps26Bp" YBR191W RPL21A 64.7 12 202.4 0.9996 1 0.972012214 0.975146199 "RPL21A -- protein synthesis -- Ribosomal protein L21 (rat L21), nearly identical to Rpl21Bp" YPL079W RPL21B 85.7 16 201.6 0.9994 1 1 0.915109144 iYPL080C 0.965890967 0.887390263 0.473357792 "RPL21B -- protein synthesis -- Ribosomal protein L21 (rat L21), nearly identical to Rpl21Ap" YHR021C RPS27B 65.6 13 192.4 0.9992 1 1 0.954280116 iYHR021C 0.975392559 0.746331237 0.337306202 "RPS27B -- protein synthesis -- Ribosomal protein S27 (yeast S27rp61YS20mammalian S27), nearly identical to Rps27Ap" YGR192C TDH3 89 18 188.1 0.999 1 0.941253994 iYGR192C 0.92473861 0.981887589 0.592117173 "TDH3 -- glycolysis -- Glyceraldehyde-3-phosphate dehydrogenase 3, converts D-glyceraldehyde 3-phosphate to 1,3-dephosphoglycerate" YLR110C YLR110C 81.6 16 183.5 0.9988 1 0.927300964 iYLR110C 0.910306302 0.4867111 0.321599115 "YLR110C -- unknown -- Cell wall manno similarity to Flo1p, Fig2p, Flo5p, Yal063p, and Ykr102p" YGL031C RPL24A 50.1 11 175.3 0.9986 1 1 0.927102758 iYGL031C IntYGL033W 0.986535535 0.484832874 0.879127838 0.815923207 0.422173566 "RPL24A -- protein synthesis -- Ribosomal protein L24A (yeast L30rp29YL21rat L24), nearly identical to Rpl24Bp" YGR118W RPS23A 52.9 11.5 173.7 0.9984 1 1 0.972694824 iYGR117C 0.959779417 0.973765432 0.00489229 "RPS23A -- protein synthesis -- Ribosomal protein S23 (yeast S28rp37YS14E. coli S12rat S23), identical to Rps23Bp" YFR031C-A RPL2A 56 12 172.1 0.9982 1 1 0.949338187 iYFR031C-A 0.969026628 0.955712788 0.126645895 RPL2A -- protein synthesis -- Ribosomal protein L2 (Yeast L5YL6rp8E. coli L2tobacco L2rat L8) YKL060C FBA1 74.1 16 167.9 0.998 0.953112516 iYKL060C 0.646653647 0.965805718 0.278021442 "FBA1 -- glycolysis -- Fructose-bisphosphate aldolase II, sixth step in glycolysis" YIL018W RPL2B 54.9 12 164.4 0.9978 1 1 0.97780263 iYIL019W 0.997316274 0.941437445 0.069866696 RPL2B -- protein synthesis -- Ribosomal protein L2 (yeast L5YL6rp8E. coli L2tobacco L2rat L8) YGR148C RPL24B 55.8 13 163.7 0.9976 1 1 0.93263124 iYGR148C 0.97676142 0.643256464 0.385214623 "RPL24B -- protein synthesis -- Ribosomal protein L24B (yeast L30rp29YL21rat L24), nearly identical to Rpl24Ap" YER102W RPS8B 47.3 11 162.7 0.9974 1 1 0.964208383 iYER101C 0.96463574 0.968863435 0.565535431 "RPS8B -- protein synthesis -- Ribosomal protein S8 (yeast S14YS9rp19mammalian S8), identical to Rps8Ap" YBL072C RPS8A 53.7 12 160 0.9972 1 1 0.954583848 iYBL072C 0.972994376 0.92496157 0.550375091 "RPS8A -- protein synthesis -- Ribosomal protein S8 (yeast S14YS9rp19mammalian S8), identical to Rps8Bp" YJL136C RPS21B 54.1 13 156.6 0.997 1 1 0.945433013 iYJL136C 0.991247823 0.854035639 0.297621986 "RPS21B -- protein synthesis -- Ribosomal protein S21 (yeast S26YS25rat S21), identical to Rps21Ap" YKL097W-A CWP2 71.6 17 153.9 0.9968 "CWP2 -- -- Mannocell wall, member of PAU1 family" YKR057W RPS21A 63 15 152.9 0.9964 1 1 0.933711948 iYKR056W 0.928363283 0.97677063 0.672865124 "RPS21A -- protein synthesis -- Ribosomal protein S21 (yeast S26YS25rat S21), identical to Rps21Bp" YDL229W SSB1 44.3 11 152.9 0.9964 1 0.652156158 iYDL230W 0.926610881 0.507519432 0.704681972 "SSB1 -- translation -- Heat shock HSP70 family, involved with the translational machinery" YGR085C RPL11B 52 12.5 152.3 0.9962 1 1 0.97041757 iYGR085C 0.978354675 0.757179297 0.428685779 "RPL11B -- protein synthesis -- Ribosomal protein L11 (yeast L16YL22rp39BE. coli L5rat L11), nearly identical to Rpl11Ap" YOL039W RPP2A 49.4 12 152.1 0.996 1 1 0.920095068 iYOL040C 0.986685069 0.600456235 0.673503591 "RPP2A -- protein synthesis -- Acidic ribosomal protein P2A (L44A2YP2alphaE. coli L12eIBhuman P2alpha), plays a role in the elongation step" YGL123W RPS2 50.1 12 148.6 0.9958 1 1 0.966318014 iYGL124C 0.991165154 0.948284118 0.246331237 RPS2 -- protein synthesis -- Ribosomal protein S2 (yeast S4YS5YP9rp12E. coli S5rat S2) YBL087C RPL23A 54.2 14 147 0.9956 1 1 0.980130282 iYBL087C 0.995291061 0.959957765 0.703114727 "RPL23A -- protein synthesis -- Ribosomal protein L23 (yeast L17aYL32E. coli L14rat L23), nearly identical to Rpl23Bp" YNL178W RPS3 52.7 14 144.4 0.9954 1 1 0.920457763 iYNL179C-0 iYNL179C-1 0.342874268 0.926242596 0.786307908 0.198493551 0.797370332 "RPS3 -- protein synthesis -- Ribosomal protein S3 (rp13YS3mammalian S3), has a possible KH domain" YJR123W RPS5 37.4 10 142.9 0.9952 1 1 0.962550344 iYJR122W 0.981281829 0.995530726 0.056799871 RPS5 -- protein synthesis -- Ribosomal small subunit RPS5 (rp14YS8S2mammalian S5) YHR203C RPS4B 45.9 12 140.7 0.995 1 1 0.959733784 iYHR203C 0.992944654 0.962083769 0.614663046 "RPS4B -- protein synthesis -- Ribosomal protein S4 (yeast S7YS6rp5rat and human S4), identical to Rps4Ap" YGL135W RPL1B 61.7 16 138.9 0.9948 1 1 0.976012195 iYGL136C 0.991967285 0.994972067 0.908959072 "RPL1B -- protein synthesis -- Large subunit ribosomal protein L1 (rat L10Aeubacterial L1archeal L1), identical to Rpl1Ap" YHR174W ENO2 61.1 17 134.7 0.9946 0.949418007 iYHR173C 0.846153169 0.932530004 0.591965096 ENO2 -- glycolysis -- Enolase 2 (2-phosphoglycerate dehydratase)converts 2-phospho-D-glycerate to phosphoenolpyruvate in glycolysis YER117W RPL23B 50.3 14 133.6 0.9944 1 1 0.959954454 iYER116C 0.988975343 0.977783263 0.286687631 "RPL23B -- protein synthesis -- Ribosomal protein L23 (yeast L17aYL32E. coli L14rat L23), nearly identical to Rpl23Ap" YDR154C YDR154C 61.4 17 130.7 0.9942 YDR154C -- unknown -- unknown function YDR050C TPI1 53.2 15 130.4 0.994 0.803376262 iYDR050C 0.858991757 0.41979116 0.807179987 "TPI1 -- glycolysis -- Triosephosphate isomerase, interconverts glyceraldehyde-3-phosphate and dihydroxyacetone phosphate" YOL121C RPS19A 45.6 13 128.2 0.9938 1 1 0.967391001 iYOL121C 0.992693026 0.962264151 0.438175351 "RPS19A -- protein synthesis -- Ribosomal protein S19 (rp55YS16Arat S19), nearly identical to Rps19Bp" YLR167W RPS31 52.5 15 126.6 0.9936 1 1 0.967557465 iYLR166C 0.98895835 0.930716695 0.74597164 RPS31 -- protein synthesis -- Fusion protein comprised of C-terminal half of ribosomal protein S31 and N-terminal half of ubiquitin (yeast S37YS24rat S27a) YGL103W RPL28 50.3 15 126.3 0.9934 1 1 0.981716523 iYGL104C IntYGL103W 0.992609447 0.95278586 0.857791754 0.337231969 0.733564572 RPL28 -- protein synthesis -- Ribosomal protein L28 (yeast L29YL24rp44mouse and rat L27a) YOL086C ADH1 51.1 15 125.6 0.9932 1 0.597234644 iYOL086C 0.965460828 0.384756584 0.399209486 "ADH1 -- glycolysis -- Alcohol dehydrogenase I, cytoplasmic isozyme reducing acetaldehyde to ethanol, regenerating NAD+" YJL190C RPS22A 39.1 12 124.1 0.993 1 1 0.975171513 iYJL190C 0.988807766 0.913986355 0.848167196 "RPS22A -- protein synthesis -- Ribosomal protein S22 (yeast S24rp50YS22rat S15A), nearly identical to Rps22Bp" YOR293W RPS10A 40.2 12 124 0.9926 1 1 0.961652867 iYOR292C 0.987197368 0.660159716 0.343378756 "RPS10A -- protein synthesis -- Ribosomal protein S10 (rat S10), nearly identical to Rps10Bp" YMR116C ASC1 43.9 13 124 0.9926 1 0.893521971 iYMR116C 0.948851403 0.871680643 0.900765243 "ASC1 -- protein synthesis (putative) -- Abundant effects on translational efficiency and cell size, has two WD (WD-40) repeats" YHR010W RPL27A 50.1 15 122.9 0.9922 1 1 0.961902721 iYHR009C IntYHR010W 0.985386052 0.925097389 0.852239768 0.235412299 0.250719987 "RPL27A -- protein synthesis -- Ribosomal protein L27 (yeast L27mammalian L27), identical to Rpl27Bp" YJL189W RPL39 46 14 122.9 0.9922 1 1 0.95258444 iYJL190C 0.988807766 0.576292666 0.848167196 RPL39 -- protein synthesis -- Ribosomal protein L39 YGR034W RPL26B 44.8 14 122.1 0.9919 1 1 0.961454784 iYGR033C 0.987378407 0.917956903 0.278131806 "RPL26B -- protein synthesis -- Ribosomal protein L26 (yeast L33YL33rat L26), nearly identical to Rpl26Ap" YJR094W-A RPL43B 41.4 13 122.1 0.9919 1 1 0.927396101 iYJR094C-0 iYJR094C-1 0.736135422 0.967842065 0.605945859 0.587077519 0.378826942 "RPL43B -- protein synthesis -- Ribosomal protein L43B (human L37A), identical to Rpl43Ap" YDR382W RPP2B 51.2 16 121.5 0.9917 1 0.952890758 iYDR381W 0.480458418 0.957025846 0.242656134 RPP2B -- protein synthesis -- Acidic ribosomal protein P2B (L45YPA1YL44CYP2 betaE. coli L12eIAhuman and rat P2) YNL302C RPS19B 42.9 13 121.4 0.9915 1 1 0.918665841 iYNL302C 0.972822332 0.840074122 0.076456504 "RPS19B -- protein synthesis -- Ribosomal protein S19 (rp55YS16Brat S19), nearly identical to Rps19Ap" YLR075W RPL10 55.5 17 120.6 0.9913 1 1 0.969570702 iYLR074C 0.965446025 0.973024741 0.430309378 RPL10 -- protein synthesis -- Ribosomal protein L10 (yeast L9) YDL130W RPP1B 40.8 12.5 120 0.9911 1 1 YDL130W-A iYDL130W-A 0.962267233 0.991910612 0.262724853 0.328560849 0.560103964 RPP1B -- protein synthesis -- Acidic ribosomal protein P1B (L44primeAxYP1betaE. coli L12eIIBhuman and rat P1beta) YOR182C RPS30B 51.2 16 119.4 0.9909 1 0.962279645 iYOR182C 0.820741405 0.428700732 0.42985365 "RPS30B -- protein synthesis -- Ribosomal protein S30B (mammalian S30), identical to Rps30Ap" YIL133C RPL16A 27.4 8 119.3 0.9907 1 1 0.945180429 iYIL133C 0.987965791 0.908368274 0.573911631 "RPL16A -- protein synthesis -- Ribosomal protein L16 (rp22), nearly identical to Rpl16Bp" YKL056C YKL056C 47.4 15 118.7 0.9905 0.852290009 iYKL056C 0.688827181 0.708495776 0.419023152 "YKL056C -- unknown -- Protein possibly involved in cytoplasmic ribosome function, has similarity to translationally controlled tumor protein (TCTP) of animal cells and higher plants" YPR132W RPS23B 42.2 13 118.1 0.9903 1 1 0.945197694 iYPR131C 0.978777689 0.561710372 0.063725095 "RPS23B -- protein synthesis -- Ribosomal protein S23 (yeast S28rp37YS14E. coli S12rat S23), identical to Rps23Ap" YLR287C-A RPS30A 54.2 17 116.6 0.9901 1 1 0.958377171 iYLR287C-A 0.992465259 0.556448993 0.323766627 "RPS30A -- protein synthesis -- Ribosomal protein S30A (mammalian S30), identical to Rps30Bp" YGL147C RPL9A 34.5 11 115.8 0.9899 1 0.945694295 iYGL147C 0.188112132 0.448884758 0.195836419 "RPL9A -- protein synthesis -- Ribosomal protein L9 (YL11rp25rp24E. coli L6rat L9), nearly identical to Rpl9Bp" YPL143W RPL33A 45.5 15 115.6 0.9897 1 1 0.948009226 iYPL144W IntYPL143W 0.96529996 0.934599878 0.875586275 0.362875972 "RPL33A -- protein synthesis -- Ribosomal protein L33 (yeast L37YL37rp47rat L35A), nearly identical to Rpl33Bp" YPL131W RPL5 37 12 115.4 0.9895 1 1 0.872377716 iYPL132W 0.96977249 0.262504224 0.637665968 "RPL5 -- protein synthesis -- Ribosomal protein L5 (yeast L1YL3rat L5), the sole 5S rRNA-associated ribosomal protein" YML026C RPS18B 29.3 9 114.8 0.9893 1 1 0.929464639 iYML026C 0.971598079 0.706864564 0.694247502 "RPS18B -- protein synthesis -- Ribosomal protein S18 (E. coli S13rat S18), identical to Rps18Ap" YBR031W RPL4A 44.6 15 113.2 0.9891 1 0.878142424 iYBR030W 0.377640571 0.956844398 0.186577398 "RPL4A -- protein synthesis -- Ribosomal protein L4 (yeast L2YL2rp2Xenopus L1Drosophila L1rat L4), nearly identical to Rpl4Bp" YDL191W RPL35A 41.2 14 113.1 0.9889 1 1 0.959142758 iYDL192W IntYDL191W 0.994037988 0.971908744 0.74663225 0.916612955 0.855607966 "RPL35A -- protein synthesis -- Ribosomal protein L35 (rat L35), identical to Rpl35Bp" YNL031C HHT2 37.6 12 111.7 0.9887 0.918971222 iYNL031C 0.486693347 0.944018714 0.575219811 "HHT2 -- chromatin structure -- Histone H3, identical to Hht1p" YML024W RPS17A 36.4 12 110.7 0.9885 1 1 0.945596734 iYML025C 0.991089628 0.90622506 0.056465274 "RPS17A -- protein synthesis -- Ribosomal protein S17 (rp51rat S17), nearly identical to Rps17Bp" YCR012W PGK1 60.4 20 110.5 0.9883 0.919472585 iYCR011C 0.746110646 0.901904263 0.217247335 PGK1 -- glycolysis -- Phosphoglycerate kinase YKL180W RPL17A 33.2 11 109.7 0.9881 1 1 0.947662388 iYKL181W 0.952801601 0.921588726 0.69668807 "RPL17A -- protein synthesis -- Ribosomal protein L17 (yeast L20YL17E. coli L22rat and human L17), nearly identical to Rpl17Bp" YDL083C RPS16B 31.2 11 109.5 0.9879 1 1 0.958887857 iYDL083C 0.998369768 0.329418723 0.683603734 "RPS16B -- protein synthesis -- Ribosomal protein S16 (rp61Rrat S16), identical to Rps16Ap" YBL092W RPL32 37 13 108.5 0.9877 1 1 0.888452823 iYBL093C 0.98206533 0.586013645 0.655546688 RPL32 -- protein synthesis -- Ribosomal protein L32 YOR234C RPL33B 36.5 12.5 107.8 0.9875 1 1 0.946819749 iYOR234C YOR235W 0.988788132 0.987736951 0.87150838 0.38624208 0.250625151 "RPL33B -- protein synthesis -- Ribosomal protein L33 (yeast L37YL37rp47rat L35A), nearly identical to Rpl33Ap" YPL220W RPL1A 44.8 16 106.9 0.9873 1 1 0.978306846 iYPL221W 0.982413434 0.946438655 0.377573823 "RPL1A -- protein synthesis -- Large subunit ribosomal protein L1 (rat L10Aeubacterial L1archeal L1), identical to Rpl1Bp" YPR080W TEF1 49.7 17 106.7 0.9871 1 0.952291632 iYPR079W 0.996651421 0.793103448 0.108430799 "TEF1 -- protein synthesis -- Translation elongation factor EF-1alpha, identical to Tef2p" YKL006W RPL14A 34.1 12 106.2 0.9869 1 1 0.964819242 iYKL006C-A 0.979317633 0.872953134 0.713733235 "RPL14A -- protein synthesis -- Ribosomal protein L14 (mammalian L14), nearly identical to Rpl14Bp" YDL075W RPL31A 45.4 16 104.4 0.9867 1 1 0.926033603 iYDL076C 0.973746268 0.614844374 0.106832098 "RPL31A -- protein synthesis -- Ribosomal protein L31 (yeast L34YL36YL28rat L31), nearly identical to Rpl31Bp" YHL015W RPS20 42.9 15 104.1 0.9863 1 1 0.962695484 iYHL016C 0.966818835 0.665880503 0.291179337 RPS20 -- protein synthesis -- Ribosomal protein S20 (E. coli S10Xenopus S22rat and human S20) YLR388W RPS29A 38.2 14 104.1 0.9863 1 1 0.75531304 iYLR387C 0.976171593 0.300501934 0.731923384 "RPS29A -- protein synthesis -- Ribosomal protein S29 (yeast S36YS29rat S29), similar to Rps29Bp" YBR010W HHT1 45.5 16 103.3 0.9861 0.914663789 iYBR009C 0.482182923 0.955566527 0.627374302 "HHT1 -- chromatin structure -- Histone H3, identical to Hht2p" YLR044C PDC1 43.7 16 103.2 0.9859 1 0.915259139 iYLR044C 0.978186951 0.733483725 0.641946191 PDC1 -- glycolysis -- Pyruvate decarboxylase isozyme 1 YLR061W RPL22A 39 14 102.1 0.9857 1 1 0.972267797 iYLR060W 0.960405458 0.613720852 0.548338374 "RPL22A -- protein synthesis -- Ribosomal protein L22, similar to Rpl22Bp" YAL038W CDC19 50.4 18 101.3 0.9855 1 0.938255472 iYAL039C-0 iYAL039C-1 0.845290926 0.947763209 0.744658157 0.825532274 0.179010375 "CDC19 -- glycolysis -- Pyruvate kinase, catalyzes final step in glycolysis" YOL109W ZEO1 39.4 15 98.9 0.9851 1 0.94145371 iYOL110W 0.9641438 0.776467505 0.019632881 ZEO1 -- zeocin resistance -- leads to resistance to zeocin when overproduced YJR009C TDH2 34.1 13 98.9 0.9851 1 0.93714383 iYJR009C-0 iYJR009C-1 0.440022378 0.374192569 0.8865048 0.541841521 0.866065627 "TDH2 -- glycolysis -- Glyceraldehyde-3-phosphate dehydrogenase 2, converts D-glyceraldehyde 3-phosphate to 1,3-dephosphoglycerate" YOR063W RPL3 36.7 14 97.4 0.9849 1 0.898423962 iYOR062C 0.452407721 0.918868837 0.740143839 "RPL3 -- protein synthesis -- Ribosomal protein L3 (YL1rp1rat L3) , responsible for trichodermin resistance and involved in maintenance of dsRNA viruses" YOL040C RPS15 30.6 12 97.2 0.9847 1 1 0.879805142 iYOL040C 0.986685069 0.435992579 0.673503591 RPS15 -- protein synthesis -- Ribosomal protein S15 (yeast S21rp52E. coli S19rat S15RIG protein) YNL162W RPL42A 32.1 12 96.2 0.9845 1 1 0.961354547 iYNL163C 0.976840993 0.891959394 0.86632083 "RPL42A -- protein synthesis -- Ribosomal protein L42 (yeast L41YL27YP44human and rat L36A), identical to Rpl42Bp" YDR450W RPS18A 33.7 13 95.4 0.9843 1 1 0.95885076 iYDR449C 0.983170496 0.818226121 0.542631282 "RPS18A -- protein synthesis -- Ribosomal protein S18 (E. coli S13rat S18), identical to Rps18Bp" YPR102C RPL11A 34.5 13 95 0.984 1 1 0.962893938 iYPR102C 0.993661589 0.738007076 0.262011173 "RPL11A -- protein synthesis -- Ribosomal protein L11 (yeast L16YL22rp39AE. coli L5rat L11), nearly identical to Rpl11Bp" YGL008C PMA1 43.1 17 95 0.984 0.914205976 iYGL008C 0.757011612 0.749888402 0.143545117 "PMA1 -- H+ homeostasis -- H+-transporting P-type ATPase of plasma membrane required for nutrient uptake and pH homeostasis, activity is rate limiting for growth at low pH" YOR369C RPS12 35.6 14 94.5 0.9838 1 1 0.792336913 iYOR369C 0.977510757 0.130364988 0.743089976 RPS12 -- protein synthesis -- Ribosomal protein S12 (rat S12) YIL052C RPL34B 34.4 14 93.8 0.9836 1 1 0.934649263 iYIL052C 0.975158775 0.959226771 0.415726716 "RPL34B -- protein synthesis -- Ribosomal protein L34 (rat L34), nearly identical to Rpl34Ap" YLR441C RPS1A 31 12.5 93.2 0.9834 1 1 iYLR441C 0.990521645 0.34002371 "RPS1A -- protein synthesis -- Ribosomal protein S1 (rp10rat S3A), nearly identical to Rps1Bp" YPR043W RPL43A 42.3 17 92.9 0.9832 1 1 0.95315301 iYPR042C 0.944816701 0.857293697 0.584206848 "RPL43A -- protein synthesis -- Ribosomal protein L43A (human L37A), identical to Rpl43Bp" YHL001W RPL14B 34.8 14 91.5 0.983 1 1 0.979612968 iYHL002W 0.983938009 0.968981631 0.266161213 "RPL14B -- protein synthesis -- Ribosomal protein L14 (mammalian L14), nearly identical to Rpl14Ap" YOL120C RPL18A 31.5 13 91.3 0.9828 1 1 0.985381504 iYOL120C 0.533483399 0.978381867 0.507297854 "RPL18A -- protein synthesis -- Ribosomal protein L18 (rp28rat L18), identical to Rpl18Bp" YGL030W RPL30 36.7 15 89.9 0.9826 1 1 0.971730122 iYGL031C 0.986535535 0.959060123 0.815923207 RPL30 -- protein synthesis -- Large-subunit ribosomal protein L30 (yeast L32YL38rp73mouse and rat L30) YBR118W TEF2 49.6 20 89.6 0.9824 1 0.96135838 iYBR117C 0.987106709 0.778387969 0.476502446 "TEF2 -- protein synthesis -- Translation elongation factor EF-1alpha, identical to Tef1p" YLR249W YEF3 26.4 11 87.7 0.9822 0.895497856 iYLR248W 0.903637948 0.856481481 0.229613385 "YEF3 -- protein synthesis -- Translation elongation factor EF-3A, member of non-transporter group of ATP-binding cassette (ABC) superfamily" YDR500C RPL37B 41.9 18 87.6 0.982 1 1 0.983298808 iYDR500C 0.989216992 0.835723493 0.149021663 "RPL37B -- protein synthesis -- Ribosomal protein L37 (yeast L46) (rat L37), nearly identical to Rpl37Bp" YBR181C RPS6B 33.8 14 87.2 0.9818 1 1 0.922309721 iYBR181C 0.992063689 0.839106145 0.532960894 "RPS6B -- protein synthesis -- Ribosomal protein S6 (yeast S10YS4rp9human, mouse, and rat S6), identical to Rps6Ap" YDR447C RPS17B 34.5 15 86.2 0.9816 1 1 0.968997895 iYDR447C 0.981874847 0.970396064 0.633419272 "RPS17B -- protein synthesis -- Ribosomal protein S17 (rp51rat S17), nearly identical to Rpl17Ap" YHR055C CUP1B 50.5 22 85.7 0.9814 0.267936511 iYHR055C 0.188794455 0.74612929 0.610055231 CUP1B -- Cu2+ ion homeostasis -- Metallothionein (copper chelatin)identical to Cup1Ap YLR185W RPL37A 32.1 14 85.2 0.9812 1 1 0.958919731 iYLR184W 0.965031569 0.912020625 0.721714803 "RPL37A -- protein synthesis -- Ribosomal protein L37 (yeast L46rat L37), nearly identical to Rpl37Bp" YIL053W RHR2 24.9 11 84.9 0.981 1 0.909242723 iYIL054W 0.886985467 0.687865497 0.303793302 RHR2 -- glycerol metabolism -- DL-glycerol phosphate phosphatase YDR461W MFA1 14.4 6 84.4 0.9808 0.692209748 iYDR460W 0.4326316 0.569026698 0.396363038 "MFA1 -- mating -- Mating pheromone a-factor, nearly identical to a-factor encoded by MFA2, exported from the cell by Ste6p" YOR096W RPS7A 26.7 11.5 83.8 0.9806 1 1 0.941135756 iYOR095C 0.976495063 0.755559136 0.509506929 "RPS7A -- protein synthesis -- Ribosomal protein S7 (rp30human S7Xenopus S8), nearly identical to Rps7Bp" YDR064W RPS13 28.2 12 83.7 0.9804 1 1 0.954455666 iYDR063W IntYDR064W 0.957834805 0.970552012 0.673779456 0.812769354 0.821881092 RPS13 -- protein synthesis -- Ribosomal protein S13 (yeast S27YS15rat S13) YDL136W RPL35B 32.1 14 82.6 0.98 1 1 0.961561597 iYDL137W 0.988039429 0.703616352 0.796727853 "RPL35B -- protein synthesis -- Ribosomal protein L35 (rat L35), identical to Rpl35Ap" YDL082W RPL13A 25.9 12 82.6 0.98 1 1 0.968217252 iYDL083C 0.998369768 0.927508373 0.683603734 "RPL13A -- protein synthesis -- Ribosomal protein L13 (rat L13), nearly identical to Rpl13Bp" YDR033W MRH1 23.6 11 82.3 0.9798 0.659137502 iYDR032C-0 iYDR032C-1 0.395648302 0.7248602 0.484047696 0.177075619 0.758853151 MRH1 -- unknown -- similarity to Yro2p YIL148W RPL40A 30.2 13.5 82.1 0.9796 1 1 0.961642831 iYIL149C 0.985554147 0.94868316 0.599821313 "RPL40A -- protein synthesis -- Fusion protein comprised of ribosomal protein L40 (C-terminal half) and ubiquitin (N-terminal half) (rat L40), identical to Rpl40Bp" YDL081C RPP1A 34.2 15 82 0.9794 1 0.783147904 iYDL081C 0.494050821 0.391263941 0.389399357 RPP1A -- protein synthesis -- Acidic ribosomal protein P1A (A1YP1alphaE. coli L12eIIAhuman and rat P1) YHR053C CUP1A 48.9 22 81.5 0.9792 0.200059486 iYHR053C 0.186288994 0.78026942 0.518437297 CUP1A -- Cu2+ ion homeostasis -- Metallothionein (copper chelatin)identical to Cup1Bp YJR145C RPS4A 25.5 12 81.2 0.979 1 1 0.963562929 iYJR145C 0.990511147 0.983954579 0.710817133 "RPS4A -- protein synthesis -- Ribosomal protein S4 (yeast S7YS6rp5rat and human S4), identical to Rps4Bp" YPL090C RPS6A 27.2 12 80.9 0.9788 1 1 0.738857503 iYPL090C 0.976084742 0.090828426 0.294988892 "RPS6A -- protein synthesis -- Ribosomal protein S6 (yeast S10YS4rp9human, mouse, and rat S6), identical to Rps6Bp" YLR406C RPL31B 24 11.3 80.1 0.9786 1 1 0.616325667 iYLR406C 0.996825698 0.449876983 0.935035914 "RPL31B -- protein synthesis -- Ribosomal protein L31 (yeast L34YL36YL28rat L31), nearly identical to Rpl31Ap" YDR471W RPL27B 22.1 10 79.9 0.9784 1 1 0.961179588 iYDR470C 0.990595751 0.931707357 0.435859459 "RPL27B -- protein synthesis -- Ribosomal protein L27 (yeast L27mammalian L27), identical to Rpl27Ap" YDR225W HTA1 29.1 13.5 79 0.9782 0.860142561 iYDR224C 0.879388188 0.828010952 0.712294554 "HTA1 -- chromatin structure -- Histone H2A, identical to Hta2p" YOL127W RPL25 28.4 13 78.5 0.978 1 1 0.970579941 iYOL128C 0.995341592 0.982818424 0.676952193 RPL25 -- protein synthesis -- Ribosomal protein L25 (YL25rp61LE. coli L23rat L23a) YOR167C RPS28A 32.8 15.5 77.6 0.9778 1 0.675310284 iYOR167C 0.663755581 0.506953016 0.375370679 "RPS28A -- protein synthesis -- Ribosomal protein S28 (yeast S33YS27mammalian S28), nearly identical to Rps28Bp" YLR448W RPL6B 25 12 77.4 0.9776 1 1 0.94931424 iYLR447C 0.989642005 0.894305509 0.705422529 "RPL6B -- protein synthesis -- Ribosomal protein L6 (yeast L17BYL16Bhuman L6), nearly identical to Rpl6Ap" YBR189W RPS9B 25.7 12 76.2 0.9774 1 1 0.979570835 iYBR188C 0.986112327 0.888844075 0.827827908 "RPS9B -- protein synthesis -- Ribosomal protein S9 (yeast S13YS11YP28rp21E. coli S4rat S9), nearly identical to Rps9Ap" YNL069C RPL16B 27.1 13 75.5 0.9772 1 1 0.942941632 iYNL069C 0.990468502 0.933128983 0.240681313 "RPL16B -- protein synthesis -- Ribosomal protein L16 (rp23), nearly identical to Rpl16Ap" YDR418W RPL12B 23.1 11 74.9 0.977 1 1 0.959245345 0.961655558 "RPL12B -- protein synthesis -- Ribosomal protein L12 (yeast L15YL23E. coli L11rat L12a), identical to Rpl12Ap" YDR134C YDR134C 37.6 19 74 0.9768 0.709140606 iYDR134C 0.661289494 0.372705507 0.238398324 "YDR134C -- unknown -- unknown function, probably pseudogene ORF, has strong similarity to FLO1" YOR312C RPL20B 25.8 13 73.7 0.9766 1 1 0.915724961 iYOR312C 0.955305225 0.646260183 0.446583951 "RPL20B -- protein synthesis -- Ribosomal protein L20, nearly identical to Rpl20Ap" YJL177W RPL17B 23.7 12 72 0.9764 1 1 0.93351642 iYJL178C 0.981795382 0.789202433 0.180526736 "RPL17B -- protein synthesis -- Ribosomal protein L17 (yeast L20YL17E. coli L22rat and human L17), nearly identical to Rpl17Ap" YGL253W HXK2 19.3 10 71.9 0.9761 0.858010052 iYGL254W 0.313906427 0.870695257 "HXK2 -- glycolysis -- Hexokinase II, converts hexoses to hexose phosphates in glycolysis and plays a regulatory role in glucose repression" YKL216W URA1 16.2 8 71.9 0.9761 0.23212202 iYKL217W 0.178964301 0.582846004 0.330164357 "URA1 -- pyrimidine biosynthesis -- Dihydroorotate dehydrogenase, catalyzes fourth step in pyrimidine biosynthesis pathway" YDR025W RPS11A 23.5 12.3 71.3 0.9759 1 1 0.917140123 0.736354776 "RPS11A -- protein synthesis -- Ribosomal protein S11 (yeast S18YS12rp41E. coli S17human and rat S11), identical to Rps11Bp" YKL156W RPS27A 26.6 14 71 0.9757 1 1 0.97383689 iYKL157W 0.98490652 0.889560263 0.444038337 "RPS27A -- protein synthesis -- Ribosomal protein S27 (yeast S27rp61YS20mammalian S27), nearly identical to Rps27Bp" YLR029C RPL15A 24.1 13 70.9 0.9755 1 0.914546422 iYLR029C 0.885812264 0.934690774 0.422169811 "RPL15A -- protein synthesis -- Ribosomal protein L15 (yeast L13YL10rp15Rrat L15), nearly identical to Rpl15Bp" YGL076C RPL7A 26.7 14 70.6 0.9753 1 1 0.934947666 iYGL076C 0.92733753 0.815055762 0.383365822 "RPL7A -- protein synthesis -- Ribosomal protein L7 (yeast L6YL8Arp11E. coli L30rat L7), nearly identical to Rpl7Bp" YBL003C HTA2 24.5 13 69.3 0.9751 0.790783736 iYBL003C 0.396439072 0.659853249 0.510546288 "HTA2 -- chromatin structure -- Histone H2A, identical to Hta1p" YKR094C RPL40B 21.7 11.5 69 0.9749 1 1 0.972994722 iYKR094C 0.988725428 0.937546285 0.5581189 "RPL40B -- protein synthesis -- Fusion protein comprised of ribosomal protein L40 (C-terminal half) and ubiquitin (N-terminal half), (rat L40), identical to Rpl40Ap" YCR031C RPS14A 33.5 18 68.6 0.9747 1 1 0.970642183 iYCR031C SNR189 0.391235882 0.982725285 0.981044724 0.415987739 0.583870448 "RPS14A -- protein synthesis -- Ribosomal protein S14A (rp59, E. coli S11, rat and human S14) involved in crytopleurine resistance, nearly identical to Rps14Bp" YHR141C RPL42B 24.4 13 67.2 0.9743 1 0.975469868 iYHR141C 0.601883986 0.976946517 0.063426911 "RPL42B -- protein synthesis -- Ribosomal protein L42 (yeast L41YL27YP44human and rat L36A), involved in replication of M1 and M2 double-stranded RNA (dsRNA) viruses, identical to Rpl42Ap" YLR300W EXG1 23.9 13 67.2 0.9743 0.785930703 iYLR299W 0.807684101 0.757142857 0.67661531 "EXG1 -- cell wall biogenesis -- Exo-beta-1,3-glucanase (I/II)major isoform involved in cell wall beta-glucan assembly" YLL045C RPL8B 23.5 13 66 0.9741 1 1 0.95757855 0.870816458 "RPL8B -- protein synthesis -- Ribosomal protein L8 (yeast L4rp6YL5human, rat, and mouse L7a), involved in maintenance of M1 dsRNA virusnearly identical to Rpl8Ap" YNL030W HHF2 23.9 14 65.3 0.9739 0.799575302 iYNL031C 0.486693347 0.708181048 0.575219811 "HHF2 -- chromatin structure -- Histone H4, identical to Hhf1p" YDR155C CPH1 30.6 17 65.1 0.9737 iYDR155C 0.292725389 0.497271513 "CPH1 -- protein folding -- Cyclophilin (peptidylprolyl cis-trans isomerase or PPIase) of cytosol, plays a role in the stress response" YER074W RPS24A 24.5 14 64.7 0.9735 1 1 0.95473387 iYER073W 0.985322246 0.68764914 0.352095517 "RPS24A -- protein synthesis -- Ribosomal protein S24 (rat S24), identical to Rps24Bp" YBR084C-A RPL19A 25.1 14 64.4 0.9733 1 1 0.940214165 iYBR084C-A 0.985655862 0.945712672 0.377094972 "RPL19A -- protein synthesis -- Ribosomal protein L19 (yeast L23YL14rp15Lrp33rat L19), nearly identical to Rpl19Bp" YKL152C GPM1 32.3 19 64 0.9731 1 0.928203959 iYKL152C 0.884347502 0.67382949 0.281359189 GPM1 -- glycolysis -- Phosphoglycerate mutase that converts 2-phosphoglycerate to 3-phosphoglycerate in glycolysis YLR333C RPS25B 20.9 12 63.9 0.9727 1 1 0.957323156 iYLR333C 0.991096001 0.949423248 0.740654206 "RPS25B -- protein synthesis -- Ribosomal protein S25B (yeast S31YS23rp45rat S25), identical to Rps25Ap" YEL027W CUP5 27.6 16 63.9 0.9727 0.343923804 iYEL028W YELCdelta3 0.667082291 0.684222885 0.467692556 0.907508862 0.514421528 CUP5 -- ATP synthesis -- Vacuolar H(+)-ATPase (V-ATPase) dicyclohexylcarbodiimide (DCCD)-binding 16 kDa proteolipid subunit (subunit c) of membrane (V0) sector YDR224C HTB1 21.2 12 63.7 0.9725 0.822197002 iYDR224C 0.879388188 0.417016375 0.712294554 HTB1 -- chromatin structure -- Histone H2B YDR385W EFT2 23.1 13 63.6 0.9723 0.820114197 iYDR384C 0.257096797 0.988207547 0.341614907 "EFT2 -- protein synthesis -- Translation elongation factor EF-2, identical to Eft1p, contains diphthamide which is not essential for its activity" YIL069C RPS24B 23.1 14 63.4 0.9721 1 1 0.91925684 iYIL069C 0.85623476 0.789434707 0.502355426 "RPS24B -- protein synthesis -- Ribosomal protein S24 (rat S24), identical to Rps24Ap" YML028W TSA1 24.9 15 62.7 0.9717 0.918401801 iYML029W 0.55127893 0.961902411 0.267403404 "TSA1 -- oxidative stress response -- Thioredoxin peroxidase, abundant thiol-specific antioxidant prevents formation of sulfur-containing radicals" YOR133W EFT1 23.9 14 62.7 0.9717 0.763899306 iYOR132W 0.560348542 0.704376479 0.713963056 "EFT1 -- protein synthesis -- Translation elongation factor EF-2, contains diphthamide which is not essential for activity, identical to Eft2p" YDR012W RPL4B 24.7 14.8 61.8 0.9715 1 0.706259641 iYDR011W 0.468295851 0.682119649 0.699898614 "RPL4B -- protein synthesis -- Ribosomal protein L4 (yeast L2YL2rp2Xenopus L1Drosophila L1rat L4), nearly identical to Rpl4Ap" YLR264W RPS28B 24 14 61.5 0.9711 1 0.821981686 iYLR263W 0.833141772 0.551799441 0.533979734 "RPS28B -- protein synthesis -- Ribosomal protein S28 (yeast S33YS27mammalian S28), nearly identical to Rps28Ap" YNL112W DBP2 11.5 7 61.5 0.9711 0.371726662 iYNL113W IntYNL112W 0.44593013 0.631942564 0.545198195 0.453878407 0.55805151 DBP2 -- mRNA decay -- ATP-dependent RNA helicase of DEAD box family YNL301C RPL18B 21.2 13 60.7 0.9709 1 1 0.980993088 iYNL301C 0.798203651 0.733524839 0.400388645 "RPL18B -- protein synthesis -- Ribosomal protein L18 (rp28rat L18), identical to Rpl18Ap" YBL027W RPL19B 23.6 14.5 60.5 0.9707 1 1 0.93891878 iYBL028C 0.982135054 0.942901235 0.831935709 "RPL19B -- protein synthesis -- Ribosomal protein L19 (yeast L23YL14rp15Lrp33rat L19), nearly identical to Rpl19Ap" YDL192W ARF1 28.5 18 59.9 0.9705 0.961435414 iYDL193W 0.896468819 0.813190383 0.809347644 "ARF1 -- secretion -- GTP-binding assembly of coated vesicles of secretory system, member of arf family" YMR142C RPL13B 19.4 12 59.7 0.9703 1 1 0.930470345 iYMR142C 0.989894369 0.697812887 0.44408788 "RPL13B -- protein synthesis -- Ribosomal protein L13 (rat L13), nearly identical to Rpl13Ap" YDR276C SNA1 21.6 13 59.6 0.9701 1 0.954511326 iYDR276C 0.967036926 0.540926685 0.829424833 "SNA1 -- unknown -- Small, abundant plasma membrane proteolipid protein, has similarity to stress-induced proteins" YEL009C GCN4 22.3 14 59.4 0.9697 1 0.927144114 iYEL009C 0.935478602 0.903727475 0.203351955 "GCN4 -- amino acid, purine biosynthesis -- Transcription factor of basic leucine zipper (bZIP) family, regulates general control in response to amino acid or purine starvation" YHR193C EGD2 26.7 17 59.4 0.9697 0.798867141 iYHR193C 0.895875186 0.58810854 0.217049679 EGD2 -- protein synthesis (putative) -- Alpha subunit of nascent polypeptide-associated complex YER056C-A RPL34A 17.2 11 59 0.9695 1 1 0.906302814 iYER056C-A 0.976564844 0.61887462 0.651478233 "RPL34A -- protein synthesis -- Ribosomal protein L34 (rat L34), nearly identical to Rpl34Bp" YGR060W ERG25 20.5 13 58.8 0.9691 0.585167903 iYGR059W SNR48 0.791032443 0.595914938 0.602484983 0.732242618 0.623831776 ERG25 -- sterol metabolism -- C-4 sterol methyl oxidaseenzyme of ergosterol biosynthesis pathway YJL158C CIS3 20.4 13 58.8 0.9691 0.590435243 iYJL158C 0.186333634 0.369949807 0.202387674 CIS3 -- unknown -- Cell wall similarity to members of Pir1p/Hsp150p/Pir3p family YDL061C RPS29B 23.4 15 58.2 0.9689 1 1 0.798890848 iYDL061C 0.989542094 0.273686755 0.337988827 "RPS29B -- protein synthesis -- Ribosomal protein S29 (yeast S36YS29rat S29), similar to Rps29Ap" YLR048W RPS0B 16.6 11 57.8 0.9687 1 1 0.948936072 iYLR047C 0.984267245 0.749526866 0.287681649 "RPS0B -- protein synthesis -- Ribosomal protein S0 (E. coli S2rat Sb), nearly identical to Rps0Ap" YKR059W TIF1 21.4 14 57.7 0.9685 0.879143402 iYKR058W 0.372263966 0.990090968 0.472937001 "TIF1 -- protein synthesis -- Translation initiation factor 4A (eIF4A) of DEAD box family, identical to Tif2p" YLR340W RPP0 24.6 16 57.6 0.9683 1 1 0.924066305 0.905219005 RPP0 -- protein synthesis -- Acidic ribosomal protein A0 YEL054C RPL12A 18.6 12 57.4 0.9682 1 1 0.952039471 iYEL054C 0.997878693 0.769005848 0.820175439 "RPL12A -- protein synthesis -- Ribosomal protein L12 (yeast L15YL23E. coli L11rat L12b), identical to Rpl12Bp" YLR325C RPL38 30.1 20 56.9 0.968 1 1 0.946285303 iYLR325C 0.087127668 0.808235867 0.066387029 RPL38 -- protein synthesis -- Ribosomal protein L38 YGR234W YHB1 8.8 6 56.3 0.9678 0.924452793 iYGR233C-0 iYGR233C-1 0.815014959 0.576538491 0.972794863 0.645357663 0.824723847 "YHB1 -- oxidative stress response (putative) -- Flavohemoglobin involved in protection from nitrosative stress, distantly related to animal hemoglobins" YDL055C PSA1 15.2 10 55.8 0.9676 1 0.86615605 iYDL055C-0 iYDL055C-1 0.953937151 0.970178413 0.936073424 0.201581028 0.564222826 PSA1 -- mannose metabolism -- Mannose-1-phosphate guanyltransferaseGDP-mannose pyrophosphorylase YEL017C-A 21.8 14.5 55.6 0.9674 0.529592957 iYEL017C-A 0.083591889 0.157844165 0.038833387 YGR214W RPS0A 17.1 11.5 55.3 0.9672 1 1 0.940348903 iYGR213C 0.96418684 0.976283301 0.395019385 "RPS0A -- protein synthesis -- Ribosomal protein S0 (E. coli S2rat Sa), nearly identical to Rps0Bp" YGR037C ACB1 15.4 10 54.7 0.967 0.212087398 iYGR037C 0.446577305 0.341021548 0.620020964 ACB1 -- fatty acid metabolism -- Acyl-coenzyme-A binding protein YPL037C EGD1 22 15 54.4 0.9668 0.709891533 iYPL037C 0.35176004 0.816588497 0.357722203 EGD1 -- transcription -- Beta subunit of nascent polypeptide-associated complex YML073C RPL6A 19.3 13 53.9 0.9666 1 1 0.961860932 iYML073C 0.981969312 0.880196584 0.673496256 "RPL6A -- protein synthesis -- Ribosomal protein L6 (yeast L17AYL16Ahuman L6), nearly identical to Rpl6Bp" YHR089C GAR1 14.4 10 53.8 0.9664 0.41590105 iYHR089C 0.621904136 0.195405311 0.598183089 GAR1 -- rRNA processing -- 35S rRNA processing and pseudouridinylationassociated with the H/ACA class small nucleolar RNAs YLL024C SSA2 20.1 14 53.4 0.9662 0.862240967 iYLL024C 0.610132337 0.803500847 0.535250162 SSA2 -- ER and mitochondrial translocation -- Cytoplasmic chaperonemember of HSP70 family YAL003W EFB1 19.1 14 52.3 0.966 0.812971521 iYAL004W 0.496737589 0.590638092 0.285497006 "EFB1 -- protein synthesis -- Translation elongation factor EF-1beta, GDP/GTP exchange factor for Tef1p/Tef2p" YMR143W RPS16A 15.8 11 52.2 0.9656 1 1 0.946407997 iYMR142C 0.989894369 0.373663208 0.44408788 "RPS16A -- protein synthesis -- Ribosomal protein S16 (rp61Rrat S16), identical to Rps16Bp" YMR251W-A HOR7 29.1 21 52.2 0.9656 0.634231444 iYMR251W 0.269827732 0.529087468 0.18612707 HOR7 -- unknown -- responsiveness to hyperosmolarity YNL096C RPS7B 14.4 10.5 51.4 0.9654 1 1 0.979211647 iYNL096C 0.941876357 0.973504484 0.092571705 "RPS7B -- protein synthesis -- Ribosomal protein S7 (rp30human S7Xenopus S8), nearly identical to Rps7Ap" YDL014W NOP1 15.2 11 51.1 0.9652 0.607520657 iYDL015C 0.800695409 0.418991196 0.311204324 "NOP1 -- rRNA processing, 35S -- Fibrillarin, protein associated with small nucleolar RNA (snoRNA) and required for 35S rRNA processing and methylation" YEL034W HYP2 25 18 50.9 0.965 1 0.96668205 iYEL035C 0.954231369 0.853996935 0.347897638 HYP2 -- protein synthesis -- Translation initiation factor eIF5Acontains essential hypusine modification YBR106W PHO88 19.8 15 50.3 0.9648 0.845240308 iYBR105C 0.647673062 0.925059856 0.453616087 PHO88 -- phosphate transport -- Membrane inorganic phosphate transport YMR230W RPS10B 17.5 13 50.1 0.9646 1 1 0.95617695 iYMR229C 0.98122463 0.658415005 0.658949746 "RPS10B -- protein synthesis -- Ribosomal protein S10 (rat S10), nearly identical to Rps10Ap" YHL033C RPL8A 20 15 49.6 0.9644 1 1 0.964788166 iYHL033C 0.942584623 0.939465409 0.345712623 "RPL8A -- protein synthesis -- Ribosomal protein L8 (yeast L4rp6YL5human, mouse, and rat L7a), involved in maintenance of M1 dsRNA virusnearly identical to Rpl8Bp" YMR242C RPL20A 15.4 12 49 0.9642 1 1 0.928128292 iYMR242C 0.958369823 0.837488686 0.750080567 "RPL20A -- protein synthesis -- Ribosomal protein L20, nearly identical to Rpl20Bp" YLR355C ILV5 14.3 11 48.5 0.964 0.883713065 iYLR355C 0.52481834 0.814874566 0.828230744 "ILV5 -- isoleucine and valine biosynthesis -- Ketol-acid reductoisomerase (acetohydroxy-acid reductoisomerase, alpha-keto-beta-hydroxylacil reductoisomerase), second step in valine and isoleucine biosynthesis pathway" YGR254W ENO1 17.1 13 48.1 0.9638 1 0.94145486 iYGR253C-0 iYGR253C-1 0.731051944 0.860937648 0.831292298 0.482618583 0.286793372 "ENO1 -- glycolysis -- Enolase 1 (2-phosphoglycerate dehydratase), converts 2-phospho-D-glycerate to phosphoenolpyruvate in glycolysis" YLR150W STM1 19.1 15 47.5 0.9636 0.577073524 iYLR149C 0.239450312 0.298073697 0.088247157 STM1 -- unknown -- specific affinity for guanine-rich quadruplex nucleic acidsmulticopy suppressor of pop2 and tom1 YLR058C SHM2 14.9 12 46 0.9634 0.492842622 iYLR058C 0.370348077 0.438688366 0.189950978 "SHM2 -- one-carbon interconversion -- Serine hydroxymethyltransferase (glycine hydroxymethyltransferase), cytosolic isoform, interconverts serine and glycine" YFL039C ACT1 21.1 17 45.5 0.963 0.859554627 iYFL039C 0.222191069 0.917660329 0.119383722 "ACT1 -- cytoskeleton -- Actin, involved in cell polarization, endocytosis, and other cytoskeletal functions" YJL138C TIF2 17 14 45.5 0.963 0.900302128 iYJL138C 0.133013606 0.945793337 0.054206663 "TIF2 -- protein synthesis -- Translation initiation factor 4A (eIF4A) of DEAD box family, identical to Tif1p" YHR183W GND1 15.5 13 45 0.9626 0.582243758 iYHR182W 0.068479845 0.85490822 0.118318008 "GND1 -- pentose phosphate cycle -- 6-Phosphogluconate dehydrogenase, decarboxylating, converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2" YER056C FCY2 14.9 12 45 0.9626 0.773786859 iYER056C 0.511137921 0.658138402 0.331108483 "FCY2 -- transport -- Cytosine/purine permease, member of purine/cytosine permease family of membrane transporters" YDR226W ADK1 16.1 13 44.4 0.9624 0.769277894 iYDR225W 0.680589283 0.942260657 0.189186603 ADK1 -- metabolism -- Adenylate kinase (GTP YEL040W UTR2 14.1 12 44.1 0.9622 0.660221451 iYEL041W 0.666938909 0.358325477 0.666913519 UTR2 -- unknown -- Cell wall protein YHR026W PPA1 22.3 19 43.9 0.9618 0.687368895 iYHR025W 0.449077469 0.771908171 0.386999909 PPA1 -- vacuolar acidification -- Proteolipid of vacuolar H(+)-ATPase (V-ATPase) YIL051C MMD1 15.9 13 43.9 0.9618 0.983338842 iYIL051C 0.674384276 0.831088166 0.49886443 MMD1 -- maintenance of mitochondrial DNA -- important for maintenance of mitochondrial DNA YGR159C NSR1 12.2 10 43.4 0.9616 1 0.613182408 0.196169194 "NSR1 -- nuclear protein targeting -- Nucleolar processing 20S to 18S rRNA, has 2 RNA recognition (RRM) domains and is member of GAR (glycine/arginine-rich repeats) family of proteins" YDL208W NHP2 13.4 11 43.1 0.9614 iYDL209C 0.390009145 0.312091635 NHP2 -- unknown -- Nucleolar protein required in association with H/ACA snoRNAs for ribosomal RNA pseudouridinylation YLR109W AHP1 26.4 23 42.8 0.9612 0.891356566 iYLR108C 0.447390395 0.764724661 0.492924528 AHP1 -- oxidative stress response -- Alkyl hydroperoxide reductase YFL026W STE2 6.7 6 42.7 0.961 0.707844704 iYFL027C 0.458348397 0.845230422 0.563482268 "STE2 -- mating -- Pheromone alpha-factor G protein-coupled receptor (GPCR), member of GPCR or seven transmembrane segments (7-TMS) superfamily" YGR209C TRX2 20.7 18 42.6 0.9608 0.66945189 iYGR209C 0.556389515 0.689203354 0.457621656 TRX2 -- DNA replication -- Thioredoxin II YLR056W ERG3 14 12 42.5 0.9606 0.859353019 iYLR055C 0.145100604 0.743494424 0.070314215 "ERG3 -- sterol metabolism -- C-5 sterol desaturaseiron, non-heme, oxygen-requiring enzyme of ergosterol biosynthesis pathway" YNL067W RPL9B 14.6 13 42.1 0.9604 1 1 0.948598733 iYNL068C 0.972523751 0.556817247 0.284591195 "RPL9B -- protein synthesis -- Ribosomal protein L9 (YL11rp25rp24E. coli L6rat L9), nearly identical to Rpl9Ap" YEL026W SNU13 17.2 15 41.9 0.9603 0.643223415 iYEL027W 0.710164741 0.581269662 0.740114904 "SNU13 -- mRNA splicing (putative) -- Component of U4/U6.U5 snRNP, has similarity to nucleolar snoRNP protein Nhp2p" YNL209W SSB2 14.8 13 41 0.9599 0.763822359 iYNL210W 0.507059677 0.844308454 0.468419779 "SSB2 -- translation -- Heat shock HSP70 family, cytoplasmic" YHR094C HXT1 11.2 10 41 0.9599 0.416531853 iYHR094C 0.628592348 0.531391426 0.501995211 "HXT1 -- transport -- Low-affinity hexose transporter, member of hexose transporter family of major facilitator superfamily (MFS), induced by glucose only at high concentration" YER055C HIS1 11.7 11 40.8 0.9597 0.83094704 iYER055C 0.828034241 0.909010244 0.908364927 "HIS1 -- histidine biosynthesis -- ATP phosphoribosyltransferase, first step in histidine biosynthesis pathway" YDR233C YDR233C 12 11 40.4 0.9595 0.836429629 iYDR233C 0.311246803 0.93612707 0.407356619 YDR233C -- unknown -- unknown function YNL327W EGT2 10.4 10 40.3 0.9593 0.677201466 iYNL328C 0.899702578 0.10728402 0.284217641 "EGT2 -- cell cycle -- Cell-cycle regulation protein, may be involved in the correct timing of cell separation after cytokinesis" YOL139C CDC33 15.6 14 40.1 0.9591 0.57856163 iYOL139C 0.458252112 "CDC33 -- protein synthesis -- Translation initiation factor eIF4E, mRNA cap-binding protein found in association with Caf20p" YDR353W TRR1 14.7 14 39.8 0.9589 0.138377754 iYDR352W 0.642644035 0.356156595 0.539727353 "TRR1 -- pyrimidine metabolism -- Thioredoxin reductase, component of yeast peroxidase" YIL078W THS1 16.6 16 39.3 0.9587 0.639666506 iYIL079C 0.26756644 0.898565904 0.51908707 "THS1 -- protein synthesis -- Threonyl-tRNA synthetase, cytoplasmic, member of class II family of aminoacyl-tRNA synthetases" YJR104C SOD1 14.7 14 38.8 0.9585 0.711805625 iYJR104C 0.416519472 0.858059738 0.850073225 SOD1 -- oxidative stress response -- Copper-zinc superoxide dismutase YCR024C-A PMP1 21.3 20 38.7 0.9583 1 0.723775786 iYCR024C-A 0.977070121 0.184481198 0.373104549 PMP1 -- H+ homeostasis -- Plasma membrane proteolipid associated with Pma1p YBR048W RPS11B 15 16 38.3 0.9579 1 1 0.934386362 iYBR047W IntYBR048W 0.996583628 0.919823061 0.703637977 0.601608187 0.55490822 "RPS11B -- protein synthesis -- Ribosomal protein S11 (yeast S18YS12rp41E. coli S17human and rat S11), identical to Rps11Bp" YPR035W GLN1 14.6 14 38.3 0.9579 0.874696058 iYPR034W 0.522099892 0.702095302 0.466020266 "GLN1 -- glutamine biosynthesis -- Glutamine synthetase, combines ammonia to glutamate in ATP-driven reaction" YDR399W HPT1 10.4 10 38.2 0.9577 0.910298287 iYDR398W 0.166504776 0.957973703 0.160119384 HPT1 -- purine biosynthesis -- Hypoxanthine-guanine phosphoribosyl transferase YBR009C HHF1 17.3 17 38 0.9575 0.82300885 iYBR009C 0.482182923 0.725299282 0.627374302 "HHF1 -- chromatin structure -- Histone H4, identical to Hhf2p" YLR372W SUR4 12.6 12 37.9 0.9573 0.549276374 iYLR371W 0.557985899 0.658898643 0.534317638 SUR4 -- fatty acid metabolism -- the conversion of 24-carbon fatty acids to 26-carbon fatty acids YMR194W RPL36A 14 14 37.6 0.9571 1 1 0.945988462 0.715234102 "RPL36A -- protein synthesis -- Ribosomal protein L36 (yeast L39YL39rat L36), nearly identical to Rpl36Bp" YDR345C HXT3 12.9 13 37.5 0.9569 0.576091326 iYDR345C-0 iYDR345C-1 0.401627794 0.816714107 0.38791423 0.871588188 0.508197857 "HXT3 -- transport -- Low-affinity hexose transporter, member of hexose transporter family of major facilitator superfamily (MFS)" YML063W RPS1B 11.2 11 37.2 0.9567 1 1 0.969580457 iYML064C 0.985399771 0.883822108 0.525299282 "RPS1B -- protein synthesis -- Ribosomal protein S1 (rp10rat S3A), nearly identical to Rps1Ap" YNL244C SUI1 12.5 13 36.7 0.9565 0.335664787 iYNL244C 0.352373365 0.335000403 0.205878822 SUI1 -- protein synthesis -- 16 kDa subunit of translation initiation factor eIF3involved in initiation and in monitoring translational accuracy during elongation YER131W RPS26B 8.4 8 36.6 0.9561 1 1 0.91030159 iYER130C 0.974083212 0.830486626 0.494533635 "RPS26B -- protein synthesis -- Ribosomal protein S26 (rat S26), nearly identical to Rps26Ap" YHR162W YHR162W 13.7 14 36.6 0.9561 0.685909492 iYHR161C 0.018329448 0.974248913 0.112893936 YHR162W -- unknown -- unknown function YER177W BMH1 16.5 17 35.3 0.9559 0.835895134 iYER176W 0.087477464 0.778301887 0.042458101 "BMH1 -- unknown -- signal transduction during filamentous growth, homolog of mammalian 14-3-3 protein" YPR074C TKL1 11.2 12 35.2 0.9557 0.870203775 iYPR074C 0.67401559 0.953232243 0.5195425 TKL1 -- pentose phosphate cycle -- Transketolase 1 YPL198W RPL7B 14.3 16.5 34.3 0.9555 1 1 0.849048121 iYPL199C SNR59 0.943936035 0.815888078 0.621924659 0.325401307 0.451556265 "RPL7B -- protein synthesis -- Ribosomal protein L7 (yeast L6YL8Brp11E. coli L30rat L7), nearly identical to Rpl7Ap" YOR045W TOM6 12.1 13 34.2 0.9553 0.925692084 iYOR044W 0.684971067 0.583333333 TOM6 -- mitochondrial protein targeting -- Mitochondrial integral outer membrane protein associated with protein translocation complex YHR007C ERG11 14.7 16 34 0.9549 0.765880141 iYHR007C 0.339797873 0.352884306 0.185851416 "ERG11 -- sterol metabolism -- Cytochrome P450 (lanosterol 14alpha-demethylase), essential for biosynthesis of ergosterol" YPR145W ASN1 12 13 34 0.9549 0.546611456 iYPR144C SNR45 0.585774404 0.811626906 0.465059399 0.51931919 0.455607669 ASN1 -- asparagine biosynthesis -- Asparagine synthetase (L-aspartate YDR002W YRB1 17.1 19 33.6 0.9545 0.310614753 iYDR001C 0.158206343 0.436286678 0.208704147 YRB1 -- nuclear protein targeting -- stimulates GTPase activity of Gsp1p and Gsp2p in the presence of Rna1p YGL055W OLE1 11.2 12 33.6 0.9545 0.726751401 iYGL056C 0.166284433 0.975067884 0.408395102 "OLE1 -- fatty acid metabolism -- Stearoyl-CoA desaturase(delta-9 fatty acid desaturase), required for synthesis of unsaturated fatty acids" YDR133C YDR133C 26.5 29 33.5 0.9543 0.830120545 0.283219623 YDR133C -- unknown -- unknown function YMR321C YMR321C 8.8 10 33 0.9541 0.872792174 iYMR321C 0.561233731 0.878877643 0.203678309 "YMR321C -- unknown -- Protein nearly identical to a fragment of Sam4p, possibly a pseudogene" YOR310C NOP5 12.2 14 32.7 0.9539 0.417829095 iYOR310C 0.422821407 0.521599605 0.456365091 NOP5 -- ribosome biogenesis -- Nucleolar protein component of box C/D snoRNPs involved in 2'-O-methylation of ribosomal RNAs YHR179W OYE2 13.6 16 31.9 0.9535 0.734879115 iYHR178W 0.668526254 0.882202713 0.784597072 "OYE2 -- unknown -- NADPH dehydrogenase (old yellow enzyme), isoform 2" YLR175W CBF5 11.2 13 31.9 0.9535 0.554193391 iYLR174W 0.790758642 0.527129022 0.6753927 "CBF5 -- mitosis -- Putative ribosomal RNA pseudouridine synthase, associated with H/ACA class small nucleolar RNAs" YNL055C POR1 13.8 16 31.7 0.9533 0.564934238 iYNL055C 0.287177472 0.81475739 0.167701863 POR1 -- transport -- Outer mitochondrial membrane porin (voltage-dependent anion-selective channel) YLR344W RPL26A 9.4 11 31.2 0.9531 1 1 0.971827448 iYLR343W iYLRCdelta21 0.555447343 0.934336642 0.907347728 0.433235867 0.737513371 "RPL26A -- protein synthesis -- Ribosomal protein L26 (yeast L33YL33rat L26), nearly identical to Rpl26Bp" YGR279C SCW4 14 17 30.9 0.9527 0.395638591 iYGR279C 0.172432106 0.314511575 0.349358716 "SCW4 -- cell wall biogenesis -- Cell wall protein, has similarity to Scw10, Bgl2p, and other cell wall glucanases" YML106W URA5 12.7 15 30.9 0.9527 0.330446614 iYML107C 0.692326372 0.861182726 0.418649673 "URA5 -- pyrimidine biosynthesis -- Orotate phosphoribosyltransferase 1, catalyzes the fifth step in the pyrimidine biosynthesis pathway" YKL164C PIR1 14.6 17 30.8 0.9525 0.57601664 iYKL164C-0 iYKL164C-1 0.276315288 0.282097354 0.402130189 0.355140187 0.379728651 "PIR1 -- unknown -- tolerance to heat shock, member of Pir1p/Hsp150p/Pir3p family" YGR027C RPS25A 14.4 17 30.7 0.952 1 1 0.96840582 iYGR027C YGRCdelta12 0.986048156 0.808963222 0.957983927 0.709417398 0.532872542 "RPS25A -- protein synthesis -- Ribosomal protein S25A (yeast S31YS23rp45rat S25), identical to Rps25Bp" YBR196C PGI1 15.4 18 30.7 0.952 0.945489988 iYBR196C 0.90277436 0.974701901 0.332903122 "PGI1 -- glycolysis -- Glucose-6-phosphate isomerase, converts glucose 6-phosphate to fructose 6-phosphate" YBL030C PET9 14.3 17 30.7 0.952 0.614959714 iYBL030C-0 iYBL030C-1 0.772236947 0.946168319 0.748901506 0.648069961 0.513618037 PET9 -- transport -- ADP/ATP carrier mitochondrial carrier (MCF) family YOR153W PDR5 12 14 30.6 0.9518 0.842604276 iYOR152C-0 iYOR152C-1 0.13747787 0.033714808 0.813886672 0.226815642 0.060834958 "PDR5 -- drug resistance -- Drug-efflux pump involved in resistance to multiple drugs, member of ATP-binding cassette (ABC) superfamily" YLR043C TRX1 14.4 18 30.4 0.9516 0.862033552 iYLR043C 0.722220869 0.891975309 0.294311956 TRX1 -- DNA replication -- Thioredoxin I YGR285C ZUO1 17 21 30.1 0.9512 0.53625071 iYGR285C 0.387558416 0.628092578 0.202007735 "ZUO1 -- unknown -- Zuotin (Z-DNA-binding protein), has region of similarity to E. coli DnaJ chaperonin" YPR062W FCY1 12.9 16 30.1 0.9512 0.304549829 iYPR061C 0.238698946 0.442689048 0.458014036 FCY1 -- pyrimidine metabolism -- Cytosine deaminase YDR433W YDR433W 11.9 15 29.9 0.951 0.206098191 0.123900944 YDR433W -- unknown -- unknown functionquestionable ORF YMR202W ERG2 12.3 15 29.8 0.9508 0.682852319 iYMR201C 0.234393932 0.916431395 0.334468903 ERG2 -- sterol metabolism -- Sterol C8-C7 isomerase (C-8 sterol isomerase)enzyme of ergosterol biosynthesis pathway YGR155W CYS4 9.4 12 29.5 0.9506 0.793808133 iYGR154C 0.121372576 0.835674381 0.209001893 CYS4 -- methionine biosynthesis -- Cystathionine beta-synthase (beta-CTSase)converts serine and homocysteine to cystathionine YER043C SAH1 11.3 14 29.4 0.9504 0.790904561 iYER043C 0.336301206 0.937000887 0.252355426 SAH1 -- methionine biosynthesis -- Adenosylhomocysteinase YKR042W UTH1 22.3 28 29.2 0.95 0.835223302 iYKR041W 0.307540688 0.461867259 0.149416518 UTH1 -- aging -- the aging processmutants have longer lifespan and better viability upon starvation YGR175C ERG1 8.4 11 29.2 0.95 0.739790533 iYGR175C 0.468855649 0.776137271 0.411338764 "ERG1 -- sterol metabolism -- Squalene monooxygenase (squalene epoxidase), an enzyme of ergosterol biosynthesis pathway" YKL009W MRT4 11.2 14 29 0.9496 0.468270691 iYKL010C 0.795549574 0.480341605 0.488385315 MRT4 -- mRNA decay -- mRNA turnover YHR143W YHR143W 6.8 9 29 0.9496 0.419304477 iYHR142W 0.869708722 0.609649123 0.739278752 YHR143W -- unknown -- unknown function YBL002W HTB2 8.4 11 28.9 0.9492 0.808880532 iYBL003C 0.396439072 0.685451166 0.510546288 "HTB2 -- chromatin structure -- Histone H2B, nearly identical to Htb1p" YGL148W ARO2 8.3 11 28.9 0.9492 0.641114444 iYGL149W 0.30864881 0.854909154 0.150168683 ARO2 -- aromatic amino acid biosynthesis -- Chorismate synthase YOR309C YOR309C 10.8 14 28.5 0.9488 0.279210048 0.053950519 YOR309C -- unknown -- unknown function YJR105W YJR105W 9.5 12 28.5 0.9488 0.751578925 iYJR104C 0.416519472 0.895020947 0.850073225 YJR105W -- unknown -- similarity to ribokinase YLR286C CTS1 10.4 14 28.1 0.9486 1 0.92171916 iYLR286C 0.990830482 0.666209567 0.467828889 CTS1 -- cell wall biogenesis -- Endochitinase YNL135C FPR1 21.3 28 28 0.9484 0.263997487 iYNL135C 0.442238122 0.355588044 0.542458911 "FPR1 -- protein folding -- FK506-binding peptidylprolyl cis-trans isomerase (PPIase) activity, homolog of human FKBP12" YKL182W FAS1 8.4 11 27.9 0.9482 0.570998846 iYKL183W 0.87834074 0.642024333 0.391223683 "FAS1 -- fatty acid metabolism -- Fatty-acyl-CoA synthase, beta chain, contains acetyl transferase, enoyl reductase, enoyl dehydratase, and malonyl/palmitoyl transferase activities in a single polypeptide" YDR077W SED1 28.3 38 27.6 0.9478 0.054261946 iYDR076W 0.768481728 0.07074399 0.340486651 SED1 -- unknown -- Abundant cell surface glycomay contribute to cell wall integrity and stress resistanceoverexpression suppresses growth defect of erd2 YGL225W GOG5 10.7 14 27.6 0.9478 0.611048677 iYGL226W itV(AAC)G3-0 0.323345311 0.62780724 0.451237031 0.116177892 0.539001371 "GOG5 -- protein glycosylation -- Golgi GDP-mannose transporter, member of nucleotide-sugar transporter (NST) family of membrane transporters" YFL045C SEC53 9.4 13 27.5 0.9474 0.740077564 iYFL045C 0.667138938 0.804748226 0.341780377 "SEC53 -- protein glycosylation -- Phosphomannomutase, involved in the synthesis of GDP-mannose and dolichol-phosphate-mannose" YPL028W ERG10 9.1 12 27.5 0.9474 0.536657727 iYPL029W 0.531756491 0.472118959 0.813809217 ERG10 -- sterol metabolism -- Acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase)first step in mevalonate/sterol pathway YAL005C SSA1 13.4 18 27.4 0.947 0.811316322 iYAL004W 0.496737589 0.733665269 0.285497006 SSA1 -- ER and mitochondrial translocation -- Cytoplasmic chaperone and heat shock HSP70 family YOR224C RPB8 8 11 27.4 0.947 0.081717615 iYOR224C 0.037623873 0.033457249 0.008612078 "RPB8 -- transcription -- Shared subunit of RNA polymerases I, II, and III (ABC14.5)" YDR341C YDR341C 8 11 27.1 0.9468 0.557317019 iYDR341C 0.518680981 0.814471243 0.5255398 "YDR341C -- protein synthesis -- Arginine-tRNA synthetase, member of class I family of aminoacyl-tRNA synthetases" YNL064C YDJ1 14 19 27 0.9466 0.193378663 iYNL064C 0.283131546 0.530398323 "YDJ1 -- mitochondrial and ER protein targeting -- import into mitochondria and ER, homolog of E. coli DnaJ" YER019C-A SBH2 9.2 13 26.8 0.9464 0.563990344 iYER019C-A 0.30579423 0.598289909 0.717128585 "SBH2 -- secretion -- Component of Ssh1p-Sss1p-Sbh2p complex, involved in protein translocation into the endoplasmic reticulum" YDR023W SES1 9.1 13 26.7 0.9462 0.924727241 iYDR022C itV(UAC)D 0.483787303 0.85656946 0.494170328 0.172948971 0.758579409 "SES1 -- protein synthesis -- Seryl-tRNA synthetase, cytoplasmicmember of class II family of aminoacyl-tRNA synthetases" YLR180W SAM1 7.2 10 26.6 0.946 0.589393219 iYLR179C 0.447228947 0.862329435 0.398107469 SAM1 -- methionine metabolism -- S-adenosylmethionine synthetase 1 YHR039C-A 11.1 16 26.5 0.9458 0.295660795 iYHR039C-B 0.412507617 0.143680962 0.22571475 YLL050C COF1 15.4 21 26.4 0.9454 0.885906356 iYLL050C 0.616791898 0.704352835 0.319996773 "COF1 -- cytoskeleton -- Cofilin, actin binding and severing protein" YBR025C YBR025C 12.3 17 26.4 0.9454 0.375846939 iYBR025C 0.564364405 0.702079272 0.232098564 YBR025C -- unknown -- Member of GTP-binding protein family YOR247W SRL1 8.9 13 26 0.945 0.009277259 iYOR246C 0.583827231 0.013647247 0.433390932 SRL1 -- unknown -- similarity to Svs1p YDL153C SAS10 7.1 10 26 0.945 0.151623003 0.268772156 "SAS10 -- silencing -- derepresses HMR, HML and telomeres when overproduced" YAR009C 12.8 18.8 25.8 0.9448 0.357042806 iYAR009C 0.102122868 0.398008722 0.132721468 YML126C HMGS 9.3 13 25.7 0.9444 0.684097757 iYML126C 0.89947136 0.716544325 0.778414132 "HMGS -- sterol metabolism -- 3-hydroxy-3-methylglutaryl coenzyme A synthase, functions in mevalonate synthesis" YML056C YML056C 7.7 11 25.7 0.9444 0.905288862 0.655158506 YML056C -- unknown -- similarity to inosine-5'-monophosphate dehydrogenase YJL034W KAR2 13.4 20 24.7 0.9441 0.790700679 iYJL035C 0.60603853 0.912403111 0.915531097 "KAR2 -- secretion -- Heat shock ER lumen required for protein translocation across the ER membrane and for nuclear fusion, member of HSP70 family of protein chaperones" YML012W ERV25 13.2 20 24.7 0.9441 0.41495255 iYML013C-A 0.276714442 0.560726965 0.13782921 ERV25 -- secretion -- Component of COPII-coated vesicles YLR293C GSP1 11.9 18 24.6 0.9439 0.607653376 iYLR293C 0.653404711 0.888575572 0.368556909 "GSP1 -- nuclear protein targeting -- Ran, a GTP-binding ras superfamily involved in trafficking through nuclear pores" YAL044C GCV3 10.6 16 24.5 0.9435 0.786729466 iYAL044C 0.440544905 0.727149078 0.661934339 "GCV3 -- glycine metabolism -- Glycine decarboxylase hydrogen carrier protein H subunit (glycine cleavage H protein), functions in the pathway for glycine degradation" YOR270C VPH1 10.3 16 24.5 0.9435 0.381480803 iYOR270C 0.388942853 0.242142616 0.200779727 "VPH1 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) 94 kDa subunit of membrane (V0) sector, essential for vacuolar acidification and vacuolar H(+)-ATPase (V-ATPase) activity" YPL273W SAM4 6.2 9 24.3 0.9433 0.764533558 iYPL274W 0.359031565 0.906270305 0.532870856 SAM4 -- unknown -- Putative cobalamin-dependent homocysteine S-methyltransferase YMR217W GUA1 8.1 12 24.1 0.9431 0.461225951 iYMR216C 0.151475731 0.538148444 0.33811504 "GUA1 -- purine metabolism -- GMP synthetase, catalyzes the amination of xanthine monophosphate to guanine monophosphate in the guanine branch of purine biosynthesis pathway" YNL134C YNL134C 8.6 13 24 0.9427 0.403836259 iYNL134C 0.075178411 0.705929745 0.0632083 YNL134C -- unknown -- similarity to C. carbonum toxD gene YGR124W ASN2 8.2 13 24 0.9427 0.642609015 iYGR123C itI(AAU)G 0.355032972 0.296151315 0.813180608 0.486679662 0.245894479 ASN2 -- asparagine biosynthesis -- Asparagine synthetase (L-aspartate YML022W APT1 5.7 9 23.8 0.9425 0.623853211 iYML023C 0.381137647 0.891467127 0.235460192 "APT1 -- purine biosynthesis -- Adenine phosphoribosyltransferase (APRT), may be a heterodimer with Apt2p" YER160C 10 15 23.6 0.9421 0.169103747 0.136951317 YML045W 9 13.5 23.6 0.9421 0.893865222 0.698830409 YOR020C HSP10 12.1 19 23.4 0.9417 0.806430623 iYOR020C-0 iYOR020C-1 0.188996133 0.308224134 0.928371768 0.181495523 0.329672187 "HSP10 -- protein folding -- Mitochondrial chaperonin that cooperates with Hsp60p, counterpart of E. coli GroES" YHR214C-B 9.4 14.5 23.4 0.9417 0.893281269 iYHRCdelta16-0 iYHRCdelta16-A 0.406427068 0.720877175 0.464144551 0.3953529 0.790773229 YPR010C RPA135 5.6 9 23.3 0.9415 0.508615092 iYPR010C tK(CUU)P 0.54721202 0.766473669 0.764297814 0.782605118 0.651556265 RPA135 -- transcription -- RNA polymerase I second largest subunit YER009W NTF2 12.1 19 23.1 0.9407 0.749309611 iYER008C 0.611858725 0.749362297 0.844135802 "NTF2 -- nuclear protein targeting -- Nuclear transport factor, homologous to mammalian cytosolic nuclear import factor NTF2" YHL034C SBP1 9.5 15 23.1 0.9407 0.445072875 iYHL034C 0.5491599 0.464082942 0.209417398 "SBP1 -- RNA processing -- Single-stranded nucleic acid-binding protein associated with small nucleolar RNAs (snoRNAs), contains two RNA recognition (RRM) domains, one ofm highly degenerate" YBL039C URA7 6.6 11 23.1 0.9407 0.471552926 iYBL039C 0.370798854 0.491635688 0.241137609 URA7 -- pyrimidine biosynthesis -- CTP synthasefinal step in pyrimidine biosynthesis pathway YOR004W YOR004W 5.2 8 23.1 0.9407 0.334743054 iYOR003W 0.340826713 0.524239735 0.276315789 YOR004W -- unknown -- unknown function YGR240C PFK1 8.8 14 23 0.9403 0.564858813 iYGR240C 0.623780019 0.661287597 0.412797662 "PFK1 -- glycolysis -- Phosphofructokinase alpha subunit, part of a complex with Pfk2p which catalyze ATP-dependent conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, a key regulatory step in glycolysis" YMR318C YMR318C 8 13 23 0.9403 0.547048794 iYMR318C 0.026719929 0.572635249 0.055636777 YMR318C -- unknown -- similarity to alcohol-dehydrogenases YOR210W RPB10 9.8 16 22.8 0.9399 0.370656794 iYOR209C 0.169128015 0.200934579 0.133122157 "RPB10 -- transcription -- Shared subunit of RNA polymerases I, II, and III (ABC10beta), has zinc-binding domain" YLR197W SIK1 7.3 12 22.8 0.9399 0.773615242 iYLR196W 0.364191433 0.941601689 0.206304868 "SIK1 -- rRNA processing -- Nucleolar protein component of box C/D snoRNPs, which are necessary for 2'-O-methylation of ribosomal RNAs" YPL234C VMA11 9.9 16 22.7 0.9397 0.218034065 iYPL234C 0.602804772 0.09228039 0.759696728 "VMA11 -- vacuolar acidification -- Proteolipid component of vacuolar H(+)-ATPase (V-ATPase), required for Cup5p assembly" YHR020W YHR020W 7.4 12 22.6 0.9389 0.662114914 iYHR019C 0.227939558 0.925139665 0.125420897 "YHR020W -- unknown -- similarity to prolyl-tRNA synthetases, member of class II aminoacyl-tRNA synthetases" YNL300W YNL300W 5.9 10 22.6 0.9389 0.594187118 iYNL301C 0.798203651 0.143915083 0.400388645 YNL300W -- unknown -- weak similarity to Mid2p YGL078C DBP3 5.7 9 22.6 0.9389 iYGL078C 0.529118345 0.341232617 DBP3 -- rRNA processing -- ATP-dependent RNA helicase CA3member of DEAD/DEAH box family YBR092C PHO3 4.9 8 22.6 0.9389 0.634314604 iYBR092C 0.372276825 0.763349104 0.367749825 "PHO3 -- thiamine uptake -- Acid phosphatase, constitutive, thiamine-binding periplasmic space" YNL160W YGP1 14.3 24 22.5 0.9385 0.297857174 iYNL161W-0 iYNL161W-1 0.762148104 0.303972748 0.766959748 0.786337445 0.506214728 YGP1 -- diauxic shift -- Secreted glycoprotein produced in response to nutrient limitation YKL181W PRS1 8 13 22.5 0.9385 0.945064284 iYKL182W 0.81704111 0.881019602 0.446474122 "PRS1 -- purine, pyrimidine, tryptophan and histidine biosynthesis -- Phosphoribosylpyrophosphate synthetase, synthesizes phosphoribosylpyrophosphate (PRPP) from ribose-5' phosphate and ATP, involved in pseudohyphal growth" YER094C PUP3 12.9 21 22.3 0.9383 0.439521716 iYER094C 0.160363637 0.3604296 0.274699428 PUP3 -- protein degradation -- Proteasome subunit beta3_sc YMR083W ADH3 8.1 13 22.2 0.9379 1 0.74364452 iYMR082C-0 iYMR082C-1 0.899019639 0.922161626 0.898403831 0.50052432 0.474231159 "ADH3 -- glycolysis -- Alcohol dehydrogenase III, mitochondrial isozyme, reduces acetaldehyde to ethanol" YMR292W GOT1 5.3 9 22.2 0.9379 0.428477003 iYMR291W 0.537753645 0.406977701 0.421311608 GOT1 -- secretion (putative) -- Membrane ER to Golgi transport YDR086C SSS1 11.5 19 22.1 0.9375 0.775100507 iYDR086C 0.153358391 0.719161879 0.097424504 "SSS1 -- secretion -- Component of Sec61p-Sss1p-Sbh1p complex and the Ssh1p-Sss1p-Sbh2p complex, involved in protein translocation into the endoplasmic reticulum" YPL061W ALD6 8.9 15 22.1 0.9375 0.774470706 iYPL062W 0.089675685 0.7626732 0.118258609 ALD6 -- ethanol utilization -- Cytosolic acetaldehyde dehydrogenase YDR429C TIF35 8.3 14 21.8 0.9373 0.638547572 iYDR429C 0.22870841 0.73025732 0.264257482 "TIF35 -- protein synthesis -- Translation inititation factor eIF3, p33 subunit" YGL220W YGL220W 8.3 14 21.7 0.9371 0.399489917 iYGL221C 0.343419139 0.410445186 0.119803988 YGL220W -- unknown -- weak similarity to Vibrio alginolyticus bolA protein YOR095C RKI1 3.6 6 21.6 0.9369 0.714869949 iYOR095C 0.976495063 0.822585794 0.509506929 RKI1 -- pentose phosphate cycle -- Ribose 5-phosphate ketol-isomerase YLR413W YLR413W 4.8 8 21.4 0.9367 0.809390214 iYLR412W-0 iYLR412W-1 0.819196785 0.829532309 0.885856708 0.724941586 0.631120432 "YLR413W -- unknown -- unknown function, induced during anaerobic growth" YBR249C ARO4 7.5 13 21.2 0.9365 0.728457697 iYBR249C 0.175940978 0.790216289 0.202304222 "ARO4 -- aromatic amino acid biosynthesis -- 2-Dehydro-3-deoxyphosphoheptonate aldolase (3-deoxy-D-arabino-heptulosonate-7-phosphate synthaseDAHP synthase), tyrosine-inhibited" YHR064C PDR13 11 19 21 0.9364 0.664999359 iYHR064C 0.152775413 0.937479858 0.114296624 "PDR13 -- drug resistance -- Pleiotropic drug resistance protein, member of Hsp70 family of heat shock proteins" YER011W TIR1 10.8 19 20.8 0.9358 0.525878709 iYER010C-0 iYER010C-1 0.527797579 0.251308313 0.479300439 0.680606544 0.275584795 "TIR1 -- stress response (putative) -- Stress-induced cell wall mannoprotein, member of seripauperine (PAU) family" YBR121C GRS1 8.6 15 20.8 0.9358 0.473087344 iYBR121C 0.637434979 0.869484553 0.729807367 "GRS1 -- protein synthesis -- Glycyl-tRNA synthetase, also involved in 3'-end formation of mRNA" YOR021C YOR021C 7 12 20.8 0.9358 0.722669742 iYOR021C 0.161631877 0.8832846 0.152166317 YOR021C -- unknown -- unknown function YGR094W VAS1 6.5 12 20.5 0.9356 0.395377328 iYGR093W 0.711215594 0.654077183 0.647093613 "VAS1 -- protein synthesis -- Valyl-tRNA synthetase (mitochondrial and cytoplasmic forms are coded from the same gene), member of class I family of aminoacyl-tRNA synthetases" YBR286W APE3 7.9 14 20.4 0.9352 0.735750462 iYBR285W 0.708059422 0.928939736 0.755328442 "APE3 -- protein degradation -- Aminopeptidase Y (yscIII, APY), major vacuolar aminopeptidase with preference for basic amino acids and proline" YLR065C YLR065C 6.5 12 20.4 0.9352 0.581753269 iYLR065C 0.48670498 0.754731328 0.557748172 YLR065C -- unknown -- unknown function YOR285W YOR285W 10.2 19 20.3 0.9346 0.376881029 iYOR284W 0.503386032 0.636046134 0.667967317 YOR285W -- unknown -- similarity to Drosophila melanogaster heat shock protein 67B2 YOR187W TUF1 7.2 13 20.3 0.9346 0.433036657 iYOR186W 0.639974577 0.57488629 0.428536164 "TUF1 -- protein synthesis -- Translation elongation factor Tu, mitochondrial" YHR133C YHR133C 6.3 11 20.3 0.9346 0.663437536 iYHR133C 0.488321835 0.937669593 0.567391394 "YHR133C -- unknown -- unknown function, has four potential transmembrane domains" YDR497C ITR1 5.2 9 20.2 0.9344 0.361923649 iYDR497C 0.227007501 0.665913653 0.142645003 "ITR1 -- transport -- Myo-inositol permease (major), closely related to Itr2p, member of hexose transporter family of major facilitator superfamily (MFS)" YML039W 7.4 13 20.1 0.934 0.268996046 0.482681564 YAR010C 5.7 11 20.1 0.934 0.509326422 iYARCdelta5 itA(UGC)A 0.758662272 0.498512049 0.650296084 0.362369044 0.695732839 YMR205C PFK2 6.8 13 20 0.9338 0.640522543 iYMR205C 0.796796572 0.472303444 0.418937806 "PFK2 -- glycolysis -- Phosphofructokinase beta subunit, part of a complex with Pfk1p which catalyzes ATP-dependent conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, a key regulatory step in glycolysis" YDR158W HOM2 9.2 17 19.9 0.9332 HOM2 -- threonine and methionine biosynthesis -- Aspartate-semialdehyde dehydrogenase (L-aspartate-beta-semialdehyde YBR012W-A 5.7 11 19.9 0.9332 0.579067142 0.477026555 YGL028C SCW11 3.9 7 19.9 0.9332 0.804037482 iYGL028C 0.477901894 0.698549965 0.174771661 SCW11 -- cell wall biogenesis -- Putative cell wall similarity to Scw10p YDL126C CDC48 10.2 19 19.8 0.9324 0.66463166 iYDL126C 0.312558789 0.477670298 0.231562703 "CDC48 -- ubiquitin mediated degredation -- AAA family of ATPases, required for cell division and homotypic membrane fusion, has two AAA domains" YLR259C HSP60 9.9 19 19.8 0.9324 0.290617701 iYLR259C 0.308902701 0.336932001 0.616679968 "HSP60 -- protein folding -- Mitochondrial chaperonin that cooperates with Hsp10p, homolog of E. coli GroEL" YOL097C WRS1 6.7 13 19.8 0.9324 0.410768373 iYOL097C 0.534158851 0.628075372 0.167877661 WRS1 -- protein synthesis -- Tryptophanyl-tRNA synthetase YMR305C SCW10 5.2 10 19.8 0.9324 0.471320879 iYMR305C 0.599325234 0.768635275 0.824349442 "SCW10 -- cell wall biogenesis -- similarity to Scw4p, Bgl2p and other putative glucanases" YDR454C GUK1 9.9 19 19.7 0.9316 0.667295528 iYDR454C 0.444039925 0.940872792 0.761452514 "GUK1 -- guanine nucleotide metabolism -- Guanylate kinase, carries out conversion of ATP + GMP to ADP + GDP" YML058W SML1 9.8 18 19.7 0.9316 0.660627505 iYML059C 0.495283635 0.369445517 0.18366922 SML1 -- DNA replication (putative) -- negatively affects dNTP pools YJL130C URA2 8.2 15 19.7 0.9316 0.648955487 iYJL130C 0.195400527 0.638228252 0.372418333 "URA2 -- pyrimidine biosynthesis -- Multifunctional pyrimidine biosynthesis pathway, contains glutamine amidotransferase, glutamine-dependent carbamylphosphate synthase (CPSase), dihydroorotase-like (DHOase) domain, and aspartate carbamyltransferase (ATCase)" YMR146C TIF34 7 13 19.7 0.9316 0.628922364 iYMR146C 0.142160826 0.790006988 0.087470072 "TIF34 -- protein synthesis -- Translation initiation factor eIF3, p39 subunithas 2 WD (WD-40) repeats" YMR186W HSC82 7.9 15 19.6 0.9314 0.574712644 iYMR185W 0.555262052 0.241090147 HSC82 -- protein folding -- Chaperonin homologous to E. coli HtpG and mammalian HSP90 YGR282C 15 29 19.2 0.9308 0.808769816 iYGR282C 0.642093416 0.847843075 0.560259511 YDR508C GNP1 7 14 19.2 0.9308 0.546955061 0.364724661 GNP1 -- transport -- Glutamine permeasehigh affinity YBR012W-B 5.5 11 19.2 0.9308 0.51141813 0.294694153 YLR359W ADE13 8.9 17 19.1 0.9302 0.633818549 iYLR358C 0.653089316 0.903399936 0.627998943 "ADE13 -- purine biosynthesis -- Adenylosuccinate lyase, carries out the eighth step in de novo purine biosynthesis" YDL212W SHR3 7.9 15 19.1 0.9302 0.054557228 iYDL213C 0.337575486 0.291061169 "SHR3 -- secretion; protein targeting, plasma membrane -- exit of amino acid permeases from the endoplasmic reticulum and subsequent appearance on the cell surface" YMR051C 5.2 10 19.1 0.9302 0.879771939 iYMRCdelta10 YMRCdelta11 0.454431871 0.722393611 0.429194438 0.334031582 0.769416694 YHR068W DYS1 7.9 15 19 0.9298 0.422525764 iYHR067W 0.52001299 0.698016951 0.487565295 "DYS1 -- hypusine biosynthesis -- Deoxyhypusine synthase, first step in hypusine biosynthesiscarries out the conversion of lysine + spermidine into deoxyhypusine" YKR074W YKR074W 5.2 10 19 0.9298 0.713900686 iYKR073C itK(UUU)K 0.516684506 0.841543635 0.845824598 0.450236566 0.62808642 YKR074W -- unknown -- unknown function YDR343C HXT6 11.1 22 18.9 0.9292 0.247347609 iYDR343C 0.702140756 0.299468257 0.880865734 "HXT6 -- transport -- High-affinity hexose transporter, member of hexose transporter family of major facilitator superfamily (MFS), nearly identical to Hxt7p" YMR260C TIF11 7.1 14 18.9 0.9292 0.491406379 iYMR260C 0.668383577 0.674437364 0.340798739 TIF11 -- protein synthesis -- Translation initiation factor eIF1A YJL196C ELO1 6.5 13 18.9 0.9292 0.492025152 iYJL196C 0.161764036 0.614481244 0.268924626 ELO1 -- fatty acid metabolism -- Fatty acid elongation elongation of tetradecanoic acid (14 YOR122C PFY1 12 24 18.8 0.929 0.367685105 iYOR122C 0.468895186 0.661235909 0.091699155 "PFY1 -- cytoskeleton -- Profilin, can act to prevent actin polymerization and to complex with monomeric actin" YDL022W GPD1 7.6 15 18.7 0.9286 1 0.966648954 0.864324847 "GPD1 -- glycerol metabolism -- Glycerol-3-phosphate dehydrogenase (NAD+), cytoplasmic, involved in glycerol production converting glycerol-3-phosphate and NAD+ to dihydroxyacetone phosphate and NADH" YBR143C SUP45 6.1 12 18.7 0.9286 0.684839439 iYBR143C 0.424999247 0.956344773 0.680686353 "SUP45 -- protein synthesis -- Translational release factor eRF1, interacts with Sup35p (eRF3) to form translational release factor complex, involved in control of translational fidelitycan act as a recessive omnipotent suppressor" YPR103W PRE2 9.8 19 18.6 0.9281 1 0.966280137 iYPR102C 0.993661589 0.448448943 0.262011173 "PRE2 -- protein degradation -- Proteasome subunit beta5_sc (protease yscE subunit Pre2/Prg1), involved in chymotrypsin-like activity of proteasome" YOR007C SGT2 11.6 23 18.6 0.9281 0.441395499 iYOR007C tR(ACG)O 0.257676675 0.828743168 0.777979736 0.302610377 0.478407992 "SGT2 -- unknown -- unknown function, contains tetratricopeptide (TPR) repeats" YBR078W ECM33 6.8 13.5 18.6 0.9281 0.651792756 iYBR077C 0.274647185 0.727357215 0.157032978 "ECM33 -- cell wall biogenesis -- predicted GPI-anchor, involved in cell wall structure or biosynthesis" YJL159W HSP150 10.9 22 18.5 0.9275 0.824496289 iYJL160C-0 iYJL160C-1 0.355272804 0.161684393 0.682442139 0.578354298 0.282494759 "HSP150 -- heat shock response -- Secreted O-glycosylated tolerance to heat shock, member of Pir1/Hsp150p/Pir3 family of proteins with variable number of tandem internal repeats" YMR295C YMR295C 10.8 22 18.5 0.9275 0.710296541 iYMR295C 0.758921214 0.641739824 0.241500399 YMR295C -- unknown -- unknown function YMR131C RSA2 4.9 10 18.5 0.9275 0.448541999 iYMR131C 0.414146422 0.426149922 0.532894737 "RSA2 -- unknown -- ribosome assembly, member of WD (WD-40) repeat family" YKL117W SBA1 11.1 22 18.4 0.9271 0.169552434 iYKLCdelta4 itA(AGC)K1 0.416811032 0.212103888 0.268333897 0.322188205 0.156005485 "SBA1 -- protein folding -- Ste5p-associated protein, putative co-chaperone with Hsp90 family proteins (Hsp82p, Hsc82p)" YGR106C YGR106C 8.2 17 18.4 0.9271 0.298653161 iYGR106C tL(GAG)G 0.431358265 0.64373521 0.826177175 0.784302654 0.514238295 YGR106C -- unknown -- similarity to Vibrio anguillarum chemotaxis methyl transferase PIR YDL137W ARF2 9.5 19 18.3 0.9259 0.984995547 iYDL138W 0.82981513 0.931374969 0.47477989 ARF2 -- secretion -- GTP-binding arf family (ras superfamily) involved in assembly of coated vesicles of secretory system YGL200C EMP24 8.1 16 18.3 0.9259 0.677837138 iYGL200C 0.301932726 0.350339964 EMP24 -- secretion -- Component of COPII-coated vesicles possibly involved in cargo sorting YJR027W 6.2 12.5 18.3 0.9259 0.53231513 0.54932645 YER025W GCD11 5.8 12 18.3 0.9259 0.711805318 iYER024W 0.211656048 0.806860426 0.184317847 GCD11 -- protein synthesis -- Translation initiation factor eIF2 gamma subunit YJR028W 5.2 10 18.3 0.9259 0.87531152 0.611700815 YGL032C AGA2 3.1 6 18.3 0.9259 0.062427944 IntYGL033W iYGL032C 0.484832874 0.459559044 0.06501573 0.422173566 0.171654433 AGA2 -- mating -- a-Agglutinin binding subunit YDR037W KRS1 8.1 16 18.2 0.9253 1 0.943503862 iYDR036C 0.98692732 0.798098614 0.255800726 "KRS1 -- protein synthesis -- Lysyl-tRNA synthetase, cytoplasmic" YDR188W CCT6 5.7 12 18.2 0.9253 1 0.972071621 0.86063191 "CCT6 -- protein folding -- Component of chaperonin-containing T-complex (TCP ring complex, TRiC)distantly related to Tcp1p and to Hsp60 family" YNL007C SIS1 9.1 19 18.2 0.9253 0.674192634 iYNL007C 0.692632051 0.449155296 0.474415205 "SIS1 -- translation -- initiation of translation, member of DnaJ family of protein chaperones" YPR165W RHO1 9 19 18.1 0.9251 0.201686192 iYPR164W 0.315679313 0.139619883 0.513269339 "RHO1 -- signaling -- GTP-binding protein required to activate the PKC1 pathway and beta-1,3-glucan synthase, member of rho family of ras superfamily" YPR028W YIP2 10.6 22 18 0.9249 0.849529847 iYPR027C tF(GAA)P2 0.514966005 0.682154939 0.923126563 0.502872592 0.402553871 YIP2 -- unknown -- similarity to human polyposis locus protein 1 YPL231W FAS2 6.3 13 17.9 0.9245 0.350396863 iYPL232W 0.569706734 0.228424179 0.756416504 "FAS2 -- fatty acid metabolism -- Fatty-acyl-CoA synthase, alpha chaincontains acyl carrier protein, beta-ketoacyl reductase, and beta-ketoacyl synthase" YNR053C YNR053C 5.2 11 17.9 0.9245 0.633963198 iYNR053C 0.372867778 0.668746154 0.400097466 "YNR053C -- unknown -- Nuclear unknown function, has similarity to human breast tumor-associated autoantigen" YPR110C RPC40 5.7 12 17.8 0.9239 1 0.875906003 iYPR110C 0.953609909 0.51707901 0.316850851 RPC40 -- transcription -- Shared subunit of RNA polymerases I and III YFL038C YPT1 12.3 26 17.8 0.9239 0.606140471 iYFL038C 0.232065054 0.702789435 0.072510474 "YPT1 -- secretion -- GTP-binding vesicle transport from ER to Golgi and within the Golgi stack, member of rab family in the ras superfamily" YMR050C 7.5 15 17.8 0.9239 0.240246074 0.065832688 YGL054C ERV14 6.4 13 17.7 0.9235 0.881611591 iYGL054C iYGLWdelta7 0.567861576 0.356137067 0.941956742 0.460763777 0.363599742 "ERV14 -- polarized growth (putative) -- ER-derived vesicles, with similarity to Drosophila melanogaster cni protein" YJR148W BAT2 6.1 13 17.7 0.9235 0.63699717 iYJR147W 0.07093998 0.799555665 0.010244414 BAT2 -- branched chain amino acid biosynthesis -- Cytosolic branched-chain amino acid transaminase YKL145W RPT1 8.2 17 17.6 0.9229 0.58385128 iYKL146W 0.174086831 0.634051874 0.547228794 "RPT1 -- protein degradation, ubiquitin-mediated -- ATPase component of 26S proteasome complex, member of AAA family of ATPases" YMR243C ZRC1 6.2 13 17.6 0.9229 0.975805797 iYMR243C 0.970519638 0.871307496 0.646629858 ZRC1 -- zinc and cadmium ion homeostasis -- Zinc- and cadmium-resistance protein YHR170W NMD3 5.2 11 17.6 0.9229 0.50502805 iYHR169W 0.021288651 0.940236065 0.078890054 "NMD3 -- mRNA decay, nonsense-mediated -- Nam7p/Upf1p-interacting stable 60S ribosomal subunit formation" YAL035W YAL035W 8.8 19 17.5 0.9223 0.61496349 iYAL036C 0.45051853 0.279655289 0.598130841 "YAL035W -- unknown -- Translation initiation factor 2, has similarity to bacterial IF2" YMR002W YMR002W 7.5 16 17.5 0.9223 0.49199608 iYMR001C 0.246608765 0.560266407 0.414924182 YMR002W -- unknown -- unknown function YER138C 7.3 15 17.5 0.9223 0.375731295 0.473503591 YPR187W RPO26 5.9 13 17.4 0.9217 0.149189035 iYPR186C 0.502021094 0.218300008 0.340813078 "RPO26 -- transcription -- Shared subunit of RNA polymerases I, II, and III (ABC23)" YJL148W RPA34 5.3 11 17.4 0.9217 0.799479001 iYJL149W snR128 0.721169552 0.692123051 0.270468197 0.559958342 0.464225216 "RPA34 -- transcription -- RNA polymerase I subunit, not shared with other RNA polymerases" YKL096W CWP1 4.3 9 17.4 0.9217 0.722480729 iYKL097W-A-0 iYKL097W-A-1 0.750455267 0.814303883 0.867446394 0.315640881 0.56735834 "CWP1 -- cell wall protein -- Mannocell wall, member of seripauperin (PAU) family" YJR029W 6.5 14.5 17.3 0.9211 0.209008646 0.095426313 YFR033C QCR6 5.4 12 17.3 0.9211 0.816500622 iYFR033C 0.789834235 0.101995211 0.256025539 QCR6 -- oxidative phosphorylation -- Ubiquinol cytochrome-c reductase subunit 6component of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex) YJR143C PMT4 4.5 10 17.3 0.9211 0.810178528 iYJR143C 0.596376779 0.956413149 0.447936972 PMT4 -- protein glycosylation -- Mannosyltransferase (dolichyl phosphate-D-mannose YLR367W RPS22B 13.6 28.8 17.2 0.9202 1 0.953522186 iYLR366W SNR44 0.826921839 0.795082652 0.966699155 0.928208438 0.649108655 "RPS22B -- protein synthesis -- RIbosomal protein S22 (yeast S24rp50YS22rat S15A), nearly identical to Rps22Ap" YBR162C YBR162C 7.4 16 17.2 0.9202 0.453652896 iYBR162C 0.186916873 0.708857442 0.267295597 YBR162C -- unknown -- similarity to Aga1p YKL054C YKL054C 6.6 14 17.2 0.9202 0.100213331 iYKL054C YKL053C-A 0.669039019 0.487910611 0.051088369 0.552114924 0.670550678 "YKL054C -- unknown -- unknown function, glutamine rich" YLR342W FKS1 6.5 14 17.2 0.9202 0.63992493 iYLR341W 0.399610295 0.374388539 0.397335932 "FKS1 -- cell wall biogenesis -- Component of beta-1,3-glucan synthase, probably functions as an alternate subunit with Gsc2p with which it has strong similarity" YKL192C ACP1 6.2 13 17.2 0.9202 0.604388833 iYKL192C 0.338008263 0.66484524 0.683240223 "ACP1 -- fatty acid biosynthesis -- Acyl carrier protein, component of mitochondrial type II fatty acid synthase" YBR158W CST13 5.2 11 17.1 0.92 0.6665962 iYBR157C-0 iYBR157C-1 0.174167472 0.59197754 0.866001596 0.313366002 0.683438155 CST13 -- Cu2+ ion homeostasis (putative) -- optimal growth and germination rate YHR128W FUR1 5.5 12 17 0.9196 0.902881308 iYHR127W 0.510283446 0.899121325 0.344021914 "FUR1 -- pyrimidine salvage pathway -- Uracil phosphoribosyltransferase, part of pyrimidine salvage pathway" YLR420W URA4 4 9 17 0.9196 0.289297797 iYLR419W itL(UAA)L 0.676984646 0.645950911 0.364805123 0.410055866 0.563523433 "URA4 -- pyrimidine biosynthesis -- Dihydroorotase, third step in pyrimidine biosynthesis pathway" YPR149W NCE102 15.5 34 16.9 0.9192 0.828048822 iYPR148C-0 iYPR148C-1 0.636746785 0.785354344 0.93802794 0.657232173 0.343466108 "NCE102 -- secretion, non-classical -- non-classical export pathway for proteins that lack standard secretory signal sequences" YGR135W PRE9 8.3 18 16.9 0.9192 0.4513156 iYGR134W 0.215314332 0.615903184 0.251707397 PRE9 -- protein degradation -- Proteasome subunit alpha3_sc YMR297W PRC1 7.7 17 16.8 0.9186 0.569114266 iYMR296C 0.494539373 0.950692878 0.310510071 "PRC1 -- sporulation -- Carboxypeptidase Y (CPY/yscY), serine-type protease" YDL182W LYS20 4.8 11 16.8 0.9186 0.780469734 iYDL183C-0 iYDL183C-1 0.885366271 0.361871438 0.810542279 0.777015164 0.315139701 "LYS20 -- lysine biosynthesis -- Homocitrate synthase isoenzyme, involved in lysine biosynthesis" YJR070C YJR070C 4 9 16.8 0.9186 0.684416857 0.981643925 YJR070C -- unknown -- unknown function YNL113W RPC19 5.5 12 16.7 0.9182 0.069299925 0.082197764 RPC19 -- transcription -- Shared subunit of RNA polymerases I and III YJR026W 4.8 11 16.7 0.9182 0.893253839 iYJR025C 0.349773688 0.601662141 0.175526337 YFL035C-B 7.3 16 16.6 0.9176 YOR276W CAF20 7.3 16 16.6 0.9176 0.549692649 iYOR275C 0.538306938 0.55553763 0.590636057 CAF20 -- protein synthesis -- mRNA cap-binding protein (eIF4F) 20K subunit YBR088C POL30 5.8 13 16.6 0.9176 0.504405964 0.689450897 "POL30 -- DNA replication -- Proliferating cell nuclear antigen (PCNA), required for DNA synthesis and DNA repair" YIL043C CBR1 10.1 23 16.5 0.9168 0.275542525 iYIL043C 0.482896906 0.865602554 0.209084177 "CBR1 -- aminosugars metabolism -- Cytochrome b5 reductase, converts 2 ferricytochrome B5 + NADH to 2 ferrocytochrome B5 + NAD(+), uses FAD cofactor" YMR173W-A 8.1 18 16.5 0.9168 0.235083553 0.391672838 YER148W SPT15 7.1 16 16.5 0.9168 0.32416975 iYER147C 0.236231547 0.399036837 0.028589994 "SPT15 -- transcription -- TATA-binding component of RNA polymerases I, II, and IIIpart of initiation factors TFIID and TFIIIB" YNL259C ATX1 4.3 9 16.5 0.9168 0.841571087 iYNL259C 0.401846609 0.647498376 0.210746604 ATX1 -- oxidative stress response -- Antioxidant protein and metal homeostasis factorfunctions in a copper trafficking pathway YDL125C HNT1 9.1 20.5 16.4 0.916 0.810280538 iYDL125C 0.512831092 0.978719948 0.809901994 HNT1 -- unknown -- Member of HIT family of Zn-binding proteins and the histidine triad nucleotide-binding protein family YDR172W SUP35 7.7 17 16.4 0.916 0.338887737 iYDR171W 0.565468008 0.753786658 0.731156595 "SUP35 -- protein synthesis -- Translational release factor eRF3, interacts with Sup45p (eRF1) to form translational release factor complex, also a prion responsible for the [PSI+] determinant" YDR304C CYP5 7.1 16 16.4 0.916 0.206486547 iYDR304C 0.228431663 0.354110136 0.248988472 "CYP5 -- protein folding -- Cyclophilin (peptidylprolyl cis-trans isomerase or PPIase) of endoplasmic reticulum, has a HDEL sequence for retention in the endoplasmic reticulum" YGR189C CRH1 6.2 14 16.4 0.916 0.383464962 iYGR189C itW(CCA)G2 0.404238045 0.56589679 0.408060654 0.262983831 0.602078634 CRH1 -- cell wall biogenesis (putative) -- Cell wall protein YOL061W PRS5 5.9 14 16.3 0.9158 0.841851106 iYOL062C 0.242611405 0.963100226 0.133203379 "PRS5 -- purine, pyrimidine, tryptophan and histidine biosynthesis -- Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase)" YNL339C YRF1-6 6.4 15 16.2 0.9148 0.919262095 iYNL339C 0.994757203 0.078529001 0.032185206 YRF1-6 -- unknown -- near identity to other subtelomerically-encoded proteins YER087C-A SBH1 6.3 14 16.2 0.9148 0.317299364 iYER087C-A 0.855522397 0.35360941 0.269828791 "SBH1 -- secretion -- Component of Sec61p-Sss1p-Sbh1p complex, involved in protein translocation into the endoplasmic reticulum" YPR113W PIS1 5.4 12 16.2 0.9148 0.03155508 iYPR112C 0.202915079 0.103622403 0.151904263 PIS1 -- phospholipid metabolism -- CDP-diacylglycerol-inositol 3-phosphatidyltransferase; YDR381W YRA1 4.8 11 16.2 0.9148 0.779155884 iYDR380W IntYDR381W 0.50534853 0.87124589 0.541594668 0.520224172 0.681865828 YRA1 -- mRNA processing -- RNA YPL211W NIP7 4.5 10 16.2 0.9148 0.281716929 iYPL212C 0.598436977 0.228252195 0.483337448 NIP7 -- rRNA processing -- Nucleolar efficient 60S ribosome subunit biogenesis YMR246W FAA4 5.5 13 16.1 0.9146 0.878101563 iYMR245W 0.38178927 0.837069526 0.261252366 FAA4 -- fatty acid metabolism -- Acyl-CoA synthase (long-chain fatty acid CoA ligase)contributes to activation of imported myristate YCL064C CHA1 4.5 10 16 0.9142 0.95339386 iYCL064C 0.377781853 0.467916999 0.186380534 CHA1 -- hydroxy amino acid metabolism -- L-serine/L-threonine deaminase YPR124W CTR1 4.3 10 16 0.9142 0.414060689 0.546733054 CTR1 -- transport -- Copper transport high-affinity uptake of copper YAL012W CYS3 8.9 21 15.9 0.9134 0.534264802 iYAL013W 0.17605463 0.697774529 0.133464988 "CYS3 -- methionine biosynthesis -- Cystathionine gamma-lyase, generates cysteine from cystathionine" YPL106C SSE1 8 18 15.9 0.9134 0.383770997 iYPL106C 0.577791473 0.629426474 0.470949721 "SSE1 -- calmodulin signaling -- Heat shock HSP70 family, multicopy suppressor of mutants with hyperactivated ras/cAMP pathway" YOR230W WTM1 7 16 15.9 0.9134 0.527497732 iYOR229W 0.25379078 0.656691135 0.459546665 WTM1 -- meiosis -- Transcriptional modulator involved in meiotic regulation and silencing YIL123W SIM1 5.8 14 15.9 0.9134 0.463911667 iYIL124W 0.290570956 0.132960894 0.307927812 SIM1 -- cell cycle -- the aging process and in regulation of cell cycle YGR180C RNR4 8.9 21 15.8 0.9128 1 0.912420715 iYGR180C itL(CAA)G3 0.942690627 0.562148257 0.898132148 0.254061079 0.395051875 "RNR4 -- DNA replication -- Component of ribonucleotide reductase (ribonucleoside-diphosphate reductase) small subunit, which is comprised of an Rnr2p-Rnr4p heterodimer" YMR308C PSE1 6.1 14 15.8 0.9128 0.684103076 iYMR308C 0.116466742 0.826861102 0.284334843 PSE1 -- nuclear protein targeting -- Beta-Karyopherin involved in nuclear import of ribosomal and other nuclear proteins YKL081W TEF4 4.5 10 15.8 0.9128 0.911651378 iYKL082C 0.866197137 0.929584273 0.189747387 TEF4 -- protein synthesis -- Translation elongation factor EF-1gamma YGL105W ARC1 9.2 22 15.7 0.9117 0.756828055 iYGL106W 0.46397608 0.594418004 0.343990217 ARC1 -- tRNA aminoacylation -- Cofactor for methionyl- and glutamyl-tRNA synthetases and G4 quadruplex nucleic acid binding protein YCR034W FEN1 6.1 14 15.7 0.9117 0.57786991 iYCR033W 0.040278014 0.678558385 0.0444282 FEN1 -- cell wall biogenesis -- the elongation of fatty acids up to 24 carbons YOR335C ALA1 5.2 12 15.7 0.9117 0.73992704 iYOR335C 0.169836688 0.478153542 0.276624395 "ALA1 -- protein synthesis -- Alanyl-tRNA synthetase, cytoplasmic" YDR062W LCB2 4.9 12 15.7 0.9117 0.838250663 iYDR061W 0.880056904 0.550032227 0.784836393 "LCB2 -- sphingolipid biosynthesis -- Subunit of serine C-palmitoyltransferase, first step in sphingolipid biosynthesis, and suppressor of calcium-sensitivity of csg2" YNR018W YNR018W 4.5 11 15.7 0.9117 0.49241914 iYNR017W 0.658940832 0.614422844 0.323549965 YNR018W -- unknown -- unknown function YNL065W YNL065W 4 10 15.7 0.9117 0.373493109 iYNL066W 0.37855929 0.557477289 0.572368962 YNL065W -- unknown -- Member of multidrug-resistance 12-spanner family of major facilitator superfamily (MFS-MDR) YGL245W YGL245W 9.8 23 15.6 0.9111 0.68359528 iYGL246C 0.233313939 0.960201429 0.228810854 "YGL245W -- protein synthesis -- Glutamyl-tRNA synthetase, member of class I aminoacyl tRNA synthetase family" YML040W 4.6 11 15.6 0.9111 0.912601205 iYML041C tP(UGG)M 0.595693264 0.551479976 0.73106671 0.770222365 0.524740623 YLR432W YLR432W 3.8 9 15.6 0.9111 0.975318665 iYLR431C 0.623571011 0.397035127 0.449161426 YLR432W -- unknown -- highly similar to Yhr216p and inosine-5'-monophosphate dehydrogenase of human and E. coli YNL255C GIS2 6.4 15 15.5 0.9105 0.845942459 iYNL255C 0.381713893 0.773277812 0.217478053 GIS2 -- unknown -- Protein possibly involved in cytoplasmic ribosome functionhas similarity to nucleic acid binding proteins YPR016C CDC95 5.3 13 15.5 0.9105 0.676534465 iYPR016C 0.51766529 0.617051013 0.124546261 CDC95 -- ribosome biogenesis (putative) -- Translation initiation factor 6 YOR271C YOR271C 4 10 15.5 0.9105 0.189476501 iYOR271C SNR8 0.516565379 0.676619441 0.516113439 0.557557805 0.32016786 "YOR271C -- unknown -- similarity to rat tricarboxylate carrier, member of mitochondrial tricarboxylate carrier family of membrane transporters" YJL026W RNR2 4.2 10 15.4 0.9093 1 0.932544145 iYJL027C 0.954392896 0.84851477 0.496996626 "RNR2 -- DNA replication -- Component of ribonucleotide reductase (ribonucleoside-diphosphate reductase) small subunit, which is comprised of an Rnr2p-Rnr4p heterodimer" YPR036W VMA13 7.4 18 15.4 0.9093 0.23309376 iYPR035W 0.227522952 0.540892193 0.160966148 "VMA13 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) 54 kDa subunit of V1 sector, required for V-ATPase activity" YHR025W THR1 6.7 16 15.4 0.9093 0.324500515 iYHR024C 0.509788834 0.49803248 0.389622946 THR1 -- threonine biosynthesis -- Homoserine kinase (ATP YGR296W YRF1-3 6.2 15 15.4 0.9093 0.920177612 iYGR295C-0 iYGR295C-1 0.992972767 0.997490691 0.222346369 0.323992853 0.002715379 YRF1-3 -- unknown -- similarity to other subtelomerically-encoded proteins including Yer190p YHR219W YHR219W 6.1 15 15.4 0.9093 0.954131638 iYHR218W 0.731705907 0.298324022 0.011293055 YHR219W -- unknown -- near identity to other subtelomerically-encoded proteins YJL080C SCP160 4.7 11 15.4 0.9093 0.3087273 iYJL080C 0.513628277 0.436086991 0.439977441 "SCP160 -- mitosis, chromosome transmission -- control of mitotic chromosome transmission, contains 14 KH motifs found in RNA-binding proteins such as Mer1p and mouse hnRNP X" YOL038W PRE6 7 17 15.3 0.9089 0.601765819 iYOL039W 0.868625546 0.76623056 0.449336129 PRE6 -- protein degradation -- Proteasome subunit alpha4_sc YHR143W-A RPC10 6.5 16 15.3 0.9089 0.18363483 iYHR143W 0.300794996 0.137270551 0.13487134 "RPC10 -- transcription -- Shared subunit of RNA polymerases I, II, and III (ABC10alpha), has zinc-binding domain" YPL283C YRF1-7 5.8 14 15.2 0.9085 0.812605515 iYPL283C-0 iYPL283C-1 0.99725631 0.996368794 0.197792459 0.02537909 0.009921755 "YRF1-7 -- unknown -- near identity to other subtelomerically-encoded protein, including Ygr296p" YNL220W ADE12 4.6 11 15.2 0.9085 0.852137541 iYNL221C 0.03292043 0.934901708 0.133629556 "ADE12 -- purine biosynthesis -- Adenylosuccinate synthetase, carries out addition of aspartic acid to IMP with GTP hydrolysis" YDR342C HXT7 9.9 24 15.1 0.9075 0.427892555 iYDR342C-0 iYDR342C-1 0.179312114 0.511910684 0.42944129 0.245126706 0.718242365 "HXT7 -- transport -- High-affinity hexose transporter, member of hexose transporter family of major facilitator superfamily (MFS), nearly identical to Hxt6p" YLR060W FRS1 7.6 19 15.1 0.9075 0.928068263 iYLR059C 0.530445635 0.672508846 0.336460133 "FRS1 -- protein synthesis -- Phenylalanyl-tRNA synthetase, alpha subunit, cytoplasmic" YPL218W SAR1 5.8 14 15.1 0.9075 0.574486917 iYPL219W 0.140021067 0.301997701 0.074211503 "SAR1 -- secretion -- Component of COPII coat of vesicles involved in endoplasmic reticulum to Golgi transport, GTP-binding arf family in the ras superfamily" YER036C YER036C 5.6 14 15.1 0.9075 0.843461716 iYER036C 0.553555565 0.92444095 0.314924182 YER036C -- unknown -- Member of non-transporter group of ATP-binding cassette (ABC) superfamily YLR467W YRF1-5 5.6 14 15.1 0.9075 0.964746041 iYLR466W 0.997341178 0.359936153 0.138626834 "YRF1-5 -- unknown -- Y'helicase with near identity to other subtelomerically-encoded proteins including Yer189p, Yml133p, and Yjl225p" YLR466W YRF1-4 5.6 14 15 0.9071 0.935927325 0.410027952 YRF1-4 -- unknown -- similarity to other subtelomerically-coded Y'-helicase proteins YDL051W LHP1 4.4 11 15 0.9071 0.532985652 iYDL052C 0.364492998 0.505618219 0.144882537 "LHP1 -- unknown -- homolog to human La autoantigen which binds to and stabilizes pre-tRNA for 3' endonucleolytic cleavage, has an RNA recognition (RRM) domain" YBR082C UBC4 9.7 24 14.9 0.9063 0.385891593 iYBR082C-0 iYBR082C-1 0.691274081 0.237478897 0.514046289 0.624203818 0.865054797 "UBC4 -- protein degradation, ubiquitin-mediated -- Ubiquitin-conjugating (E2) enzymetogether with Ubc5p is responsible for the majority of ubiquitin-dependent protein degradation of short-lived and abnormal proteins" YER190W YRF1-2 5.9 15 14.9 0.9063 0.953996325 0.464711569 YRF1-2 -- unknown -- similarity to other subtelomerically-encoded proteins including Yil177p YHR208W BAT1 5.6 14 14.9 0.9063 0.820134764 iYHR207C 0.331297962 0.964782358 0.723884811 BAT1 -- branched chain amino acid degradation -- Mitochondrial branched-chain amino acid transaminase YNL110C YNL110C 4.7 12 14.9 0.9063 0.267081486 iYNL110C 0.248269586 0.155147646 0.14574762 "YNL110C -- unknown -- unknown function, contains one RNA recognition (RRM) domain" YPR033C HTS1 5.8 15 14.8 0.9061 0.322343381 iYPR033C 0.134331049 0.663063644 0.068460462 "HTS1 -- protein synthesis -- Histidyl-tRNA synthetase, mitochondrial and cytoplasmic" YJL191W RPS14B 7.9 20 14.7 0.9049 1 1 0.979153526 iYJL192C 0.979489177 0.982391179 0.718175959 "RPS14B -- protein synthesis -- Ribosomal protein S14B (rp59E. coli S11rat and human S14), nearly identical to Rps14Ap" YOR248W YOR248W 5.2 13 14.7 0.9049 0.003283327 0.01635514 YOR248W -- unknown -- unknown function YLR153C ACS2 4.6 12 14.7 0.9049 0.565879927 iYLR153C 0.192035298 0.572152341 0.070999854 ACS2 -- acetyl-CoA biosynthesis -- Acetyl-CoA synthetase YLR009W YLR009W 4.2 10 14.7 0.9049 0.251363411 iYLR008C 0.115557319 0.33516994 0.187157589 YLR009W -- protein synthesis -- Possible ribosomal similarity to ribosomal protein L24 YOR212W STE4 4 10 14.7 0.9049 0.504014444 iYOR211C 0.378113733 0.567996808 0.704629943 "STE4 -- signaling, pheromone pathway -- Beta subunit of guanine nucleotide-binding mediates signal transduction by pheromones, member of WD (WD-40) repeat family" YJR024C YJR024C 3.7 9 14.7 0.9049 0.295763325 iYJR024C 0.632963084 0.55626901 0.39011181 "YJR024C -- unknown -- unknown function, has similarity to enterobacterial L-ribose-5-phosphate 4-epimerases" YNL066W SUN4 3.3 8 14.6 0.9044 1 0.548725142 iYNL067W 0.92305359 0.76397624 0.659603609 SUN4 -- aging -- the aging process YPL160W CDC60 4.8 12 14.6 0.9044 0.587508823 iYPL161C 0.751955933 0.593619078 0.818773234 "CDC60 -- protein synthesis -- Leucyl-tRNA synthetase, cytoplasmic" YAL059W ECM1 3.4 8 14.6 0.9044 0.389431263 iYAL060W 0.67526952 0.337941249 0.63788442 ECM1 -- cell wall biogenesis -- Protein possibly involved in cell wall structure or biosynthesis YPL010W RET3 6.3 16 14.5 0.9032 0.738016428 iYPL011C 0.517983275 0.794573025 0.443832984 RET3 -- secretion -- Coatomer (COPI) complex zeta chain (zeta-COP) of secretory pathway vesiclesrequired for retrograde Golgi to endoplasmic reticulum transport YDR045C RPC11 5.3 13 14.5 0.9032 0.484189633 iYDR045C 0.384994568 0.394981413 0.304751149 "RPC11 -- transcription -- RNA polymerase III subunit C11, required for RNA cleavage activity and transcription termination" YLR229C CDC42 5.3 13 14.5 0.9032 0.4968592 0.769686497 "CDC42 -- signaling, filamentous or polarized growth -- Rho-type GTPase involved in bud site assembly and cell polarity, member of rho family of ras superfamily" YPR163C TIF3 5.2 13 14.5 0.9032 0.229423693 iYPR163C 0.532701959 0.100104864 0.343470194 TIF3 -- protein synthesis -- Translation initiation factor eIF4Bhas 1 RNA recognition (RRM) domain YOL002C YOL002C 3.5 9 14.5 0.9032 0.190464627 iYOL002C 0.217319451 0.704515919 YOL002C -- unknown -- unknown function YNL141W AAH1 2.5 6 14.5 0.9032 0.220492802 iYNL142W 0.616870356 0.475179569 0.553496616 "AAH1 -- purine metabolism -- Adenine deaminase (adenine aminohydrolase), enzyme of purine salvage pathwayhas similarity to adenosine deaminases" YBL076C ILS1 5.8 15 14.4 0.902 0.693345165 iYBL076C 0.721861726 0.865157148 0.369202226 "ILS1 -- protein synthesis -- Isoleucyl-tRNA synthetase, cytoplasmic" YBR154C RPB5 4.9 13 14.4 0.902 0.608560394 iYBR154C 0.740325109 0.723318828 0.474035395 "RPB5 -- transcription -- Shared subunit of RNA polymerases I, II, and III (ABC27)" YBR187W YBR187W 4.6 12 14.4 0.902 0.922064737 iYBR186W 0.693021518 0.506687077 0.586604131 YBR187W -- unknown -- similarity to ND5 and PSB2 YNR021W YNR021W 4.4 11 14.4 0.902 0.578379191 iYNR020C 0.489209578 0.705666401 0.41106818 YNR021W -- unknown -- unknown function YNL248C RPA49 3.9 10 14.4 0.902 0.459196303 iYNL248C 0.299300587 0.862344455 0.340079034 RPA49 -- transcription -- RNA polymerase I third largest subunit YGR103W YGR103W 3.4 9 14.4 0.902 0.213520705 iYGR102C 0.388843515 0.465682362 0.620281131 YGR103W -- unknown -- Nuclear unknow function with similarity to zebrafish pescadillo YNL044W YIP3 5.5 14 14.3 0.9012 0.476688239 iYNL045W 0.603990469 0.809873356 0.660552061 YIP3 -- unknown -- unknown function YER165W PAB1 5.3 14 14.3 0.9012 0.556633574 iYER164W 0.497709587 0.864644852 0.29579737 "PAB1 -- mRNA 3'-end processing -- Poly(A)-binding cytoplasm and nucleus, part of 3'-end RNA-processing complex (cleavage factor I), has 4 RNA recognition (RRM) domains" YLR303W MET17 3.8 10 14.3 0.9012 0.487859718 0.80407058 MET17 -- methionine biosynthesis -- O-acetylhomoserine sulfhydrylase (OAH SHLase)converts O-acetylhomoserine into homocysteine YNL186W UBP10 3.6 9 14.3 0.9012 0.36378548 iYNL187W 0.383406642 0.437350359 0.329658493 "UBP10 -- protein degradation, ubiquitin-mediated -- Ubiquitin C-terminal hydrolaseinvolved in telomeric silencing" YGL012W ERG4 6.6 17 14.2 0.9006 0.719619556 iYGL013C 0.642780309 0.779758512 0.611373166 ERG4 -- sterol metabolism -- Sterol C-24 (28) reductase YDR139C RUB1 5.7 14.5 14.2 0.9006 0.501122381 iYDR139C 0.149855978 0.768169718 0.235324948 "RUB1 -- protein degradation -- Ubiquitin-related protein, becomes conjugated to other proteins including Cdc53p in a process requiring Uba3p, Ula1p and Ubc12p" YLR285W YLR285W 3.7 10 14.2 0.9006 0.669062965 iYLR284C 0.455280746 0.734364081 0.526618848 YLR285W -- unknown -- unknown function YEL046C GLY1 5.2 14 14.1 0.9 1 0.936902573 0.753806238 "GLY1 -- glycine, serine, and threonine metabolism -- Threonine aldolase, required for glycine biosynthesis" YOR099W KTR1 6.1 16 14.1 0.9 0.652014686 iYOR098C 0.426588612 0.731125299 0.736595167 KTR1 -- protein glycosylation -- Mannosyltransferase of KRE2 family involved in N-linked and O-linked glycosylation YDR545W YRF1-1 5.5 14 14.1 0.9 0.939363925 iYDR544C 0.997659272 0.186890838 0.12959763 "YRF1-1 -- unknown -- near identity to the family of subtelomerically-encoded proteins including Yil177p, Yhl049p, and Yjl225p" YJR064W CCT5 5.8 15 14 0.8994 0.631771433 iYJR063W 0.982275218 CCT5 -- protein targeting -- Component of chaperonin-containing T-complex (TCP ring complex and TRiC)homologous to mammalian CCT family of chaperonin proteins YGR061C ADE6 4.7 12 14 0.8994 0.356574044 iYGR061C 0.761998957 0.352504638 0.715758211 "ADE6 -- purine biosynthesis -- 5'-phosphoribosylformyl glycinamidine synthetase, has glutamine amidotransferase domain and aminator domain" YOR145C YOR145C 3.6 10 14 0.8994 0.314741202 0.45351273 YOR145C -- unknown -- unknown function YLR447C VMA6 6.5 17 13.9 0.8988 0.930971238 iYLR447C 0.989642005 0.39065903 0.705422529 "VMA6 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) 36 kDa subunit (subunit D) of membrane (V0) sector, required for V-ATPase assembly" YHR019C DED81 5.4 15 13.9 0.8988 0.834487414 iYHR019C 0.227939558 0.881675307 0.125420897 "DED81 -- protein synthesis -- Asparaginyl-tRNA synthetase, cytoplasmic" YLR395C COX8 5.2 14 13.9 0.8988 0.316691647 iYLR395C 0.793487866 0.572944932 0.717773123 COX8 -- oxidative phosphorylation -- Cytochrome-c oxidase subunit VIII YJR077C MIR1 6.2 16 13.8 0.898 0.620680299 iYJR077C 0.212610549 0.77296165 0.358040606 MIR1 -- transport -- Phosphate transporter of mitochondrial carrier (MCF) family YLR038C COX12 5.8 16 13.8 0.898 0.250402197 iYLR038C 0.221362054 0.417762362 0.164313947 "COX12 -- oxidative phosphorylation -- Cytochrome-c oxidase, subunit VIb" YPR052C NHP6A 4 11 13.8 0.898 0.914555531 0.549568444 NHP6A -- chromatin structure -- Protein related to mammalian nonhistone protein HMG1function redundant with Nhp6Bp YGL029W CGR1 3.6 10 13.8 0.898 0.61799849 iYGL030W 0.803006286 0.419811321 0.603244339 "CGR1 -- unknown -- Predicted coiled-coil protein, down-regulated after diauxic shift" YDL007W RPT2 7.1 19 13.7 0.8972 0.508783933 iYDL008W itT(AGU)D 0.782751145 0.799012466 0.766435707 0.691125087 0.602651173 "RPT2 -- protein degradation -- ATPase component of 26S the proteasome complex, member of AAA family of ATPases" YDL084W SUB2 7.1 19 13.7 0.8972 0.698242813 iYDL085W 0.373923847 0.552753392 0.508812432 "SUB2 -- mRNA splicing -- similarity to nuclear RNA helicases (DEAD/DEAH family), probably involved in pre-mRNA splicing" YGR191W HIP1 5.2 14 13.7 0.8972 0.733689983 0.767625081 HIP1 -- transport -- Histidine permease YER145C FTR1 3.4 9 13.7 0.8972 0.490497438 iYER145C 0.540582037 0.695012995 0.253609744 FTR1 -- transport -- Iron permease that mediates high-affinity iron uptake YBL113C YBL113C 5.6 15 13.6 0.8968 0.976121094 0.573018194 YBL113C -- unknown -- unknown functionsubtelomerically encoded YDR297W SUR2 3.6 10 13.6 0.8968 0.599002758 iYDR296W 0.02930225 0.935736032 0.120195667 SUR2 -- sphingolipid metabolism -- Hydroxylase involved in sphingolipid metabolism YFR004W RPN11 6.2 17 13.5 0.8959 0.203974191 iYFR003C 0.101399638 0.393153954 0.09657245 "RPN11 -- transcription -- 19S regulatory particle of proteasome, has similarity to S. pombe PAD1 gene product" YNL268W LYP1 5.4 15 13.5 0.8959 0.205212292 iYNL269W 0.209593125 0.309018356 0.180584838 LYP1 -- transport -- Lysine-specific permeasehigh affinity YBR252W DUT1 4.7 13 13.5 0.8959 0.832659273 iYBR251W 0.687837348 0.890912572 "DUT1 -- pyrimidine metabolism -- dUTP pyrophosphatase, converts dUTP to dUMP preventing uracil incorporation into DNA" YNR016C ACC1 4.5 12 13.5 0.8959 0.571484618 iYNR016C-0 iYNR016C-1 0.025447048 0.004345731 0.509962088 0.032008558 0.055652486 "ACC1 -- fatty acid metabolism -- Acetyl-CoA carboxylase, first and rate-limiting step in fatty acid biosynthesis pathway" YBR084W MIS1 4 11 13.5 0.8959 0.801059128 iYBR083W 0.156080151 0.965440632 0.121371082 "MIS1 -- folate metabolism -- C1-tetrahydrofolate synthase (trifunctional enzyme), mitochondrial" YOL077C YOL077C 4.3 12 13.4 0.8957 0.52951555 iYOL078W iYOL077C 0.302396744 0.342022386 0.923623304 0.116419594 0.272896249 YOL077C -- unknown -- similarity to C. elegans Kq2H4.3 protein YNL190W YNL190W 9.9 28 13.3 0.8949 1 0.344045881 iYNL191W 0.927923003 0.388011602 0.759259259 YNL190W -- unknown -- unknown function YLR421C YLR421C 7.4 20 13.3 0.8949 0.241824142 iYLR421C 0.252145054 0.221274079 0.435612606 YLR421C -- unknown -- unknown function YPL117C IDI1 4.2 12 13.3 0.8949 0.42258826 iYPL117C 0.163108505 0.331289828 0.118571546 IDI1 -- isoprenoid biosynthesis -- Isopentenyl-diphosphate delta-isomerase (IPP isomerase)catalyzes a step in the cholesterol biosynthesis pathway YGR181W TIM13 4 11 13.3 0.8949 0.156429918 iYGR180C itL(CAA)G3 0.942690627 0.562148257 0.216130604 0.254061079 0.395051875 TIM13 -- mitochondrial protein targeting -- Mitochondrial intermembrane space transport of proteins into the inner membrane YPR204W YPR204W 5.4 15 13.2 0.8947 0.953034672 iYPR203W 0.922745819 0.217450854 0.486384144 "YPR204W -- unknown -- DNA helicase, encoded in the subtelomeric Y' elements" YJR085C YJR085C 8.4 24 13.1 0.8935 0.076060698 iYJR085C 0.076939899 0.50568686 0.442413905 YJR085C -- unknown -- unknown function YBR159W YBR159W 6.1 17 13.1 0.8935 0.635233252 iYBR158W 0.494662036 0.685971349 0.339424951 "YBR159W -- unknown -- Hypothetical transmembrane protein essential for viability, has similarity to human 17beta-hydroxysteroid dehydrogenase (17beta-HSD)" YML001W YPT7 5.1 14 13.1 0.8935 0.634126599 iYML002W 0.273286378 0.805591363 0.125873515 "YPT7 -- endocytosis -- GTP-binding role in protein transport between endosome-like compartments, member of rab family in the ras superfamily" YGR086C YGR086C 4.4 12 13.1 0.8935 0.970229791 iYGR086C 0.730726274 0.862305586 0.552174694 YGR086C -- unknown -- unknown functioninduced by high salt and low pH YMR241W YHM2 4 11 13.1 0.8935 0.638578598 iYMR240C 0.190110411 0.620876018 0.163087304 "YHM2 -- unknown -- Suppressor of abf1 mutant that affects mitochondrial HMG-like DNA-binding protein, member of mitochondrial carrier family (MCF) of membrane transporters" YOR253W YOR253W 4 11 13.1 0.8935 0.803674933 iYOR252W 0.39708642 0.80425601 0.168304866 YOR253W -- unknown -- unknown function YBR221C PDB1 8.5 24 13 0.8931 0.791173866 iYBR221C 0.068997251 0.85575578 0.121636188 "PDB1 -- glycolysis -- Pyruvate dehydrogenase complex, E1-beta subunit" YOR254C SEC63 4.6 13 13 0.8931 0.269425076 iYOR254C 0.125487127 0.505116959 0.039606356 "SEC63 -- secretion -- Component of ER protein-translocation subcomplexwhich includes Sec62p, Sec63p, Sec66p, and Sec72p, member of DnaJ protein family" YJR139C HOM6 5.9 17 12.9 0.8927 1 0.98626209 iYJR139C 0.97508984 0.94877793 0.071961115 HOM6 -- methionine and threonine biosynthesis -- Homoserine dehydrogenase (L-homoserine YML074C NPI46 5.2 15 12.9 0.8927 0.467482321 iYML074C-0 iYML074C-1 0.75378892 0.739700157 0.234961136 0.964506173 0.923722538 "NPI46 -- protein folding -- Peptidylprolyl cis-trans isomerase (PPIase) of nucleolus, has FK506- and rapamycin-binding activity" YMR145C YMR145C 6.3 18 12.8 0.8921 0.724023397 iYMR145C 0.343879848 0.556272594 0.305031447 YMR145C -- unknown -- Mitochondrial NADH dehydrogenase that catalyzes cytosolic NADH oxidation YGR020C VMA7 5.6 16 12.8 0.8921 0.664334504 iYGR020C 0.247132131 0.703996133 0.23231427 VMA7 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) 14 kDa subunit (subunit F) of catalytic (V0) sector YLR354C TAL1 5.2 15 12.8 0.8921 0.776732996 iYLR354C 0.850297572 0.953190461 0.502137614 "TAL1 -- pentose phosphate cycle -- Transaldolase, component of non-oxidative part of pentose-phosphate pathway" YNL151C RPC31 3.4 10 12.7 0.8911 1 0.32137578 iYNL151C 0.901574989 0.285412606 0.251013923 "RPC31 -- transcription -- RNA polymerase III, small subunit, essential subunit, not shared" YBR011C IPP1 12.3 36 12.7 0.8911 0.752000922 iYBR011C YBRCdelta11 0.807497759 0.811419558 0.784241789 0.914482879 0.604173381 "IPP1 -- phosphate metabolism -- Inorganic pyrophosphatase, cytoplasmic" YER178W PDA1 7.3 21 12.7 0.8911 0.862162029 iYER177W 0.480542108 0.994918125 0.421069614 PDA1 -- glycolysis -- Pyruvate dehydrogenase complex E1-alpha subunit (pyruvate YFR044C YFR044C 6.5 19 12.7 0.8911 0.508311917 iYFR044C 0.224623604 0.972977333 0.119395712 "YFR044C -- unknown -- unknown function, has similarity to Ybr281p" YJL052W TDH1 3.6 10 12.7 0.8911 0.906983029 iYJL053W 0.506704908 0.856792835 0.417037636 "TDH1 -- glycolysis -- Glyceraldehyde-3-phosphate dehydrogenase 1, converts D-glyceraldehyde 3-phosphate to 1,3-diphosphoglycerate" YDR519W FKB2 4.4 13 12.6 0.8907 0.109827774 iYDR518W 0.359476858 0.36649387 0.340289571 "FKB2 -- protein folding -- FK506-binding endoplasmic reticulum, predicted peptidylprolyl cis-trans isomerase, homolog of human FKBP13" YKR081C YKR081C 3.7 11 12.6 0.8907 0.415809302 iYKR081C 0.716013722 0.751705653 0.617587295 YKR081C -- unknown -- unknown function YDL232W OST4 5.6 17 12.5 0.8899 0.675560948 iYDL233W 0.254243276 0.408797937 0.26424581 OST4 -- protein glycosylation -- Oligosaccharyltransferase subunit of length 36 amino acids YMR123W PKR1 5.6 17 12.5 0.8899 0.413917572 iYMR122C-0 iYMR122C-1 0.377522607 0.033755916 0.432523998 0.221787709 0.177650661 PKR1 -- killer toxin sensitivity (Pichia farinosa toxin) -- unknown function YGR157W CHO2 4.9 15 12.5 0.8899 0.54589645 iYGR156W 0.82445248 0.595922677 0.913551402 "CHO2 -- phospholipid metabolism -- Phosphatidylethanolamine N-methyltransferase, carries out first methylation step in the phosphatidylcholine biosynthesis pathway" YKL172W EBP2 3.7 11 12.5 0.8899 0.332666211 iYKL173W 0.372687981 0.068874701 0.114430468 EBP2 -- unknown -- similarity to human nucleolar protein p40 YMR011W HXT2 7 21 12.4 0.8897 0.583955572 iYMR010W-0 iYMR010W-1 0.590738321 0.06596271 0.666693522 0.706413149 0.115216632 "HXT2 -- transport -- High-affinity hexose transporter, member of hexose transport family of major facilitator superfamily (MFS)" YDR210W YDR210W 6.5 20 12.3 0.8884 0.448380971 iYDR208W 0.31008941 0.86451782 0.30837938 YDR210W -- unknown -- unknown function YER012W PRE1 6.2 19 12.3 0.8884 0.817509446 iYER011W iYERWdelta7 0.781818994 0.779783626 0.922218626 0.896249002 0.807017544 PRE1 -- protein degradation -- Proteasome subunit beta4_sc (C11protease yscE subunit 11) YOR046C DBP5 4.3 13 12.3 0.8884 0.258795891 iYOR046C 0.176048988 0.688473018 0.136807292 "DBP5 -- mRNA export -- ATP-dependent cytosolic RNA helicase, required for poly(A+) RNA export" YIL094C LYS12 4 12 12.3 0.8884 0.582490897 iYIL094C 0.436703638 0.786225623 0.443658281 "LYS12 -- lysine biosynthesis -- Homoisocitrate dehydrogenase, converts homoisocitrate to alpha-ketoadipate, the fourth step in the lysine biosynthesis pathway" YPL050C MNN9 3.5 11 12.3 0.8884 0.427789715 iYPL050C 0.057921421 0.455101328 0.021575821 "MNN9 -- protein glycosylation -- complex N-glycosylation, subunit of Anp1p-Hoc1p-Mnn11p-Mnn9p mannosyltransferase complex" YNL175C YNL175C 3.1 10 12.3 0.8884 0.431072575 0.608315863 "YNL175C -- unknown -- similarity to Nsr1p, has two RNA recognition (RRM) domains" YML123C PHO84 2.2 7 12.3 0.8884 0.910383989 iYML123C 0.554130389 0.687908365 0.318240413 "PHO84 -- transport -- High-affinity inorganic phosphate/H+ symporter, member of phosphate" YDL157C YDL157C 5.7 18 12.2 0.888 0.473085979 iYDL157C 0.222632287 0.588287489 0.537270551 YDL157C -- unknown -- unknown function YBL001C ECM15 5.6 17 12.2 0.888 0.142313065 iYBL001C CEN2 0.267929416 0.675732556 0.178037687 0.162101192 0.400890689 ECM15 -- cell wall biogenesis -- Protein possibly involved in cell wall structure or biosynthesis YPL081W RPS9A 4.5 14 12.1 0.887 1 1 0.963311628 iYPL082C IntYPL081W 0.953480189 0.963957202 0.836830412 0.128651237 0.821085747 "RPS9A -- protein synthesis -- Ribosomal protein S9 (yeast S13YS11YP28rp21E. coli S4rat S9), nearly identical to Rps9Bp" YOR327C SNC2 4.4 14 12.1 0.887 0.131952308 iYOR327C 0.135793801 0.205450734 0.366563715 SNC2 -- secretion -- Synaptobrevin (v-SNARE) homolog present on post-Golgi vesicles YHL050C YHL050C 4.3 12.5 12.1 0.887 0.959311634 iYHL050C 0.923903199 0.512370311 0.712149375 "YHL050C -- unknown -- similarity to other subtelomerically-encoded proteins, putative DNA helicase" YOR184W SER1 4.2 13 12.1 0.887 0.956205586 iYOR183W 0.900399634 0.938771276 0.16603653 "SER1 -- serine biosynthesis -- 3-phosphoserine transaminase, involved in synthesis of serine from 3-phosphoglycerate" YNL153C GIM3 3.6 11 12.1 0.887 0.975068804 iYNL153C 0.811096033 0.575034941 0.112739138 "GIM3 -- protein folding -- Prefoldin subunit 4, component of Gim protein complex that promotes formation of functional alpha- and gamma-tubulin, and actin" YOL129W YOL129W 6.2 19 12 0.8864 0.291389195 iYOL130W 0.494824197 0.286549708 0.373638784 YOL129W -- unknown -- unknown function YER126C YER126C 3.4 10 12 0.8864 0.219757092 iYER126C 0.474346952 0.635856708 0.250119713 YER126C -- unknown -- Nuclear unknown function YNL075W IMP4 3.1 10 12 0.8864 0.689725501 iYNL076W 0.133168437 0.822027071 0.331124057 "IMP4 -- rRNA processing -- Component of U3 snoRNP, required for pre-18S rRNA processing" YGL106W MLC1 5.7 18 11.9 0.8852 0.33549693 iYGL107C 0.162585011 0.322591041 0.125191579 MLC1 -- cytoskeleton -- Myosin light chain YDL004W ATP16 5.5 17 11.9 0.8852 0.537649257 iYDL005C 0.14698607 0.759421702 0.44172812 ATP16 -- ATP synthesis -- Delta subunit of F1-ATP synthase YOR260W GCD1 4.7 15 11.9 0.8852 0.28011134 iYOR259C 0.287923515 0.678546471 0.410239801 "GCD1 -- protein synthesis -- Translation initiation factor eIF2B (guanine nucleotide exchange factor), 58 kDa subunit" YAL036C YAL036C 3.9 12 11.9 0.8852 0.694103167 iYAL036C 0.45051853 0.576901289 0.598130841 YAL036C -- unknown -- similarity to Xenopus laevis DRG GTP-binding protein YPL163C SVS1 3.5 11 11.9 0.8852 0.461082392 iYPL163C 0.873184532 0.421864847 0.24285013 SVS1 -- vanadate resistance -- Serine- and threonine-rich vanadate resistance YER146W LSM5 2.9 9 11.9 0.8852 0.853865831 iYER145C 0.540582037 0.906542056 0.253609744 LSM5 -- mRNA splicing (putative) -- U6 snRNA-associated Sm-like group YFL037W TUB2 6.5 20 11.8 0.884 0.429722094 iYFL038C 0.232065054 0.762840671 0.072510474 "TUB2 -- cytoskeleton -- Tubulin beta chain, required for mitosis and karyogamy" YJL167W ERG20 5.5 17 11.8 0.884 0.654551129 iYJL168C 0.362992295 0.914961014 0.330855019 "ERG20 -- sterol metabolism -- Farnesyl pyrophosphate synthetase (FPP synthetase), may be rate-limiting step in sterol biosynthesis pathway" YDR510W SMT3 5.4 17 11.8 0.884 0.265541399 iYDR509W 0.171081217 0.428731045 0.315302144 "SMT3 -- protein degradation -- Ubiquitin-related protein, homolog of human SUMO-1 protein, becomes conjugated to other proteins in a process requiring ATP, Uba2p, Aos1p, and Ubc9p" YMR226C YMR226C 5.4 17 11.8 0.884 0.383959295 iYMR226C 0.31596249 0.303738318 0.064612406 YMR226C -- unknown -- similarity to insect-type short-chain alcohol dehydrogenase YDR055W PST1 4.7 15 11.8 0.884 0.574799901 iYDR054C 0.761858507 0.446699353 0.928906443 PST1 -- unknown -- similarity to members of Sps2p-Ecm33p-Ycl048p family YER030W YER030W 4.3 13 11.8 0.884 0.685794364 iYER029C 0.486484716 0.086448598 0.033918595 YER030W -- unknown -- unknown function YIL062C ARC15 5.1 16 11.7 0.8832 0.424412369 iYIL062C 0.321136883 0.677280329 0.046539961 ARC15 -- cytoskeleton -- Component of ARP2/3 actin-organizing complexinvolved in actin assembly and function YOR361C PRT1 5.1 16 11.7 0.8832 0.596597261 iYOR361C 0.167020582 0.635594586 0.150486073 "PRT1 -- protein synthesis -- Translation initiation factor eIF3 beta subunit (p90), has an RNA recognition (RRM) domain" YOL092W YOL092W 3.8 12 11.7 0.8832 0.529137345 iYOL093W 0.282727698 0.739284563 0.210694334 YOL092W -- unknown -- unknown function YCL018W LEU2 3.3 10 11.7 0.8832 0.509250435 iYCLWdelta5 tL(CAA)C 0.720981297 0.688560526 0.881969062 0.455753551 0.641611424 "LEU2 -- leucine biosynthesis -- 3-Isopropylmalate dehydrogenase, catalyzes the third step in the leucine biosynthesis pathway" YCL043C PDI1 6.7 21 11.6 0.8822 0.805759676 0.85794347 PDI1 -- protein folding -- disulfide isomerase and oxidoreductase YIR037W HYR1 5.6 18 11.6 0.8822 0.319631801 iYIR036C 0.459906116 0.541021548 0.223386279 HYR1 -- oxidative stress response -- Glutathione peroxidase involved in oxidative stress response YKL085W MDH1 4.8 16 11.6 0.8822 0.340043563 iYKL086W 0.298575613 0.83569453 0.112897986 "MDH1 -- TCA cycle -- Malate dehydrogenase, mitochondrial" YLL008W DRS1 3.3 10 11.6 0.8822 0.309106419 iYLL009C 0.04426658 0.361968238 0.02258611 DRS1 -- rRNA processing -- RNA helicase of DEAD box family involved in rRNA biogenesis YKL209C STE6 3 10 11.6 0.8822 0.276461414 iYKL209C tT(CGU)K 0.394399308 0.664897092 0.721069433 0.48028731 0.233979255 "STE6 -- mating -- Membrane transporter responsible for export of ""a"" factor mating pheromone member of ATP-binding cassette (ABC) superfamily" YPL225W YPL225W 8 26 11.5 0.8807 0.876153473 iYPL226W 0.570060886 0.586831604 YPL225W -- unknown -- unknown function YCL019W 7 22 11.5 0.8807 0.358042964 0.644510769 YAR020C PAU7 6.1 20 11.5 0.8807 0.780022984 iYAR020C-0 iYAR020C-1 0.355097735 0.369927761 0.651788592 0.7138564 0.663708962 "PAU7 -- unknown -- Member of seripauperin (PAU) family, has strong similarity to Pau3p/Ycr104p" YKL190W CNB1 5.3 17.5 11.5 0.8807 0.466937372 iYKL191W 0.263992409 0.483502016 0.115915141 CNB1 -- signaling -- Calcineurin regulatory (B) subunit YLR294C YLR294C 5.2 17 11.5 0.8807 0.77747484 0.654735456 "YLR294C -- unknown -- unknown function, possibly involved in respiration" YIR012W SQT1 4.2 13 11.5 0.8807 0.64513199 iYIR011C 0.134793521 0.748842777 0.142615749 SQT1 -- ribosome biogenesis (putative) -- may be required for ribosomal assemblyhas WD (WD-40) repeat motifs YOR168W GLN4 3.9 13 11.5 0.8807 0.548059005 iYOR167C 0.663755581 0.661565046 0.375370679 GLN4 -- protein synthesis -- Glutaminyl-tRNA synthetase YER091C MET6 3.5 11 11.5 0.8807 0.630628294 iYER091C YER091C-A 0.613276725 0.28527004 0.848843907 0.549004193 0.125120851 "MET6 -- methionine biosynthesis -- Homocysteine methyltransferase (5-methyltetrahydropteroyl triglutamate-homocysteine methyltransferase), methionine synthase, cobalamin-independent" YEL077C 4.2 13 11.4 0.8803 0.872429982 iYEL077C 0.835749566 0.29708246 0.411793176 YJL225C YJL225C 4.2 14 11.4 0.8803 0.963671807 iYJL225C-0 iYJL225C-1 0.995603761 0.996758778 0.481326127 0.078441649 0.357542726 "YJL225C -- unknown -- near identity to other subtelomerically-encoded proteins including Yil177p, Yhr219p, and Yhl079p" YLL018C DPS1 5.5 18 11.3 0.8793 0.687881505 iYLL018C 0.370187354 0.866016758 0.725541353 "DPS1 -- protein synthesis -- Aspartyl-tRNA synthetase, cytoplasmic" YOR259C RPT4 5.5 18 11.3 0.8793 0.142747868 iYOR259C 0.287923515 0.176980387 0.410239801 RPT4 -- protein degradation -- Component of 26S proteasome complex and member of AAA family of ATPases YLR192C HCR1 4.9 16 11.3 0.8793 0.176597714 iYLR192C 0.284911585 0.282651072 0.497701057 "HCR1 -- unknown -- Putative component of translation initiation factor eIF3, has similarity to human eIF3 p35 subunit" YML008C ERG6 4.3 14 11.3 0.8793 0.394261793 iYML008C 0.303277182 0.428525016 0.365203512 "ERG6 -- sterol metabolism -- S-adenosylmethionine delta-24-sterol-C-methyltransferase, carries out methylation of zymosterol as part of ergosterol biosynthesis pathway" YKL099C YKL099C 2.9 10 11.3 0.8793 0.243639944 iYKL099C 0.538981092 0.350199521 0.727864143 YKL099C -- unknown -- unknown function YPL271W ATP15 5.4 18 11.2 0.8781 0.361821053 iYPL272C-0 iYPL272C-1 0.144273674 0.26695951 0.32291331 0.324685788 0.328911795 ATP15 -- ATP synthesis -- Epsilon subunit of F1-ATP synthaseone copy is found in each F1 oligomer YMR045C 5.1 16 11.2 0.8781 0.2021772 0.178145314 YBR162W-A YSY6 3.9 13 11.2 0.8781 0.406986212 iYBR162C 0.186916873 0.614004772 0.267295597 YSY6 -- secretion (putative) -- probable function in the secretory pathway YIL008W YIL008W 3.9 13 11.2 0.8781 0.687538128 iYIL009W 0.725769459 0.861014762 0.874681149 YIL008W -- unknown -- Ubiquitin-related protein conjugated to other proteins by Uba4p YNR043W MVD1 3.5 12 11.2 0.8781 0.271404454 iYNR042W 0.453397067 0.554595573 0.28013213 MVD1 -- sterol metabolism -- Mevalonate diphosphate (MVAPP) decarboxylase (MVA-5-pyrophosphate decarboxylase) YJL157C FAR1 2.6 9 11.2 0.8781 0.544190312 iYJL157C 0.442586664 0.898723065 0.527134876 FAR1 -- cell cycle -- Inhibitor of Cdc28p-Cln1p and Cdc28p-Cln2p kinase complexes involved in cell cycle arrest for mating YOR355W GDS1 2.9 10 11.1 0.8769 1 0.571358977 iYOR354C-0 iYOR354C-1 0.925420027 0.965657265 0.519094289 0.610055866 0.242568228 "GDS1 -- respiration (putative) -- suppresses nam9-1 glycerol deficient phenotype when overexpressed, involved in nuclear control of mitochondria" YOR332W VMA4 6.4 21 11.1 0.8769 0.298152965 0.199772886 "VMA4 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) hydrophilic subunit (subunit E), 27 kDa subunit of V1 sector" YKL196C YKT6 4.5 15 11.1 0.8769 0.720705152 iYKL196C 0.301026728 0.857267645 0.475308642 "YKT6 -- secretion -- Synaptobrevin (v-SNARE) homolog with similarity to Sec22p, Snc1p, and Snc2p, essential for endoplasmic reticulum-Golgi transport" YLR074C YLR074C 3.7 12 11.1 0.8769 0.95406189 iYLR074C 0.965446025 0.752355426 0.430309378 "YLR074C -- unknown -- unknown function, has a single C2H2-type zinc finger" YDR321W ASP1 3.1 10 11.1 0.8769 0.673529231 iYDR320C 0.29164636 0.875750843 0.539793849 "ASP1 -- asparagine utilization -- Asparaginase, (L-asparagine aminohydrolase I), intracellular isozyme that converts asparagine to aspartate and ammonia" YNR067C YNR067C 2.8 9 11.1 0.8769 0.763269944 iYNR067C 0.714942969 0.697287199 0.821585605 "YNR067C -- unknown -- similarity to C. albicans Eng1p, endo-1,3-beta-glucanase" YCL036W YCL036W 2.9 10 11 0.8755 1 0.977096742 iYCL037C 0.960346205 0.320662768 0.151642208 YCL036W -- unknown -- unknown function YDR071C YDR071C 6.1 20 11 0.8755 0.570320637 iYDR071C 0.528921528 0.736439359 0.553359684 YDR071C -- unknown -- unknown function YML052W SUR7 4 13 11 0.8755 0.698119761 iYML053C 0.505701537 0.596031298 0.506900769 SUR7 -- endocytosis (putative) -- unknown functionoverproduction suppresses the rvs167 mutation YNL149C YNL149C 4 14 11 0.8755 0.925008723 iYNL149C 0.441711143 0.192872117 0.111397919 YNL149C -- unknown -- unknown function YGL256W ADH4 3.9 13 11 0.8755 0.722133394 iYGL257C 0.185512606 0.850151563 0.074541101 ADH4 -- glycolysis -- Alcohol dehydrogenase IV YKR013W PRY2 3.4 11 11 0.8755 0.252456996 0.351214003 PRY2 -- unknown -- expressed under starvation conditions YNL015W PBI2 3.3 11 11 0.8755 0.324761144 iYNL016W 0.609046615 0.21109946 0.593129415 "PBI2 -- unknown -- Protease B (yscB or Prb1p) inhibitor 2 (I2B), has activity related to vacuolar fusion that is not related to protease activity" YOR010C TIR2 5.1 17 10.9 0.8747 0.343161105 iYOR010C-0 iYOR010C-1 0.234709768 0.457545768 0.37309902 0.193614745 0.610308946 "TIR2 -- unknown -- Cold-shock induced protein, member of seripauperin (PAU) family" YIL076W SEC28 4.9 17 10.9 0.8747 0.361282832 iYIL077C 0.267643764 0.72337838 0.70207502 SEC28 -- secretion -- Coatomer (COPI) complex epsilon chain (epsilon-COP) of secretory pathway vesiclesrequired for retrograde transport from Golgi to endoplasmic reticulum YER049W YER049W 3.6 12 10.9 0.8747 0.386184774 iYER048W-A YER048W-A 0.746795843 0.586645929 0.625359993 0.845688009 0.856912665 YER049W -- unknown -- unknown function YIL015W BAR1 2 7 10.9 0.8747 0.507089312 iYIL016W 0.733502123 0.866959064 0.909322801 BAR1 -- mating -- Secreted pepsin-like protease that degrades alpha-factor YCL011C GBP2 7.2 25 10.8 0.8739 0.248951068 iYCL011C 0.605731727 0.25450506 0.600988574 "GBP2 -- unknown -- Potential telomere-associated binds single-stranded G-strand telomere sequence, has three RNA recognition (RRM) domains" YCR028C-A RIM1 5.3 18.5 10.8 0.8739 0.600254993 iYCR028C-A 0.459294806 0.664405427 0.687470072 "RIM1 -- mitochondrial DNA maintenance -- binds single-stranded DNA, required for replication in mitochondria, has three C2H2-type zinc fingers" YLL014W YLL014W 4.8 17 10.8 0.8739 0.599959039 iYLL015W 0.582843863 0.818069612 0.453996133 YLL014W -- unknown -- unknown function YML125C YML125C 3.8 13 10.8 0.8739 0.7414408 iYML125C 0.348495917 0.883074138 0.134452399 YML125C -- unknown -- similarity to NADH-cytochrome b5 reductase YGL187C COX4 4.9 17 10.7 0.8726 0.987116684 iYGL187C 0.89576702 0.992023848 0.680211139 COX4 -- oxidative phosphorylation -- Cytochrome-c oxidase subunit IV YDL067C COX9 4.8 17 10.7 0.8726 0.289090763 iYDL067C 0.331189849 0.191427651 0.31007097 "COX9 -- oxidative phosphorylation -- Cytochrome-c oxidase subunit VIIA, essential component of cytochrome-c holoenzyme" YJL001W PRE3 4.5 16 10.7 0.8726 0.425308383 iYJL002C 0.485607212 0.465921788 0.814814815 PRE3 -- protein degradation -- Proteasome subunit beta1_sc involved in peptidyl-glutamyl peptide hydrolytic activity of proteasome YDR035W ARO3 4.4 15 10.7 0.8726 0.529674434 iYDR034W-B YDR034W-B 0.412770992 0.573438379 0.384346611 0.346698113 0.389542378 ARO3 -- aromatic amino acid biosynthesis -- 2-Dehydro-3-deoxyphosphoheptonate aldolase (DAHPS)phenylalanine-inhibited YNR050C LYS9 3.7 13 10.7 0.8726 0.360743217 iYNR050C 0.708368838 0.843553459 0.392657622 "LYS9 -- lysine biosynthesis -- Saccharopine dehydrogenase (saccharopine reductaseNADP+, L-glutamate forming), seventh step in lysine biosynthesis pathway" YMR049C YMR049C 3 11 10.7 0.8726 0.237875628 iYMR049C-0 iYMR049C-1 0.415694056 0.30648017 0.440383081 0.594821328 0.506541595 "YMR049C -- unknown -- similarity to mouse Bop1 growth supressor, has one WD (WD-40) domain" YGR260W TNA1 2.5 9 10.7 0.8726 0.62478269 0.569653583 TNA1 -- unknown -- similarity to Dal5p and member of allantoate permease family of major facilitator superfamily (MFS) YLR208W SEC13 5.3 18 10.6 0.8714 0.604781816 iYLR207W 0.295414274 0.55994152 0.196181142 "SEC13 -- secretion -- Component of COPII coat of vesicles involved in endoplasmic reticulum to Golgi transport, contains six WD (WD-40) repeats" YJL055W YJL055W 5.2 18 10.6 0.8714 0.246813347 iYJL056C 0.739039973 0.163148566 0.221892746 YJL055W -- unknown -- unknown function YLR027C AAT2 5.2 18 10.6 0.8714 0.748005466 iYLR027C 0.559631037 0.937464001 0.479968077 "AAT2 -- aspartate metabolism -- Aspartate aminotransferase (2-oxoglutarate aminotransferase), cytosolic and peroxisomal" YDR483W KRE2 5.1 18 10.6 0.8714 0.775946488 iYDR482C 0.079084345 0.941181165 0.118433774 "KRE2 -- protein glycosylation -- Alpha-1,2-mannosyltransferase of KRE2 family, acts in the Golgi to add the third mannose onto O-linked carbohydrate chains" YLR295C ATP14 4.7 16 10.6 0.8714 0.755095305 iYLR295C 0.419459284 0.46269739 0.753229655 ATP14 -- ATP synthesis -- Subunit h of ATP synthase YHR092C HXT4 3.1 11 10.6 0.8714 0.57521077 iYHR092C 0.425806929 0.304267161 0.644254475 "HXT4 -- transport -- Moderate- to low-affinity hexose transporter, member of hexose transporter family of major facilitator superfamily (MFS)" YOR375C GDH1 7.7 27 10.5 0.8704 0.33168529 iYOR375C 0.446154014 0.371428571 0.503333965 "GDH1 -- glutamate biosynthesis -- Glutamate dehydrogenase (NADP+), combines ammonia and alpha-ketoglutarate to form glutamate" YDL185W VMA1 7.4 26 10.5 0.8704 0.75691766 iYDL186W 0.896502193 0.558733484 0.24450828 "VMA1 -- vacuolar acidification -- Catalytic subunit (subunit A) of vacuolar H(+) ATPase V1 complex, generated upon protein splicing of full-length unspliced precursor protein by ligation of N-terminal and C-terminal exein moieties" YPL246C YPL246C 3.9 14 10.5 0.8704 0.128595079 iYPL246C 0.078829945 0.169193935 0.045503168 YPL246C -- unknown -- unknown function YHL003C LAG1 2.9 10 10.5 0.8704 0.840849776 iYHL003C 0.395280012 0.969787303 0.335804061 "LAG1 -- aging -- Protein required with Lac1p for ER-to-Golgi transport of GPI-anchored proteins, has indirect effect on cell longevity" YDR101C YDR101C 2.7 9 10.5 0.8704 0.668730655 iYDR101C 0.371276441 0.858282307 0.353633944 YDR101C -- unknown -- unknown function YPL237W SUI3 5.8 21 10.4 0.8688 0.321662315 0.361517219 SUI3 -- protein synthesis -- Translation initiation factor eIF2beta subunit YNL322C KRE1 5.6 20 10.4 0.8688 0.404804028 iYNL322C 0.25315304 0.666779317 0.230145319 "KRE1 -- cell wall biogenesis -- Cell wall protein needed for cell wall beta-1,6-glucan assembly, probably involved in side-chain addition to form mature beta-1,6-glucan" YOR136W IDH2 5.6 20 10.4 0.8688 0.638502058 0.912639405 "IDH2 -- TCA cycle -- Isocitrate dehydrogenase (NAD+) subunit 2, mitochondrial, required for oxidative function of tricarboxylic acid cycle" YAL042W YAL042W 3.9 14 10.4 0.8688 0.613623447 0.706023959 "YAL042W -- unknown -- unknown function, has 2 potential transmembrane segments" YDR492W 3.7 13 10.4 0.8688 0.39153106 0.426177175 YOL151W GRE2 3.6 13 10.4 0.8688 0.168866672 iYOL152W 0.447398104 0.769273743 0.059367178 GRE2 -- unknown -- diamide tolerance and induced by osmotic stress YLR083C EMP70 3.1 11 10.4 0.8688 0.31986471 iYLR083C 0.765404191 0.690708252 0.677570093 EMP70 -- secretion (putative) -- Endosomal membrane similarity to human putative ion transporter EMP70 YMR012W CLU1 3.1 11 10.4 0.8688 0.612309417 iYMR011W YMRCtau1 0.294584755 0.508449161 0.324236517 0.186671987 0.586564091 "CLU1 -- protein synthesis -- Translation initiation factor eIF3, p135 subunit" YJR007W SUI2 3.7 13 10.3 0.868 0.386757326 iYJR006W 0.546737482 0.801596169 0.766728625 SUI2 -- protein synthesis -- Translation initiation factor eIF2alpha subunit YGR162W TIF4631 3.4 12 10.3 0.868 0.404650734 iYGRCdelta30 itV(AAC)G2 0.458437891 0.239094299 0.491146849 0.654612159 0.162473795 TIF4631 -- protein synthesis -- mRNA cap-binding protein (eIF4F) 150K subunit YJL173C RFA3 3.3 12 10.3 0.868 0.609494033 iYJL173C 0.367959432 0.626651627 0.4896249 "RFA3 -- DNA replication -- DNA replication factor A, 13K subunit" YGR200C ELP2 2.8 10 10.3 0.868 0.405684034 iYGR200C 0.519385645 0.726393812 0.296326136 "ELP2 -- unknown -- 90 kDa subunit of elongator and elongating RNA polymerase II holoenzyme, has WD (WD-40) repeats" YFL031W HAC1 4 15 10.2 0.8668 0.662988164 0.735266316 "HAC1 -- unfolded protein response -- Transcription factor that activates the unfolded protein response (UPR) pathway, regulated mRNA splicing is initiated by Ire1p, and only the product of spliced mRNA is able to induce the response" YDL095W PMT1 3.9 14 10.2 0.8668 0.482385582 0.642645003 PMT1 -- protein glycosylation -- Mannosyltransferase (dolichyl phosphate-D-mannose YDL078C MDH3 3.3 12 10.2 0.8668 0.346240289 iYDL078C 0.256181634 0.300913355 0.339751502 "MDH3 -- TCA cycle -- Malate dehydrogenase, peroxisomal" YOR342C YOR342C 2.5 9 10.2 0.8668 0.70603893 iYOR342C 0.913426985 0.453053931 0.32580463 YOR342C -- unknown -- unknown function YDL060W YDL060W 2.4 8 10.2 0.8668 0.67000609 iYDL061C 0.989542094 0.247194493 0.337988827 YDL060W -- unknown -- unknown function YGR187C HGH1 2.2 8 10.2 0.8668 0.236848607 iYGR187C 0.430382205 0.334384752 0.488644305 HGH1 -- unknown -- similarity to human HMG1 and HMG2 proteins YNL070W TOM7 5.2 19 10.1 0.8656 0.541120669 iYNL071W 0.551724138 0.622233193 0.301040574 TOM7 -- mitochondrial protein targeting -- Small subunit of translocase involved in mitochondrial protein import YPL094C SEC62 3.6 13 10.1 0.8656 0.853980053 iYPL094C 0.673786755 0.134205546 0.626676541 "SEC62 -- secretion -- Component of ER protein-translocation subcomplex which includes Sec62p, Sec63p, Sec66p, and Sec72p" YER072W NRF1 3.1 11 10.1 0.8656 0.828152125 iYER071C 0.563065542 0.62962963 0.768437297 "NRF1 -- signaling, polarized growth (putative) -- the distribution of V-ATPase and other membrane proteins" YGL120C PRP43 2.9 11 10.1 0.8656 0.600063892 iYGL120C 0.557116181 0.792530451 0.514587701 "PRP43 -- mRNA splicing -- Pre-mRNA splicing factor, member of DEAH-box RNA helicase family" YDL219W YDL219W 2.8 10 10.1 0.8656 0.366332317 iYDL220C 0.658118106 0.680572698 0.720577559 YDL219W -- unknown -- D-Tyr-tRNA[Tyr] deacylase YPL012W YPL012W 2.2 8 10.1 0.8656 0.462927877 iYPL013C 0.148858047 0.363687151 0.119787045 YPL012W -- unknown -- unknown function YFL022C FRS2 3.8 14 10 0.8643 1 0.848191633 iYFL022C 0.990286547 0.53506847 0.286136432 "FRS2 -- protein synthesis -- Phenylalanyl-tRNA synthetase, beta subunit, cytoplasmic" YJL166W QCR8 5.6 21 10 0.8643 0.581384586 iYJL167W 0.379848948 0.724930119 0.4632083 QCR8 -- oxidative phosphorylation -- Ubiquinol cytochrome-c reductase subunit 8 (11 kDa protein)component of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex) YEL001C YEL001C 3.5 13 10 0.8643 0.443902808 iYEL001C CEN5 0.488654179 0.770569932 0.735867446 0.516711158 0.280460296 YEL001C -- unknown -- unknown function YER007C-A 3.3 12 10 0.8643 0.229416482 iYER007C-A snR14 0.848138918 0.74363914 0.604332445 0.962962963 0.564387394 YDR144C MKC7 3.1 12 10 0.8643 0.195761769 iYDR144C 0.510090063 0.138736706 0.633203379 "MKC7 -- protein degradation -- Aspartyl protease found in the periplasmic space, has similarity to Yps1p and Bar1p" YLR196W PWP1 3.1 12 10 0.8643 0.103412235 iYLR195C 0.432717076 0.168635275 0.36054256 "PWP1 -- unknown -- Periodic tryptophan protein, has WD (WD-40) repeats" YJR048W CYC1 2.6 10 10 0.8643 0.588642197 iYJR047C 0.66482383 0.744776962 0.180127694 "CYC1 -- oxidative phosphorylation -- Cytochrome-c isoform 1, predominant isoform during aerobic growth" YBR111C YSA1 5.1 19 9.9 0.8625 0.582900602 iYBR111C 0.503001711 0.877860135 0.542568352 YSA1 -- unknown -- Nucleoside diphosphate-sugar hydrolase of MutT (nudix) family YJR121W ATP2 4.3 16 9.9 0.8625 0.763337379 iYJR120W 0.609403696 0.751955307 0.371817596 "ATP2 -- ATP synthesis -- Beta subunit of F1-ATP synthase, three copies are present in each F1 complex" YDL124W YDL124W 3.7 14 9.9 0.8625 0.635187136 iYDL125C 0.512831092 0.776340509 0.809901994 YDL124W -- unknown -- unknown function YOL143C RIB4 3.6 13 9.9 0.8625 0.57473842 iYOL143C 0.072553962 0.805840123 0.307493748 "RIB4 -- riboflavin biosynthesis -- Riboflavin biosynthesis pathway enzyme, 6,7-dimethyl-8-ribityllumazine synthase" YGR105W VMA21 3.5 13 9.9 0.8625 0.80890953 iYGR104C 0.261918161 0.909514316 0.330977908 VMA21 -- vacuolar acidification -- vacuolar H(+)-ATPase (V-ATPase) assembly YLR449W FPR4 3.5 13 9.9 0.8625 0.103053501 iYLR448W 0.826317134 0.042866378 0.936718486 FPR4 -- protein folding (putative) -- Nucleolar peptidylprolyl cis-trans isomerase (PPIase) YKL191W DPH2 3.4 13 9.9 0.8625 0.42917633 iYKL192C 0.338008263 0.785873903 0.683240223 "DPH2 -- diphthamide biosynthesis -- Diptheria toxin resistance protein, required for diphthamide biosynthesis" YDL039C YDL039C 3.1 12 9.9 0.8625 0.041493587 0.073880116 YDL039C -- unknown -- unknown function YOL124C YOL124C 3.1 12 9.9 0.8625 0.37725338 iYOL124C 0.531809555 0.702729045 0.876695164 YOL124C -- unknown -- unknown function YNL010W YNL010W 3.3 12 9.8 0.8607 1 0.943292522 iYNL011C 0.967623943 0.894813261 0.422117996 YNL010W -- unknown -- unknown function YBR127C VMA2 5.8 22 9.8 0.8607 0.604854631 iYBR127C 0.723097865 0.791804469 0.628988076 "VMA2 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) regulatory subunit (subunit B) involved in nucleotide binding, 58 kDa subunit of V1 ATP-hydrolysis domain" YDR039C ENA2 4.9 19 9.8 0.8607 0.356153748 iYDR039C 0.702074356 0.482699805 0.92345387 ENA2 -- transport -- P-type ATPase involved in Na+ efflux YDR190C RVB1 4.4 16 9.8 0.8607 0.751940595 iYDR190C 0.589241448 0.918038822 0.440302144 RVB1 -- unknown -- Putative 3' to 5' DNA/RNA helicase involved in ribosomal RNA processing YOR232W MGE1 3.6 14 9.8 0.8607 0.419968814 iYOR231W 0.467311879 0.631335283 0.673622301 "MGE1 -- mitochondrial protein targeting -- Homolog of E. coli GrpE, participates with Ssc1p and Mdj1p in folding of proteins during mitochondrial import" YNL098C RAS2 3.5 13 9.8 0.8607 0.755827829 iYNL098C 0.214949158 0.873195128 0.408077053 "RAS2 -- signaling, Ras pathway -- GTP-binding regulation of cAMP pathway, homolog of mammalian proto-oncogene ras" YJL217W YJL217W 3 11 9.8 0.8607 0.545447034 iYJL218W 0.4276005 0.788416552 0.729450674 YJL217W -- unknown -- unknown function YOR078W YOR078W 2.5 9 9.8 0.8607 0.058993908 iYOR077W 0.168917408 0.104253948 0.112365895 YOR078W -- unknown -- unknown function YCR087C-A 2.1 8 9.8 0.8607 YBR283C SSH1 5.1 19 9.7 0.8601 0.349952577 iYBR283C 0.371552176 0.562330289 0.38531514 "SSH1 -- secretion -- Component of Ssh1p-Sss1p-Sbh2p complex, involved in protein translocation into the endoplasmic reticulum" YJL151C YJL151C 3.4 13 9.7 0.8601 0.679637252 iYJL151C 0.125789218 0.734777484 0.060734238 YJL151C -- unknown -- unknown function YOR246C YOR246C 3.3 13 9.7 0.8601 0.126541152 iYOR246C 0.583827231 0.407494759 0.433390932 YOR246C -- unknown -- unknown function YLR100W ERG27 3.9 15 9.6 0.8589 0.48895891 iYLR099C 0.308696027 0.534929647 0.39896874 "ERG27 -- unknown -- 3-Keto sterol reductase, required for ergosterol biosynthesis" YMR120C ADE17 3.7 14 9.6 0.8589 0.347054782 iYMR120C 0.454936183 0.403933185 0.682423167 ADE17 -- purine biosynthesis -- 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase YHR045W YHR045W 3.4 13 9.6 0.8589 0.432953586 iYHR044C 0.550011383 0.682261838 0.772283617 "YHR045W -- unknown -- unknown function, has 5 potential transmembrane domains" YDL131W LYS21 3 12 9.6 0.8589 0.946360201 iYDL132W 0.475607111 0.988545616 0.36480825 "LYS21 -- lysine biosynthesis -- Homocitrate synthase isoenzyme, involved in lysine metabolism" YDR465C RMT2 2.7 10 9.6 0.8589 0.337371356 iYDR465C 0.342592912 0.590891567 0.360569407 RMT2 -- arginine metabolism -- Putative protein arginine methyltransferasehas similarity to human guanidinoacetate N-methyltransferase YAL025C MAK16 2.5 10 9.6 0.8589 0.121989157 iYAL025C 0.444424237 0.260883691 0.362749052 "MAK16 -- dsRNA virus propagation -- Nuclear HMG-like acidic region, required for propagation of M1 double-stranded RNA" YDR011W SNQ2 6.3 24 9.5 0.8573 0.615507075 iYDR010C 0.470414755 0.384280215 0.444828437 "SNQ2 -- 4-nitroquinoline-N-oxide resistance -- Drug-efflux pump involved in resistance to multiple drugs, member of ATP-binding cassette (ABC) superfamily" YDL100C YDL100C 6.1 23 9.5 0.8573 0.295762255 iYDL100C 0.119276172 0.503752357 0.140788283 YDL100C -- unknown -- similarity to E. coli ArsA ATPase component of arsenite-antimonite efflux pump YKR043C YKR043C 4.5 17 9.5 0.8573 0.162751267 iYKR043C 0.144533921 0.089831059 0.313088587 YKR043C -- unknown -- similarity to phosphoglycerate mutase YLL009C COX17 4.2 16 9.5 0.8573 0.452154193 iYLL009C 0.04426658 0.241429378 0.02258611 COX17 -- respiration -- Cytoplasmic proteininvolved in delivery of copper ions to mitochondrial cytochrome oxidase YIL011W YIL011W 3.9 15 9.5 0.8573 0.34995186 iYIL012W 0.29080083 0.176007147 0.252703616 YIL011W -- unknown -- Member of seripauperin (PAU) family of possible cell wall mannoproteins YGR229C SMI1 3.3 13 9.5 0.8573 0.207931195 iYGR229C 0.484844066 0.257940942 0.841374269 "SMI1 -- cell wall biogenesis -- beta-1,3-glucan synthesis, possibly through regulation of cell wall glucan and chitin synthesis" YNL232W CSL4 3.1 12 9.5 0.8573 0.55591688 iYNL233W 0.206193122 0.385397896 0.184118117 "CSL4 -- mitosis, chromosome segregation -- member of both the cytoplasmic and nucleolar forms of exosome 3'->5' exonuclease complex, possibly involved in kinetochore-related function" YKL122C SRP21 3 12 9.5 0.8573 0.510659395 iYKL122C 0.338214021 0.285988819 0.468305814 SRP21 -- secretion -- Signal recognition particle subunitno homologous subunit yet detectable in mammals YCL030C HIS4 5.1 20 9.4 0.856 1 0.917384174 iYCL030C 0.974354786 0.660482375 0.323788013 "HIS4 -- histidine biosynthesis -- Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase / histidinol dehydrogenase, second, third, and tenth steps of histidine biosynthesis pathway" YGL026C TRP5 5.7 23 9.4 0.856 0.861885584 iYGL026C 0.546243906 0.971872816 0.405426975 "TRP5 -- tryptophan biosynthesis -- Tryptophan synthase, last (fifth) step in tryptophan biosynthesis pathway" YPL078C ATP4 5.3 21 9.4 0.856 0.449211788 iYPL078C 0.418490689 0.301605227 0.206914869 "ATP4 -- ATP synthesis -- Subunit 4 of F0-ATP synthase, has similarity to bovine subunit b" YGR151C YGR151C 3.4 13.5 9.4 0.856 0.784548597 0.633939239 YGR151C -- unknown -- unknown function YML105C SEC65 3.1 12 9.4 0.856 0.266579549 iYML105C 0.765736796 0.508242442 0.685756603 SEC65 -- secretion -- Signal recognition particle subunit SRP19 YEL003W GIM4 3 12 9.4 0.856 0.7194249 iYEL004W 0.269788714 0.636797499 0.561633903 "GIM4 -- protein folding -- Prefoldin subunit 2, component of Gim protein complex that promotes formation of functional alpha- and gamma-tubulin, and actin" YBL042C FUI1 2.5 10 9.4 0.856 0.438605645 iYBL042C 0.376613043 0.806138402 0.326939411 "FUI1 -- transport -- Uridine permease, member of uracil/allantoin family of membrane transporters" YGL202W ARO8 5.4 21 9.3 0.855 0.46876493 iYGL203C iYGLWdelta3 0.530542452 0.772277815 0.938307713 0.469054581 0.78371768 ARO8 -- aromatic amino acid biosynthesis -- Aromatic amino acid aminotransferase I YBR034C HMT1 3.4 14 9.3 0.855 0.770927128 iYBR034C 0.573473467 0.862552369 0.392166543 HMT1 -- protein processing -- arginine methyltransferase YNL308C KRI1 3.4 13 9.3 0.855 0.576013121 iYNL308C 0.332670435 0.816012507 0.238644305 "KRI1 -- unknown -- unknown function, binds Krr1p and has weak similarity to Mgm1p" YOR265W RBL2 2.7 11 9.3 0.855 0.296496066 iYOR264W 0.727232234 0.155333548 0.558180367 RBL2 -- cytoskeleton -- rescues excess beta-tubulin lethality YCR047C YCR047C 2.4 9 9.3 0.855 0.177189574 iYCR047C 0.592784333 0.325617284 YCR047C -- unknown -- similarity to rat methylglycine transferase YNL281W HCH1 5.7 23 9.2 0.8524 0.329388662 iYNL282W 0.320680233 0.343973359 0.276234568 HCH1 -- stress response (putative) -- unknown function YDR388W RVS167 4.5 18 9.2 0.8524 0.824587924 iYDR387C 0.849569531 0.986397432 0.587576539 "RVS167 -- cytoskeleton -- affects actin distribution and bipolar budding, has an SH3 domain" YPL154C PEP4 4.4 18 9.2 0.8524 0.399578576 iYPL154C 0.080947273 0.757781325 0.556167016 PEP4 -- protein degradation -- Proteinase A (PrA/yscA/saccharopepsin)aspartyl protease required for activation of various degradative enzymes YER133W GLC7 4.2 17.5 9.2 0.8524 0.521606264 iYER132C SNR52 0.406371807 0.740996484 0.902395741 0.156257714 0.489066241 "GLC7 -- glycogen metabolism -- Protein serine/threonine phosphatase PP1 required for glucose repression, membrane bilayer mixing, and ER-to-Golgi and endocytic vesicular trafficking" YGR204W ADE3 3.9 16 9.2 0.8524 0.687318422 iYGR203W 0.763014378 0.862649641 0.47608874 "ADE3 -- purine biosynthesis -- C1-tetrahydrofolate synthase (trifunctional enzyme), cytoplasmic" YGR063C SPT4 3.8 15 9.2 0.8524 0.102573652 0.114604948 "SPT4 -- transcription -- chromatin structure that influences expression of many genes, has a zinc finger" YPL091W GLR1 3.8 15 9.2 0.8524 0.550115593 iYPL092W 0.721019085 0.458818835 0.828355139 "GLR1 -- glutathione metabolism -- Glutathione reductase, converts oxidized glutathionine + NADPH into 2 glutathionine + NADP+" YLR244C MAP1 3.7 15 9.2 0.8524 0.526298595 iYLR244C 0.424237951 0.767040413 0.392120529 "MAP1 -- protein processing -- Methionine aminopeptidase isoform 1, cleaves N-terminal methionine if next residue is small (gly, pro, ser, thr, val) and not if next residue is charged or bulky (arg, his, tyr, met, leu)" YER159C BUR6 3.1 12 9.2 0.8524 0.152504221 iYER159C 0.232038479 0.008539505 0.007211097 BUR6 -- transcription -- Alpha subunit of NC2 (Dr1/Drap1) repressor of class II transcription YBL006C YBL006C 3 12 9.2 0.8524 0.54412 iYBL006C 0.502100337 0.778183886 0.662299092 YBL006C -- unknown -- unknown function YDR496C YDR496C 2.9 12 9.2 0.8524 0.772132757 iYDR496C 0.433755145 0.4540767 0.04363959 YDR496C -- unknown -- unknown function YGL126W SCS3 2.4 9 9.2 0.8524 0.529247048 iYGL127C 0.459000327 0.43256809 0.198759265 SCS3 -- phospholipid metabolism -- inositol phospholipid biosynthesis YGR280C YGR280C 1.9 8 9.2 0.8524 0.100709934 iYGR280C 0.357014334 0.030965682 0.262465817 YGR280C -- unknown -- unknown function YBR086C IST2 4.4 18 9.1 0.8506 0.344052701 iYBR086C 0.643744418 0.570460595 0.630765808 "IST2 -- salt tolerance (putative) -- Putative ion channel protein, has a role in sensitivity to NaCl" YGL048C RPT6 4.4 18 9.1 0.8506 0.722923749 iYGL048C 0.190391532 0.800185874 0.129449322 "RPT6 -- protein degradation -- ATPase component of 26S proteasome complex, member of AAA family of ATPases" YPR069C SPE3 3.6 15 9.1 0.8506 0.672576688 iYPR069C 0.767032144 0.541737073 0.799266247 "SPE3 -- polyamine biosynthesis -- Putrescine aminopropyltransferase, spermidine synthase" YMR296C LCB1 3.4 14 9.1 0.8506 0.776881675 iYMR296C 0.494539373 0.852544971 0.310510071 "LCB1 -- sphinogolipid metabolism -- Component of serine C-palmitoyltransferase, first step in biosynthesis of long-chain base component of sphingolipids" YDR398W YDR398W 2.7 11 9.1 0.8506 0.23087093 iYDR397C 0.123579382 0.457253319 0.116959064 YDR398W -- unknown -- unknown function YGR090W YGR090W 2.6 11 9.1 0.8506 0.482147636 iYGR089W-0 iYGR089W-1 0.043605756 0.449542041 0.782880387 0.148749022 0.86258537 YGR090W -- unknown -- unknown function YHR052W YHR052W 2.5 10 9.1 0.8506 0.520518467 iYHR051W 0.684007507 0.91015206 0.557302586 YHR052W -- unknown -- unknown function YLR129W DIP2 2.4 10 9.1 0.8506 0.46475774 iYLR128W 0.558213735 0.691105382 0.637589785 "DIP2 -- unknown -- Dom34p-interacting protein, has WD (WD-40) repeats" YNL111C CYB5 2 8 9.1 0.8506 0.335931283 iYNL111C 0.125964114 0.370854933 0.069061367 CYB5 -- lipid metabolism -- Cytochrome b5 YBR039W ATP3 5.3 22 9 0.8485 0.766773833 iYBR038W 0.505064353 0.959699041 0.537974163 ATP3 -- ATP synthesis -- Gamma subunit of F1-ATP synthase YAR015W ADE1 4.3 18 9 0.8485 0.512548739 iYAR014C 0.312322622 0.660493827 0.326519916 "ADE1 -- purine biosynthesis -- Phosphoribosylamidoimidazole-succinocarboxamide synthase (SAICAR synthetase), catalyzes the seventh step in de novo purine biosynthesis pathway" YGL221C NIF3 4.2 17 9 0.8485 0.225433058 iYGL221C 0.343419139 0.524820431 0.119803988 NIF3 -- unknown -- Ngg1p-interaction factor YBR054W YRO2 3.8 16 9 0.8485 0.636649828 iYBR053C-0 iYBR053C-1 0.346370596 0.570428566 0.726343359 0.840799227 0.921548284 "YRO2 -- unknown -- Protein paralog of Mrh1p, has similarity to heat shock protein Hsp30" YKL160W YKL160W 3.8 16 9 0.8485 0.14077518 iYKL161C-0 iYKL161C-1 0.228181122 0.338853606 0.042018171 0.44507529 0.15266608 YKL160W -- unknown -- unknown function YDL122W UBP1 3.5 14 9 0.8485 0.456847102 iYDL123W 0.14650471 0.610728647 0.364362346 "UBP1 -- protein degradation, ubiquitin-mediated -- Ubiquitin-specific protease (ubiquitin C-terminal hydrolase), cleaves at the C-terminus of ubiquitin" YLR017W MEU1 2.9 12 9 0.8485 0.749367325 iYLR016C 0.436914802 0.982092442 0.448410347 MEU1 -- glucose derepression -- regulates ADH2 gene expression YOR283W YOR283W 2.9 12 9 0.8485 0.067002779 iYOR282W 0.424200613 0.22002924 0.379632614 YOR283W -- unknown -- similarity to phosphoglycerate mutases YOR206W YOR206W 2.7 11 9 0.8485 0.634268251 iYOR205C 0.276502633 0.555171563 0.197228489 YOR206W -- unknown -- unknown function YJR025C BNA1 2.1 9 9 0.8485 0.43891749 iYJR025C 0.349773688 0.80695318 0.175526337 "BNA1 -- nicotinic acid biosynthesis -- 3-hydroxyanthranilate 3,4-dioxygenase, involved in biosynthesis of nicotinic acid from tryptophan" YJL122W YJL122W 2 8 9 0.8485 0.599967622 iYJL123C 0.111162923 0.540273024 0.025086715 YJL122W -- unknown -- unknown function YNL208W YNL208W 6.5 27 8.9 0.8471 0.802881754 iYNL209W 0.85354507 0.818007955 0.512102014 YNL208W -- unknown -- unknown function YOR362C PRE10 5.8 24 8.9 0.8471 0.122740596 iYOR362C 0.127657966 0.095291301 0.239425379 PRE10 -- protein degradation -- Proteasome subunit alpha7_sc (YC1protease yscE subunit 1) YML092C PRE8 5.3 22 8.9 0.8471 0.665128703 iYML092C 0.417060575 0.442173305 PRE8 -- protein degradation -- Proteasome subunit alpha2_sc (protease yscE subunit Y7) YLR301W YLR301W 4.8 20 8.9 0.8471 0.714175256 iYLR300W 0.663158754 0.962330407 0.427466469 YLR301W -- unknown -- unknown function YBR069C VAP1 4.4 18 8.9 0.8471 0.732009235 iYBR069C 0.736831473 0.764217149 0.924830809 "VAP1 -- transport -- Amino acid permease that transports valine, leucine, isoleucine, tyrosine, and tryptophan" YKL080W VMA5 4 17 8.9 0.8471 0.659727354 iYKL081W 0.473513965 0.906428975 0.277709208 "VMA5 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) hydrophilic subunit (subunit C), 42 kDa subunit of V1 sector" YPL093W NOG1 2.7 11 8.9 0.8471 0.743488016 iYPL094C 0.673786755 0.711785109 0.626676541 "NOG1 -- unknown -- Putative nucleolar G-protein, has similarity to Halobacterium cutirubrum GTP-binding protein (SP" YGL161C YGL161C 5.4 23 8.8 0.8463 0.25481355 iYGL161C 0.463002287 0.74537037 0.450999753 YGL161C -- unknown -- unknown function YIL040W YIL040W 3.5 15 8.8 0.8463 0.65541525 iYIL041W 0.715654537 0.884502924 0.334362532 YIL040W -- unknown -- unknown function YBR090C YBR090C 3.4 14.5 8.8 0.8463 0.787606238 iYBR090C 0.46183534 0.872872469 0.416048985 YBR090C -- unknown -- unknown function YPL086C ELP3 2 9 8.8 0.8463 0.419929315 iYPL086C 0.392190594 0.566226233 0.442284424 "ELP3 -- chromatin structure -- subunit of elongator/RNAPII holoenzyme, has histone acetyltransferase activity" YDR529C QCR7 6.1 26 8.7 0.8443 0.603493303 iYDR529C 0.392637278 0.558719969 0.345251397 "QCR7 -- respiration -- Ubiquinol cytochrome-c reductase subunit 7 (14 kDa protein), component of ubiquinol cytochrome-c reductase complex" YDR032C PST2 5.7 24 8.7 0.8443 0.116995695 iYDR032C-0 iYDR032C-1 0.395648302 0.7248602 0.288125828 0.177075619 0.758853151 PST2 -- unknown -- similarity to Ycp4p and S. pombe OBR1 brefeldin A resistance protein YDR099W BMH2 4.6 20 8.7 0.8443 0.38854806 iYDRCsigma1 YDRCdelta9 0.28383535 0.662836085 0.351677149 0.400642109 0.72330407 "BMH2 -- unknown -- Homolog of mammalian 14-3-3 protein, has strong similarity to Bmh1p" YFL005W SEC4 4.4 19 8.7 0.8443 0.735546458 iYFL006W 0.262452806 0.737580264 0.104934099 "SEC4 -- secretion -- GTP-binding vesicular transport between Golgi and plasma membrane, member of rab family in the ras superfamily" YFR050C PRE4 4.2 17 8.7 0.8443 0.637744749 iYFR050C 0.451301671 0.860761705 0.238148444 PRE4 -- protein degradation -- Proteasome subunit beta7_scinvolved in cleavage on the C-terminal side of acidic residues YLL067C YLL067C 3.5 15 8.7 0.8443 0.93690575 iYLL067C-0 iYLL067C-1 0.984077498 0.997782381 0.288269417 0.820198435 0.014152884 YLL067C -- unknown -- Protein similar to other subtelomerically-encoded proteins YBR079C RPG1 3.3 14 8.7 0.8443 0.498596486 iYBR079C 0.475308815 0.476283301 0.505167673 "RPG1 -- protein synthesis -- Translation initiation factor eIF3, p110 subunit" YER048C CAJ1 2.9 12 8.7 0.8443 0.849232277 iYER048C YERCdelta8 0.345806581 0.423943708 0.681165204 0.447711892 0.550663871 "CAJ1 -- unknown -- Homolog of E. coli DnaJ, has a leucine zipper" YIR022W SEC11 2.9 13 8.7 0.8443 0.44215773 iYIR021W 0.631501369 0.684982275 0.64757673 SEC11 -- secretion -- Signal sequence processing signal peptide cleavage and normal rate of secretion YML067C ERV41 2.7 12 8.7 0.8443 0.702132366 iYML067C 0.868975124 0.692233323 0.951083159 ERV41 -- unknown -- unknown function YJL002C OST1 4.5 19 8.6 0.8431 0.587293862 iYJL002C 0.485607212 0.671856094 0.814814815 "OST1 -- protein glycosylation -- Oligosaccharyltransferase alpha subunit, member of a complex of 8 ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif" YPL013C YPL013C 4.3 19 8.6 0.8431 0.06482524 iYPL013C 0.148858047 0.059902905 0.119787045 YPL013C -- protein synthesis -- similarity to Neurospora crassa mitochondrial ribosomal protein S24 YER120W SCS2 3.5 15 8.6 0.8431 0.386658345 0.648163068 SCS2 -- inositol metabolism -- Type II integral ER membrane the activation of INO1 expression YNL147W LSM7 2.8 12 8.6 0.8431 0.445116722 iYNL148C 0.285741962 0.799441341 0.336093275 LSM7 -- mRNA splicing (putative) -- U6 snRNA-associated Sm class YPL252C YAH1 2.7 12 8.6 0.8431 0.223386819 0.048560136 YAH1 -- unknown -- similarity to adrenodoxin and ferrodoxin YJR063W RPA12 1.8 8 8.6 0.8431 0.439296915 iYJR062C 0.405049637 0.702771206 0.312575623 RPA12 -- transcription -- RNA polymerase I subunit A12.2 YMR229C RRP5 2.6 11 8.5 0.8417 1 0.617939924 iYMR229C 0.98122463 0.580368859 0.658949746 RRP5 -- rRNA processing -- processing of pre-rRNA to 18S and 5.8S rRNA YMR071C YMR071C 4 17 8.5 0.8417 0.244254176 iYMR071C 0.159902764 0.308350804 0.073842514 YMR071C -- unknown -- unknown function YLL066C YLL066C 3.6 16.5 8.5 0.8417 0.950016335 iYLL066C-0 iYLL066C-1 0.983384079 0.997405681 0.39514295 0.843510527 0.029375463 "YLL066C -- unknown -- near identity to other subtelomerically-encoded proteins including Yhl050p, Yil177p, and Yhr219p" YML078W CPR3 3.5 15 8.5 0.8417 0.578144029 iYML079W 0.608078975 0.748869749 0.323443989 CPR3 -- protein folding -- Cyclophilin (peptidylprolyl cis-trans isomerase or PPIase) of mitochondria YNL046W YNL046W 3.1 14 8.5 0.8417 0.121741946 iYNL047C 0.320122196 0.287838392 0.30922609 YNL046W -- unknown -- unknown function YMR038C LYS7 2.6 12 8.5 0.8417 0.208147414 iYMR038C 0.255390395 0.294094174 0.215697346 LYS7 -- oxidative stress response -- Copper chaperone for superoxide dismutase Sod1p YMR272C SCS7 2.2 10 8.5 0.8417 0.414845626 iYMR272C 0.21152344 0.609811566 0.336775026 SCS7 -- fatty acid metabolism -- Ceramide hydroxylase that hydroxylates the C-26 fatty-acyl moiety of inositol-phosphorylceramide YGR183C QCR9 5.7 25 8.4 0.84 0.869132146 iYGR183C 0.480520186 0.792365479 0.490653389 QCR9 -- oxidative phosphorylation -- Ubiquinol cytochrome-c reductase subunit 9 (7.3 kDa protein)component of ubiquinol cytochrome-c reductase complex YBL005W-B 4.8 20 8.4 0.84 0.566023706 0.812807801 YBR096W YBR096W 4.8 21 8.4 0.84 0.687327379 iYBR095C 0.557440309 0.905964853 0.421446987 "YBR096W -- unknown -- unknown function, has a role in pseudohyphal growth and in resistance to elevated concentrations of NaCl and H2O2" YJR045C SSC1 4.3 19 8.4 0.84 0.940872164 iYJR045C 0.200441981 0.950119713 0.019168291 "SSC1 -- mitochondrial protein targeting -- Mitochondrial acts as an import motor with Tim44p and plays a chaperonin role in receiving and folding of protein chains during import, heat shock HSP70 family" YKL067W YNK1 3.9 17 8.4 0.84 0.173922298 iYKL068W itH(GUG)K 0.582759426 0.617986271 0.268411092 0.77184249 0.312197873 "YNK1 -- nucleotide metabolism -- Nucleoside diphosphate kinase, responsible for synthesis of all nucleoside triphosphates except ATP" YDR174W HMO1 3.3 14 8.4 0.84 0.571349012 iYDR173C 0.206121069 0.941195582 0.670022064 "HMO1 -- chromatin structure -- DNA helicase with HMG-box DNA-binding domain, interacts with FK506-binding protein Fpr1p" YDR092W UBC13 3.1 14 8.4 0.84 0.340038596 iYDR091C 0.42983511 0.631763767 0.879809631 "UBC13 -- protein degradation, ubiquitin-mediated -- Ubiquitin-conjugating (E2) enzyme" YGL020C YGL020C 3.1 14 8.4 0.84 0.727316437 iYGL020C 0.087253562 0.9013471 0.089424951 YGL020C -- unknown -- unknown function YNR061C YNR061C 2.9 13 8.4 0.84 0.218229337 iYNR061C 0.484790524 0.251181355 0.485476837 YNR061C -- unknown -- unknown function YGR295C COS6 4.5 20 8.3 0.839 0.935034713 iYGR295C-0 iYGR295C-1 0.992972767 0.997490691 0.673902634 0.323992853 0.002715379 COS6 -- unknown -- Member of COS family of subtelomerically-encoded proteins YDR346C YDR346C 2.9 13 8.3 0.839 0.470440964 iYDR346C 0.197126888 0.739488192 0.192007797 YDR346C -- unknown -- unknown function YJL192C YJL192C 2.9 13 8.3 0.839 0.982134047 iYJL192C 0.979489177 0.609730344 0.718175959 YJL192C -- unknown -- weak similarity to E. coli phosphoribosylformylglycinamide synthase YHR121W YHR121W 2.8 12 8.3 0.839 0.95870152 iYHR120W 0.910640245 0.115642458 0.606065443 YHR121W -- unknown -- unknown function YNR044W AGA1 2.4 11 8.3 0.839 0.025687298 iYNR043W 0.282409715 0.076591943 0.335481792 AGA1 -- mating -- a-Agglutinin anchor subunit YEL031W SPF1 4.4 20 8.2 0.8378 0.95669654 iYEL032W 0.684989473 0.683713802 0.772798742 "SPF1 -- transport -- Putative Ca2+-transporting ATPases, member of P-type ATPase superfamily" YHR018C ARG4 3.5 16 8.2 0.8378 0.57567086 iYHR018C 0.511661224 0.980047885 0.340476958 ARG4 -- arginine biosynthesis -- Argininosuccinate lyasecatalyzes the final step in arginine biosynthesis YDL064W UBC9 2.9 13 8.2 0.8378 0.594259989 iYDL065C 0.641216796 0.468954509 0.547326417 "UBC9 -- protein degradation, ubiquitin-mediated -- Smt3p-conjugating enzyme required for G2/M transition" YLR276C DBP9 2.5 11 8.2 0.8378 0.418000653 iYLR276C 0.768148341 0.767766395 0.840059399 DBP9 -- unknown -- similarity to DEAD box RNA helicases YNR017W TIM23 2.5 11 8.2 0.8378 0.698376522 iYNR016C-0 iYNR016C-1 0.025447048 0.004345731 0.944692737 0.032008558 0.055652486 "TIM23 -- mitochondrial protein targeting -- Mitochondrial inner membrane import of proteins destined for the mitochondrial matrix, part of translocation channel with Tim17p/Mpi2p" YJL178C YJL178C 2.4 11 8.2 0.8378 0.966475704 iYJL178C 0.981795382 0.84039961 0.180526736 YJL178C -- unknown -- unknown function YPL111W CAR1 2.6 12 8.1 0.8356 1 0.968531216 iYPL112C tM(CAU)P 0.577330501 0.688328293 0.317434741 0.150331936 0.365241636 "CAR1 -- arginine metabolism -- Arginase, catalyzes the first step in arginine degradation and acts as an allosteric regulator of ornithine carbamyltransferase" YOR340C RPA43 2.4 11 8.1 0.8356 1 0.869044945 iYOR340C 0.960055208 0.458414555 0.723278203 RPA43 -- transcription -- RNA polymerase I subunitnot shared with other polymerases YPL227C ALG5 2.2 10 8.1 0.8356 1 0.96980735 iYPL227C 0.955560952 0.323463687 ALG5 -- protein glycosylation -- Dolichol-P-glucose synthetase YMR314W PRE5 4 19 8.1 0.8356 0.600978929 iYMR313C 0.487248705 0.763350613 0.489508763 PRE5 -- protein degradation -- Proteasome subunit alpha6_sc YGL231C YGL231C 3.9 18 8.1 0.8356 0.424002804 iYGL231C 0.625241301 0.884916201 0.160957414 YGL231C -- unknown -- unknown function YJL008C CCT8 3.5 16 8.1 0.8356 0.806297555 iYJL008C YJLWtau4 0.549110517 0.733113428 0.965522745 0.848766475 0.907844165 CCT8 -- protein folding -- Component of Chaperonin-containing T-complex YDR432W NPL3 3.1 14 8.1 0.8356 0.113381481 iYDR431W 0.54126941 0.154889539 0.39639893 "NPL3 -- mRNA export; protein import -- 18S and 25S rRNA processing, export of RNA from the nucleus, import of proteins into the nucleus, associated with U1 snRNP, has 2 RNA recognition (RRM) domains" YNL231C PDR16 2.7 12 8.1 0.8356 0.671614179 iYNL231C 0.154565129 0.747644574 0.257642978 PDR16 -- drug resistance -- lipid biosynthesis and multidrug resistance YGL186C YGL186C 2.4 11 8.1 0.8356 0.686076412 iYGL186C 0.523192348 0.770615073 0.655422374 YGL186C -- unknown -- Member of purine/cytosine permease family of membrane transporters YOR108W YOR108W 2.4 11 8.1 0.8356 0.312332549 iYOR107W 0.649049541 0.813790834 0.656529806 YOR108W -- unknown -- Alpha-isopropylmalate syntase II YER127W LCP5 2 9 8.1 0.8356 0.197464561 iYER126C 0.474346952 0.710968572 0.250119713 "LCP5 -- rRNA processing, putative -- ribosomal RNA processing" YCR053W THR4 7.4 34 8 0.8334 0.150040762 iYCR052W 0.577791628 0.45578198 0.670287172 "THR4 -- threonine biosynthesis -- Threonine synthase (O-P-homoserine P-lyase), second and final step of threonine biosynthesis pathway" YDR328C SKP1 5.8 27 8 0.8334 0.300167366 iYDR328C 0.333533513 0.687237719 0.333055866 SKP1 -- mitosis -- Component (subunit d) of Cbf3 kinetochore complex and component with Cdc53p and Cdc34p of SCF (Skp1p-cullin-F-box) complexes which target many proteins for ubiquitin-dependent degradation YDR177W UBC1 4.9 23 8 0.8334 0.417000431 iYDR176W 0.227623521 0.941911054 0.313704929 "UBC1 -- protein degradation, ubiquitin-mediated -- Ubiquitin conjugating enzyme (E2) that plays a role early in spore germination" YOL123W HRP1 3.8 18 8 0.8334 0.51509159 iYOL124C 0.531809555 0.556102283 0.876695164 "HRP1 -- mRNA processing -- Nuclear polyadenylated RNA-binding protein, has 2 RNA recognition (RRM) domains" YPR041W TIF5 3.6 17 8 0.8334 0.638450628 iYPR040W 0.471832803 0.76009577 0.390779766 "TIF5 -- protein synthesis -- Translation initiation factor eIF5, catalyzes hydrolysis of GTP on the 40S ribosomal subunit-initiation complex followed by joining to 60S ribosomal subunit" YOR286W YOR286W 3.5 16 8 0.8334 0.465823365 iYOR285W 0.433317016 0.45405311 0.459783062 YOR286W -- unknown -- similarity to Drosophila melanogaster heat shock protein 67B2 YGL234W "ADE5,7" 3.4 16 8 0.8334 0.577116734 iYGL235W 0.048600987 0.579678363 0.120931357 "ADE5,7 -- purine biosynthesis -- Phosphoribosylamine-glycine ligase (GARSase) plus Phosphoribosylformylglycinamidine cyclo-ligase (AIRSase)bifunctional protein" YER003C PMI40 2.5 11 8 0.8334 0.383549981 iYER003C 0.322021823 0.41641822 0.321243726 "PMI40 -- mannose metabolism -- Mannose-6-phosphate isomerase, generates mannose-6-phosphate for synthesis of GDP-mannose and dolichol-phosphate-mannose" YOR067C ALG8 2.2 10 8 0.8334 0.148279561 iYOR067C 0.665862931 0.558804418 0.291522142 ALG8 -- protein glycosylation -- Glucosyltransferase of endoplasmic reticulumhas a role in adding glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein YPL177C CUP9 2.2 10 8 0.8334 0.401352472 iYPL177C-0 iYPL177C-1 0.116130766 0.270232909 0.487616226 0.203700575 0.008540122 CUP9 -- Cu2+ ion homeostasis -- Homeodomain copper homeostasis and in regulation of peptide import YDR397C NCB2 1.8 9 8 0.8334 0.360284874 iYDR397C 0.123579382 0.820024574 0.116959064 NCB2 -- transcription -- Beta subunit of NC2 (Dr1/Drap1) repressor of class II transcription YDR298C ATP5 5.1 24 7.9 0.8311 0.63485276 iYDR298C 0.497548034 0.799629391 0.456493716 "ATP5 -- ATP synthesis -- Subunit 5 of F0-ATP synthase, oligomycin sensitivity-conferring subunit" YKL046C YKL046C 3.7 18 7.9 0.8311 0.351186363 iYKL046C 0.379005976 0.686826298 0.391872309 "YKL046C -- unknown -- unknown function, has 2 predicted transmembrane segments" YMR108W ILV2 3.7 17 7.9 0.8311 0.87395452 iYMR107W 0.105047516 0.917700252 0.05927223 "ILV2 -- isoleucine and valine biosynthesis -- Acetolactate synthase (acetohydroxyacid synthase), first step in valine and isoleucine biosynthesis pathway" YOR103C OST2 3.6 17 7.9 0.8311 0.674214206 iYOR103C 0.756728032 0.225219473 0.585688368 "OST2 -- protein glycosylation -- Oligosaccharyltransferase epsilon subunit, member of a complex of 8 ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif" YLR186W YLR186W 3.1 15 7.9 0.8311 0.669176115 iYLR185W 0.863732758 0.714185884 0.640509185 YLR186W -- unknown -- unknown function YPL239W YAR1 3.1 15 7.9 0.8311 0.48846389 iYPL240C 0.543840163 0.670684836 0.598686565 YAR1 -- unknown -- 2 ankyrin repeats YBR171W SEC66 3 14 7.9 0.8311 0.393311663 iYBR170C 0.449703662 0.719626168 0.624431449 "SEC66 -- secretion -- Component of ER protein-translocation subcomplex with Sec62p, Sec63p, Sec66p, and Sec72p" YGL009C LEU1 3 14 7.9 0.8311 0.500690826 iYGL009C 0.861306385 0.879535917 0.549640862 "LEU1 -- leucine biosynthesis -- 3-Isopropylmalate dehydratase, second step in leucine biosynthesis pathway" YGL001C ERG26 2.6 12 7.9 0.8311 0.857918912 iYGL001C CEN7 0.41465844 0.546346169 0.995402113 0.593457944 0.335471729 "ERG26 -- unknown -- C-3 sterol dehydrogenase, C-4 decarboxylase, required for ergosterol biosynthesis" YPL207W YPL207W 2.6 12 7.9 0.8311 0.116885968 iYPL208W 0.18787335 0.043778872 0.097076715 YPL207W -- unknown -- unknown function YPL266W DIM1 2.1 10 7.9 0.8311 0.275420168 iYPL267W 0.297796848 0.627661372 0.317998711 "DIM1 -- rRNA processing, 18S -- Dimethyladenosine transferase, (rRNA (adenine-N6,N6-)-dimethyltransferase), responsible for m6[2]Am6[2]A dimethylation in 3'-terminal loop of 18S rRNA" YIR026C YVH1 2 9 7.9 0.8311 0.574827941 iYIR026C 0.54780511 0.880604288 0.324771882 YVH1 -- sporulation -- Protein-tyrosine phosphatase (PTPase) with similarity to vaccinia VH1 YER031C YPT31 3.4 16 7.8 0.8299 1 0.982644965 iYER031C 0.969337599 0.844630672 0.112043236 "YPT31 -- secretion -- GTP-binding protein required in the secretory pathway at the stage of formation of trans-Golgi vesicles, member of rab family in the ras superfamily of small GTP-binding proteins" YNR036C YNR036C 3.4 16 7.8 0.8299 0.16909487 iYNR036C 0.264973194 0.165935673 0.254716981 "YNR036C -- unknown -- Putative mitochondrial ribosomal small subunit, has similarity to ribosomal protein S12" YEL058W PCM1 3.1 15 7.8 0.8299 0.509393838 iYEL059W 0.608920522 0.48420883 0.382561676 "PCM1 -- aminosugars metabolism -- Hexosephosphate mutase (phosphoacetylglucosamine mutase, N-acetylglucosamine-phosphate mutase)converts N-acetyl-D-glucosamine 1-phosphate to N-acetyl-D-glucosamine 6-phosphate" YDL213C YDL213C 3 14 7.8 0.8299 iYDL213C 0.337575486 0.291061169 "YDL213C -- unknown -- hydrophilin family, has an N-terminal RNA recognition (RRM) domain" YGL068W YGL068W 2.5 12 7.8 0.8299 0.839998585 0.910946197 "YGL068W -- unknown -- Putative mitochondrial ribosomal protein, possible homolog of E. coli L7/L12 ribosomal protein" YOR175C YOR175C 2.5 12 7.8 0.8299 0.361236842 iYOR175C 0.106501143 0.600225588 0.335887715 "YOR175C -- unknown -- weak similarity to Drosophila nessy, a putative transmemberne protein expressed in embryogenesis" YAR075W YAR075W 3.7 17 7.7 0.8283 0.966536145 0.403323385 "YAR075W -- unknown -- strong similarity to inosine-5'-monophosphate dehydrogenase, frameshifted from YAR073W, possible pseudogene" YNL104C LEU4 3.6 17 7.7 0.8283 0.390976602 iYNL104C 0.259169329 0.804791482 0.452465356 "LEU4 -- leucine biosynthesis -- 2-Isopropylmalate synthase, first step in leucine biosynthesis pathway" YDR378C LSM6 2.9 14 7.7 0.8283 0.633074387 iYDR378C 0.285153998 0.987246681 0.502540937 LSM6 -- mRNA splicing (putative) -- U6 snRNA-associated Sm-like group YHR042W NCP1 2.8 13 7.7 0.8283 0.521099191 iYHR041C 0.461805327 0.641509434 0.450996209 NCP1 -- microsomal electron transfer -- NADP-cytochrome P450 reductase YNL247W YNL247W 2.8 14 7.7 0.8283 0.144139474 iYNL248C 0.299300587 0.409597837 0.340079034 YNL247W -- protein synthesis -- Cysteinyl-tRNA synthetase YNR046W YNR046W 2.6 13 7.7 0.8283 0.081902244 iYNR045W 0.075006716 0.268923885 0.083896587 YNR046W -- unknown -- unknown function YDL112W TRM3 2.4 12 7.7 0.8283 0.588486148 iYDL113C 0.371309075 0.200451722 0.32555905 "TRM3 -- tRNA processing -- tRNA 2'-O-ribose methyltransferase, required for the formation of Gm18 modification" YER124C YER124C 2 10 7.7 0.8283 0.670533597 iYER124C 0.435684358 0.94557063 0.410598206 YER124C -- unknown -- unknown function YOR303W CPA1 4.5 22 7.6 0.8267 1 0.683860117 0.476855547 "CPA1 -- arginine biosynthesis -- Carbamoylphosphate synthase of arginine biosynthetic pathway, amidotransferase small subunit" YBR109C CMD1 8.3 41 7.6 0.8267 0.792213048 iYBR109C 0.057840957 0.910623538 0.016121309 "CMD1 -- signaling -- Calmodulin, calcium-binding many processes including cell polarization, nuclear division, and chromosome maintenance" YGR008C STF2 5.8 29 7.6 0.8267 0.377230152 iYGR008C 0.306027442 0.540856659 0.273910105 "STF2 -- ATP synthesis -- ATPase stabilizing factor, binds to F0-ATPasefacilitates binding of inhibitor and 9 kDa protein to F1-ATPase" YOR194C TOA1 2.8 14 7.6 0.8267 0.007097014 iYOR194C 0.082918644 0.007861635 0.030527442 "TOA1 -- transcription -- RNA polymerase II transcription initiation factor TFIIA, large chain" YJR015W YJR015W 2.5 12 7.6 0.8267 0.626912241 iYJR014W 0.184762849 0.890215375 0.342592593 YJR015W -- unknown -- similarity to Sng1p and multidrug resistance proteins YHR196W YHR196W 2.4 12 7.6 0.8267 0.615236845 iYHR195W 0.314299191 0.814977258 0.499758298 YHR196W -- unknown -- unknown function YHR005C GPA1 2.2 11 7.6 0.8267 0.669253484 iYHR005C 0.62192296 0.888028731 0.716860035 "GPA1 -- signaling, pheromone pathway -- Guanine nucleotide-binding protein alpha subunit of pheromone response pathway" YDR120C TRM1 1.9 9 7.6 0.8267 0.170766139 iYDR120C 0.18605031 0.535449565 0.173866535 "TRM1 -- tRNA processing -- N2,N2-dimethylguanine tRNA methyltransferase, required for methylation of G26 of both mitochondrial and cytoplasmic tRNAs" YPL135W ISU1 4.8 24 7.5 0.8248 0.550020721 iYPL136W 0.254161418 0.569273743 0.376705653 ISU1 -- iron homeostasis -- similarity to iron-sulfur cluster nitrogen fixation proteins YNL071W LAT1 4 20 7.5 0.8248 0.715286625 iYNL072W 0.026125519 0.889305666 0.183160234 LAT1 -- glycolysis -- Dihydrolipoamide S-acetyltransferase component (E2) of pyruvate dehydrogenase complex YKR080W MTD1 3.6 18 7.5 0.8248 0.768547818 iYKR079C 0.588401422 0.962781484 0.828391879 "MTD1 -- nucleotide metabolism -- NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase" YGR264C MES1 3.3 16 7.5 0.8248 0.67675218 0.921052632 "MES1 -- protein synthesis -- Methionyl-tRNA synthetase, cytoplasmic, member of class I aminoacyl tRNA synthetase family" YMR149W SWP1 3.1 15 7.5 0.8248 0.313129373 iYMR148W 0.224789541 0.764734581 0.197437629 "SWP1 -- protein glycosylation -- Oligosaccharyltransferase delta subunit, member of a complex of 8 ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif" YBR244W GPX2 2.9 14 7.5 0.8248 0.357867811 iYBR243C 0.593411041 0.796648045 "GPX2 -- mitochondrial morphology (putative) -- Glutathione peroxidase, has a role in mitochondrial morphology" YBR142W MAK5 2.6 13 7.5 0.8248 0.291587513 iYBR141C 0.169228227 0.68772156 0.030168589 "MAK5 -- mRNA splicing -- Probable pre-mRNA splicing RNA-helicase of DEAD box family, involved in maintenance of M double-stranded RNA (dsRNA) killer plasmid" YDR245W MNN10 2.6 13 7.5 0.8248 0.287917338 iYDR244W 0.591883066 0.479090184 0.618367692 "MNN10 -- cell wall biogenesis -- subunit of Anp1p-Hoc1p-Mnn10p-Mnn11p-Mnn9p mannosyltransferase complex, M-Pol II" YGL097W SRM1 2.4 12 7.5 0.8248 0.822014035 iYGL098W YGLWdelta4 0.169432383 0.716350866 0.965522916 0.358818835 0.376529833 SRM1 -- nuclear targeting; mating -- GDP/GTP exchange factor for Gsp1p and Gsp2p YDR087C RRP1 2.1 10 7.5 0.8248 0.102086804 iYDR087C 0.350778913 0.434557063 0.127214685 RRP1 -- rRNA processing -- maturation of 25S rRNA YLR179C YLR179C 5.1 25 7.4 0.8212 0.205407161 iYLR179C 0.447228947 0.912156167 0.398107469 YLR179C -- unknown -- similarity to Tfs1p Cdc25p-dependent nutrient- and ammonia-response protein YHR051W COX6 4 20 7.4 0.8212 0.826950314 iYHR050W 0.622466112 0.973093063 0.824660231 COX6 -- oxidative phosphorylation -- Cytochrome-c oxidase subunit VI YPR108W RPN7 4 20 7.4 0.8212 0.604802755 iYPR107C 0.174933676 0.560534591 0.247157245 RPN7 -- protein degradation -- Non-ATPase of 26S proteasome complex YMR276W DSK2 3.6 18 7.4 0.8212 0.571847595 iYMR275C 0.232602647 0.23308324 0.118272639 DSK2 -- spindle pole body dupl -- Protein required with Rad23p for duplication of spindle pole bodyhas similarity to ubiquitin YNL131W TOM22 3.6 18 7.4 0.8212 0.355847762 iYNL132W 0.339818313 0.602638015 0.546870222 TOM22 -- mitochondrial protein targeting -- Component of mitochondrial outer membrane receptor complexrequired for protein import and cell viability YLR028C ADE16 3.4 17 7.4 0.8212 0.548032816 iYLR028C 0.507563302 0.684748428 0.371842343 ADE16 -- purine biosynthesis -- 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase YFR024C YFR024C 3 15 7.4 0.8212 0.120377727 0.678698034 "YFR024C -- unknown -- similarity to Ysc84p, Rvs167p, Abp1p, and Sla1p, has an SH3 domain" YML133C YML133C 2.9 14.5 7.4 0.8212 0.917350004 iYML133C-0 iYML133C-1 0.995641669 0.99633417 0.224142187 0.271280052 0.153711093 "YML133C -- unknown -- similarity to other subtelomerically-encoded proteins including Yer189p, and Yjl225p" YOR305W YOR305W 2.9 15 7.4 0.8212 0.209482119 iYOR304C-A 0.218545113 0.624197364 0.07750564 YOR305W -- unknown -- unknown function YBL068W PRS4 2.8 14 7.4 0.8212 0.695757457 iYBL069W 0.669010938 0.90548351 0.613168396 "PRS4 -- pentose phosphate cycle -- Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase), enxyme that synthesizes phosphoribosylpyrophosphate (PRPP) from ribose-5' phosphate and ATP" YOL126C MDH2 2.8 14 7.4 0.8212 0.616361338 iYOL126C 0.546030005 0.903041058 0.262753319 "MDH2 -- TCA cycle -- Malate dehydrogenase, cytosolic, probably functions in the glyoxylate cycle" YPR118W YPR118W 2.5 12 7.4 0.8212 0.425384234 iYPR117W 0.205214952 0.521707901 0.143431167 YPR118W -- unknown -- unknown function YPL129W ANC1 2.2 11 7.4 0.8212 0.108242802 iYPL130W 0.352764472 0.139051332 0.355056365 "ANC1 -- transcription -- RNA polymerase II transcription initiation factor TFIIF (factor g), small subunit, component of RNA polymerase holoenzyme, Kornberg's mediator (SRB) subcomplex, and the SWI-SNF complex" YDL166C YDL166C 2.1 11 7.4 0.8212 0.131560707 iYDL166C 0.626510243 0.149049307 0.590899182 YDL166C -- unknown -- Essential protein important for Skn7p-dependent transcription of target genes during oxidative stress YLL034C YLL034C 2.1 10 7.4 0.8212 0.296798323 iYLL034C 0.206500119 0.412423461 0.220354126 "YLL034C -- unknown -- similarity to mammalian valosin-containing protein (VCP), member of AAA family of ATPases" YKL165C MCD4 1.9 10 7.4 0.8212 0.685041282 iYKL165C itE(UUC)K 0.455150356 0.267804639 0.644878843 0.62849406 0.26458014 MCD4 -- sporulation -- glycosylphosphatidylinositol (GPI) anchor synthesis YLR154C YLR154C 1.9 9 7.4 0.8212 0.260904933 iYLR154C tQ(UUG)L 0.331777793 0.554422714 0.274586009 0.273283919 0.369034318 YLR154C -- unknown -- unknown function YJL145W YJL145W 1.7 8 7.4 0.8212 0.556785265 iYJL146W 0.38588311 0.874476313 0.42124475 YJL145W -- unknown -- unknown function YDL072C YDL072C 4.4 22 7.3 0.8196 0.352118337 iYDL072C 0.261075366 0.364997477 0.49277128 YDL072C -- unknown -- unknown function YGL080W YGL080W 3.5 18 7.3 0.8196 0.327557334 iYGL081W 0.332869385 0.685334244 0.074074074 YGL080W -- unknown -- unknown function YKL094W YJU3 3.4 17 7.3 0.8196 0.665950374 iYKL095W 0.305957547 0.914518208 0.257302474 YJU3 -- unknown -- unknown function YMR079W SEC14 2.7 14 7.3 0.8196 0.55349559 iYMR078C 0.482929292 0.685664788 0.54769392 SEC14 -- secretion -- Phosphatidylinositol/phosphatidylcholine (PI/PC)-transfer proteinrequired for transport of secretory proteins from Golgi complex YMR309C NIP1 2.6 13 7.3 0.8196 0.735932989 iYMR309C 0.479163994 0.791551854 0.373800113 "NIP1 -- nuclear protein targeting -- Subunit of translation initiation complex eIF3, also required for nuclear importhas weak similarity to Nsr1p" YOL103W ITR2 2.5 13 7.3 0.8196 0.175307593 iYOL104C iYOLWdelta5 0.162452487 0.226478275 0.467836257 0.401843684 0.045360079 "ITR2 -- transport -- Myo-inositol permease (minor), closely related to Itr1p, member of hexose transporter family of major facilitator superfamily (MFS)" YER154W OXA1 2.2 11 7.3 0.8196 0.220589363 iYER153C 0.051573364 0.812014194 0.070175439 OXA1 -- respiration -- assembly of F1F0-ATP synthase and cytochrome oxidase YDR365C YDR365C 2 10 7.3 0.8196 0.178003306 iYDR365C 0.192052934 0.6326136 0.276803119 YDR365C -- unknown -- unknown function YLR113W HOG1 4.5 23 7.2 0.8163 0.73510205 iYLR112W 0.776586565 0.673742138 0.20609088 "HOG1 -- signaling, high osmolarity pathway -- MAP kinase (MAPK) central to the high-osmolarity signal transduction pathway" YDL015C YDL015C 4.3 22 7.2 0.8163 0.595386909 iYDL015C 0.800695409 0.675486005 0.311204324 YDL015C -- unknown -- similarity to rat synaptic glycoprotein SC2 YHR190W ERG9 4 21 7.2 0.8163 0.393444492 iYHR189W 0.259310876 0.484623184 0.009976057 "ERG9 -- sterol metabloism -- Squalene synthetase (farnesyl-diphosphate farnesyltransferase), acts at a branch point in the isoprenoid biosynthesis pathway" YOR198C BFR1 3.3 17 7.2 0.8163 0.246478292 iYOR198C 0.314674164 0.239035088 0.021206489 BFR1 -- secretion -- can suppress brefeldin A-induced lethality when overexpressed YER006W YER006W 2.6 13 7.2 0.8163 0.404329691 iYER005W 0.176898372 0.558250081 0.157669462 "YER006W -- unknown -- Nuclear unknown function, has similarity to mouse Mmr1 protein" YJL014W CCT3 2.6 13 7.2 0.8163 0.590003267 0.724018761 "CCT3 -- protein folding -- Component of Chaperonin-containing T-complex (TCP ring complex, TRiC)homologous to mouse CCT3" YJR016C ILV3 2.5 13 7.2 0.8163 0.384397367 iYJR016C 0.8273836 0.807701802 0.690013518 "ILV3 -- isoleucine and valine biosynthesis -- Dihydroxyacid dehydratase (DAD), third step in valine and isoleucine biosynthesis pathway" YKR085C MRPL20 2.5 13 7.2 0.8163 0.235067128 iYKR085C 0.326876682 0.321329407 0.369234801 MRPL20 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL20) YMR058W FET3 2.5 13 7.2 0.8163 0.656912027 iYMR057C 0.618276262 0.908445592 0.266799681 FET3 -- transport -- Cell surface ferroxidaserequired for high-affinity ferrous iron uptake YPR063C YPR063C 2.5 12 7.2 0.8163 0.457283099 iYPR063C 0.395372382 0.757734451 0.83345676 YPR063C -- unknown -- unknown function YER073W ALD5 2.1 11 7.2 0.8163 0.933783859 iYER072W 0.860631437 0.83270146 0.932127883 ALD5 -- fermentation -- Mitochondrial aldehyde dehydrogenase YFR001W LOC1 2.1 11 7.2 0.8163 0.459378052 CEN6 iCEN6 0.542307057 0.60528639 0.372379455 0.372617421 0.476589797 "LOC1 -- unknown -- binds double-stranded RNA, involved in localization of mRNA" YNL283C WSC2 2.1 11 7.2 0.8163 0.043011366 iYNL283C 0.533663139 0.167621199 0.266422082 WSC2 -- cell wall biogenesis -- maintenance of cell wall integrity and for the stress response YEL044W YEL044W 2 11 7.2 0.8163 0.713693058 iYEL045C 0.917222031 0.599190629 0.332196231 YEL044W -- unknown -- unknown function YMR290C HAS1 1.8 9 7.2 0.8163 0.192429781 0.510071475 HAS1 -- unknown -- RNA helicase of DEAD/DEAH box family YPR112C MRD1 1.7 8 7.2 0.8163 0.485706942 iYPR112C 0.202915079 0.269854681 0.151904263 "MRD1 -- unknown -- similarity to Pab1p, Pub1p, Nsr1p, Nop4p and other RNA-binding proteins, contains four RNA recognition (RRM) domains" YER070W RNR1 1.5 8 7.2 0.8163 0.848796197 iYER069W 0.446775551 0.845223402 0.516679968 "RNR1 -- DNA replication -- Ribonucleotide reductase (ribonucleoside-diphosphate reductase) large subunit, converts deoxyribonucleoside diphosphate to ribonucleoside diphosphate" YNL002C RLP7 1.9 10 7.1 0.8145 1 0.464471498 iYNL002C 0.553694885 0.450743494 0.268587361 "RLP7 -- protein synthesis -- similarity to ribosomal proteins including Rpl6p, gene has low codon bias" YDR427W RPN9 5.3 28 7.1 0.8145 0.88126369 iYDR426C 0.28111056 0.904628891 0.49324096 "RPN9 -- protein degradation -- Non-ATPase subunit of 26S proteasome complex, required for efficient assembly of complex" YDL029W ARP2 4.8 25 7.1 0.8145 0.33299074 iYDL030W 0.566036693 0.415617543 0.407669997 ARP2 -- cytoskeleton -- Actin-related ARP2/3 complexinvolved in cell polarity and endocytosis YHR200W RPN10 3.6 19 7.1 0.8145 0.611380929 iYHR199C 0.367103494 0.764587701 0.334957765 RPN10 -- protein degradation -- Non-ATPase component of 26S proteasome complex YGR210C YGR210C 3 16 7.1 0.8145 0.649272114 iYGR210C 0.892957974 YGR210C -- unknown -- unknown function YAL023C PMT2 2.7 14 7.1 0.8145 0.544815492 iYAL023C 0.588671588 0.667438148 0.455031679 PMT2 -- protein glycosylation -- Mannosyltransferase(dolichyl phosphate-D-mannose YDR487C RIB3 2.5 13 7.1 0.8145 0.799260391 iYDR487C 0.388638018 0.96149885 0.324110672 "RIB3 -- flavin biosynthesis -- DBP synthase(3,4-dihydroxy-2-butanone 4-phosphate synthase), part of riboflavin biosynthesis pathway" YGR044C RME1 2.1 11 7.1 0.8145 0.319374024 0.710769981 RME1 -- meiosis -- Zinc-finger transcription factor that represses meiosis in non-a/alpha cells YHR085W YHR085W 1.5 8 7.1 0.8145 0.390857897 iYHR084W 0.205833746 0.416991553 0.221673661 YHR085W -- unknown -- unknown function YOR341W RPA190 2 11 7 0.8125 1 0.649767524 iYOR340C 0.960055208 0.299707602 0.723278203 RPA190 -- transcription -- RNA polymerase I largest subunit YCR051W YCR051W 2.8 15 7 0.8125 0.483814231 iYCR050C 0.871142118 0.438830686 0.823344358 YCR051W -- unknown -- similarity to ankyrin and coiled-coil protein YMR235C RNA1 2.8 15 7 0.8125 0.157116635 iYMR235C 0.34936877 0.35046729 0.215778011 "RNA1 -- RNA export -- GTPase-activating (GAP) protein for Gsp1p (Ran), involved in nuclear export" YIL047C SYG1 2.7 14 7 0.8125 0.48920618 iYIL047C 0.101755046 0.509236106 0.002842755 "SYG1 -- signaling (putative) -- for which truncation and overexpression can suppress lethality of Gpa1p deficiency, member of divalent anion" YHL011C PRS3 2.5 13 7 0.8125 0.50512678 iYHL011C 0.14770467 0.59792498 0.038609364 "PRS3 -- purine biosynthesis -- Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase II)component of yeast 20S proteasome, with a role in cell cycle regulation" YHR070W YHR070W 2.4 13 7 0.8125 0.492161749 iYHR069C 0.80025672 0.552209331 0.198376532 YHR070W -- unknown -- similarity to met-10+ of Neurospora crassa YBL112C 2.2 12 7 0.8125 0.895891251 0.447389623 YDR531W YDR531W 2.2 12 7 0.8125 0.174441562 iYDR530C 0.491280253 0.465892053 0.326257862 YDR531W -- unknown -- Putative panthothenate kinase involved in coenzyme A biosynthesis YDR165W YDR165W 2 11 7 0.8125 0.700336798 iYDR164C 0.729258102 0.95990566 0.889445672 YDR165W -- unknown -- unknown function YGR245C SDA1 1.7 9 7 0.8125 0.095658125 iYGR245C 0.17284577 0.089668616 0.143954369 SDA1 -- unknown -- Essential normal organization of actin cytoskeleton YMR256C COX7 3.8 21 6.9 0.8103 0.725621031 iYMR256C 0.709092655 0.6422463 0.642382949 "COX7 -- oxidative phosphorylation -- Cytochrome-c oxidase, subunit VII" YDR377W ATP17 3.6 19 6.9 0.8103 0.912769934 iYDR376W 0.60733812 0.997990915 0.525046382 ATP17 -- ATP synthesis -- ATP synthase subunit f YIL109C SEC24 3.6 19 6.9 0.8103 0.081937454 iYIL109C 0.509956289 0.545037061 0.519585702 SEC24 -- secretion -- Component of COPII coat of vesiclesinvolved in endoplasmic reticulum to Golgi transport YMR215W YMR215W 3.6 19 6.9 0.8103 0.273499611 iYMR214W 0.406459333 0.552387914 0.592365785 YMR215W -- unknown -- similarity to Gas1p YKL077W YKL077W 3.4 18 6.9 0.8103 0.845085284 iYKL078W 0.603854443 0.956171447 0.675690637 YKL077W -- unknown -- unknown function YML132W COS3 3 16 6.9 0.8103 0.933750101 iYML133C-0 iYML133C-1 0.995641669 0.99633417 0.660015962 0.271280052 0.153711093 COS3 -- unknown -- Member of COS family of subtelomerically-encoded proteins YEL038W UTR4 2.9 16 6.9 0.8103 0.605850273 iYEL039C 0.41910428 0.707635506 0.432215234 UTR4 -- unknown -- unknown function YJL111W CCT7 2.7 14 6.9 0.8103 0.388440516 iYJL112W 0.633701371 0.756489747 0.731386626 "CCT7 -- protein folding -- Component of Chaperonin-containing T-complex (TCP ring complex, TRiC), has similarity to Tcp1p" YDL008W APC11 2.1 11 6.9 0.8103 0.365208541 iYDL009C 0.616924038 0.796241026 0.635913807 "APC11 -- mitosis -- Component of anaphase-promoting complex (APC), required for Clb2p degradation and for the metaphase-anaphase transition" YOR243C YOR243C 1.9 10 6.9 0.8103 0.146886504 iYOR243C 0.430019062 0.558479532 0.498515024 YOR243C -- unknown -- unknown function YHR066W SSF1 1.7 9 6.9 0.8103 0.410614279 iYHR065C 0.765501052 0.414547848 0.436728395 SSF1 -- mating (putative) -- potential role in mating YER002W YER002W 3.4 18 6.8 0.8092 0.265380315 iYER001W 0.178562588 0.047677063 0.467048018 YER002W -- unknown -- Nuclear unknown function YDR339C YDR339C 2.7 15 6.8 0.8092 0.589689528 iYDR339C 0.644579552 0.812454626 0.610960257 "YDR339C -- unknown -- unknown function, with strong similarity to C. elegans and human proteins of unknown function" YJL117W PHO86 2.7 15 6.8 0.8092 0.498981572 iYJL118W 0.116835612 0.822589099 0.053721174 "PHO86 -- transport -- associated with phosphate transport complex, regulates Pho81p" YPR088C SRP54 2.5 14 6.8 0.8092 0.105112708 iYPR088C 0.070565175 0.311311634 0.053197065 SRP54 -- secretion -- Signal recognition particle subunit YML113W DAT1 2.4 13 6.8 0.8092 0.156586725 iYML114C 0.582617619 0.186754753 0.662809258 "DAT1 -- transcription (putative) -- Datin, oligo (DA)/oligo (DT)-binding protein" YDR060W YDR060W 2 11 6.8 0.8092 0.507637035 iYDR059C 0.641611062 0.308945713 0.794094174 YDR060W -- unknown -- 60S ribosomal subunit biogenesis YEL036C ANP1 3 17 6.7 0.805 1 0.765967132 iYEL036C 0.940501863 0.250719768 0.175717048 "ANP1 -- protein glycosylation -- cis Golgi with a role in retention of glycosyltransferases in the Golgi, subunit of Anp1p-Hoc1p-Mnn11p-Mnn9p mannosyltransferase complex" YNL138W SRV2 4.4 25 6.7 0.805 0.382640869 iYNL139C 0.331354701 0.841922947 0.727924589 SRV2 -- signaling -- Adenylate cyclase-associated protein (CAP) that may provide a link between growth signals and the cytoskeleton YER136W GDI1 4.3 24 6.7 0.805 0.52560336 iYER135C itV(AAC)E1 0.799137616 0.35467646 0.859410248 0.827442056 0.383560539 GDI1 -- secretion -- GDP dissociation inhibitor YGR253C PUP2 3.7 21 6.7 0.805 0.525683303 iYGR253C-0 iYGR253C-1 0.731051944 0.860937648 0.648140679 0.482618583 0.286793372 PUP2 -- protein degradation -- Proteasome subunit alpha5_sc (protease yscE subunit PUP2) YIL021W RPB3 3.3 18 6.7 0.805 0.785479127 iYIL022W 0.430581236 0.914011454 0.225346439 "RPB3 -- transcription -- RNA polymerase II, third-largest subunit (B45)" YML009C MRPL39 3 16 6.7 0.805 0.399748488 iYML009C 0.324211402 0.320378506 0.066467934 MRPL39 -- protein synthesis -- Mitochondrial ribosomal large subunit YKL016C ATP7 2.8 16 6.7 0.805 0.906709635 iYKL016C 0.917633344 0.904815681 0.790686432 "ATP7 -- ATP synthesis -- Subunit 7 of F0-ATP synthase, homolog of bovine F0-ATP synthase subunit d" YML086C ALO1 2.7 15 6.7 0.805 0.427928767 iYML086C 0.71614152 0.848359324 0.766771488 "ALO1 -- D-erythroascorbic acid biosynthesis -- D-arabinino-1,4-lactone oxidase (L-galactono-gamma-lactone oxidase)" YBR218C PYC2 2.4 13 6.7 0.805 0.562328061 iYBR218C 0.264213679 0.526360257 0.263474039 PYC2 -- TCA cycle -- Pyruvate carboxylase 2 YDR156W RPA14 2.4 13 6.7 0.805 iYDR155C 0.292725389 0.497271513 RPA14 -- transcription -- RNA polymerase I subunit A14 YLR214W FRE1 2.4 13 6.7 0.805 0.640901943 iYLR213C 0.897660006 0.493832376 0.601580879 FRE1 -- iron homeostasis -- Membrane-associated flavocytochrome with ferric and cupric reductase activitiesacts on ferric iron chelates external to the cell to facilitate iron uptake YGR079W YGR079W 2.2 12 6.7 0.805 0.450947988 iYGR078C 0.577788571 0.777526821 0.738872645 YGR079W -- unknown -- unknown function YNL061W NOP2 2.1 12 6.7 0.805 0.166020453 iYNL062C 0.368487236 0.301330033 0.317901235 "NOP2 -- nuclear organization -- Nucleolar protein, has strong similarity to human proliferation-associated p120 nucleolar antigen" YNL280C ERG24 2.1 12 6.7 0.805 0.379771939 iYNL280C 0.156579657 0.68128655 0.485601355 "ERG24 -- sterol metabolism -- C-14 sterol reductasecarries out reduction of delta 14,15 double bond of ergosterol precursor 4,4-dimethylcholesta-8,24,24 trienol" YGL255W ZRT1 2 11 6.7 0.805 0.696211854 iYGL256W-0 iYGL256W-1 0.266661307 0.366943116 0.878588553 0.395711501 0.365551193 "ZRT1 -- transport -- High-affinity zinc transport protein, member of ZIP family of metal ion transporters" YDR412W YDR412W 1.9 11 6.7 0.805 0.225017358 iYDR411C 0.42703309 0.301332034 0.27559399 YDR412W -- unknown -- Cytoplasmic unknown function YKL154W SRP102 1.9 10 6.7 0.805 0.702027599 iYKL155C 0.256943554 0.720858161 0.16588785 "SRP102 -- secretion -- Signal recognition particle receptor beta subunit, interacts with alpha subunit Srp101p" YLR435W YLR435W 1.9 10 6.7 0.805 0.228651022 0.319074425 YLR435W -- unknown -- unknown function YJL198W YJL198W 1.8 10 6.7 0.805 0.468967616 iYJL199C 0.144337803 0.667278532 0.105347167 "YJL198W -- unknown -- strong similarity to Pho87p and Ynr013p, member of phosphate permease family of membrane transporters" YDL201W YDL201W 1.7 10 6.7 0.805 0.073775607 iYDL202W 0.669902673 0.29702729 0.613840204 "YDL201W -- unknown -- Putative methyltransferase, highly conserved among eukaryotes" YDR361C YDR361C 1.7 9 6.7 0.805 0.736145643 iYDR361C 0.463907813 0.975192173 0.794795359 YDR361C -- unknown -- unknown function YDR404C RPB7 3.1 17 6.6 0.8024 0.585037875 iYDR404C 0.286281723 0.96217079 0.306606437 "RPB7 -- transcription -- RNA polymerase II, non-essential subunit, not shared" YEL051W VMA8 3 17 6.6 0.8024 0.657085927 iYEL052W 0.696381249 0.707980846 0.688853948 VMA8 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) subunit of V1 catalytic sector YOL049W GSH2 3 17 6.6 0.8024 0.174334571 iYOL050C 0.089338728 0.431311254 0.131659999 "GSH2 -- glutathione biosynthesis -- Glutathione synthetase, carries out synthesis of glutathione from gamma-glutamylcysteine and glycine" YBR263W SHM1 2.9 17 6.6 0.8024 0.351510264 0.618133419 "SHM1 -- one-carbon interconversion -- Serine hydroxymethyltransferase (glycine hydroxymethyltransferase), mitochondrial" YDR072C IPT1 2.8 16 6.6 0.8024 0.702036474 iYDR072C 0.501691559 0.915529565 0.548567435 "IPT1 -- sphingolipid biosynthesis -- Inositolphosphotransferase 1, required for synthesis of mannosyl diphosphorylinositol ceramide (M(IP)2C) the most abundant and complex sphingolipid" YJL123C YJL123C 2.7 15 6.6 0.8024 0.154420719 iYJL123C 0.111162923 0.138068635 0.025086715 YJL123C -- unknown -- unknown function YMR089C YTA12 2.6 15 6.6 0.8024 0.240781075 iYMR089C 0.352043753 0.497482131 0.599760575 "YTA12 -- protein folding -- Mitochondrial protein involved with Afg3p in proteolytic and chaperonin activities in the inner membrane, member of AAA family of ATPases" YKL004W AUR1 2.5 14 6.6 0.8024 0.647259987 iYKL005C 0.243838337 0.731305961 0.361101724 AUR1 -- sphingolipid metabolism -- Phosphatidylinositol YML127W YML127W 2.4 14 6.6 0.8024 0.128195395 iYML128C 0.421654812 0.402078405 0.44837783 YML127W -- unknown -- unknown function YPL243W SRP68 2.4 13 6.6 0.8024 0.500880026 iYPL244C 0.098721762 0.577566602 0.105181936 SRP68 -- secretion -- Signal recognition particle subunit YPL199C YPL199C 2.2 12 6.6 0.8024 0.934641048 iYPL199C SNR59 0.943936035 0.815888078 0.840223464 0.325401307 0.451556265 YPL199C -- unknown -- unknown function YPL244C YPL244C 1.8 10 6.6 0.8024 0.097589701 iYPL244C 0.098721762 0.085873903 0.105181936 YPL244C -- unknown -- unknown function YGL171W ROK1 1.6 9 6.6 0.8024 0.207544115 iYGL172W 0.354930539 0.497243479 0.531795947 "ROK1 -- rRNA processing -- ATP-dependent RNA helicase required for rRNA processing, member of DEAD box family" YKL035W UGP1 5.5 31 6.5 0.7995 0.651147033 0.495356578 UGP1 -- pyrimidine metabolism -- UDP-glucose pyrophosphorylase (UTP-glucose-1-P uridylyltransferase) YGL206C CHC1 3.4 19 6.5 0.7995 0.715544482 iYGL206C 0.298483591 0.575292398 0.832943454 "CHC1 -- endocytosis and secretion -- Clathrin heavy chain, required for the internalization step of endocytosis" YDL128W VCX1 3.1 18 6.5 0.7995 0.609948881 iYDL129W 0.49661213 0.833078556 0.692820013 VCX1 -- transport -- Calcium transport (H+/Ca2+ exchange) vacuolar membrane YML004C GLO1 2.8 16 6.5 0.7995 0.399474322 iYML004C 0.183732396 0.634669678 0.1836932 GLO1 -- amino acid metabolism -- Glyoxalase Iconverts hemimercaptal adduct of methylglyoxal and glutathione into S-D-lactoylglutathione YKL058W TOA2 2.7 16 6.5 0.7995 0.30774134 iYKL059C 0.243142617 0.166142558 0.415941317 TOA2 -- transcription -- RNA polymerase II transcription initiation factor TFIIA small subunit YDR533C YDR533C 2.6 15 6.5 0.7995 0.617916329 iYDR533C 0.61489719 0.77465219 0.85649754 YDR533C -- unknown -- unknown function YDL198C YHM1 2.5 14 6.5 0.7995 0.533141488 iYDL198C 0.197453172 0.637455772 0.282732294 YHM1 -- transport -- mitochondrial carrier (MCF) family that when overexpressed suppresses loss of Abf2p YLR008C YLR008C 2.4 13 6.5 0.7995 0.442800868 iYLR008C 0.115557319 0.342964293 0.187157589 YLR008C -- unknown -- unknown function YGR082W TOM20 2.2 13 6.5 0.7995 0.349342453 iYGR081C 0.21200467 0.586170865 0.345824598 TOM20 -- mitochondrial protein targeting -- Mitochondrial primary import receptor of outer membranehas tetratricopeptide (TPR) repeats YPR037C YPR037C 2.2 13 6.5 0.7995 0.467326739 0.077758578 YPR037C -- unknown -- similarity to Erv1p YBR206W YBR206W 2.1 12 6.5 0.7995 0.625106297 0.821149242 YBR206W -- unknown -- unknown functionquestionable ORF YLR222C YLR222C 2.1 12 6.5 0.7995 0.300532628 iYLR222C 0.519346768 0.606187773 0.62859074 "YLR222C -- unknown -- unknown function, overproduction causes chromosome instability and increased mitotic recombination, contains WD (WD-40) repeats" YOL022C YOL022C 1.8 10 6.5 0.7995 0.522786671 iYOL022C itG(GCC)O2 0.621294022 0.376265926 0.892014102 0.744857627 0.371611487 YOL022C -- unknown -- unknown function YOR272W YTM1 1.6 9 6.5 0.7995 0.255119825 iYOR271C SNR8 0.516565379 0.676619441 0.527615335 0.557557805 0.32016786 "YTM1 -- cytoskeleton (putative) -- Microtubule-associated protein essential for the G1/S transition, member of WD (WD-40) repeat family" YOL102C TPT1 1.3 8 6.5 0.7995 0.358460296 iYOL102C 0.393503697 0.506623879 0.276909442 TPT1 -- tRNA splicing -- NAD-dependent 2'-phosphotransferase in tRNA splicing YOR056C YOR056C 1.9 11 6.4 0.7957 1 0.407804086 iYOR056C 0.96074641 0.099680766 0.573534151 YOR056C -- unknown -- associates with the 26S proteasome YHR027C RPN1 4.6 27 6.4 0.7957 0.378787178 iYHR027C 0.414985127 0.257781325 0.284100992 RPN1 -- protein degradation -- Non-ATPase component of 26S proteasome complexrequired for degration of proteins of endoplasmic reticulum YBL091C MAP2 3.5 20 6.4 0.7957 0.360934722 iYBL091C 0.8525615 0.703216374 0.691269645 "MAP2 -- protein processing -- Methionine aminopeptidase isoform 2, cleaves N-terminal methionine" YJL143W TIM17 3.5 20 6.4 0.7957 0.046789437 iYJL144W 0.072525319 0.051494477 0.100551304 "TIM17 -- mitochondrial protein targeting -- Part of mitochondrial inner-membrane translocation channel with Tim23p, involved in import of proteins destined for mitochondrial matrix" YBL099W ATP1 3.4 20 6.4 0.7957 0.748684775 0.856743536 ATP1 -- ATP synthesis -- Alpha subunit of F1-ATP synthase YBR016W YBR016W 3.3 19 6.4 0.7957 0.150667693 iYBR015C 0.348277517 0.234956105 0.30782976 YBR016W -- unknown -- unknown function YIL142W CCT2 3.3 19 6.4 0.7957 0.702652582 iYIL143C 0.54870046 0.889213775 0.328708559 "CCT2 -- protein folding -- Component of Chaperonin-containing T-complex (TCP ring complex, TRiC)homologous to mouse CCT2" YDR212W TCP1 2.7 16 6.4 0.7957 0.579404372 iYDR211W 0.728025351 0.968378756 0.398754096 "TCP1 -- protein folding -- Component of chaperonin-containing T-complex (TCP ring complex, TRiC), homologous to mouse TCP1/CCT1" YIR044C YIR044C 2.7 16 6.4 0.7957 0.911466973 0.260175579 "YIR044C -- unknown -- Probable pseudogeneputative product has similarity to N-terminal region of Ybr302p, Ycr007p, and Ykl291p" YPR143W YPR143W 2.4 13 6.4 0.7957 0.01994023 0.02443841 YPR143W -- unknown -- unknown function YER062C HOR2 2.1 12 6.4 0.7957 0.671893156 iYER062C 0.413223122 0.794143744 0.568240413 HOR2 -- glycerol metabolism -- DL-glycerol phosphate phosphatase YGR029W ERV1 2.1 12 6.4 0.7957 0.577533381 iYGR028W 0.292642717 0.609626136 0.47317199 ERV1 -- mitochondrial biogenesis -- essential for mitochondrial biogenesis and cell viability YKR025W RPC37 2.1 12 6.4 0.7957 0.879104633 iYKR024C 0.516756351 0.480825008 0.578911795 "RPC37 -- transcription -- RNA polymerase III, C37 subunit" YML080W YML080W 1.9 11 6.4 0.7957 0.393992706 iYML081W 0.636728153 0.776184338 0.593443731 YML080W -- unknown -- weak similarity to Azospirillum brasilense nifR3 protein YMR269W YMR269W 1.9 11 6.4 0.7957 0.046415223 iYMR268C 0.105213645 0.052194733 0.093697195 "YMR269W -- unknown -- unknown function, rich in lysine and serine" YAL039C CYC3 1.8 11 6.4 0.7957 0.782985395 iYAL039C-0 iYAL039C-1 0.845290926 0.947763209 0.639213775 0.825532274 0.179010375 "CYC3 -- cytochrome c biosynthesis -- Holocytochrome-c synthase (cytochrome-c heme lyase), catalyzes covalent linkage of heme to apocytochrome c" YGR272C YGR272C 1.8 10 6.4 0.7957 0.482209914 iYGR272C 0.556892442 0.738089361 0.420727085 YGR272C -- unknown -- unknown function YJL125C GCD14 1.8 11 6.4 0.7957 0.191682482 iYJL125C 0.24063972 0.403825996 0.250081222 GCD14 -- protein synthesis -- translational repression of GCN4 mRNA YPR058W YMC1 1.8 11 6.4 0.7957 0.792884911 iYPR057W 0.423104751 0.923942538 0.714631002 YMC1 -- transport -- Member of mitochondrial carrier (MCF) family of membrane transporters YMR015C ERG5 2.1 12 6.3 0.793 1 0.919660862 iYMR015C 0.969506711 0.907961604 0.216818892 ERG5 -- sterol metabolism -- Cytochrome P450 YKR092C SRP40 1.8 11 6.3 0.793 1 0.670462679 iYKR092C-0 iYKR092C-1 0.980492887 0.721771985 0.30931167 0.346938776 0.712027103 SRP40 -- transcription (putative) -- Suppressor of rpc40 and rpb10 mutations YGR185C TYS1 4.5 26 6.3 0.793 0.408137882 iYGR185C 0.353307196 0.393376141 0.483228512 TYS1 -- protein synthesis -- Tyrosyl-tRNA synthetase YDL046W YDL046W 3.4 20 6.3 0.793 0.551799462 iYDL047W 0.364920987 0.646285392 0.388897841 YDL046W -- unknown -- unknown function YER057C HIG1 3.1 19 6.3 0.793 0.969688138 iYER057C 0.693018127 0.788028731 0.189091202 HIG1 -- heat shock response -- inhibits cell growthcontributes to cell death at high temperature YDR234W LYS4 2.7 16 6.3 0.793 0.478782807 iYDR233C 0.311246803 0.927824479 0.407356619 "LYS4 -- lysine biosynthesis -- Homoaconitate hydratase (homoaconitase), third step in lysine biosynthesis pathway, converts homoaconitate to homoisocitrate" YGL209W MIG2 2.7 16 6.3 0.793 0.53549276 iYGL210W 0.19928582 0.173455114 0.320003291 "MIG2 -- glucose repression -- Zinc-finger glucose repression of SUC2, has two tandem zinc-fingers" YMR264W CUE1 2.7 16 6.3 0.793 0.124131409 iYMR263W 0.510647557 0.528890662 0.197501747 "CUE1 -- protein degradation, ubiquitin-mediated -- recruits the soluble ubiquitin-conjugating enzyme Ubc7p to the membrane" YNL306W YNL306W 2.6 15 6.3 0.793 0.455676849 iYNL307C 0.270938314 0.712753085 0.167695219 "YNL306W -- protein synthesis -- Mitochondrial ribosomal small subunit (YmS18), has similarity to bacterial and chloroplast ribosomal protein S11" YDR091C RLI1 2.1 13 6.3 0.793 0.881142169 iYDR091C 0.42983511 0.968137453 0.879809631 "RLI1 -- unknown -- Putative ortholog of human Rnase L inhibitor (RLI) of interferon-regulated 2-5A pathway, putative ortholog of C. elegans Y39E4B.1, member of non-transporter group in the ATP-binding cassette (ABC) superfamily" YJR144W MGM101 2.1 12 6.3 0.793 0.842462338 iYJR143C 0.596376779 0.727113906 0.447936972 MGM101 -- mitochondrial genome maintenance -- Mitochondrial genome maintenance protein YOR176W HEM15 2 12 6.3 0.793 0.522577257 iYOR175C 0.106501143 0.78158234 0.335887715 "HEM15 -- heme biosynthesis -- Ferrochelatase (protoheme ferrolyase), last step in heme biosynthesis pathwaycatalyzes insertion of ferrous iron into protoporphyrin IX" YOR294W RRS1 1.8 11 6.3 0.793 0.373164317 iYOR293W 0.701444479 0.112246681 0.582984209 RRS1 -- ribosome biogenesis (putative) -- Regulator of ribosome synthesis YDR299W 1.7 10 6.3 0.793 0.743481554 iYDR298C 0.497548034 0.546049481 0.456493716 YML124C TUB3 3.5 21 6.2 0.7908 0.644218495 iYML124C 0.850335038 0.683288077 0.639832217 "TUB3 -- cytoskeleton -- Tubulin alpha-3 chain, non-essential" YMR072W ABF2 2.6 16 6.2 0.7908 0.748153225 iYMR071C 0.159902764 0.911778924 0.073842514 "ABF2 -- mitochondrial genome maintenance -- Abundant mitochondrial DNA-binding maintenance, transmission and recombination of mitochondrial genome, contains two HMG-box DNA-binding domains" YDL236W PHO13 2.5 15 6.2 0.7908 0.446718034 iYDL237W 0.510189996 0.69377494 0.794224409 PHO13 -- unknown -- 4-Nitrophenylphosphatase YBR052C YBR052C 2.4 14 6.2 0.7908 0.498143411 iYBR052C 0.455175463 0.658475669 0.456995607 "YBR052C -- unknown -- similarity to Ycp4p, S. pombe obr1, and E. coli trp repressor binding protein" YFR024C-A 2.4 14 6.2 0.7908 0.351255386 iYFR024C-A 0.27891212 0.333071279 0.485315243 YJL206C-A 2.2 13 6.2 0.7908 YLR297W YLR297W 2 12 6.2 0.7908 0.176567753 iYLR296W 0.321767948 0.367691788 0.398324202 YLR297W -- unknown -- unknown function YHR197W YHR197W 1.9 12 6.2 0.7908 0.331082053 iYHR196W 0.615932516 0.725104822 0.643704122 YHR197W -- unknown -- unknown function YJR101W YJR101W 1.8 11 6.2 0.7908 0.732068112 iYJR100C itL(UAG)J 0.694910399 0.565460757 0.752274541 0.649109015 0.506284241 YJR101W -- unknown -- respiratory growthmay have a role in stress resistance and pseudohyphal growth YML093W YML093W 1.6 10 6.2 0.7908 0.13115017 iYML094W 0.575387655 0.138645224 0.464792137 YML093W -- unknown -- unknown function YPL183C YPL183C 1.3 8 6.2 0.7908 0.663449944 iYPL183C 0.428272036 0.654916512 0.516422082 "YPL183C -- unknown -- unknown function, has WD (WD-40) repeats" YDR324C YDR324C 1.7 10 6.1 0.7874 1 0.924212222 iYDR324C 0.98405641 0.321368073 0.604979053 YDR324C -- unknown -- multiple WD40 repeats YIL041W YIL041W 4.5 27 6.1 0.7874 0.30554054 iYIL042C 0.073313307 0.487689584 0.252238445 YIL041W -- unknown -- unknown function YBL040C ERD2 3.7 23 6.1 0.7874 0.431657121 iYBL040C 0.55338365 0.573767847 0.967417104 ERD2 -- ER protein retention -- receptor-mediated retrieval of lumenal ER protein from the secretory pathway YDR129C SAC6 3.5 21 6.1 0.7874 0.456039341 iYDR129C 0.310884137 0.66991621 0.409775364 "SAC6 -- cytoskeleton -- Actin filament bundling protein, fimbrinessential for polarized secretion" YGL070C RPB9 3.3 20 6.1 0.7874 0.746119394 iYGL070C 0.306721837 0.660981157 0.385899814 "RPB9 -- transcription -- RNA polymerase II, non-essential subunit, not shared" YDR424C DYN2 3.1 19 6.1 0.7874 iYDR424C 0.098426469 0.105590062 DYN2 -- cytoskeleton -- Cytoplasmic dynein light chain YGR267C FOL2 3 19 6.1 0.7874 0.60112111 iYGR267C 0.238672976 0.896648045 0.496329757 "FOL2 -- folate biosynthesis -- GTP cyclohydrolase I, catalyzes synthesis of D-erythro-7,8-dihydroneopterintriphosphate from GTP" YMR238W DFG5 3 18 6.1 0.7874 0.295913216 iYMR237W 0.399787484 0.307578376 0.485820174 "DFG5 -- pseudohyphal growth -- filamentous growth, cell polarity, and cellular elongation" YGL040C HEM2 2.7 16 6.1 0.7874 0.326843941 iYGL040C-0 iYGL040C-1 0.361018348 0.619067798 0.728557505 0.404044473 0.673630717 "HEM2 -- heme biosynthesis -- Porphobilinogen synthase (delta-aminolevulinic acid dehydratase), second step in heme biosynthesis pathway" YER086W ILV1 2.6 16 6.1 0.7874 0.40820695 iYER085C 0.38118724 0.681051867 0.329096828 "ILV1 -- isoleucine and valine biosynthesis -- Serine and threonine dehydratase (anabolic), first step in isoleucine biosynthesis pathway" YML085C TUB1 2.6 15 6.1 0.7874 0.515040241 iYML085C 0.562090283 0.842754875 0.569403371 "TUB1 -- cytoskeleton -- Tubulin alpha-1 chain, required for mitosis and karyogamy" YDL040C NAT1 2 13 6.1 0.7874 0.770398636 iYDL040C 0.436968146 0.803420182 0.370807128 "NAT1 -- protein processing -- N-acetyltransferase subunit, mating functions are reduced in mutants due to derepression of silent mating type loci" YDR384C YDR384C 2 12 6.1 0.7874 0.277147142 iYDR384C 0.257096797 0.56485659 0.341614907 "YDR384C -- unknown -- unknown function, has strong similarity to Ynr002p and Ycr010p" YHR136C SPL2 2 12 6.1 0.7874 0.340335662 iYHR136C 0.092128744 0.330974843 0.078066914 "SPL2 -- cell cycle -- Putative inhibitor of Pho80p-Pho85p cyclin-dependent protein kinase, may block phosphorylation of novel factors other than Pho4p" YNL016W PUB1 2 13 6.1 0.7874 0.237780489 0.31485659 "PUB1 -- mRNA processing -- Major polyadenylated RNA-binding nucleus and cytoplasm, contains 3 RNA recognition (RRM) domains and 3 gln-asn-rich domains" YKL021C MAK11 1.8 11 6.1 0.7874 0.181292348 iYKL021C 0.583360034 0.466806316 0.374249343 MAK11 -- dsRNA virus propagation -- essential for replication of M double-stranded RNA (dsRNA) virusmember of WD (WD-40) repeat family YBR268W MRPL37 1.7 10 6.1 0.7874 0.251093325 iYBR267W 0.720597844 0.744292974 0.967169476 MRPL37 -- protein synthesis -- Mitochondrial ribosomal large subunit YDL147W RPN5 4.6 28 6 0.7835 0.578947223 iYDL148C 0.34709714 0.497136404 0.437928531 RPN5 -- protein degradation -- Non-ATPase subunit of 26S proteasome complex YNL079C TPM1 4.4 27 6 0.7835 0.023524495 iYNL079C 0.082929148 0.02014295 0.01161775 "TPM1 -- cytoskeleton -- Tropomyosin, coiled-coil protein localized to actin cables" YDR238C SEC26 3.1 19 6 0.7835 0.554424765 iYDR238C 0.360992292 0.396310023 0.704309657 SEC26 -- secretion -- Coatomer (COPI) complex beta chain (beta-COP) of secretory pathway vesiclesrequired for retrograde transport from Golgi to endoplasmic reticulum YPL235W RVB2 3.1 20 6 0.7835 0.22451713 iYPL236C 0.415252046 0.362265064 0.742921675 RVB2 -- unknown -- Putative 5' to 3' DNA helicase involved in ribosomal RNA processing YGL157W YGL157W 3 19 6 0.7835 0.288970682 iYGL158W 0.222006693 0.722029523 0.315164221 YGL157W -- unknown -- weak similarity to tomato dihydroflavonol 4-reductase YLR034C SMF3 3 19 6 0.7835 0.573923853 iYLR034C 0.230228738 0.852625635 0.544721468 "SMF3 -- trnasport (putative) -- Possible metal transporter, has similarity to Smf1p and Smf2p" YGL173C KEM1 2.9 18 6 0.7835 0.465866791 iYGL173C 0.452494843 0.47725796 0.783415342 "KEM1 -- mRNBA decay -- Nuclease with 5'-3' exonuclease activity for single-stranded RNA and DNA, primary role is to degrade decapped mRNA" YDR019C GCV1 2.8 17 6 0.7835 0.783404805 iYDR019C 0.49390349 0.758570622 0.425937749 "GCV1 -- amino acid metabolism -- Glycine decarboxylase T subunit (glycine cleavage T protein), functions in the pathway for glycine degradation" YGR055W MUP1 2.8 17 6 0.7835 0.778593928 iYGR054W 0.583627354 0.796807662 0.714668616 MUP1 -- transport -- High-affinity methionine permease YGL198W YGL198W 2.7 17 6 0.7835 0.623181286 0.944606888 YGL198W -- unknown -- similarity to NADH-ubiquinone oxidoreductase chain 2 of C. elegans YOR204W DED1 2.6 16 6 0.7835 0.719858729 0.593055108 DED1 -- RNA processing -- ATP-dependent RNA helicase of DEAD box family involved in protein synthesis YIL157C YIL157C 2.5 15 6 0.7835 0.287833755 iYIL157C 0.142493844 0.69077594 0.237721678 YIL157C -- unknown -- unknown function YKR026C GCN3 2.4 14 6 0.7835 0.746080598 iYKR026C YKRCdelta9 0.681586709 0.478148878 0.691187361 0.861612131 0.361374193 "GCN3 -- protein synthesis -- Translation initiation factor eIF2B (guanine nucleotide exchange factor), 34 kDa (alpha) subunit" YGR095C RRP46 2.2 14 6 0.7835 iYGR095C 0.584555237 0.330529125 RRP46 -- rRNA processing -- component of exosome 3'-5' exoribonuclease complex involved in involved 3'end processing of multiple small RNA species YDR084C YDR084C 1.9 11 6 0.7835 0.447507281 iYDR084C 0.483841412 0.602161813 0.455067837 YDR084C -- unknown -- unknown function YDR280W RRP45 1.9 12 6 0.7835 0.328884959 iYDR279W 0.5443326 0.538522013 0.535514765 RRP45 -- rRNA processing -- component of exosome 3'-5' exoribonuclease complex involved in involved in 3'-end processing of multiple small RNA species YDL121C YDL121C 1.8 11 6 0.7835 0.77827393 iYDL121C 0.587989388 0.472465887 0.862945493 YDL121C -- unknown -- unknown function YOL010W RCL1 1.8 11 6 0.7835 0.699252351 iYOL011W 0.299425067 0.787230331 0.26217079 RCL1 -- unknown -- Putative RNA 3'-terminal phosphate cyclase YEL007W YEL007W 1.7 10 6 0.7835 0.356312478 iYEL008W 0.969046063 0.210483008 0.134665367 YEL007W -- unknown -- unknown functionhas similarity to Yhr177p YFL017C GNA1 1.7 10 6 0.7835 0.655923869 iYFL017C 0.247979458 0.705204641 0.055335968 GNA1 -- UDP-N-acetylglucosamine biosynthesis -- Phosphoglucosamine acetyltransferase YBL041W PRE7 4 25 5.9 0.7811 0.472550749 iYBL042C 0.376613043 0.884390685 0.326939411 PRE7 -- protein degradation -- Proteasome subunit beta6_sc YGL122C NAB2 3.1 20 5.9 0.7811 0.613836204 iYGL122C 0.682217952 0.475738228 0.696408619 "NAB2 -- mRNA processing -- Nuclear poly(A)-binding protein, required for proper polyadenylation of pre-mRNA and for mRNA export" YBR090C-A 3 19 5.9 0.7811 YNL312W RFA2 3 19 5.9 0.7811 0.356535006 iYNL313C 0.397146539 0.239430468 0.448505523 "RFA2 -- DNA replication -- DNA replication factor A, 36K subunitphosphorylated at the G1/S transition and dephosphorylated at mitosis" YNL189W SRP1 2.6 16 5.9 0.7811 0.844103218 iYNL190W 0.824111202 0.89998253 0.668868837 "SRP1 -- nuclear protein targeting -- Karyopherin-alpha or importin, involved in nuclear import, nuclear structure, chromosome segregation, and cell cycle" YDR272W GLO2 2.1 14 5.9 0.7811 0.637643212 iYDR271C 0.518442116 0.852201258 0.311757512 GLO2 -- methylglyoxal resistance -- Glyoxalase-II YIL118W RHO3 2 13 5.9 0.7811 0.402205912 iYIL119C-0 iYIL119C-1 0.40958394 0.248512242 0.492852502 0.324968507 0.586835525 "RHO3 -- cytoskeleton -- GTP-binding control of actin cytoskeleton and exocytosis, member of rho family in the ras superfamily" YPR100W YPR100W 2 13 5.9 0.7811 0.217419459 YPR100W -- unknown -- unknown function YJL097W YJL097W 1.8 11 5.9 0.7811 0.976606767 iYJL098W 0.849750812 0.784947971 YJL097W -- unknown -- Essential unknown function YLR375W STP3 1.8 11 5.9 0.7811 0.393169854 0.65545809 "STP3 -- tRNA splicing -- strong similarity to Stp1p, which is involved in tRNA splicing and branched-chain amino acid uptake" YNL062C GCD10 1.6 10 5.9 0.7811 0.264044034 iYNL062C 0.368487236 0.317901235 GCD10 -- protein synthesis -- RNA-binding subunit of initiation factor eIF3 YNL132W YNL132W 1.6 10 5.9 0.7811 0.321676079 iYNL133C itF(GAA)N 0.522228475 0.062028022 0.569818152 0.475910409 0.067758329 YNL132W -- unknown -- unknown function YKL065C YET1 4.4 28 5.8 0.7777 0.476108616 iYKL065C 0.221918966 0.400724101 0.270988268 YET1 -- unknown -- Transmembrane endoplasmic reticulum YFR053C HXK1 3.7 23 5.8 0.7777 0.529418846 iYFR053C-0 iYFR053C-1 0.327337239 0.371360174 0.866796621 0.459452234 0.156838856 "HXK1 -- glycolysis -- Hexokinase I, converts hexoses to hexose phosphates in glycolysisrepressed by glucose" YKL210W UBA1 3.4 21 5.8 0.7777 0.489480679 iYKL211C SNR64 0.031634378 0.072374343 0.729294231 0.024261772 0.003910615 "UBA1 -- protein degradation, ubiquitin-mediated -- Ubiquitin-activating (E1) enzyme" YBR302C COS2 2.9 19 5.8 0.7777 0.931432918 YCLWTy5-1A 0.990963 0.560355468 0.43955276 COS2 -- unknown -- Member of COS family of subtelomerically-encoded proteins YBR014C YBR014C 2.5 15 5.8 0.7777 0.692993505 iYBR014C 0.78928572 0.804245865 0.689116003 YBR014C -- unknown -- similarity to glutaredoxin YPR148C YPR148C 2.5 16 5.8 0.7777 0.195220784 iYPR148C-0 iYPR148C-1 0.636746785 0.785354344 0.178914253 0.657232173 0.343466108 YPR148C -- unknown -- unknown function YAL007C ERP2 2.2 14 5.8 0.7777 0.35441453 iYAL007C YALCdelta2 0.367046351 0.717986077 0.823724668 0.615041929 0.463905898 "ERP2 -- membrane trafficking; secretion (putative) -- similarity to COPII-coated vesicle proteins Emp24p and Erv25p, forms an Erp1p-Erp2p-Emp24p-Erv25p heteromeric complex" YER174C GRX4 2 13 5.8 0.7777 0.859266636 iYER174C 0.215546307 0.989916915 0.091500507 "GRX4 -- oxidative stress response -- Glutaredoxin, has similarity to Grx3p and Grx5p" YCL059C KRR1 1.9 12 5.8 0.7777 0.323075946 iYCL059C 0.572319733 0.664918932 0.227420403 KRR1 -- unknown -- essential for cell division and spore germination YJL079C PRY1 1.9 12 5.8 0.7777 0.100511438 iYJL079C 0.631524344 0.143437297 0.147626071 "PRY1 -- unknown -- similarity to plant pathenogenesis-related proteins, may have a role in mating efficiency" YPL043W NOP4 1.9 13 5.8 0.7777 0.208559305 0.15188434 "NOP4 -- rRNA processing -- Nucleolar ribosome biogenesis, has 3 canonical RNA recognition (RRM) domains and one degenerate RNA recognition (RRM) domain" YPR166C MRP2 1.9 12 5.8 0.7777 0.601731638 iYPR166C 0.118156635 0.691296281 0.245543277 MRP2 -- protein synthesis -- Mitochondrial ribosomal small subunit YDR119W YDR119W 1.7 11 5.8 0.7777 0.323421625 iYDR118W 0.298907393 0.736819904 0.202336872 YDR119W -- unknown -- Member of major facilitator superfamily (MFS) multidrug-resistance (MFS-MDR) protein family YDR302W GPI11 1.7 11 5.8 0.7777 0.441349786 iYDR301W 0.374938175 0.618201267 0.319688109 "GPI11 -- unknown -- glycosylphosphatidylinositol (GPI) biosynthesis, with similarity to GPI-anchor biosynthesis PIG-F" YPL127C HHO1 1.6 10 5.8 0.7777 0.470677392 iYPL127C 0.044362566 0.234976204 0.111083683 HHO1 -- chromatin structure -- Histone H1 YHR013C ARD1 1.5 9 5.8 0.7777 0.355252387 iYHR013C 0.409046184 0.604743083 0.447851153 "ARD1 -- protein processing -- N-acetyltransferase subunit, functions in a complex with Nat1prequired for transcriptional silencing at telomeres and transcriptional repression of silent HML locus" YKL029C MAE1 1.5 9 5.8 0.7777 0.835422289 iYKL029C 0.865540771 0.465356107 0.405267358 "MAE1 -- pyruvate metabolism -- Mitochondrial malate dehydrogenase (NADP+, oxaloacetate-decarboxylating)" YLR216C CPR6 5.3 34 5.7 0.7748 0.334804081 0.562436634 "CPR6 -- protein folding (putative) -- Cyclophilin (peptidylprolyl cis-trans isomerase or PPIase), interacts with Hsp82p, homolog of mammalian cyclophilin Cyp40" YJL174W KRE9 4 26 5.7 0.7748 0.500074619 iYJL175W 0.104798863 0.667579762 0.082202713 "KRE9 -- cell wall biogenesis -- Glyco cell surface beta-1,6-glucan assemblymutants are resistant to K1 killer toxin" YOR151C RPB2 3.9 26 5.7 0.7748 0.492209352 iYOR151C 0.444870957 0.792700612 0.57576849 "RPB2 -- transcription -- RNA polymerase II, second-largest subunit" YFR009W GCN20 2.8 18 5.7 0.7748 0.666526553 iYFR008W iYFRCdelta8 0.454625645 0.454265825 0.90758943 0.204560103 "GCN20 -- protein synthesis -- Component of a protein complex required for activation of Gcn2p protein kinase in response to amino acid starvation, member of non-transporter group within the ATP-binding cassette (ABC) superfamily" YGR132C PHB1 2.8 18 5.7 0.7748 0.490851091 iYGR132C 0.253742934 0.789105571 0.197851153 "PHB1 -- antiproliferative protein -- Prohibitin, involved in determination of replicative lifespanmember of prohibitin complex with Phb2p" YPR098C YPR098C 2.8 19 5.7 0.7748 0.679617938 iYPR098C 0.392927148 0.425738501 YPR098C -- unknown -- unknown function YBR262C YBR262C 2.5 16 5.7 0.7748 0.101189317 0.207821229 YBR262C -- unknown -- unknown function YOR209C NPT1 2.5 16 5.7 0.7748 0.217125958 iYOR209C 0.169128015 0.385916855 0.133122157 "NPT1 -- NAD biosynthesis -- Nicotinate phosphoribosyltransferase (NAPRTase), first step in the Preiss-Handler pathway leading to the synthesis of NAD" YJL012C PHM3 2.1 14 5.7 0.7748 0.60053904 iYJL012C 0.445911655 0.601998066 0.769193935 PHM3 -- unknown -- Putative polyphosphate synthetase YNR024W YNR024W 1.9 12 5.7 0.7748 0.236076943 iYNR023W 0.350934848 0.512491265 0.538632436 YNR024W -- unknown -- unknown function YOR164C YOR164C 1.8 12 5.7 0.7748 0.720332229 iYOR164C 0.480636519 0.849090759 0.544063194 YOR164C -- unknown -- unknown function YIL127C YIL127C 1.7 11 5.7 0.7748 0.238370778 iYIL127C 0.157529047 0.410650983 0.041300315 YIL127C -- unknown -- unknown function YKL120W OAC1 1.7 11 5.7 0.7748 0.63252673 iYKL121W 0.307237177 0.667198723 0.280443162 "OAC1 -- transport -- Mitochondrial oxaloacetate transporter, member of mitochondrial carrier (MCF) family" YLR221C YLR221C 1.7 11 5.7 0.7748 0.143487596 iYLR221C 0.201887936 0.145560767 0.370310916 YLR221C -- unknown -- unknown function YLR243W YLR243W 1.7 11 5.7 0.7748 0.151977432 iYLR242C 0.182361815 0.446640316 0.167627533 YLR243W -- unknown -- unknown function YOL030W YOL030W 5.1 33 5.6 0.7714 0.473126113 iYOL031C 0.224688506 0.343342878 YOL030W -- unknown -- similarity to Gas1p YDR513W TTR1 3.4 22 5.6 0.7714 0.282433142 0.291572672 "TTR1 -- electron carrier -- Glutaredoxin (thioltransferase, glutathione reductase)" YBR068C BAP2 3.1 21 5.6 0.7714 0.569973684 iYBR068C 0.653665631 0.386706461 0.858514157 "BAP2 -- transport -- Branched-chain amino acid permease specific for leucine, valine, and isoleucine" YGR038W ORM1 2.8 19 5.6 0.7714 0.835838894 iYGR037C 0.446577305 0.945536578 0.620020964 ORM1 -- unknown -- unknown function YBL102W SFT2 2.6 17 5.6 0.7714 0.791048357 iYBL103C 0.455717456 0.919996751 0.811260224 "SFT2 -- unknown -- Membrane ER to Golgi transport, can suppress temperature-sensitive mutants of SED5 when overexpressed" YHR135C YCK1 2.6 17 5.6 0.7714 0.368666158 iYHR135C 0.335119828 0.386982638 0.201417983 YCK1 -- unknown -- Casein kinase I isoform YKL024C URA6 2.6 17 5.6 0.7714 0.900538922 iYKL024C 0.386514489 0.966374269 0.207138253 URA6 -- pyrimidine metabolism -- Uridine-monophosphate kinase (uridylate kinase)converts ATP and UMP to ADP and UDP YER042W MXR1 2.4 16 5.6 0.7714 0.812627804 iYER041W 0.282390115 0.931530214 0.079938695 MXR1 -- oxidative stress response -- Peptide methionine sulfoxide reductase involved in cellular antioxidation YGR195W SKI6 2.4 16 5.6 0.7714 0.674516378 iYGR194C 0.432163898 0.852302977 0.501520784 "SKI6 -- rRNA processing -- Component of exosome 3'-5' exoribonuclease complex involved in 3' processing of ribosomal 5.8S rRNA, of snoRNAs and of U4 snRNA, and in degradation of poly(A)- mRNAs, confers antiviral activity by repressing replication of double-stranded RNA viruses" YDR211W GCD6 2.2 15 5.6 0.7714 0.641933008 YDRCTy1-2D iYDRCTy1-2 0.157914951 0.78575864 0.867996808 0.136530398 0.457562668 "GCD6 -- protein synthesis -- Translation initiation factor eIF2B (guanine nucleotide exchange factor), 81 kDa (beta) subunit" YBR105C VID24 2 13 5.6 0.7714 0.50922778 iYBR105C 0.647673062 0.783878691 0.453616087 VID24 -- vacuolar protein targeting -- vacuolar import and degradation of Fbp1p YPR138C MEP3 1.8 12 5.6 0.7714 0.119104114 iYPR138C 0.127271216 0.190541412 0.188836009 MEP3 -- transport -- Ammonia permease of high capacity and low affinity YJL212C OPT1 1.7 11 5.6 0.7714 0.386930788 iYJL212C 0.126679618 0.661630929 OPT1 -- unknown -- member of oligopeptide transporter (OPT) family YER001W MNN1 1.6 11 5.6 0.7714 0.64780127 iYEL001C CEN5 0.488654179 0.770569932 0.39586354 0.516711158 0.280460296 "MNN1 -- protein glycosylation -- Alpha-1,3-mannosyltransferase, required for complex glycosylation of both N- and O-oligosaccharides" YLL011W SOF1 1.6 11 5.6 0.7714 0.329826673 iYLL012W 0.680961824 0.426643627 0.633917551 SOF1 -- rRNA processing -- associated with U3 small nucleolar RNA (snoRNA) and involved in 18S pre-rRNA maturationhas 7 WD (WD-40) repeats YBR267W YBR267W 1.3 9 5.6 0.7714 0.351866454 0.536160865 "YBR267W -- unknown -- unknown function, has a single C2H2-type zinc finger" YGR128C YGR128C 1.2 8 5.6 0.7714 0.701679805 iYGR128C 0.440337556 0.97669593 0.604097766 YGR128C -- unknown -- similarity to Haemophilus glutamate-ammonia-ligase adenylyltransferase (glnE) PIR YIL075C RPN2 3.7 25 5.5 0.7679 0.714133685 iYIL075C 0.664225838 0.626100551 0.90933759 "RPN2 -- tRNA processing -- Non-ATPase component of 26S proteasome complex, has an effect on the tRNA splicing system" YNR001C CIT1 3.7 25 5.5 0.7679 iYNR001C itP(AGG)N 0.763498366 0.670278212 0.724820431 0.668874701 "CIT1 -- TCA cycle -- Citrate synthase, mitochondrial, converts acetyl-CoA and oxaloacetate into citrate plus CoA" YOR027W STI1 3.6 24 5.5 0.7679 0.451444312 iYOR026W 0.389873733 0.213225017 0.170151636 "STI1 -- protein folding -- Stress-induced optimal growth at high and low temperature, has tetratricopeptide (TPR) repeats" YBR062C YBR062C 3.4 23 5.5 0.7679 0.686917439 iYBR062C 0.313566721 0.7436634 0.577414206 YBR062C -- unknown -- unknown function YGL011C SCL1 3.1 21 5.5 0.7679 0.700987072 iYGL011C 0.499335276 0.947964884 0.651305189 "SCL1 -- protein degradation -- Proteasome subunit alpha1_sc(YC7alpha/Y8, protease yscE subunit 7)" YNL052W COX5A 3.1 21 5.5 0.7679 0.581638395 iYNL053W 0.303315533 0.900089971 0.74240858 COX5A -- oxidative phosphorylation -- Cytochrome-c oxidase subunit Va YMR286W MRPL33 2.9 20 5.5 0.7679 0.493209966 iYMR285C 0.653610973 0.212609737 0.529992594 MRPL33 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL33E. coli L30) YDR368W YPR1 2.6 17 5.5 0.7679 0.651094143 iYDR367W 0.424779605 0.984596967 0.641122852 YPR1 -- unknown -- similarity to members of aldo/keto reductase family YDR449C YDR449C 2.4 15 5.5 0.7679 0.966164805 iYDR449C 0.983170496 0.989674921 0.542631282 "YDR449C -- unknown -- unknown function, localized to the nucleus" YER022W SRB4 2 14 5.5 0.7679 0.305381932 iYER021W 0.585757947 0.776616121 0.457846004 SRB4 -- transcription -- Component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YDL174C DLD1 1.9 13 5.5 0.7679 0.417173159 iYDL174C 0.190036226 0.334119497 0.188271605 "DLD1 -- pyruvate metabolism -- D-lactate dehydrogenase (cytochrome), (D-lactate ferricytochrome c oxidoreductase, D-LCR), mitochondrial" YNR037C YNR037C 1.9 12 5.5 0.7679 0.505915278 iYNR037C 0.065828161 0.536658073 0.341961143 "YNR037C -- unknown -- Putative mitochondrial ribosomal small subunit, has similarity to prokaryotic ribosomal protein S19" YOR323C PRO2 1.8 12 5.5 0.7679 0.099734554 iYOR323C 0.570360171 0.451176281 0.186190783 "PRO2 -- proline biosynthesis -- Gamma-glutamyl phosphate reductase (phosphoglutamate dehydrogenase), proline biosynthetic enzyme" YGL232W YGL232W 1.6 11 5.5 0.7679 0.511539587 iYGL233W 0.569169908 0.750907478 0.132596416 YGL232W -- unknown -- similarity to dihydropteroate synthase YGR108W CLB1 1.6 11 5.5 0.7679 0.508843982 iYGR107W 0.324995953 0.903214535 CLB1 -- cell cycle -- G2/M-phase-specific cyclin YPL217C BMS1 1.5 10 5.5 0.7679 0.389205911 iYPL217C 0.517485328 0.168763103 0.635314996 BMS1 -- unknown -- bud site selection in diploidsinteracts genetically with BMH1 YGR286C BIO2 1.3 9 5.5 0.7679 0.330695319 iYGR286C-0 iYGR286C-1 0.16424454 0.109862845 0.647086991 0.545379742 0.167379205 "BIO2 -- biotin biosynthesis -- Biotin synthetase, catalyzes insertion of a sulfur atom between two carbon atoms of dethiobiotin in the last step of biotin synthesis pathway" YOR051C YOR051C 1.3 9 5.5 0.7679 0.498834311 iYOR051C 0.448641983 0.73774283 0.302061495 YOR051C -- unknown -- Nuclear unknown function YCR104W PAU3 3.6 25 5.4 0.7639 0.938802808 iYCR103C 0.944820843 0.640186916 0.759135275 PAU3 -- unknown -- Member of seripauperin (PAU) family YFL010C YFL010C 3.5 24 5.4 0.7639 0.307058938 iYFL010C 0.611762802 0.468815514 0.669221492 YFL010C -- unknown -- unknown function YFL062W COS4 3 21 5.4 0.7639 0.945875106 iYFL063W 0.996910256 0.396789546 0.146548177 COS4 -- unknown -- Member of COS family of subtelomerically-encoded proteins YDR007W TRP1 2.6 18 5.4 0.7639 0.391735 iYDR006C 0.55090115 0.302476755 0.346454787 "TRP1 -- tryptophan biosynthesis -- Phosphoribosylanthranilate isomerase, catalyzes the third step in the tryptophan biosynthesis pathway" YPL004C YPL004C 2.6 18 5.4 0.7639 0.611847049 iYPL004C 0.349786946 0.605865292 0.297344514 YPL004C -- unknown -- weak similarity to tropomyosin YKL211C TRP3 2.5 17 5.4 0.7639 0.674336398 iYKL211C SNR64 0.031634378 0.072374343 0.927306693 0.024261772 0.003910615 TRP3 -- tryptophan biosynthesis -- Anthranilate synthase YML072C YML072C 2.5 17 5.4 0.7639 0.764899784 iYML072C 0.76973251 0.286601597 0.877334397 YML072C -- unknown -- unknown function YGL077C HNM1 2.1 15 5.4 0.7639 0.552326053 iYGL077C 0.471822934 0.55373437 0.547131808 "HNM1 -- transport -- Choline permease, member of amino acid permease family of membrane transporters" YOR222W YOR222W 2 13 5.4 0.7639 0.675941973 iYOR221C 0.451293249 0.591443764 0.509421542 "YOR222W -- unknown -- similarity to mitochondrial ADP/ATP carrier proteins, member of mitochondrial carrier family (MCF) of membrane transporters" YDR098C GRX3 1.9 13 5.4 0.7639 0.238336465 iYDR098C itQ(UUG)D2 0.616702421 0.440722839 0.296648045 0.355421561 0.471827614 "GRX3 -- oxidative stress response -- Glutaredoxin, has similarity to Grx4p and Grx5p" YER110C KAP123 1.9 13 5.4 0.7639 0.643557424 iYER110C 0.590599701 0.810614525 0.177462289 KAP123 -- nuclear protein targeting -- Karyopherin-beta involved in nuclear import of ribosomal proteins YIL083C YIL083C 1.8 12 5.4 0.7639 0.444437836 iYIL083C YILWTy3-1A 0.288970845 0.024954553 0.926332034 0.702873105 0.03056664 YIL083C -- unknown -- unknown function YKL128C PMU1 1.8 12 5.4 0.7639 0.796893076 iYKL128C itK(CUU)K 0.853569694 0.68225225 0.919742411 0.932748899 0.803721174 PMU1 -- unknown -- Possible phosphomutasemulticopy suppressor of temperature sensitivity of tps2 YOR091W YOR091W 1.7 12 5.4 0.7639 0.149076203 iYOR090C 0.452177831 0.386592179 0.334876297 YOR091W -- unknown -- unknown function YDL038C YDL038C 1.6 11 5.4 0.7639 0.525594785 iYDL038C 0.191206311 0.509720094 0.607212476 YDL038C -- unknown -- unknown function YDR410C STE14 1.6 11 5.4 0.7639 0.752256785 iYDR410C 0.565416661 0.934090348 0.611679662 STE14 -- mating -- Farnesyl cysteine YKL008C LAC1 1.5 10 5.4 0.7639 0.896102419 iYKL008C 0.767560673 0.988962295 0.790191175 LAC1 -- aging -- Protein required with Lag1p for ER-to-Golgi transport of GPI-anchored proteins YMR239C RNT1 1.3 9 5.4 0.7639 0.361302652 iYMR239C 0.535097781 0.443814844 0.561342272 "RNT1 -- rRNA processing -- Double-strand-specific ribonuclease required for rRNA processing, homolog of E. coli RNase III" YHR144C DCD1 1.2 9 5.4 0.7639 0.680322809 iYHR144C 0.350817156 0.953253707 0.567423096 DCD1 -- pyrimidine metabolism -- Deoxycytidylate deaminase YNR003C RPC34 1 7 5.4 0.7639 0.555770728 iYNR003C 0.628936417 0.920240416 0.763564003 "RPC34 -- transcription -- RNA polymerase III, essential subunit, not shared" YLR378C SEC61 3.4 24 5.3 0.7596 0.519010211 0.774122807 "SEC61 -- secretion -- Component of Sec61p-Sss1p-Sbh1p complex, involved in protein translocation into the endoplasmic reticulum" YDL145C COP1 2.8 20 5.3 0.7596 0.497575425 iYDL145C 0.734071142 0.416687238 0.854427171 "COP1 -- secretion -- Coatomer (COPI) complex alpha chain (alpha-COP) of secretory pathway vesicles required for retrograde Golgi to endoplasmic reticulum transport, member of WD (WD-40) repeat family" YNL100W YNL100W 2.6 18 5.3 0.7596 0.160320223 iYNL101W 0.119107191 0.353312051 0.111572227 YNL100W -- unknown -- unknown function YFL028C CAF16 2.5 17 5.3 0.7596 0.552482877 iYFL028C 0.235380595 0.79584996 0.209600697 "CAF16 -- transport -- associates with Ccr4p, member of non-transporter group of ATP-binding cassette (ABC) superfamily" YAL049C YAL049C 2.4 16 5.3 0.7596 0.747196822 iYAL049C 0.470616609 0.82975397 0.653929438 YAL049C -- unknown -- unknown function YDL165W CDC36 2.2 15 5.3 0.7596 iYDL166C 0.626510243 0.590899182 CDC36 -- transcription -- Nuclear negatively affects basal transcription from many promoterspart of CCR4 transcription complex YPR060C ARO7 2.2 16 5.3 0.7596 0.361050389 iYPR060C 0.733723905 0.649021663 0.545240416 ARO7 -- aromatic amino acid biosynthesis -- Chorismate mutaserequired for the synthesis of both phenylalanine and tyrosine YDR502C SAM2 2.1 15 5.3 0.7596 0.865749306 iYDR502C 0.65897685 0.954085411 0.240452856 SAM2 -- methionine biosynthesis -- S-adenosylmethionine synthetase 2 YGL242C YGL242C 2.1 15 5.3 0.7596 0.22172607 iYGL242C 0.067101748 0.353163828 0.034591195 YGL242C -- unknown -- similarity to ankyrin and coiled-coil proteins YIL027C YIL027C 2.1 15 5.3 0.7596 0.714501755 iYIL027C 0.158428849 0.711492418 0.405892735 "YIL027C -- unknown -- unknown function, has a hydrophobic domain" YJR072C YJR072C 2.1 15 5.3 0.7596 0.169733476 iYJR072C 0.567960952 0.515630281 0.289424861 YJR072C -- unknown -- unknown function YNL032W SIW14 2.1 15 5.3 0.7596 0.581188279 iYNL033W 0.342042225 0.863300889 0.385830659 SIW14 -- cell cycle -- Protein tyrosine phosphatase (PTPase) involved in nutritional control of cell cycle YDR046C BAP3 2 14 5.3 0.7596 0.567410471 iYDR046C 0.585744249 0.235130761 0.776104666 "BAP3 -- transport -- Branched chain amino acid permease, valine transporter" YEL037C RAD23 1.9 13 5.3 0.7596 0.619550215 iYEL037C 0.641219162 0.211013567 0.571347907 "RAD23 -- DNA repair, nucleotide excision -- Nucleotide excision repair ubiquitin-like domain, ortholog of human XP-C complementing genes hHR23B and hHR23A" YKR093W PTR2 1.9 13 5.3 0.7596 0.710849272 iYKR092C-0 iYKR092C-1 0.980492887 0.721771985 0.694322406 0.346938776 0.712027103 PTR2 -- transport -- Peptide permease nitrogen-repressible transporter of di- and tri-peptides and member of proton-dependent oligopeptide transporter family YOR116C RPO31 1.8 12 5.3 0.7596 0.268702721 iYOR116C 0.34392447 0.312762281 0.437751995 "RPO31 -- transcription -- RNA polymerase III, largest subunit" YLR022C YLR022C 1.7 11 5.3 0.7596 0.531736314 iYLR022C 0.475842109 0.56191014 0.257815018 YLR022C -- unknown -- unknown function YJL109C YJL109C 1.6 11 5.3 0.7596 0.586319502 iYJL109C 0.697114191 0.834526454 0.858755686 YJL109C -- unknown -- weak similarity to Drs2p YBL024W NCL1 1.5 10 5.3 0.7596 0.840248285 iYBL025W 0.166133454 0.942294694 0.379347958 "NCL1 -- unknown -- Methyltransferase that methylates cytidine to 5-methyl-cytidine (m5C) at several positions in different tRNAs, has similarity to human proliferating cell nucleolar antigen (p120), a proliferation antigen of human tumors" YDR083W YDR083W 1.5 10 5.3 0.7596 0.267428376 iYDR082W 0.538510513 0.237596087 0.428698034 YDR083W -- unknown -- cleavage at site A2 in pre-rRNA in the pathway of ribosomal RNA processing YBR247C ENP1 1.3 10 5.3 0.7596 0.289114436 iYBR247C 0.084357729 0.401991614 0.222484277 ENP1 -- protein glycosylation -- Essential nuclear effects on N-glycosylation of proteins in the secretory pathway YAR002W NUP60 1.2 9 5.3 0.7596 0.338644744 iYAL001C CEN1 0.283867159 0.793589121 0.386400258 0.552472372 0.597331661 NUP60 -- unknown -- Nuclear pore protein (nucleoporin) YBL022C PIM1 2.4 17 5.2 0.7558 1 0.933206917 iYBL022C 0.99363863 0.681598453 0.663568773 "PIM1 -- respiration -- Serine protease required for intramitochondrial proteolysis and maintenance of respiratory function, related to E. coli ATP-dependent protease La, member of AAA+ family of putative ATPases" YPL262W FUM1 3.1 22 5.2 0.7558 0.147105012 iYPL263C 0.293100117 0.415006988 0.283858998 "FUM1 -- TCA cycle -- Fumarate hydratasemitochondrial and cytoplasmic fumarase, converts L-malate to fumarate as part of TCA cycle" YBR151W APD1 2.6 18 5.2 0.7558 0.293613198 iYBR150C 0.594337097 0.303443795 0.574282952 "APD1 -- cytoskeleton (putative) -- normal cellular structure, localization of actin patches, and resistance to copper" YBR164C ARL1 2.5 18 5.2 0.7558 0.232806368 iYBR164C 0.314041092 0.720435348 0.435949082 "ARL1 -- secretion -- GTP-binding arf-sar family in the ras superfamily, possibly involved in signal transduction" YDL143W CCT4 2.4 17 5.2 0.7558 0.423363822 iYDL144C 0.262360483 0.488028731 0.503898635 "CCT4 -- protein folding -- Component of Chaperonin-containing T-complex(TCP ring complex, TRiC), homologous to mouse CCT4" YOR039W CKB2 2.4 17 5.2 0.7558 0.397781172 iYOR038C 0.07715158 0.736495643 0.275331936 "CKB2 -- salt tolerance -- Casein kinase II Protein kinase CK2, regulatory (beta-prime) subunit" YFR006W YFR006W 2.2 16 5.2 0.7558 0.594417943 iYFR005C 0.053423992 0.936593619 0.093729695 YFR006W -- unknown -- weak similarity to human X-pro dipeptidase YDR115W YDR115W 2.1 15 5.2 0.7558 0.583193355 0.745327103 YDR115W -- unknown -- similarity to prokaryotic L34 ribosomal protein YLR291C GCD7 2.1 15 5.2 0.7558 0.708900236 iYLR291C 0.500176857 0.854817918 0.492040286 "GCD7 -- protein synthesis -- Translation initiation factor eIF2B (guanine nucleotide exchange factor), 43 kDa (beta) subunit" YHR063C YHR063C 1.9 14 5.2 0.7558 0.587947323 iYHR063C 0.369029912 0.774300234 0.355387071 "YHR063C -- unknown -- Putative ketopantoate reductase (2-dehydropantoate 2-reductase) involved in coenzyme A synthesis, has similarity to Cbs2p" YIR035C YIR035C 1.9 14 5.2 0.7558 0.371641866 iYIR035C 0.520952216 0.84509178 0.407186594 YIR035C -- unknown -- similarity to proteins of human corticosteroid 11-beta-dehydrogenase and short-chain alcohol dehydrogenase family YDR127W ARO1 1.8 13 5.2 0.7558 0.412499221 iYDR126W 0.129521591 0.504799548 0.339664804 ARO1 -- aromatic amino acid biosynthesis -- Arom pentafunctional enzyme YJR069C HAM1 1.8 13 5.2 0.7558 0.308406166 iYJR069C 0.491027646 0.592505241 0.095587642 HAM1 -- 6-N-hydroxylaminopurine resistance -- controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis YML053C YML053C 1.8 13 5.2 0.7558 0.535291187 iYML053C 0.505701537 0.289832285 0.506900769 YML053C -- unknown -- unknown function YOR159C SME1 1.8 13 5.2 0.7558 0.044750539 iYOR159C 0.283022579 0.070869912 0.165108629 "SME1 -- mRNA splicing -- Spliceosomal snRNA-associated Sm core mRNA splicing, also likely associated with telomerase TLC1 RNA" YFL002C SPB4 1.7 12 5.2 0.7558 0.469092347 iYFL002C 0.488667638 0.867608837 0.292292849 "SPB4 -- rRNA processing, 25S -- ATP-dependent RNA helicase of DEAH box familyrequired for processing of of 25S ribosomal RNA precursor" YIL039W YIL039W 1.7 12 5.2 0.7558 0.701007847 iYIL040W 0.303916708 0.869060098 0.32781345 YIL039W -- unknown -- unknown function YDL048C STP4 1.2 9 5.2 0.7558 0.253149722 iYDL048C-0 iYDL048C-1 0.424348861 0.342138379 0.205849178 0.354509178 0.255474624 "STP4 -- tRNA splicing -- strong similarity to Stp1p, which is involved in tRNA splicing and branched-chain amino acid uptake" YGR145W YGR145W 1.1 8 5.2 0.7558 0.537663799 iYGR144W 0.365284782 0.441141974 0.192522711 YGR145W -- unknown -- similarity to MESA gene of Plasmodium falciparum YDL031W DBP10 1.8 13 5.1 0.7515 1 0.495007989 iYDL032W 0.782064598 0.43973574 0.562071469 "DBP10 -- unknown -- Putative RNA helicase involved in ribosome biogenesis, has similarity to RNA helicases of DEAD/DEAH box family" YCR009C RVS161 3.5 26 5.1 0.7515 0.684852985 iYCR009C 0.301099931 0.622426177 0.123602376 "RVS161 -- cytoskeleton -- viability after N, C, or S starvation, for internalization step of endocytosis, and for cell fusion during matingroles in endocytosis and in cell fusion are independent of one another" YDL097C RPN6 2.8 20 5.1 0.7515 0.593272402 iYDL097C 0.462565766 0.664717349 0.680078993 RPN6 -- protein degradation -- Non-ATPase subunit of 26S proteasome complex YHR132C ECM14 2.8 21 5.1 0.7515 0.18198626 iYHR132C 0.153098185 0.510392024 0.228012769 ECM14 -- cell wall biogenesis -- Protein possibly involved in cell wall structure or biosynthesis YGR024C YGR024C 2.7 20 5.1 0.7515 0.767666211 0.825937749 YGR024C -- unknown -- unknown function YMR074C YMR074C 2.7 19 5.1 0.7515 0.443379875 iYMR074C 0.238841436 0.896914142 0.395061728 YMR074C -- unknown -- unknown function YHR152W SPO12 2.4 17 5.1 0.7515 0.222500746 iYHR151C 0.35514504 0.351364522 0.066926576 SPO12 -- meiosis; mitotic cell cycle -- Sporulation chromosome division in meiosis I YOR089C VPS21 2.4 17 5.1 0.7515 0.140569503 iYOR089C 0.442615429 0.430719838 0.340409775 "VPS21 -- endocytosis -- GTP-binding sorting of vacuolar proteins and involved in late stage of endocytosis, member of rab family in the ras superfamily" YLL025W YLL025W 2.1 16 5.1 0.7515 0.726369903 iYLL026W iYLLCdelta1 0.413516374 0.635267279 0.476364522 0.869273743 0.654349561 YLL025W -- unknown -- Member of seripauperin (PAU) family YGR083C GCD2 2 14 5.1 0.7515 0.285436627 iYGR083C 0.640582732 0.333709768 0.540686432 "GCD2 -- protein synthesis -- Translation initiation factor eIF2B (guanine nucleotide exchange factor), 71 kDa (delta) subunit" YHR181W YHR181W 2 14 5.1 0.7515 0.528007123 iYHR180W itT(UGU)H 0.075674339 0.794472192 0.872386273 0.284503843 0.57497863 "YHR181W -- unknown -- unknown function, has 4 potential transmembrane domains" YML010W-A 2 14 5.1 0.7515 YDL226C GCS1 1.9 14 5.1 0.7515 0.347376914 iYDL226C 0.622969964 0.736111111 0.633259278 "GCS1 -- secretion -- GTPase-activating protein (GAP) for ADP-ribosylation factors Arf1p and Arf2p, member of Gcs1p/Glo3p/Sps18p family" YPR023C YPR023C 1.9 14 5.1 0.7515 0.045015655 iYPR023C 0.216326888 0.118415746 0.331531822 YPR023C -- unknown -- unknown function YCR016W YCR016W 1.7 12 5.1 0.7515 0.196734306 iYCR015C SNR33 0.71492119 0.332006864 0.213842059 0.505708919 0.154269753 YCR016W -- unknown -- unknown function YDR232W HEM1 1.7 12 5.1 0.7515 0.35118214 iYDR231C 0.558968779 0.710037175 0.814284539 "HEM1 -- heme biosynthesis -- 5-Aminolevulinate synthase, first step in heme biosynthesis pathway" YJR068W RFC2 1.6 11 5.1 0.7515 0.684335185 iYJR067C 0.315289932 0.94371345 0.175759072 "RFC2 -- DNA replication -- Replication factor C, second subunit, homologous to human 37 kDa subunit" YML055W SPC2 1.6 11 5.1 0.7515 0.762230574 0.829452161 SPC2 -- secretion -- Component of signal peptidase complex YNL087W YNL087W 1.6 11 5.1 0.7515 0.173887568 iYNL088W 0.347207396 0.392817239 0.469161957 YNL087W -- unknown -- unknown function YAR008W SEN34 1.5 10 5.1 0.7515 0.635349529 iYAR007C 0.087857507 0.680389945 0.155360168 "SEN34 -- tRNA splicing -- tRNA splicing endonuclease, gamma subunit, has active site for 3' splice site cleavage" YJL134W LCB3 1.5 11 5.1 0.7515 0.951768031 0.291796202 "LCB3 -- sphingolipid metabolism -- Sphingoid base-phosphate phosphatase, putative regulator of sphingolipid metabolism and stress response" YJR001W YJR001W 1.5 11 5.1 0.7515 0.679614229 iYJL001W CEN10 0.395354471 0.641552326 0.961176088 0.356025539 0.420140378 YJR001W -- unknown -- Putative membrane transporter of amino acid/auxin permease (AAAP) family YLR003C YLR003C 1.3 10 5 0.7485 1 0.963725004 iYLR003C 0.756237791 0.714769702 0.166290682 YLR003C -- unknown -- unknown function YKR048C NAP1 3.6 27 5 0.7485 0.242930537 iYKR048C 0.157636204 0.505310793 0.178994918 "NAP1 -- chromatin structure -- Nucleosome assembly plays a role in assembly of histones into octamer, required for full expression of Clb2p functions" YLR304C ACO1 3.1 23 5 0.7485 0.634928683 iYLR304C 0.741757524 0.645171588 0.377394954 "ACO1 -- TCA cycle -- Aconitate hydratase (aconitase), converts citrate to cis-aconitate" YBL007C SLA1 2.9 22 5 0.7485 0.477502011 iYBL007C 0.097212213 0.775026216 0.086352753 "SLA1 -- cytoskeleton -- assembly of cortical actin cytoskeleton, has three SH3 domains" YGL137W SEC27 2.6 19 5 0.7485 0.756313399 iYGL138C 0.581727278 0.487629689 0.703990423 "SEC27 -- secretion -- Coatomer (COPI) complex beta' chain (beta'-COP) of secretory pathway vesiclesrequired for retrograde transport from Golgi to endoplasmic reticulum, member of WD (WD-40) repeat family" YDL092W SRP14 2.4 18 5 0.7485 0.504313264 iYDL093W 0.602453691 0.411139726 0.872630475 "SRP14 -- secretion -- Signal recognition particle subunit, has strong similarity to mammalian SRP14 subunit" YDR167W TAF25 1.9 14 5 0.7485 0.166094978 iYDR166C 0.831309697 0.823830409 0.808874913 "TAF25 -- transcription -- Component of TAF(II) complex (TBP-associated protein complex) and SAGA complex (Spt-Ada-Gcn5-acetyltransferase), required for activated transcription by RNA polymerase II" YER095W RAD51 1.8 13 5 0.7485 0.374008672 iYER094C 0.160363637 0.183370931 0.274699428 "RAD51 -- DNA repair and recombination -- stimulates pairing and strand-exchange between homologous single-stranded and double-stranded DNA, functionally similar to E. coli RecA protein" YIL177C YIL177C 1.8 12.5 5 0.7485 0.963573995 iYHR219W iYIL177C-0 0.977859297 0.994824164 0.571134699 0.022216737 0.080538085 "YIL177C -- unknown -- similarity to subtelomerically-encoded proteins including Yjl225p, Yfl068p, and Yhl093p" YJL124C LSM1 1.8 14 5 0.7485 0.67698368 iYJL124C 0.035890058 0.723142214 0.095435348 "LSM1 -- mRNA splicing (putative) -- Sm class of RNA-binding proteins, involved in control of mRNA decay" YLR172C DPH5 1.8 14 5 0.7485 0.524283805 iYLR172C 0.709008188 0.812777285 0.656743815 "DPH5 -- diphthamide biosynthesis -- Diphthamide methyltransferase, required for diphthamide biosynthesis" YML018C YML018C 1.7 12 5 0.7485 0.686567341 iYML018C 0.304058164 0.906300354 0.693820456 YML018C -- unknown -- unknown function YOL020W SCM2 1.7 13 5 0.7485 0.473832302 iYOL021C 0.327677194 0.616609837 0.528598603 "SCM2 -- transport -- Tryptophan permease, high affinity" YOR320C YOR320C 1.7 12 5 0.7485 0.647163018 iYOR320C 0.453284537 0.417756932 0.372903564 YOR320C -- unknown -- similarity to K. lactis N-acetylglucosaminyltransferase YML019W OST6 1.3 10 5 0.7485 0.666229114 iYML020W 0.373773207 0.930474334 0.552513966 OST6 -- protein glycosylation -- Oligosaccharyltransferase subunit of 37 kDa YFL014W HSP12 3.4 25 4.9 0.7452 1 0.944622299 iYFL015C 0.962757269 0.279082678 0.294028273 "HSP12 -- glucose and lipid utilization -- Heat shock 12 kDa, induced by heat, osmotic stress, oxidative stress and in stationary phase" YPL226W NEW1 2.5 18 4.9 0.7452 1 0.742587391 iYPL227C 0.955560952 0.31141261 0.323463687 NEW1 -- unknown -- Member of non-transporter group of ATP-binding cassette (ABC) superfamily YDR408C ADE8 2.2 17 4.9 0.7452 1 0.840769125 iYDR408C 0.9351431 0.791991553 0.625312576 "ADE8 -- purine biosynthesis -- Phosphoribosylglycinamide formyltransferase (GART), third step in de novo purine biosynthesis pathway" YNL154C YCK2 2.1 16 4.9 0.7452 1 0.85790571 iYNL154C 0.971615723 0.641420591 0.261208577 YCK2 -- unknown -- Casein kinase I isoform YOR302W YOR302W 2.7 20 4.9 0.7452 0.2709098 iYOR301W 0.935960453 0.056035547 0.326619401 "YOR302W -- unknown -- Arginine attenuator peptide, mediates translational regulation of a downstream geneencoded by the 5'-leader of carbamyl-phosphate synthetase small subunit (CPA1) mRNA" YOR207C RET1 2.4 18 4.9 0.7452 0.398711521 iYOR207C 0.017275553 0.677811795 0.010220126 "RET1 -- transcription -- RNA polymerase III, second-largest subunit (C128)" YKR018C YKR018C 2.2 17 4.9 0.7452 0.274984343 iYKR018C 0.149900816 0.848269743 0.193899966 YKR018C -- unknown -- unknown function YPR181C SEC23 2.2 17 4.9 0.7452 0.081774465 iYPR181C 0.595905382 0.132066277 0.198261858 "SEC23 -- secretion -- Component of COPII coat of vesicles involved in endoplasmic reticulum to Golgi transport, has GTPase-activation (GAP) activity for Sar1p" YDL135C RDI1 2.1 16 4.9 0.7452 0.89434988 iYDL135C 0.718356743 0.821787709 0.692657622 RDI1 -- signaling -- Rho GDP dissociation inhibitor (rho GDI) with activity towards Rho1p YMR203W TOM40 2.1 17 4.9 0.7452 0.434239776 iYMR202W 0.433954984 0.843591191 0.233187135 TOM40 -- mitochondrial protein targeting -- Forms mitochondrial outer membrane import channelintegral outer membrane protein import YBL026W LSM2 2 15.5 4.9 0.7452 0.914488729 iYBL027W 0.728384719 0.908746811 0.779068043 LSM2 -- mRNA splicing -- U6 snRNA-associated Sm-like group YCR090C YCR090C 2 16 4.9 0.7452 0.761597517 iYCR090C-0 iYCR090C-1 0.599159867 0.081383281 0.825733161 0.77014295 0.091335473 YCR090C -- unknown -- unknown function YIR006C PAN1 1.8 14 4.9 0.7452 0.408956597 iYIR006C itE(UUC)I 0.506956588 0.792105475 0.181165204 0.493458405 0.426232206 PAN1 -- cytoskeleton and endocytosis -- organization of actin cytoskeleton and in endocytosis YKL127W PGM1 1.8 13 4.9 0.7452 0.638241613 iYKL128C itK(CUU)K 0.853569694 0.68225225 0.845724907 0.932748899 0.803721174 "PGM1 -- glycolysis -- Phosphoglucomutase, minor isoform, interconverts Glc-1-P and Glc-6-P" YDL148C YDL148C 1.7 12 4.9 0.7452 0.329744082 iYDL148C 0.34709714 0.245411014 0.437928531 YDL148C -- unknown -- Nuclear unknown function YNL124W YNL124W 1.7 13 4.9 0.7452 0.062128849 iYNL125C 0.062573782 0.089993502 0.131901588 YNL124W -- unknown -- unknown function YEL042W GDA1 1.3 10 4.9 0.7452 0.550652785 iYEL043W 0.47783768 0.545038098 0.503786658 GDA1 -- Golgi organization -- Guanosine diphosphatase of Golgi membrane YBL081W YBL081W 1.3 10 4.8 0.7418 1 0.610097275 iYBL082C 0.939385673 0.228948288 0.454851983 YBL081W -- unknown -- 37% identity to Drosophila l (2)not protein YNL156C YNL156C 3.3 25 4.8 0.7418 0.284490379 iYNL156C 0.493966305 0.634708347 0.59587496 YNL156C -- unknown -- unknown function YDL111C RRP42 2.6 19 4.8 0.7418 0.457234015 iYDL111C 0.437398756 0.844962491 0.456871345 "RRP42 -- rRNA processing -- Component of exosome 3'-5' exoribonuclease complex that is required for 3' processing of ribosomal 5.8S rRNA, of snoRNAS, and of U4 snRNA" YGR007W MUQ1 2.2 17 4.8 0.7418 0.584907719 iYGR006W 0.19589851 0.723654528 0.269097362 MUQ1 -- phospholipid metabolism -- Ethanolaminephosphate cytidylyltransferase YOR009W YOR009W 2.2 18 4.8 0.7418 0.176621915 iYOR008C-A 0.495709892 0.223322518 0.293631939 YOR009W -- unknown -- Member of seripauperin (PAU) family of possible cell wall mannoproteins YPL098C YPL098C 2.2 18 4.8 0.7418 0.033196163 iYPL098C 0.208660408 0.080363382 0.03879971 YPL098C -- unknown -- unknown function YBR042C YBR042C 2 15 4.8 0.7418 0.617012417 iYBR042C 0.263639439 0.75974863 0.127154444 YBR042C -- unknown -- Putative acyltransferase with similarity to Ydr018p YKL170W MRPL38 1.7 13 4.8 0.7418 0.476641506 iYKL171W 0.579062949 0.665442937 0.480870021 MRPL38 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL38) YLL031C GPI13 1.6 12 4.8 0.7418 0.256446332 iYLL031C 0.799336247 0.580601555 0.422868623 "GPI13 -- unknown -- glycosylphosphatidylinositol biosynthesis, probably responsible for adding phosphoethanolamine to the third mannose" YOL012C HTA3 1.6 12 4.8 0.7418 0.703336852 iYOL012C 0.360315012 0.594341079 0.498227558 HTA3 -- chromatin structure -- Histone-related can suppress histone H4 point mutation YER118C SHO1 1.5 11 4.8 0.7418 0.749433455 iYER118C 0.353098698 0.873024741 0.44420078 "SHO1 -- signaling, high osmolarity pathway -- Osmosensor in the HOG1 MAP kinase, high-osmolarity signal transduction pathway, has an SH3 domain" YML035C AMD1 1.5 12 4.8 0.7418 0.190221791 iYML035C 0.183217008 0.564290706 0.443632229 "AMD1 -- protein glycosylation -- AMP deaminase, converts AMP to IMP and ammonia" YNR009W YNR009W 1.3 10 4.8 0.7418 0.054333443 iYNR008W 0.310214696 0.17387631 0.121722997 YNR009W -- unknown -- unknown function YMR310C YMR310C 1.2 10 4.8 0.7418 0.198466673 iYMR310C 0.040489392 0.451083159 0.036305594 YMR310C -- unknown -- unknown function YNL217W YNL217W 1.2 10 4.8 0.7418 0.875567291 iYNL218W 0.882629108 0.639552437 0.913168396 YNL217W -- unknown -- Protein possibly involved in cytoplasmic ribosome function YPL063W YPL063W 1.2 9 4.8 0.7418 0.38255344 iYPL064C 0.547384783 0.596967279 0.61797209 YPL063W -- unknown -- unknown function YPL256C CLN2 1.2 10 4.8 0.7418 0.213166042 iYPL256C 0.130227367 0.153007773 0.154776598 "CLN2 -- cell cycle -- G1/S-specific cyclin, interacts with Cdc28p protein kinase to control events at START" YAL033W POP5 1.2 10 4.7 0.7377 1 0.956388282 iYAL034C 0.992893737 0.754834032 0.673907677 "POP5 -- tRNA processing -- Subunit of both RNase P and RNase MRP, which are involved in tRNA processing and 5.8S rRNA processing, respectively" YLR350W YLR350W 2.7 22 4.7 0.7377 0.24357529 iYLR349W 0.29789869 0.550133097 0.242023848 YLR350W -- unknown -- unknown function YMR315W YMR315W 2.7 21 4.7 0.7377 0.429700433 iYMR314W 0.394387265 0.811231067 0.56372865 YMR315W -- unknown -- unknown function YKR066C CCP1 2.6 20 4.7 0.7377 0.121399085 iYKR066C 0.559358887 0.564083821 0.923557969 "CCP1 -- oxidative stress response -- Cytochrome-c peroxidase, involved in destruction of toxic radicals in the cell" YML069W POB3 2.5 19 4.7 0.7377 0.250326691 iYML070W 0.160527409 0.563491931 0.136645963 POB3 -- DNA replication (putative) -- binds to DNA polymerase I YGL019W CKB1 1.9 15 4.7 0.7377 0.166698102 iYGL020C 0.087253562 0.410202655 0.089424951 "CKB1 -- salt tolerance -- Casein kinase II (Protein kinase CK2), regulatory (beta) subunit" YML077W BET5 1.8 14 4.7 0.7377 0.586670878 iYML078W 0.641363661 0.625812216 0.828731045 BET5 -- secretion (putative) -- TRAPP (Transport Protein Particle) complex involved in vesicular transport from endoplasmic reticulum to the Golgi YPR053C 1.7 13 4.7 0.7377 0.435506064 0.701884308 YBR248C HIS7 1.6 12 4.7 0.7377 0.357697912 iYBR248C 0.266923508 0.418151642 HIS7 -- histidine biosynthesis -- Glutamine amidotransferase YKR070W YKR070W 1.6 12 4.7 0.7377 0.524854991 iYKR069W 0.35353137 0.929174789 0.494232476 YKR070W -- unknown -- unknown function YLR130C ZRT2 1.6 12 4.7 0.7377 0.412824924 iYLR130C 0.667643791 0.62157492 0.613734783 "ZRT2 -- transport -- Low-affinity zinc transport protein, member of ZIP family of metal ion transporters" YLR407W YLR407W 1.6 13 4.7 0.7377 0.94418157 iYLR406C 0.996825698 0.911625549 0.935035914 YLR407W -- unknown -- unknown function YOR115C TRS33 1.6 12 4.7 0.7377 0.101887999 iYOR115C 0.628254724 0.501933613 0.592917479 TRS33 -- secretion (putative) -- TRAPP (Transport Protein Particle) complex involved in protein transport from endoplasmic reticulum to Golgi YDR367W 1.5 12 4.7 0.7377 0.753928738 0.977813248 YIR029W DAL2 1.5 12 4.7 0.7377 0.145822869 iYIR028W 0.482215549 0.249563242 0.62555457 "DAL2 -- allantoin utilization -- Allantoicase, carries out the second step in the degradation of allantoinallows purines to be used as nitrogen sources" YML075C HMG1 1.5 12 4.7 0.7377 0.568527382 iYML075C 0.671408256 0.507089913 0.927853152 "HMG1 -- sterol metabolism -- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase 1, rate limiting enzyme for sterol biosynthesis, converts HMG-CoA to mevalonate" YDL003W MCD1 1.3 10 4.7 0.7377 0.285508921 iYDL004W 0.523116416 0.404286175 0.410273741 "MCD1 -- mitosis, sister chromatid cohesion -- Cohesin, mitotic chromatid cohesion" YKL113C RAD27 1.3 10 4.7 0.7377 0.329446148 iYKL113C 0.095336791 0.503625524 0.335594573 RAD27 -- DNA repair -- Single-stranded DNA endonuclease and 5'-3' exonuclease that functions in the MSH2-MLH1-PMS1-dependent mismatch repair system YPR005C HAL1 1.3 11 4.7 0.7377 0.147581381 iYPR005C 0.101927475 0.167103424 0.111102159 HAL1 -- salt tolerance -- ion homeostasis YHL013C YHL013C 1.2 10 4.7 0.7377 0.48747142 iYHL013C 0.294803303 0.94035147 0.02997076 YHL013C -- unknown -- unknown function YLR068W YLR068W 1.2 9 4.7 0.7377 0.090876088 iYLR067C 0.333615938 0.111722572 0.066507205 YLR068W -- unknown -- unknown function YJR058C APS2 1.8 14 4.6 0.7319 1 0.968200095 iYJR058C 0.983866033 0.704191033 0.144737925 "APS2 -- secretion -- Clathrin-associated protein (AP) complex, small subunit" YGR283C YGR283C 1.5 12 4.6 0.7319 1 0.959815268 iYGR283C 0.949954929 0.721879371 0.484324237 YGR283C -- unknown -- unknown function YGL037C PNC1 6.5 52 4.6 0.7319 0.831270347 iYGL037C 0.344123974 0.806341719 0.095929769 PNC1 -- unknown -- Pyrazinamidase and nicotinamidase YPL048W CAM1 3.1 26 4.6 0.7319 0.36912767 iYPL049C 0.31983238 0.663293014 0.296552292 CAM1 -- protein synthesis -- Translation elongation factor EF-1gamma YER021W RPN3 3 25 4.6 0.7319 0.689051149 iYER020W 0.311382399 0.966403481 0.227071066 RPN3 -- protein degradation -- Non-ATPase component of 26S proteasome complex YKL157W APE2 3 24 4.6 0.7319 0.926375929 iYKL158W 0.326085637 0.82485637 0.298217311 "APE2 -- protein degradation -- Aminopeptidase II (yscII), plays a nutritional role in releasing leucine from peptides externally cleaved at leucine" YBL058W SHP1 2.8 23 4.6 0.7319 0.653313928 iYBL059W 0.87733522 0.919632881 0.886671987 SHP1 -- glucose repression -- Potential regulatory subunit for Glc7p YOR117W RPT5 2.8 23 4.6 0.7319 0.50336428 iYOR116C 0.34392447 0.848034438 0.437751995 "RPT5 -- protein degradation -- ATPase component of 26S proteasome complex, member of AAA family of ATPases" YBR035C PDX3 2.7 21 4.6 0.7319 0.56192191 iYBR035C iTLC1 0.305555225 0.645261686 0.893955276 0.200197482 0.440793093 PDX3 -- sterol uptake (putative) -- Pyridoxine (pyridoxamine) phosphate oxidase[P (N/M)P oxidase] YER141W COX15 2.7 21 4.6 0.7319 0.427782739 iYER140W 0.421126666 0.763051885 0.425022183 COX15 -- respiration -- cytochrome oxidase assembly YCR035C RRP43 2.5 20 4.6 0.7319 0.398642185 iYCR035C 0.292014083 0.654488604 0.319606888 "RRP43 -- rRNA processing -- Component of exosome 3'-5' exoribonuclease complex that is required for 3' processing of ribosomal 5.8S rRNA, of snoRNAs, and of U4 snRNA" YDL066W IDP1 2.5 20 4.6 0.7319 0.536853413 iYDL067C 0.331189849 0.633368861 0.31007097 "IDP1 -- TCA cycle -- Isocitrate dehydrogenase (NADP+), mitochondrial" YDL195W SEC31 2.5 20 4.6 0.7319 0.216003052 iYDL196W 0.362274069 0.361827264 0.484649123 "SEC31 -- secretion -- Component (p150) of COPII coat of secretory pathway vesicles involved in endoplasmic reticulum to Golgi transportassociated with Sec13p, member of WD (WD-40) repeat family" YKL028W TFA1 2.5 20 4.6 0.7319 0.310259302 iYKL029C 0.865540771 0.648124501 0.405267358 "TFA1 -- transcription -- RNA polymerase II transcription initiation factor TFIIE (factor a), 66 kDa subunit" YFR051C RET2 2.4 19 4.6 0.7319 0.270584201 iYFR051C 0.164495071 0.529824265 0.337984996 RET2 -- secretion -- Coatomer (COPI) complex delta chain (delta-COP) of secretory pathway vesiclesrequired for retrograde Golgi to endoplasmic reticulum transport YNL263C YIF1 2.4 19 4.6 0.7319 0.221970751 iYNL263C 0.16353584 0.745451592 0.669052909 YIF1 -- unknown -- Essential unknown functionhas similarity to NADH dehydrogenases YMR236W TAF17 2.2 18 4.6 0.7319 0.371087239 iYMR235C 0.34936877 0.70525127 0.215778011 TAF17 -- transcription -- Component of TAF(II) complex (TBP-associated protein complex) and the SAGA HAT complex YDR468C TLG1 2 17 4.6 0.7319 0.2730123 iYDR468C 0.508739339 0.389698017 0.345922677 "TLG1 -- endocytosis -- Syntaxin homolog (t-SNARE), involved in efficient endocytosis and in maintenance of resident proteins in the trans-Golgi network" YEL002C WBP1 1.9 15 4.6 0.7319 0.726264169 iYEL002C 0.753195595 0.861760884 0.897685029 "WBP1 -- protein glycosylation -- Oligosaccharyltransferase beta subunit, member of a complex of 8 ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif" YHR188C YHR188C 1.9 15 4.6 0.7319 0.543808019 iYHR188C 0.5206696 0.93282976 0.677408959 YHR188C -- unknown -- Protein possibly involved in the TCA cycle YOR306C YOR306C 1.9 15 4.6 0.7319 0.38337698 iYOR306C 0.535649465 0.202912861 0.333870448 "YOR306C -- unknown -- similarity to human X-linked PEST-containing transporter, member of monocarboxylate porter (MCP) family of major facilitator superfamily (MFS)" YDR063W YDR063W 1.8 15 4.6 0.7319 0.976644066 iYDR062W 0.935224425 0.782527881 0.497408047 YDR063W -- unknown -- unknown function YDR395W SXM1 1.6 13 4.6 0.7319 0.649595832 iYDR394W 0.394362575 0.950617284 0.331546459 SXM1 -- mRNA export; nuclear protein targeting -- Beta-karyopherin involved in nuclear protein import of mRNA-binding proteins YER156C YER156C 1.6 12 4.6 0.7319 0.876311761 iYER156C 0.238641273 0.975104737 0.390106349 YER156C -- unknown -- unknown function YHR072W ERG7 1.6 12 4.6 0.7319 0.563692458 iYHR071W itF(GAA)H1 0.792455885 0.81198682 0.829369513 0.446766922 0.236760884 ERG7 -- sterol metabolism -- Lanosterol synthasecarries out complex cyclization step of squalene to lanosterol in ergosterol biosynthesis pathway YBR242W YBR242W 1.5 12 4.6 0.7319 0.278716152 iYBR241C 0.64440667 0.49431449 0.666290232 YBR242W -- unknown -- normal growth rate on glucose and for normal copper sensitivity YKL144C RPC25 1.5 12 4.6 0.7319 0.580730458 iYKL144C 0.403711658 0.735177866 0.414498141 "RPC25 -- transcription -- RNA polymerase III, subunit C25" YGL099W YGL099W 1.3 11 4.6 0.7319 0.540848674 iYGL100W 0.460021454 0.725633528 0.68216728 "YGL099W -- unknown -- normal growth, morphology, mating, and sporulationhas similarity to human possible GTP-binding protein HSR1" YPL049C DIG1 1.2 10 4.6 0.7319 0.062634275 iYPL049C 0.31983238 0.1685884 0.296552292 DIG1 -- invasive growth -- MAP kinase-associated negative regulation of invasive growth YOR344C TYE7 1.9 16 4.5 0.7268 1 0.574329487 iYOR344C-0 iYOR344C-1 0.973512779 0.905107682 0.202480783 0.527881041 0.709273521 TYE7 -- glycolysis -- Basic helix-loop-helix transcription factor that can suppress the Gcr1p requirement for glycolytic gene expression YOL136C PFK27 1.7 14 4.5 0.7268 1 0.848372013 iYOL136C 0.944342485 0.901118099 0.295555376 "PFK27 -- fructose metabolism -- 6-Phosphofructose-2-kinase, isozyme 2" YHR049W YHR049W 4.7 39 4.5 0.7268 0.592088746 iYHR048W 0.706249955 0.797695778 0.736240241 YHR049W -- unknown -- unknown function YAL016W TPD3 3.3 27 4.5 0.7268 0.591458123 iYAL017W 0.100259572 0.846293096 0.206943336 "TPD3 -- tRNA biosynthesis, cytokinesis, ceramide-mediated signaling -- Protein serine/threonine phosphatase 2A (PP2A) regulatory subunit A, ceramide-activated protein phosphatase A subunit" YDL140C RPO21 2.9 24 4.5 0.7268 0.147426829 iYDL140C 0.721555102 0.201083159 0.646471157 "RPO21 -- transcription -- RNA polymerase II, largest subunit" YDL171C GLT1 2.9 24 4.5 0.7268 0.261351768 iYDL171C 0.595067293 0.33580705 0.666419814 "GLT1 -- glutamate biosynthesis -- Glutamate synthase (NADPH, GOGAT)involved with glutamine synthetase (Gln1p) in glutamate biosynthesis" YJL121C RPE1 2.6 21 4.5 0.7268 0.332890651 0.639348229 "RPE1 -- pentose phosphate cycle -- Ribulose-5-phosphate 3-epimerase, interconverts ribulose-5-phosphate and xylulose-5-phosphate" YNL056W YNL056W 2.6 21 4.5 0.7268 0.674108955 iYNL057W 0.417728116 0.779455721 0.697368421 YNL056W -- unknown -- similarity to Siw14p and Ynl099cp protein tyrosine phosphatases (PTP's) and which may compete with PTP's for substrates YDR194C MSS116 2.5 20 4.5 0.7268 0.774169474 iYDR194C 0.261595418 0.963658424 0.274807827 "MSS116 -- mRNA splicing, mitochondrial -- Mitochondrial RNA helicase of DEAD box family, required for splicing of group II introns of COX1 and COB" YPR086W SUA7 2.4 20 4.5 0.7268 0.123028169 iYPR085C 0.237089202 0.158805031 0.13471001 "SUA7 -- transcription -- RNA polymerase II transcription initiation factor TFIIB (factor e), functions in selection of site for transcriptional initiation" YKL146W YKL146W 2.2 18 4.5 0.7268 0.311081772 0.2735834 YKL146W -- unknown -- Putative membrane transporter of amino acid/auxin permease (AAAP) family YER088C DOT6 2.1 18 4.5 0.7268 0.221271695 iYER088C 0.460105162 0.140480942 0.234623184 DOT6 -- silencing (telomere) -- telomere silencing YNR052C POP2 2.1 17 4.5 0.7268 0.193413834 iYNR052C IntYNR053C 0.653807069 0.475438163 0.471398646 POP2 -- glucose derepression -- Component of CCR4 complex required for glucose derepression YDR292C SRP101 2 16 4.5 0.7268 0.370707545 iYDR292C 0.261842535 0.216293047 0.4471668 "SRP101 -- secretion -- Signal recognition particle receptor, alpha subunit, interacts with beta subunit, Srp102p" YNL121C TOM70 1.9 16 4.5 0.7268 0.387845399 iYNL121C 0.275689455 0.341631726 0.312980433 "TOM70 -- mitochondrial protein targeting -- Mitochondrial specialized import receptor of outer membrane, has tetratricopeptide (TPR) repeats" YDR261C EXG2 1.7 14 4.5 0.7268 0.711090806 iYDR261C-0 iYDR261C-1 0.399390388 0.488364032 0.824392998 0.510876571 0.466130604 "EXG2 -- cell wall biogenesis -- Exo-beta-1,3-glucanase (beta-1,3-D-glucanglucanohydrolase), minor isoform" YMR270C RRN9 1.6 12 4.5 0.7268 0.246586441 iYMR270C 0.720916247 0.554266436 0.799965059 "RRN9 -- transcription -- Component of Upstream Activation Factor (UAF) complex, involved in activation of RNA polymerase I" YOR001W RRP6 1.5 12 4.5 0.7268 0.426906265 iYOL001W CEN15 0.600271149 0.759368659 0.779551933 0.583086528 0.498225752 "RRP6 -- rRNA processing, 5.8S -- 5.8S ribosomal RNA 3' end processing, involved in degradation of aberrant poly(A)- mRNAs in the nucleus, component of nuclear form of exosome" YPL263C KEL3 1.5 12 4.5 0.7268 0.066989943 iYPL263C 0.293100117 0.093619078 0.283858998 KEL3 -- unknown -- similarity to Kel1p and Kel2p YER029C SMB1 1.3 11 4.5 0.7268 0.700290183 iYER029C 0.486484716 0.53460039 0.033918595 "SMB1 -- mRNA splicing -- Spliceosomal snRNA-associated Sm core protein, also likely associated with telomerase TLC1 RNA" YDL181W INH1 1.2 10 4.5 0.7268 0.394981173 iYDL182W 0.499338952 0.63819633 0.544486569 INH1 -- ATP synthesis -- Inhibitor of mitochondrial ATPase that forms a complex with ATP synthase to inhibit enzyme activity YJL069C YJL069C 1.2 10 4.5 0.7268 0.219509712 iYJL069C 0.507789924 0.380403461 0.672655495 YJL069C -- unknown -- Essential unknown function YJL186W MNN5 1.2 11 4.5 0.7268 0.439757136 iYJL187C 0.299054294 0.706624102 0.365090968 MNN5 -- protein glycosylation -- Mannosyltransferaserequired for forming and extending the mannose branches of outer chain mannans YKL084W YKL084W 1.2 10 4.5 0.7268 0.434898714 iYKL085W 0.205295334 0.61054256 0.103770545 YKL084W -- unknown -- unknown function YNL040W YNL040W 1.2 10 4.5 0.7268 0.570584426 iYNL041C 0.649701422 0.902110688 0.817031905 YNL040W -- unknown -- unknown function YIL064W YIL064W 1 8 4.5 0.7268 0.50906589 iYIL065C 0.494430234 0.91844887 0.710119239 YIL064W -- unknown -- Predicted methyltransferase protein YOR261C RPN8 2.9 24 4.4 0.7224 0.25600686 iYOR261C 0.176334806 0.531501772 0.351133339 RPN8 -- protein degradation -- Non-ATPase subunit of 26S proteasome complex YJR044C YJR044C 2.7 22 4.4 0.7224 0.424434849 iYJR044C 0.654152263 0.472222222 0.396925227 YJR044C -- unknown -- similarity to Drosophila yakuba NADH dehydrogenase chain 5 YER122C GLO3 2.6 22 4.4 0.7224 0.45272145 iYER122C 0.483179877 0.673083171 0.309429701 "GLO3 -- cell proliferation -- GTPase-activating protein (GAP) for ADP-ribosylation factors Arf1p and Arf2p, involved in retrograde transport between Golgi and ER" YKL002W YKL002W 2.5 21 4.4 0.7224 0.439603996 iYKL003C 0.164667547 0.567031905 0.248630358 "YKL002W -- unknown -- unknown function, has similarity to human BC-2 breast adenocarcinoma marker protein" YNR035C ARC35 2.4 20 4.4 0.7224 0.58973076 iYNR035C 0.151599876 0.613886672 0.265630035 "ARC35 -- cytoskeleton -- Component of ARP2/3 actin-organizing complexinvolved in actin assembly and function, and endocytosis" YPR173C VPS4 2.2 19 4.4 0.7224 0.16827371 iYPR173C 0.214402988 0.138978408 0.15027933 "VPS4 -- vacuolar protein targeting -- vacuolar sorting that causes a novel pre-vacuolar organelle to become prominent, member of AAA ATPase family" YBR029C CDS1 2.1 18 4.4 0.7224 0.609312404 iYBR029C 0.483721685 0.643096568 0.466000645 CDS1 -- lipid metabolism -- CDP-diacylglycerol (CDP-DAG) synthasephosphatidate cytidylyltransferase YNL243W SLA2 2 17 4.4 0.7224 0.504436642 iYNL244C 0.352373365 0.347969707 0.205878822 "SLA2 -- cytoskeleton -- Talin-like membrane cytoskeleton assembly, required for cell polarization, also required for the internalization phase of endocytosis" YGL172W NUP49 1.9 16 4.4 0.7224 0.330884622 iYGL173C 0.452494843 0.773445053 0.783415342 "NUP49 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) of GLFG familyacts in a complex with Nic96p, Nsp1p, and Nup57p" YKL195W YKL195W 1.9 16 4.4 0.7224 0.221263245 iYKL196C 0.301026728 0.407023144 0.475308642 YKL195W -- unknown -- unknown function YNL336W COS1 1.9 19 4.4 0.7224 iYNL337W 0.990761339 0.271588188 COS1 -- unknown -- Member of COS family of subtelomerically-encoded proteins YDR056C YDR056C 1.8 16 4.4 0.7224 0.226083898 iYDR056C 0.733608548 0.270061728 0.853190288 YDR056C -- unknown -- unknown function YEL024W RIP1 1.8 15 4.4 0.7224 0.587663915 iYEL025C 0.596573841 0.571891498 "RIP1 -- respiration -- Ubiquinol cytochrome-c reductase iron-sulfur protein (Rieske iron-sulfur protein), component of ubiquinol cytochrome-c reductase complex" YML094W GIM5 1.8 15 4.4 0.7224 0.459604251 0.67282407 "GIM5 -- protein folding -- Prefoldin subunit 5, component of Gim protein complex that promotes formation of functional alpha-tubulin, gamma-tubulin, and actin" YBL093C ROX3 1.7 14 4.4 0.7224 0.965712974 iYBL093C 0.98206533 0.738317757 0.655546688 ROX3 -- transcription -- Component of RNA polymerase II holoenzyme and mediator subcomplex YBR254C TRS20 1.7 14 4.4 0.7224 0.430505253 iYBR254C 0.481852301 0.600239425 0.141857977 TRS20 -- secretion (putative) -- TRAPP (Transport Protein Particle) complex involved in vesicular transport from endoplasmic reticulum to Golgi YKR060W YKR060W 1.6 13 4.4 0.7224 0.583661644 iYKR059W 0.565111108 0.949269466 0.340557525 YKR060W -- unknown -- unknown function YDR047W HEM12 1.5 12 4.4 0.7224 0.430235798 iYDR046C 0.585744249 0.365572316 0.776104666 "HEM12 -- heme biosynthesis -- Uroporphyrinogen decarboxylase, carries out sequential decarboxylation of 4 acetyl side chains of uroporphyrinogen to yield coproporphyrinogen" YDR312W SSF2 1.5 12 4.4 0.7224 0.45940848 iYDR311W 0.755534219 0.56217079 0.730260177 SSF2 -- signaling (putative) -- potential role in mating YIL090W YIL090W 1.5 12 4.4 0.7224 0.345155943 iYIL091C 0.024172759 0.502450152 0.038015305 YIL090W -- unknown -- unknown function YOR356W YOR356W 1.2 11 4.4 0.7224 0.695430773 iYOR355W 0.326203986 0.469415343 0.22731306 YOR356W -- unknown -- similarity to human electron transfer flavoprotein-ubiquinone oxidoreductase YML014W YML014W 1.1 10 4.4 0.7224 0.165539467 iYML015C 0.403653055 0.409880007 0.159437947 YML014W -- unknown -- similarity to Diptheria toxin resistance protein YGR026W YGR026W 4 35 4.3 0.7169 0.887242998 0.857718337 YGR026W -- unknown -- similarity to NADH-ubiquinone oxidoreductase chain 5 YIL158W YIL158W 2.7 23 4.3 0.7169 0.525282075 iYIL159W 0.306963921 0.738870447 0.157267161 YIL158W -- unknown -- similarity to Ykr100p YGR231C PHB2 2.6 22 4.3 0.7169 0.230049569 iYGR231C 0.393658637 0.71025248 0.522465113 "PHB2 -- aging -- Prohibitin, involved in determination of replicative lifespanmember of prohibitin complex with Phb1p" YDR373W FRQ1 2.2 19 4.3 0.7169 0.77231106 iYDR372C 0.447827723 0.997563353 0.633258137 FRQ1 -- unknown -- similarity to human BDR-1 protein and other calcium binding proteins YKL126W YPK1 2.2 19 4.3 0.7169 0.452548187 iYKL127W 0.695313128 0.663596214 0.820179218 "YPK1 -- unknown -- Serine/threonine protein kinase with similarity to protein kinase C, possibly involved in a sphingolipid-mediated signaling pathway" YOL068C HST1 2.2 20 4.3 0.7169 0.513668707 iYOL068C 0.402857839 0.558874352 0.204207503 "HST1 -- silencing -- similarity to Sir2p, member of SIR2 family" YDR184C ATC1 2.1 19 4.3 0.7169 0.471984599 iYDR184C 0.342072962 0.681611436 0.247998512 ATC1 -- cell polarity -- cation homeostasisinteracts with Bud6p/Aip3p YPR082C DIB1 1.9 16 4.3 0.7169 0.254543359 iYPR082C 0.203729839 0.485499651 0.118959108 "DIB1 -- unknown -- Component of U4/U6.U5 snRNP, also required for mitotic spindle formation or function" YAL060W YAL060W 1.8 16 4.3 0.7169 0.644585142 iYAL061W 0.481221375 0.724569111 0.836515715 "YAL060W -- unknown -- similarity to alcohol/sorbitol dehydrogenase, member of zinc-containing alcohol dehydrogenase family" YHR069C RRP4 1.8 16 4.3 0.7169 0.268120243 iYHR069C 0.80025672 0.656883298 0.198376532 "RRP4 -- rRNA processing -- 3'-5' exoribonuclease required for 3' processing of ribosomal 5.8S rRNA, component of both the nucleolar and cytoplasmic forms of 3'-5' exosome complex" YHR163W SOL3 1.8 15 4.3 0.7169 0.174041363 iYHR162W 0.784363075 0.484450532 0.775765978 "SOL3 -- tRNA splicing, putative -- Possible 6-phosphogluconolactonase, involved indirectly in tRNA synthesis and function" YLR170C APS1 1.8 15 4.3 0.7169 0.336828892 0.478564963 "APS1 -- secretion -- Clathrin-associated protein (AP) complex, small subunit" YCR072C YCR072C 1.6 14 4.3 0.7169 0.431854784 iYCR072C 0.713484977 0.617877714 0.477212229 "YCR072C -- unknown -- unknown function, member of WD (WD-40) repeat family" YDR170C SEC7 1.6 14 4.3 0.7169 0.39545815 iYDR170C itQ(UUG)D3 0.339530656 0.770678914 0.354694607 0.567925615 0.441397112 SEC7 -- secretion -- Component of non-clathrin vesicle coat required for protein trafficking within the Golgi YGR036C CWH8 1.6 13 4.3 0.7169 0.603147648 iYGR036C 0.369456632 0.741147052 0.438352827 CWH8 -- cell wall biogenesis -- generation of mannolayer of cell wall YKL082C YKL082C 1.6 13 4.3 0.7169 0.506127071 iYKL082C 0.866197137 0.014502095 0.189747387 YKL082C -- unknown -- unknown function YLR050C YLR050C 1.6 14 4.3 0.7169 0.181586038 iYLR050C 0.194408514 0.392603932 0.260802469 YLR050C -- unknown -- similarity to C-terminal region of human MAC30 YNR030W ECM39 1.6 14 4.3 0.7169 0.211016606 iYNR029C 0.219911411 0.628683322 0.399720475 ECM39 -- cell wall biogenesis -- cell wall structure or biosynthesis YBR261C YBR261C 1.5 13 4.3 0.7169 0.193785454 iYBR261C 0.314948144 0.710774142 0.10814116 YBR261C -- unknown -- Putative S-adenosylmethionine-dependent methyltransferase of unknown role YHR081W YHR081W 1.5 12 4.3 0.7169 0.390179572 iYHR080C 0.513032216 0.452304222 0.187056438 YHR081W -- unknown -- unknown function YHR088W YHR088W 1.5 12 4.3 0.7169 0.303501335 iYHR087W 0.638756808 0.5792498 0.500960867 YHR088W -- unknown -- unknown function YHR201C PPX1 1.5 13 4.3 0.7169 0.530985009 iYHR201C 0.413266282 0.716964418 0.429337232 "PPX1 -- unknown -- Exopolyphosphatase, degrades polyphosphate with conversion of ADP to ATP" YJL200C YJL200C 1.5 12 4.3 0.7169 0.584879819 iYJL200C itT(AGU)J 0.783664282 0.767812134 0.810097834 0.696091173 0.653345725 "YJL200C -- unknown -- similarity to aconitase, has potential mitochondrial transit peptide" YBL004W YBL004W 1.3 12 4.3 0.7169 0.607173367 YBLWdelta10 iYBLWdelta10 0.772392844 0.561668832 0.490891755 0.799790525 0.595610535 "YBL004W -- unknown -- similarity to human DRIM, a protein differentially produced in metastatic and nonmetastatic human breast carcinoma cells" YJL011C YJL011C 1.3 12 4.3 0.7169 0.593366693 iYJL011C itK(CUU)J 0.421482921 0.633361658 0.545130575 0.98977722 YJL011C -- unknown -- RNA polymerase III subunit C17 YDR161W TCI1 1.2 11 4.3 0.7169 iYDR160W 0.717158513 0.456584198 TCI1 -- unknown -- interacts with protein phosphatase 2C YNL108C YNL108C 1.2 11 4.3 0.7169 0.282258169 iYNL108C 0.461378084 0.44567234 0.34616967 "YNL108C -- unknown -- similarity to RNA polymerase III transcription initiation factor TFIIIC tau subunit, Tfc7p" YHR041C SRB2 1.1 10 4.3 0.7169 0.585780473 iYHR041C 0.461805327 0.718063535 0.450996209 SRB2 -- transcription -- Component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YJL133W MRS3 1.3 11 4.2 0.711 1 iYJL134W 0.980153545 0.187106918 "MRS3 -- transport -- Splicing protein and member of mitochondrial carrier (MCF) family, suppresses mitochondrial splicing defects" YLL026W HSP104 4.9 44 4.2 0.711 0.814666154 iYLL027W 0.496847242 0.642523364 0.379017846 "HSP104 -- heat shock response /thermotolerance -- Heat shock induced thermotolerance and for resolubilizing aggregates of denatured proteins, important for the [psi-] to [PSI+] prion conversion" YLR370C ARC18 2.9 26 4.2 0.711 0.422227845 iYLR370C 0.20265614 0.310295291 0.239265762 ARC18 -- cytoskeleton -- Component of ARP2/3 actin-organizing complexinvolved in actin assembly and function YFL018C LPD1 2.5 22 4.2 0.711 0.806171556 iYFL018C 0.376385277 0.941196062 0.30726257 "LPD1 -- TCA cycle -- Dihydrolipoamide dehydrogenase, (E3) component of pyruvate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex, branched chain 2-oxoacid dehydrogenase complex, and glycine carboxylase complex" YLR257W YLR257W 2.5 22 4.2 0.711 0.557841679 iYLRWdelta14 YLRWdelta15 0.783816113 0.36533978 0.39481245 0.705088302 0.380333952 YLR257W -- unknown -- unknown function YHR065C RRP3 2.2 20 4.2 0.711 0.209292204 iYHR065C 0.765501052 0.66129552 0.436728395 RRP3 -- rRNA processing -- Helicase required for maturation of pre-rRNA YIL034C CAP2 2.2 20 4.2 0.711 0.129082357 iYIL034C 0.252966269 0.378898635 0.064289748 "CAP2 -- cytoskeleton -- Actin-capping protein, beta subunit" YPR159W KRE6 2.2 20 4.2 0.711 0.179497463 iYPR158W YPRCdelta22 0.488091587 0.503154391 0.359713487 0.720712474 0.373772057 "KRE6 -- cell wall biogenesis -- Glucan synthase subunit required for synthesis of beta-1,6-glucan" YBR146W MRPS9 2.1 19 4.2 0.711 0.580247994 iYBR145W 0.550691951 0.855462456 0.605100715 "MRPS9 -- protein synthesis -- Mitochondrial ribosomal small subunit S9, member of prokaryotic ribosomal protein S9 family" YJR017C ESS1 2 18 4.2 0.711 0.503016349 0.806969428 ESS1 -- protein folding -- Peptidylpropyl-cis/trans-isomeraseinvolved in transcription termination or 3'-end processing of pre-mRNA YBR137W YBR137W 1.9 17 4.2 0.711 0.197544228 iYBR136W 0.703758038 0.616552956 0.769912211 YBR137W -- unknown -- unknown function YKR006C MRPL13 1.9 17 4.2 0.711 0.665705198 iYKR006C 0.01777473 0.923610551 0.001117318 MRPL13 -- protein synthesis -- Mitochondrial ribosomal large subunit YLR079W SIC1 1.9 17 4.2 0.711 0.11415264 iYLR078C 0.261998553 0.05734243 0.15471485 SIC1 -- cell cycle -- P40 inhibitor of Cdc28p-Clb protein kinase complex YLR292C SEC72 1.9 17 4.2 0.711 0.650539547 iYLR292C 0.860639549 0.758540122 0.845633258 "SEC72 -- secretion -- Component of ER protein-translocation subcomplex that includes Sec62p, Sec63p, Sec66p, and Sec72p" YNL085W MKT1 1.9 17 4.2 0.711 0.206059951 iYNL086W 0.266135635 0.606846046 0.510820374 MKT1 -- viral propagation -- propagation of M2 double-stranded RNA (dsRNA) satellite of L-A virus at temperature above 30 deg YDR100W YDR100W 1.8 16 4.2 0.711 0.614882451 iYDR099W 0.739248311 0.319028797 0.424178896 YDR100W -- unknown -- unknown function YHR012W VPS29 1.8 16 4.2 0.711 0.510361017 iYHR011W 0.600492635 0.949826571 0.706656793 "VPS29 -- vacuolar protein targeting -- vacuolar sorting, mutant has vacuoles of normal morphology" YOR370C MRS6 1.8 16 4.2 0.711 0.916070995 iYOR370C 0.281103088 0.661793372 0.08727918 MRS6 -- protein processing -- Rab geranylgeranyltransferase regulatory component (component A) and rab guanine nucleotide dissociation inhibitor YPL145C KES1 1.7 15 4.2 0.711 0.914952007 iYPL145C YPL144W 0.976723293 0.933625264 0.72904735 0.202117888 0.60622506 "KES1 -- sterol metabolism -- implicated in ergosterol biosynthesis, member of KES1/HES1/OSH1/YKR003W family of oxysterol-binding (OSBP) proteins" YPL245W YPL245W 1.7 15 4.2 0.711 0.292536028 iYPL246C 0.078829945 0.522106943 0.045503168 YPL245W -- unknown -- unknown function YMR043W MCM1 1.6 14 4.2 0.711 0.080377286 iYMR042W 0.2516589 0.080896686 0.300879245 "MCM1 -- transcription -- Transcription factor of MADS (Mcm1p, Agamous, Deficiens, SRF) box family, recruits coregulatory proteins for both gene activation and repression at a variety of loci" YNL004W HRB1 1.5 13 4.2 0.711 0.174361362 iYNL005C 0.83130145 0.123267805 0.455977908 "HRB1 -- unknown -- similarity to Rlf6p, has 3 RNA recognition (RRM) domains" YDR267C YDR267C 1.3 12 4.2 0.711 0.313870158 iYDR267C 0.409901626 0.357701516 0.723217303 YDR267C -- unknown -- similarity to Sec13p and other proteins with WD (WD-40) repeats YLR051C YLR051C 1.3 11 4.2 0.711 0.30918224 iYLR051C 0.247953254 0.30993194 0.121593291 YLR051C -- unknown -- unknown function YNL207W YNL207W 1.3 12 4.2 0.711 0.485110335 iYNL208W 0.802610904 0.294231389 0.79785432 YNL207W -- unknown -- unknown function YOL147C PEX11 1.3 12 4.2 0.711 0.119943994 iYOL147C 0.146768227 0.54950997 0.117100372 PEX11 -- peroxisome biogenesis -- Peroxisomal biogenesis protein (peroxin) involved in peroxisome inheritance and peroxisomal proliferation YBR219C 1.1 10 4.2 0.711 0.404249583 0.688766597 YDL227C HO 1.1 10 4.2 0.711 0.744615892 iYDL227C-0 iYDL227C-1 0.482904434 0.709617406 0.390903632 0.693296089 0.915482841 "HO -- mating type switching -- Homothallic switching endonuclease, initiates mating type interconversion by making a double-stranded break in the expressed MAT gene" YBR155W CNS1 1 9 4.2 0.711 0.193832784 iYBR154C 0.740325109 0.200319234 0.474035395 "CNS1 -- unknown -- Component of Hsp90 chaperpne complex, has tetratricopeptide (TPR) repeats" YIL096C YIL096C 1 9 4.2 0.711 0.27551491 iYIL096C itI(AAU)I1 0.31027442 0.508074447 0.400641817 0.225870156 0.508853151 YIL096C -- unknown -- unknown function YLL039C UBI4 2.5 22 4.1 0.7033 1 0.897547077 iYLL039C 0.967851759 0.883650128 0.778508772 "UBI4 -- protein degradation, ubiquitin-mediated -- Ubiquitin polyprotein, mature ubiquitin is cleaved from polyubiquitin (Ubi4p) or from fusions with ribosomal proteins Rps31p, Rpl40Ap, or Rpl40Bp" YGL115W SNF4 2 18 4.1 0.7033 1 0.975556114 iYGL116W 0.984643384 0.936920223 0.056603774 "SNF4 -- glucose derepression -- derepression of glucose-repressed genes, acts with Snf1p" YDR300C PRO1 1.6 14 4.1 0.7033 1 0.968952516 iYDR300C 0.980802672 0.679338435 0.225183916 "PRO1 -- proline biosynthesis -- Glutamate 5-kinase, carries out first step in proline biosynthesis pathway" YMR008C PLB1 2.5 22 4.1 0.7033 0.310364866 iYMR008C 0.482848742 0.666048237 0.195133742 "PLB1 -- phospholipid metabolism -- Phospholipase B, preferentially deacylates phosphatidylcholine and phosphatidylethanolamine" YER050C YER050C 2.4 21 4.1 0.7033 0.538882994 iYER050C 0.770974514 0.723894543 0.784809057 YER050C -- unknown -- unknown function YPL178W CBC2 2.4 22 4.1 0.7033 0.314880622 iYPL179W tE(UUC)P 0.642184425 0.769245249 0.285075818 0.580367119 0.576630618 "CBC2 -- meiosis, recombination -- Small subunit of nuclear cap-binding protein complex" YBR073W RDH54 2.2 21 4.1 0.7033 0.618327549 iYBR072W 0.151528023 0.674897527 0.591536712 RDH54 -- meiosis -- mitotic diploid-specific recombination and repair and for meiosis YGR208W SER2 2.2 21 4.1 0.7033 0.633421969 iYGR207C 0.441993902 0.665243313 0.526564347 "SER2 -- glycine, serine, and threonine metabolism -- Phosphoserine phosphataseinvolved in synthesis of serine from 3-phosphoglycerate" YBR115C LYS2 2.1 19 4.1 0.7033 0.545663979 iYBR115C 0.773240237 0.593535515 0.780834073 "LYS2 -- lysine biosynthesis -- Alpha-aminoadipate-semialdehyde dehydrogenase large chain, sixth step in lysine biosynthesis pathway" YIL038C NOT3 2 18 4.1 0.7033 0.469726404 iYIL038C 0.625371814 0.724677034 0.560408922 "NOT3 -- transcription -- Component of CCR4 transcriptional complex, involved in transcriptional regulation" YLR351C NIT3 2 18 4.1 0.7033 0.764443327 iYLR351C 0.405853704 0.926362683 0.70351273 NIT3 -- unknown -- Nitrilase YDL052C SLC1 1.9 18 4.1 0.7033 0.488771584 iYDL052C 0.364492998 0.251624431 0.144882537 "SLC1 -- phospholipid metabolism -- Fatty acyltransferase (sn2-acylglyceride fatty acyltransferase), second step of phosphatidic acid synthesis" YOL005C RPB11 1.9 17 4.1 0.7033 0.267553047 iYOL005C 0.261649477 0.696987598 0.241421871 "RPB11 -- transcription -- RNA polymerase II, essential subunit, not shared" YIL070C MAM33 1.8 17 4.1 0.7033 0.641288214 iYIL070C 0.502356072 0.914285714 0.226089895 MAM33 -- respiration -- Mitochondrial normal respiratory growth YMR091C NPL6 1.8 16 4.1 0.7033 0.448723363 iYMR091C 0.642240803 0.531595192 0.511452242 NPL6 -- nuclear protein targeting -- Nuclear protein localization factor YPR051W MAK3 1.8 16 4.1 0.7033 0.207476947 0.482442348 "MAK3 -- viral propagation -- N-acetyltransferase, acetylates N-terminus of L-A virus GAG protein" YDR481C PHO8 1.7 15 4.1 0.7033 0.698578422 iYDR481C 0.269438092 0.939844542 0.273049931 "PHO8 -- phosphate metabolism -- Vacuolar alkaline phosphatase (ALP), repressible, carries out dephosphorylation of phosphopeptides" YGR076C MRPL25 1.7 16 4.1 0.7033 0.488879119 iYGR076C 0.394204306 0.630878438 0.485867446 MRPL25 -- protein synthesis -- Mitochondrial ribosomal large subunit YMR26 (YmL25) YGR173W YGR173W 1.7 15 4.1 0.7033 0.862621076 iYGR172C 0.357319183 0.932162423 0.370206252 YGR173W -- unknown -- similarity to human GTP-binding protein PIR YOL021C DIS3 1.7 15 4.1 0.7033 0.292569892 iYOL021C 0.327677194 0.652232459 0.528598603 "DIS3 -- RNA processing -- Ran-binding mitotic control, component of exosome 3'-5' exoribonuclease complex involved in 3' end processing of multiple small RNA species" YPL212C PUS1 1.7 15 4.1 0.7033 0.316231892 iYPL212C 0.598436977 0.370770222 0.483337448 PUS1 -- tRNA processing -- Pseudouridine synthase responsible for specific pseudouridine modifications in tRNA and in U2 snRNA YBR205W KTR3 1.6 14 4.1 0.7033 0.311188233 iYBR204C 0.509500273 0.653336625 0.800919577 "KTR3 -- protein glycosylation -- Alpha-1,2-mannosyltransferase of KRE2 family" YFR047C YFR047C 1.6 14 4.1 0.7033 0.222291028 iYFR047C 0.544852359 0.91027583 0.333508036 "YFR047C -- unknown -- Putative quinolinic acid phosphoribosyltransferase, active in the pathway of tryptophan degradation and nicotinic acid synthesis" YGR277C YGR277C 1.6 14 4.1 0.7033 0.214614973 iYGR277C 0.542159261 0.338574423 0.131524342 YGR277C -- unknown -- unknown function YLR078C BOS1 1.6 14 4.1 0.7033 0.736069235 iYLR078C 0.261998553 0.872582848 0.15471485 BOS1 -- secretion -- Synaptobrevin (v-SNARE) homologinvolved in ER to Golgi transport YML048W GSF2 1.6 14 4.1 0.7033 0.708440155 iYML049C 0.601116415 0.841181165 0.540223464 "GSF2 -- glucose repression -- glucose repression, also possibly involved in cell wall structure or biosynthesis" YNL315C ATP11 1.6 15 4.1 0.7033 0.633249864 iYNL315C 0.448145189 0.883762201 0.477441703 ATP11 -- ATP synthesis -- F1-ATP synthase assembly protein YDR512C YDR512C 1.5 13 4.1 0.7033 0.149000882 0.162182177 YDR512C -- unknown -- unknown functionquestionable ORF YJL183W MNN11 1.5 13 4.1 0.7033 0.517124008 iYJL184W 0.130391671 0.791411537 0.248538012 MNN11 -- unknown -- Subunit of Anp1p-Hoc1p-Mnn10-Mnn11p-Mnn9p mannosyltransferase complex YPR137W RRP9 1.5 13 4.1 0.7033 0.250651051 0.345387841 "RRP9 -- rRNA processing -- associated with the U3 small nucleolar RNA, required for pre-ribosomal RNA processing" YKL001C MET14 1.3 12 4.1 0.7033 0.696388711 iYKL001C CEN11 0.598715805 0.664723148 0.938387869 0.942647415 0.406304868 "MET14 -- sulfate assimilation -- Adenosine-5'-phosphosulfate 3'-phosphotransferase (adenylylsulfate kinase), part of sulfate assimilation pathway" YLR188W MDL1 1.3 13 4.1 0.7033 0.163822808 iYLR187W 0.340118125 0.461401952 0.256674552 "MDL1 -- transport -- Member of ATP-binding cassette (ABC) superfamily, equivalent to a ""half-sized"" ABC one ATP-binding domain and one transmembrane domain" YNR015W SMM1 1.3 12 4.1 0.7033 0.294943042 iYNR014W 0.114953993 0.681759587 0.100389864 "SMM1 -- protein synthesis, mitochondrial (putative) -- High-copy suppressor of mitochondrial mutation in tRNA(asp) gene" YOL149W DCP1 1.3 12 4.1 0.7033 0.553488397 iYOL150C 0.285022045 0.862508735 0.343043481 DCP1 -- mRNA decay -- mRNA decapping enzyme involved in mRNA turnover YDR044W HEM13 1.2 11 4.1 0.7033 0.592235112 iYDR043C-0 iYDR043C-1 0.37678677 0.30698206 0.503383179 0.329945269 0.797566746 "HEM13 -- heme biosynthesis -- Coproporphyrinogen III oxidase, oxygen-repressed, sixth step in heme biosynthetic pathway" YNL240C NAR1 1.2 11 4.1 0.7033 0.614760029 iYNL240C 0.157910853 0.884165772 0.182814799 NAR1 -- nuclear organization and biogenesis (putative) -- similarity to human nuclear prelamin A recognition factor YPL126W NAN1 1.2 11 4.1 0.7033 0.455101085 iYPL127C 0.044362566 0.307914046 0.111083683 NAN1 -- unknown -- Nucleolar protein associated with Net1p YPR183W DPM1 1.2 11 4.1 0.7033 0.316361604 iYPR182W 0.763976463 0.70810506 0.363291137 DPM1 -- protein glycosylation -- Dolichol-phosphate mannosyltransferasetransfers mannose from GDP-Man to Dol-P YHR148W IMP3 1.1 10 4.1 0.7033 0.238566101 iYHR147C 0.160191031 0.600107116 0.439864483 "IMP3 -- rRNA processing -- Component of U3 snoRNP, required for pre-18S rRNA processing" YEL056W HAT2 1.5 14 4 0.6982 1 0.91996741 iYEL057C 0.959510459 0.480606544 0.8471668 "HAT2 -- chromatin structure -- Histone acetyltransferase subunit 2, contains seven WD (WD-40) repeats" YOR125C CAT5 1.5 13 4 0.6982 1 0.982203059 iYOR125C 0.743637037 0.821327741 0.502274722 CAT5 -- ubiquinone biosynthesis -- derepression of gluconeogenic enzymes and for coenzyme Q (ubiquinone) biosynthesis YCL035C GRX1 5.1 47 4 0.6982 0.349851103 iYCL035C 0.128573789 0.034503843 0.113993711 "GRX1 -- oxidative stress response -- Putative glutaredoxin, has similarity to thioltransferase Ttr1p" YOR157C PUP1 3.5 32 4 0.6982 0.374426417 iYOR157C 0.40757311 0.522579597 0.491702055 "PUP1 -- protein degradation -- Proteasome subunit beta2_sc (protease yscE subunit PUP1), involved in trypsin-like activity of proteasome" YLR037C YLR037C 3 28 4 0.6982 0.871202221 iYLR037C-0 iYLR037C-1 0.351101766 0.428568807 0.678861102 0.421558351 0.224701901 YLR037C -- unknown -- Member of seripauperin (PAU) family YBR149W ARA1 2.5 24 4 0.6982 0.274124876 iYBR148W 0.587739135 0.817918144 0.622745411 ARA1 -- arabinose metabolism -- Subunit of NADP+-dependent D-arabinose dehydrogenase YDL173W YDL173W 2.2 21 4 0.6982 0.228705151 iYDL174C 0.190036226 0.519561184 0.188271605 YDL173W -- unknown -- unknown function YNL037C IDH1 2 19 4 0.6982 0.446951428 iYNL037C 0.722587462 "IDH1 -- TCA cycle -- Isocitrate dehydrogenase (NAD+) subunit 1, mitochondrial, required for oxidative function of tricarboxylic acid cycle" YER083C YER083C 1.9 18 4 0.6982 0.571126611 0.875977654 YER083C -- unknown -- unknown function YML030W YML030W 1.9 18 4 0.6982 0.352761476 iYML031W 0.412432342 0.303818885 0.125887124 YML030W -- unknown -- unknown function YBL036C YBL036C 1.8 17 4 0.6982 0.403892565 iYBL036C 0.349735527 0.764405427 0.12240091 YBL036C -- unknown -- similarity to Pseudomonas aeroginosa twitching motility protein YCL002C YCL002C 1.8 17 4 0.6982 0.652581177 iYCL002C 0.194936938 0.667747678 0.418826627 YCL002C -- unknown -- unknown function YER107C GLE2 1.7 16 4 0.6982 0.746949055 iYER107C iYER108C 0.317862763 0.13198534 0.9767645 0.345640419 0.117609099 "GLE2 -- nuclear protein targeting -- Nuclear pore poly(A)+ RNA export, has WD (WD-40) repeats" YKL186C MTR2 1.7 15 4 0.6982 0.305334475 iYKL186C 0.441512475 0.561213089 0.3896249 "MTR2 -- mRNA export -- mRNA transport, has similarity to E. coli mbeA" YEL050C RML2 1.5 14 4 0.6982 0.513198458 iYEL050C SNR67 0.716215544 0.84668702 0.582983625 0.705538085 0.6632083 RML2 -- protein synthesis -- Mitochondrial ribosomal protein L2 of large subunit YHR060W VMA22 1.5 13 4 0.6982 0.254576787 iYHR059W 0.433461253 0.240143655 0.190502793 "VMA22 -- vacuolar acidification -- vacuolar H(+)-ATPase (V-ATPase) assembly or function, essential for V-ATPase activity" YLR147C SMD3 1.5 14 4 0.6982 0.154578603 iYLR147C 0.299166727 0.230229807 0.179194503 "SMD3 -- mRNA splicing -- Spliceosomal snRNA-associated Sm core pre-mRNA splicing, also associated with telomerase TLC1 RNA" YFR011C YFR011C 1.3 13 4 0.6982 0.527344844 iYFR011C itY(GUA)F1 0.708943017 0.77874145 0.699138222 0.252980986 0.690219143 YFR011C -- unknown -- unknown function YHL049C YHL049C 1.3 12 4 0.6982 0.972803169 iYHL049C-0 iYHL049C-1 0.995609492 0.995478522 0.876902822 0.017238627 0.269654088 "YHL049C -- unknown -- similarity to other subtelomerically-encoded proteins including Yer189p, Yml133p, and Yjl225p, coded from a subtelomeric Y' region" YOR165W YOR165W 1.3 13 4 0.6982 0.203406854 iYOR164C 0.480636519 0.434298621 0.544063194 "YOR165W -- unknown -- similarity in the C-terminal region to human GBP1, an interferon-induced GTP-binding protein" YBL054W YBL054W 1.2 12 4 0.6982 0.263447146 iYBL055C 0.628223746 0.490895907 0.78754988 YBL054W -- unknown -- unknown function YDR017C KCS1 1.2 12 4 0.6982 0.649707752 iYDR017C 0.796716759 0.279888268 0.667940951 "KCS1 -- cell wall organization -- Inositol (1,2,3,4,5,6) hexaphosphate kinase, suppressor of temperature-sensitive growth and hyperrecombination in pkc1-4" YDR201W SPC19 1.2 11 4 0.6982 0.290492815 iYDR200C 0.227409272 0.633298393 0.07443393 SPC19 -- cytoskeleton -- spindle pole body YMR158W YMR158W 1.2 11 4 0.6982 0.627220838 iYMR157C 0.58225271 0.869470911 0.488989272 YMR158W -- unknown -- weak similarity to E. coli ribosomal protein S8 YOR098C NUP1 1.2 12 4 0.6982 0.39176198 iYOR098C 0.426588612 0.283630328 0.736595167 NUP1 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) with XFXFG motifsrelated to Nsp1p YOL080C REX4 0.8 8 4 0.6982 0.240308617 0.219972574 "REX4 -- unknown -- Member of 3' -to 5' exonuclease family, has similarity to Rnh70p and Pan2p" YOR383C YOR383C 5.4 51 3.9 0.6936 0.140494822 iYOR383C 0.299554502 0.122139865 0.082442139 YOR383C -- unknown -- unknown function YCR004C YCP4 4.6 43 3.9 0.6936 0.766436324 iYCR004C 0.656667159 0.955634428 0.635594573 YCP4 -- unknown -- similarity to S. pombe brefeldin A resistance protein obr1 and E. coli WrbA protein which stimulates binding of Trp repressor to DNA YLL028W TPO1 2.7 25 3.9 0.6936 0.833185947 iYLL029W 0.465194042 0.701659684 0.798897392 "TPO1 -- transport -- Polyamine transport protein, member of multidrug-resistance 12-spanner family of major facilitator superfamily (MFS-MDR)" YCR084C TUP1 2.1 21 3.9 0.6936 0.101966617 iYCR084C 0.310011711 0.230100715 0.10001747 "TUP1 -- transcription -- General repressor of RNA polymerase II transcription that is brought to target promoters by regulated, sequence-specific DNA-binding proteins, has seven WD repeats, exists in a complex with Ssn6p" YPR004C YPR004C 2 19 3.9 0.6936 0.32366551 iYPR004C 0.361565269 0.667455221 0.353689977 YPR004C -- unknown -- Electron transfer flavoprotein alpha subunit YNL123W YNL123W 1.9 18 3.9 0.6936 0.122924404 iYNL124W 0.217823003 0.411572227 0.056316468 "YNL123W -- unknown -- unknown function, has possible serine protease domain" YNL229C URE2 1.8 17 3.9 0.6936 0.210612986 iYNL229C 0.23403912 0.420220204 0.293103448 URE2 -- catabolite repression -- Regulator of nitrogen catabolite repressionacts by inhibition of Gln3p regulator in the presence of preferred nitrogen sources YOR047C STD1 1.8 17 3.9 0.6936 iYOR047C 0.569568886 0.727676051 STD1 -- glucose repression -- Dosage-dependent modulator of glucose repressionincreased dosage restores invertase expression in snf4 mutants YDL178W AIP2 1.7 16 3.9 0.6936 0.298765466 iYDL179W 0.386096567 0.466369672 0.344552638 AIP2 -- unknown -- D-lactate dehydrogenase YNR041C COQ2 1.7 16 3.9 0.6936 0.640334497 0.296383913 "COQ2 -- ubiquinone biosynthesis -- Para-hydroxybenzoate--polyprenyltransferase, second step in coenzyme Q (ubiquinone) biosynthesis pathway" YCR057C 1.6 15 3.9 0.6936 0.514782751 iYCR057C 0.516900673 0.669378866 0.559856345 YOL051W GAL11 1.6 15 3.9 0.6936 0.313400469 iYOL052C 0.724410666 0.198598131 0.5896249 GAL11 -- transcription -- Component of RNA polymerase II holoenzyme and Kornberg's mediator complex with positive and negative effects on transcription of individual genes YER152C YER152C 1.5 14 3.9 0.6936 0.530036577 0.88292099 YER152C -- unknown -- unknown function YOL142W RRP40 1.5 14 3.9 0.6936 0.157823562 iYOL143C 0.072553962 0.741916808 0.307493748 "RRP40 -- rRNA processing -- ribosomal RNA processing, component of exosome complex responsible for 3' end processing and degradation of many RNA species" YHL039W YHL039W 1.3 12 3.9 0.6936 0.630795328 iYHL040C 0.347111402 0.73622301 0.598619846 YHL039W -- unknown -- weak similarity to protein lysine methyltransferases YNL180C RHO5 1.3 13 3.9 0.6936 0.245247165 0.567596478 RHO5 -- signaling -- unknown function member of rho family in the ras superfamily YOL004W SIN3 1.3 13 3.9 0.6936 0.222078752 iYOL005C 0.261649477 0.328947368 0.241421871 SIN3 -- transcription -- Transcriptional regulator of RNA polymerase IIhas negative and positive effects on individual gene expression YML116W ATR1 1.2 12 3.9 0.6936 0.261497885 iYML117W-A 0.859175776 0.378057303 0.786862334 "ATR1 -- aminotriazole resistance -- Membrane transporter conferring aminotriazole and 4-nitroquinoline-1-oxide (4NQO) resistance, member of multidrug-resistance 14-spanner family of major facilitator superfamily (MFS-MDR)" YNL022C YNL022C 1.2 12 3.9 0.6936 0.206605204 iYNL022C 0.590932705 0.464092599 0.232342007 YNL022C -- unknown -- unknown function YOL019W YOL019W 1.2 11 3.9 0.6936 0.128748756 iYOL020W itY(GUA)O 0.602775202 0.53109438 0.143248469 0.491354706 0.802682465 YOL019W -- unknown -- unknown function YIL004C BET1 1.1 10 3.9 0.6936 0.474784014 iYIL004C 0.54978259 0.724653599 0.729938769 BET1 -- secretion -- Synaptobrevin (v-SNARE) homologpresent on ER vesicles recycling from Golgi YDR021W FAL1 0.9 9 3.9 0.6936 0.641664217 iYDR020C 0.433498885 0.60415004 0.419069456 FAL1 -- rRNA processing -- Putative ATP-dependent RNA helicase with similarity to eukaryotic initiation factor 4A subfamily of DEAD-box proteins YGR206W YGR206W 0.9 9 3.9 0.6936 0.801683053 iYGR205W 0.581835843 0.78013213 0.567503778 YGR206W -- unknown -- unknown function YDL188C PPH22 1.8 17 3.8 0.6867 1 0.891775595 iYDL188C 0.990657068 0.714018843 0.905376868 "PPH22 -- cell cycle -- Protein serine/threonine phosphatase PP2A-2, highly homologous to Pph21p, member of PPP family of protein phosphatases" YOR101W RAS1 1 10 3.8 0.6867 1 0.690904253 iYOR100C 0.957059997 0.442365088 0.14051332 "RAS1 -- signaling, Ras pathway -- GTP-binding regulation of cAMP pathway, homolog of mammalian proto-oncogene ras" YCL040W GLK1 3.7 36 3.8 0.6867 0.83854991 0.967819424 "GLK1 -- glycolysis -- Glucokinase, specific for aldohexoses" YKR014C YPT52 3.1 31 3.8 0.6867 0.118039155 iYKR014C 0.275882176 0.129050279 0.540534 YPT52 -- endocytosis -- GTP-binding rab family (ras superfamily) involved in endocytosis and transport of proteins to the vacuole YBL045C COR1 2.8 27 3.8 0.6867 0.718181199 iYBL045C 0.759867416 0.917032781 0.514985498 "COR1 -- oxidative phosphorylation -- Ubiquinol cytochrome-c reductase core protein 1, component of ubiquinol cytochrome-c reductase complex" YGR235C YGR235C 2.5 24 3.8 0.6867 0.594924501 iYGR235C 0.648545193 0.538759377 0.695496274 YGR235C -- unknown -- unknown function YOR360C PDE2 2.4 23 3.8 0.6867 0.880767377 iYOR360C 0.486296039 0.907074292 0.522642785 "PDE2 -- signaling (putative) -- 3',5'-Cyclic-nucleotide phosphodiesterase, high-affinity" YMR092C AIP1 2.1 20 3.8 0.6867 0.819371739 iYMR092C 0.898791799 0.748003549 0.098850963 "AIP1 -- cytoskeleton -- Actin interacting protein, contains four WD (WD-40) repeats" YAR073W YAR073W 1.8 18 3.8 0.6867 0.976319121 iYAR071W 0.85967054 0.500974659 0.39709993 "YAR073W -- unknown -- strong similarity to inosine-5'-monophosphate dehydrogenase, frameshifted from YAR075W, possible pseudogene" YBR230C YBR230C 1.8 18 3.8 0.6867 0.090129103 iYBR230C LSR1 0.066963352 0.893120389 0.172433398 0.007512229 0.094700331 YBR230C -- unknown -- unknown function YGR033C YGR033C 1.7 16 3.8 0.6867 iYGR033C 0.987378407 0.278131806 YGR033C -- unknown -- unknown function YNR055C HOL1 1.7 17 3.8 0.6867 0.322974124 iYNR055C 0.318221577 0.514061508 0.553443594 "HOL1 -- transport -- Membrane transporter, member of multidrug-resistance 12-spanner family of major facilitator superfamily (MFS-MDR)" YOR086C YOR086C 1.7 16 3.8 0.6867 0.174875562 iYOR086C itN(GUU)O2 0.759457355 0.644670068 0.170402859 0.491041404 0.495557645 YOR086C -- unknown -- unknown function YOR123C LEO1 1.7 16 3.8 0.6867 0.119549737 iYOR123C 0.17905721 0.024820431 0.141081871 "LEO1 -- unknown -- unknown function, extremely hydrophilic" YJL004C SYS1 1.6 15 3.8 0.6867 0.40533805 iYJL004C 0.440914259 0.710171816 0.73565904 SYS1 -- secretion (putative) -- Multicopy suppressor of ypt6 null mutation YNL221C POP1 1.6 15 3.8 0.6867 0.432089754 iYNL221C 0.03292043 0.58315863 0.133629556 "POP1 -- rRNA and tRNA processing -- component of both RNase P and RNase MRP, involved in both tRNA maturation (RNase P) and in 5.8S rRNA processing (RNase MRP)" YNL241C ZWF1 1.6 16 3.8 0.6867 0.598130912 iYNL241C 0.488159089 0.76836995 0.411214953 ZWF1 -- pentose phosphate cycle -- Glucose-6-phosphate dehydrogenase YDR347W MRP1 1.5 15 3.8 0.6867 0.274032511 iYDR346C 0.197126888 0.718834856 0.192007797 MRP1 -- protein synthesis -- Mitochondrial ribosomal small subunit YNL088W TOP2 1.5 14 3.8 0.6867 0.298165514 iYNL089C 0.302978792 0.307251754 0.288134226 "TOP2 -- DNA replication -- DNA topoisomerase II, hydrolyzes ATP to make double-stranded breaks in DNA" YNL219C ALG9 1.5 14 3.8 0.6867 0.361421402 iYNL219C 0.498269551 0.567434315 0.686408106 "ALG9 -- protein glycosylation -- Mannosyltransferase involved in N-glycosylation, catalyzes transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides" YDL070W BDF2 1.3 13 3.8 0.6867 0.587539394 0.428439186 BDF2 -- unknown -- Bromodomain affects telomere function YHL025W SNF6 1.3 13 3.8 0.6867 0.775971615 iYHL026C 0.100743248 0.826754386 0.015634 "SNF6 -- transcription -- Component of SWI-SNF global transcription activator complex, acts to assist gene-specific activators through chromatin remodeling" YJR133W XPT1 1.3 13 3.8 0.6867 0.637658421 iYJR132W 0.431331066 0.745664274 0.23025856 XPT1 -- xanthine utilization -- Xanthine phosphoribosyl transferase YML010W-B 1.3 14.5 3.8 0.6867 YMR112C MED11 1.3 13 3.8 0.6867 0.34964064 iYMR112C 0.298669045 0.192762345 0.492635563 MED11 -- transcription -- Component of RNA polymerase II mediator (SRB) subcomplex YMR128W ECM16 1.3 13 3.8 0.6867 0.658368506 iYMR127C 0.860523065 0.38945744 0.607422187 ECM16 -- cell wall biogenesis -- Protein possibly involved in cell wall structure or biosynthesis YLR198C YLR198C 1.2 12 3.8 0.6867 0.334367854 iYLR198C 0.512344388 0.293535515 0.148635478 YLR198C -- unknown -- unknown function YNL206C RTT106 1.2 12 3.8 0.6867 0.494546199 0.390183559 RTT106 -- unknown -- similarity to SSRP proteins YIL065C YIL065C 1.1 11 3.8 0.6867 0.47464186 iYIL065C 0.494430234 0.674142059 0.710119239 YIL065C -- unknown -- unknown function YIL114C POR2 1.1 11 3.8 0.6867 0.650665087 iYIL114C 0.593536458 0.966542887 0.879723672 POR2 -- mitochondrial transport -- Outer mitochondrial membrane porinvoltage-dependent anion-selective channel YJR124C YJR124C 1 10 3.8 0.6867 0.810955456 iYJR124C 0.512540816 0.788005248 0.616036138 YJR124C -- unknown -- Member of multidrug-resistance 12-spanner family of major facilitator superfamily (MFS-MDR) YJL078C PRY3 0.9 9 3.8 0.6867 0.395247554 iYJL078C 0.880912545 0.254350628 0.71728972 "PRY3 -- unknown -- similarity to plant pathenogenesis-related proteins, may have a role in mating efficiency" YOL101C YOL101C 0.9 9 3.8 0.6867 0.108943285 iYOL101C 0.277357888 0.37240091 0.578285069 YOL101C -- unknown -- unknown function YPL039W YPL039W 0.9 9 3.8 0.6867 0.478773019 iYPL040C 0.281074117 0.5471668 0.220439398 YPL039W -- unknown -- unknown function YPR147C YPR147C 0.9 9 3.8 0.6867 0.316541782 iYPR147C 0.180078784 0.479648843 0.510984942 YPR147C -- unknown -- unknown function YOR359W YOR359W 1.6 15 3.7 0.6808 1 0.726474392 iYOR358W 0.930468764 0.306624102 0.325025346 YOR359W -- unknown -- unknown function YJL096W MRPL49 1.2 13 3.7 0.6808 1 0.972984949 0.784643893 MRPL49 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL49) YHR008C SOD2 2.4 24 3.7 0.6808 0.772961469 iYHR008C 0.387086886 0.680992313 0.217801276 "SOD2 -- oxidative stress response -- Manganese superoxide dismutase, mitochondrial" YBR160W CDC28 2.2 23 3.7 0.6808 0.200513888 iYBR159W 0.37666955 0.629991127 0.303783173 "CDC28 -- cell cycle -- Cyclin-dependent protein kinase essential for completion of START and for mitosis, associates with Cks1p and cyclins" YNL287W SEC21 2.2 22 3.7 0.6808 0.443232524 iYNL288W 0.51325635 0.852061507 0.091020266 SEC21 -- secretion -- Coatomer (COPI) complex gamma chain (gamma-COP) of secretory pathway vesiclesrequired for retrograde Golgi to endoplasmic reticulum transport YDR196C YDR196C 2.1 21 3.7 0.6808 0.3663405 iYDR196C 0.398655905 0.830823582 0.239977414 YDR196C -- unknown -- unknown function YNL130C CPT1 2.1 21 3.7 0.6808 0.313236109 iYNL130C 0.079974097 0.713775179 0.332487195 "CPT1 -- phospholipid metabolism -- sn-1,2-Diacylglycerol cholinephosphotransferasecatalyzes the synthesis of phosphatidylcholine from CDP-choline and diacylglycerol" YFL006W YFL006W 1.9 19 3.7 0.6808 0.405675494 iYFL007W 0.364335438 0.873619233 0.221174004 YFL006W -- unknown -- unknown function YOR052C YOR052C 1.8 18 3.7 0.6808 0.095954647 iYOR052C 0.068335174 0.101998066 0.029175402 YOR052C -- unknown -- unknown function YGR158C MTR3 1.6 16 3.7 0.6808 0.862444499 iYGR158C 0.65958837 0.890106349 0.774411859 "MTR3 -- mRNA transport -- mRNA transport, component of exosome complex responsible for 3'-5' degradation of mRNA and for 3'-end processing of multiple small RNA species" YLR384C IKI3 1.6 15 3.7 0.6808 0.388565006 iYLR384C 0.261460891 0.22851153 0.445339962 "IKI3 -- killer toxin sensitivity -- Component of elongator complex, associated with RNA Polymerase II during transcriptional elongation" YGR054W YGR054W 1.5 15 3.7 0.6808 0.624089364 iYGR053C 0.483706469 0.923115918 0.750431992 "YGR054W -- unknown -- possible role in signal transduction, has significant similarity to C. elegans E04D5.1 protein" YJR032W CPR7 1.5 14 3.7 0.6808 0.363935696 iYJR031C 0.392373739 0.622059967 0.170159194 "CPR7 -- protein folding -- Cyclophilin (peptidylprolyl cis-trans isomerase or PPIase), homolog of mammalian cyclophilin Cyp40" YBR185C MBA1 1.3 13 3.7 0.6808 0.562688063 iYBR185C 0.339734032 0.81629979 0.107045387 MBA1 -- respiration -- the assembly of mitochondrial respiratory complexes YJR060W CBF1 1.3 14 3.7 0.6808 0.489611965 iYJR059W 0.312285972 0.541819633 0.034241789 "CBF1 -- mitosis -- Basic helix-loop-helix (bHLH) kinetochore protein which binds to centromeric element CDE I, required for chromosome stability and for methionine prototrophy" YLR335W NUP2 1.3 14 3.7 0.6808 0.639484451 iYLRWdelta20 itE(UUC)L 0.931203095 0.793918361 0.540131801 0.518373824 0.66419295 NUP2 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) with XFXFG motifshas functional overlap with other proteins of nuclear pore complex YOL130W ALR1 1.3 14 3.7 0.6808 0.681006127 iYOL131W 0.645941715 0.762166272 0.819931774 "ALR1 -- aluminum resistance -- Putative cytoplasmic magnesium and cobalt transporter, member of metal ion transporter family of membrane transporters" YOR016C ERP4 1.3 14 3.7 0.6808 0.254429272 iYOR016C 0.045248503 0.156189084 0.035275339 ERP4 -- membrane trafficking; secretion (putative) -- similarity to COPII-coated vesicle proteins Emp24p and Erv25p YPL019C PHM2 1.3 14 3.7 0.6808 0.550147011 iYPL019C 0.773113362 0.572396548 0.740009747 PHM2 -- unknown -- Putative polyphosphate synthetase YBR015C MNN2 1.2 12 3.7 0.6808 0.729739146 iYBR015C 0.348277517 0.877470356 0.30782976 MNN2 -- protein glycosylation -- Mannosyltransferase required for forming and extending the mannose branches of outer chain mannans YDL144C YDL144C 1.2 13 3.7 0.6808 0.458506668 iYDL144C 0.262360483 0.58254717 0.503898635 YDL144C -- unknown -- unknown function YDL237W YDL237W 1.2 13 3.7 0.6808 0.242159425 iYDL238C 0.594176005 0.574236517 0.811728644 YDL237W -- unknown -- unknown function YKL068W NUP100 1.2 13 3.7 0.6808 0.325597899 iYKL069W itV(AAC)K1-0 0.505198127 0.670412009 0.603554678 0.30057652 0.933073424 NUP100 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) of GLFG familymay be involved in binding and translocation of proteins during nucleocytoplasmic transport YPR125W YPR125W 1.2 13 3.7 0.6808 0.524027848 iYPR124W 0.350892026 0.581834315 0.349923369 YPR125W -- unknown -- Suppressor of mrs2-1 mutation YPR139C YPR139C 1.2 12 3.7 0.6808 0.265586019 iYPR139C 0.17880289 0.532543405 0.050173429 YPR139C -- unknown -- unknown function YLL022C HIF1 1.1 11 3.7 0.6808 0.260317079 iYLL022C 0.078223236 0.522980737 0.340063847 "HIF1 -- chromatin structure -- interacts with histone acetyltransferase, Hat1p" YMR006C PLB2 1.1 11 3.7 0.6808 0.260609417 iYMR006C 0.304412494 0.329712828 0.549145988 "PLB2 -- phospholipid metabolism -- Phospholipase B2 (lysophospholipase), releases fatty acids from lysophospholipids" YJR067C YAE1 1 11 3.7 0.6808 0.591458959 iYJR067C 0.315289932 0.643087335 0.175759072 YAE1 -- unknown -- Essential unknown function YML115C VAN1 1 11 3.7 0.6808 0.642013024 iYML115C 0.753632903 0.803254915 0.648646425 "VAN1 -- protein glycosylation and vanadate resistance -- Vanadate resistance proteincomponent of mannan polymerase M-Pol I, which includes Mnn9p and Van1p" YNL182C YNL182C 0.8 8 3.7 0.6808 0.430065262 iYNL182C 0.441682709 0.809257781 0.491977923 YNL182C -- unknown -- unknown function YDL168W SFA1 2.9 30 3.6 0.6737 1 0.941243507 iYDL169C 0.962482739 0.359975542 0.820590583 SFA1 -- formaldehyde metabolism -- Long-chain alcohol dehydrogenase (ADH) with similarity to mammalian ADH class III YNL288W YNL288W 1.6 16 3.6 0.6737 1 0.963832758 iYNL289W-0 iYNL289W-1 0.957784362 0.990701204 0.823586352 0.588219885 0.749294184 YNL288W -- unknown -- unknown function YKR068C BET3 2.5 26 3.6 0.6737 0.171810742 iYKR068C 0.181868448 0.384665367 0.521269739 BET3 -- secretion -- Low molecular weight subunit of Transport Protein Particle (TRAPP) complex that is involved in targeting and fusion of ER to Golgi transport vesicleshydrophilic acts in conjunction with SNARE proteins YOL133W HRT1 2.5 26 3.6 0.6737 0.703063584 0.625684821 HRT1 -- unknown -- Activator of Cdc53p-containing SCF-Cdc4p ubiquitin ligase required for ubiquitination of Sic1p and for the G1 to S cell cycle transitionRING-box protein YGR172C YIP1 1.9 19 3.6 0.6737 0.177592439 iYGR172C 0.357319183 0.757075472 0.370206252 YIP1 -- unknown -- vesicular transportinteracts with transport GTPases Ypt1p and Ypt31p at the Golgi membrane YBR087W RFC5 1.8 19 3.6 0.6737 0.569676518 iYBR086C 0.643744418 0.863999355 0.630765808 "RFC5 -- DNA replication -- Replication factor C, 40 kDa subunit" YBR041W FAT1 1.7 17 3.6 0.6737 0.711455918 iYBR040W 0.851923837 0.488256168 0.903346329 FAT1 -- transport -- Very long-chain acyl-CoA synthetase (VLCS) YKL125W RRN3 1.7 17 3.6 0.6737 0.135514791 iYKL126W 0.347087483 0.34612929 0.599661208 RRN3 -- transcription -- RNA polymerase I transcription factor YNL084C END3 1.7 17 3.6 0.6737 0.65713819 iYNL084C 0.104502111 0.813987255 0.06645209 END3 -- endocytosis -- endocytosis and cytoskeletal organization YIL063C YRB2 1.6 17 3.6 0.6737 0.116041393 iYIL063C 0.69193691 0.137995452 0.224900239 YRB2 -- nuclear export -- Nuclear transport factor similar to Yrb1p and Nup2p YJR075W HOC1 1.6 16 3.6 0.6737 0.445412309 iYJR074W 0.344791698 0.725795971 0.146219041 HOC1 -- protein glycosylation -- Subunit of Anp1p-Hoc1p-Mnn11p-Mnn9p mannosyltransferase complex of Golgi involved in cell wall integrity YPL032C SVL3 1.6 16 3.6 0.6737 0.383034217 iYPL032C 0.27960447 0.24660814 0.215938872 SVL3 -- unknown -- vacuolar uptake of endocytosed vital dyes YBL085W BOI1 1.5 15 3.6 0.6737 0.523176519 iYBL086C 0.885386609 0.259524397 0.733120511 "BOI1 -- bud growth -- Bem1p-binding protein, has an SH3 domain and a PH (pleckstrin) domain" YBR276C PPS1 1.5 15 3.6 0.6737 0.323700826 iYBR276C 0.505658246 0.496571751 PPS1 -- unknown -- Protein tyrosine phosphatase (PTPase) with dual specificity YKL063C YKL063C 1.5 15 3.6 0.6737 0.374443451 iYKL063C-0 iYKL063C-1 0.450425784 0.905779505 0.175357375 0.213450292 YKL063C -- unknown -- unknown function YOR281C PLP2 1.5 15 3.6 0.6737 0.124520628 0.306530214 "PLP2 -- unknown -- Phosducin homologue, essential protein likely to be involved in regulation of pheromone response" YCR059C YCR059C 1.3 14 3.6 0.6737 0.513982603 iYCR059C 0.445807086 0.880112428 0.534553972 "YCR059C -- unknown -- unknown function, has similarity to mouse Impact protein" YFL018W-A SMX2 1.3 14 3.6 0.6737 "SMX2 -- -- Spliceosomal snRNA-associated Sm core protein, also likely associated with telomerase TLC1 RNA" YKR024C DBP7 1.3 14 3.6 0.6737 iYKR024C 0.516756351 0.578911795 DBP7 -- ribosome biogenesis -- Member of Dead-box family of putative RNA helicases and involved in 60S ribosomal large subunit biogenesis YOR251C YOR251C 1.3 13 3.6 0.6737 0.108729726 iYOR251C 0.315101262 0.467209152 0.206896552 "YOR251C -- unknown -- Rhodanese (thiosulfate sulfurtransferase), functions to detoxify cyanide" YPL030W YPL030W 1.3 14 3.6 0.6737 0.542423775 iYPL031C 0.156765013 0.429012346 0.201926326 YPL030W -- unknown -- unknown function YHR032W YHR032W 1.2 13 3.6 0.6737 0.910030121 iYHR031C 0.509132268 0.580808895 0.261220066 YHR032W -- unknown -- Member of multiple antimicrobiotic resistance (MAR) family of membrane transporters YNL050C YNL050C 1.2 12 3.6 0.6737 0.217850633 iYNL050C 0.500179299 YNL050C -- unknown -- unknown function YOL057W YOL057W 1.2 12 3.6 0.6737 0.393605144 iYOL058W 0.502007031 0.75982781 0.493264499 YOL057W -- unknown -- unknown function YOL146W YOL146W 1.2 13 3.6 0.6737 0.360757034 iYOL147C 0.146768227 0.811233403 0.117100372 YOL146W -- unknown -- unknown function YOR106W VAM3 1.2 13 3.6 0.6737 0.135259835 iYOR105W 0.589656619 0.306799871 0.305027393 "VAM3 -- vacuole biogenesis -- Syntaxin homolog (t-SNARE), required for vacuolar assembly" YPL092W SSU1 1.2 12 3.6 0.6737 0.275282851 iYPL093W 0.537998935 0.32849162 0.625070582 SSU1 -- sulfite tolerance -- Plasma membrane transporter involved in sulfite tolerance YKL119C VPH2 1.1 12 3.6 0.6737 0.813915055 YKLCdelta4 0.56903518 0.915302089 0.289545092 VPH2 -- vacuolar acidification -- Vacuolar H(+)-ATPase (V-ATPase) assembly protein acting in the endoplasmic reticulum YGR081C YGR081C 1 11 3.6 0.6737 0.597636487 iYGR081C 0.21200467 0.719948437 0.345824598 "YGR081C -- unknown -- unknown function, has putative coiled-coil domain" YGR123C PPT1 1 10 3.6 0.6737 0.829827432 iYGR123C itI(AAU)G 0.355032972 0.296151315 0.986809923 0.486679662 0.245894479 "PPT1 -- unknown -- Protein serine/threonine phosphatase of unknown function, member of PPP family of protein phosphatases and related to PP5 phosphatases, has tetratricopeptide (TPR) repeats" YHR169W DBP8 1 10 3.6 0.6737 0.165048267 iYHR168W 0.282508527 0.534477255 0.403039832 DBP8 -- unknown -- similarity to DEAD box family of RNA helicases YLR380W CSR1 1 11 3.6 0.6737 0.192459201 iYLR379W 0.056756974 0.420665765 0.490170802 CSR1 -- unknown -- unknown function YMR003W YMR003W 1 11 3.6 0.6737 0.437370019 iYMR002W 0.61548356 0.473927875 0.631039768 YMR003W -- unknown -- unknown function YNL303W YNL303W 1 10 3.6 0.6737 0.61119267 0.526698209 YNL303W -- unknown -- unknown function YNR054C YNR054C 1 11 3.6 0.6737 0.12480393 iYNR054C-0 iYNR054C-1 0.141845947 0.403746184 0.205130273 0.094795539 0.555904962 "YNR054C -- unknown -- similarity to mouse ABT1, an activator of RNA Polymerase II basal transcription" YLR002C YLR002C 0.9 10 3.6 0.6737 0.597387428 iYLR002C 0.814753175 0.612523657 0.23575419 YLR002C -- unknown -- unknown function YPL144W YPL144W 1.5 16 3.5 0.6654 1 0.933625264 iYPL145C 0.976723293 0.60622506 0.202117888 YPL144W -- unknown -- unknown function YBR067C TIP1 10.7 114 3.5 0.6654 0.629008272 iYBR067C 0.883988064 0.533229556 0.472211019 "TIP1 -- stress response (putative) -- Cold- and heat-shock induced mannocell wall, member of seripauperin (PAU) family" YBR256C RIB5 3.1 33 3.5 0.6654 0.455890019 iYBR256C 0.395114573 0.68132482 0.768616802 "RIB5 -- flavin biosynthesis -- Riboflavin synthase, last step of riboflavin synthesis, converts 6,7-dimethyl-8-ribityllumazine to riboflavin" YOR128C ADE2 3.1 33 3.5 0.6654 0.333289264 iYOR128C 0.379776048 0.629552046 0.510070899 "ADE2 -- purine biosynthesis -- Phosphoribosylaminoimidazole carboxylase (AIR decarboxylase), sixth step in de novo purine biosynthesis pathway" YNL157W YNL157W 3 33 3.5 0.6654 0.536569143 iYNL158W 0.539155472 0.687718379 0.440621979 YNL157W -- unknown -- similarity to Yhr132w-ap and with weak similarity to human ENSA alpha-endosulfine and human ARPP-19 cAMP-regulated phosphoprotein YDL012C YDL012C 2.7 27 3.5 0.6654 0.402848567 iYDL012C 0.349522422 0.451045125 0.3439977 YDL012C -- unknown -- unknown function YER044C YER044C 2.1 22 3.5 0.6654 0.779044786 iYER044C 0.165808823 0.819702602 0.227682888 YER044C -- unknown -- unknown function YGR211W ZPR1 2.1 23 3.5 0.6654 0.583146666 iYGR210C 0.655311446 ZPR1 -- unknown -- Zinc finger unknown function YCL056C YCL056C 2 21 3.5 0.6654 0.038830135 iYCL056C 0.165835203 0.006937162 0.041814373 YCL056C -- unknown -- unknown function YMR054W STV1 1.9 21 3.5 0.6654 0.424176492 iYMR053C 0.263557887 0.701555172 0.259023526 STV1 -- vacuolar acidification -- Subunit of V0 sector of vacuolar ATPase YIL176C YIL176C 1.8 19 3.5 0.6654 0.934822683 0.50660651 YIL176C -- unknown -- Member of seripauperin (PAU) family (PAU1 and YIL176C code for identical proteins) YOR015W YOR015W 1.8 19 3.5 0.6654 0.379728029 0.335866527 YOR015W -- unknown -- unknown function YDL158C YDL158C 1.7 18 3.5 0.6654 0.552735003 0.443676458 YDL158C -- unknown -- unknown function YHR037W PUT2 1.7 18 3.5 0.6654 0.609808893 iYHR036W 0.294595265 0.653039832 0.129097668 "PUT2 -- amino acid biosynthesis -- Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase), carries out the second step in proline degradationallows proline to be used as a nitrogen source" YBL033C RIB1 1.6 16 3.5 0.6654 0.564231882 iYBL033C 0.714523253 0.497744119 0.602964873 "RIB1 -- flavin biosynthesis -- GTP cyclohydrolase II, initial and rate-limiting step in the riboflavin biosynthesis pathway" YDR051C YDR051C 1.6 17 3.5 0.6654 0.19737292 iYDR051C 0.525037184 0.119714325 0.478071258 YDR051C -- unknown -- unknown function YIL085C KTR7 1.6 16 3.5 0.6654 0.4391817 iYIL085C 0.555840838 0.827214685 0.769738962 KTR7 -- protein glycosylation -- Putative mannosyltransferase of KRE2 family YNL005C MRP7 1.6 17 3.5 0.6654 0.820607228 iYNL005C 0.83130145 0.466896856 0.455977908 MRP7 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL2) YGR244C LSC2 1.5 16 3.5 0.6654 0.212275681 iYGR244C 0.381207392 0.485237596 0.426393482 LSC2 -- TCA cycle -- Succinyl-CoA ligasebeta subunit of succinyl-CoA synthetase complex which has succinyl-CoA ligase and succinate thiokinase activities YHR098C SFB3 1.5 16 3.5 0.6654 0.741525711 iYHR098C 0.274049424 0.853471668 0.359749916 "SFB3 -- unknown -- transport of plasma membrane ATPase Pma1p from the ER to the Golgi, possible component of COPII vesicles" YHR147C MRPL6 1.5 16 3.5 0.6654 iYHR147C 0.160191031 0.439864483 "MRPL6 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL16), belongs to L6 family of prokaryotic ribosomal proteins" YLR052W YLR052W 1.5 15 3.5 0.6654 0.203212714 iYLR051C 0.247953254 0.176275332 0.121593291 YLR052W -- unknown -- unknown function YCR060W YCR060W 1.3 14 3.5 0.6654 0.201083971 iYCR059C 0.445807086 0.239606832 0.534553972 "YCR060W -- unknown -- similarity to stress inducible protein Sti1p, has tetratricopeptide (TPR) repeats" YDL200C MGT1 1.3 14 3.5 0.6654 0.320122348 iYDL200C 0.652450876 0.423516827 0.36217079 MGT1 -- DNA repair -- O6-methylguanine DNA repair methyltransferase that carries out a suicide reaction YFR055W YFR055W 1.3 15 3.5 0.6654 0.900773317 0.932482043 YFR055W -- unknown -- similarity to E. coli cystathionine beta-lyase YLR020C YLR020C 1.3 15 3.5 0.6654 0.205922828 iYLR020C 0.316167798 0.371173058 0.184221493 YLR020C -- unknown -- similarity to triacylglycerol lipase YBL032W YBL032W 1.2 13 3.5 0.6654 0.760659082 iYBL033C 0.714523253 0.97571475 0.602964873 "YBL032W -- unknown -- four KH RNA binding motifs, has similarity to mouse hnRNP X protein" YKL114C APN1 1.2 12 3.5 0.6654 0.369137634 iYKL114C 0.480652741 0.652690426 0.416955715 "APN1 -- DNA repair -- AP endonuclease, DNA (apurinic or apyrimidinic site) lyase" YNL199C GCR2 1.2 13 3.5 0.6654 0.222775572 0.45601909 GCR2 -- glycolysis -- Transcriptional activator involved in regulation of glycolytic gene expression YKL112W ABF1 1.1 12 3.5 0.6654 0.234568236 iYKL113C 0.095336791 0.438410269 0.335594573 ABF1 -- transcription -- ARS-binding factor involved in the activation of DNA-replication and transcriptional regulation of various genes YML006C GIS4 1.1 12 3.5 0.6654 0.343957723 iYML006C tS(AGA)M 0.357106052 0.641661297 0.522823262 0.313352827 0.30573631 GIS4 -- unknown -- unknown function YNL107W YAF9 1.1 11 3.5 0.6654 0.440461786 iYNL108C 0.461378084 0.440950384 0.34616967 YAF9 -- unknown -- similarity to human AF-9 protein YOL094C RFC4 1.1 11 3.5 0.6654 0.53131406 iYOL094C 0.548142064 0.794392523 0.174790356 "RFC4 -- DNA replication -- Replication factor C, 37 kDa subunit" YBR104W YMC2 1 11 3.5 0.6654 0.652540044 iYBR103W 0.500672263 0.897636525 0.426561343 YMC2 -- transport -- Member of mitochondrial carrier (MCF) family of membrane transporters YGL257C MNT2 1 11 3.5 0.6654 0.571933337 iYGL257C 0.185512606 0.337662338 0.074541101 MNT2 -- protein glycosylation -- Mannosyltransferase required for addition of terminal mannose residues to O-linked oligosaccharides YGR078C PAC10 1 11 3.5 0.6654 0.139102348 iYGR078C 0.577788571 0.537791401 0.738872645 "PAC10 -- cytoskeleton -- Prefoldin subunit 3, component of Gim protein complex that promotes formation of functional alpha- and gamma-tubulin, and actin" YMR247C YMR247C 1 11 3.5 0.6654 0.320407581 iYMR247C itA(AGC)M2 0.669269026 0.632236905 0.613454868 0.314534322 0.468903767 YMR247C -- unknown -- unknown function YMR274C RCE1 1 11 3.5 0.6654 0.42145329 iYMR274C 0.622739747 0.933712793 0.449947568 RCE1 -- protein processing -- Protease involved in ras and a-factor C-terminal proteolysis YOR119C RIO1 1 11 3.5 0.6654 0.207115717 iYOR119C 0.645225185 0.198667966 0.779396034 RIO1 -- unknown -- similarity to Aspergillus nidulans SUDD suppressor of bimD6 chromosome-spindle attachment defect YOR229W WTM2 1 10 3.5 0.6654 0.220360837 iYOR228C 0.207274703 0.527120649 0.263391755 "WTM2 -- transcription -- Transcriptional modulator meiotic regulation and silencing, member of WD (WD-40) repeat family" YER087W YER087W 0.9 10 3.5 0.6654 0.359681275 iYER086W 0.589187409 0.637896265 0.517896816 YER087W -- unknown -- similarity to E. coli prolyl-tRNA synthetase YJR002W MPP10 0.9 10 3.5 0.6654 0.366059672 iYJR001W 0.354136312 0.482213439 0.235181479 "MPP10 -- rRNA processing -- Component of U3 snoRNP, required for pre-18S rRNA processing" YGR084C MRP13 1.9 21 3.4 0.6561 1 0.849622465 iYGR084C 0.928789504 0.819926779 0.695458552 MRP13 -- protein synthesis -- Mitochondrial ribosomal small subunit YDR041W YDR041W 1.7 18 3.4 0.6561 1 0.842492574 iYDR040C 0.973324248 0.776426039 0.397645601 YDR041W -- protein synthesis -- Putative mitochondrial ribosomal protein YMR099C YMR099C 1.7 18 3.4 0.6561 1 0.909520035 iYMR099C 0.941633151 0.867916999 0.461303284 YMR099C -- unknown -- unknown function YGR182C YGR182C 2.4 26 3.4 0.6561 0.79850828 iYGR182C 0.644273096 0.630050193 0.762228964 YGR182C -- unknown -- unknown function YHR057C CYP2 2.2 25 3.4 0.6561 0.62967088 iYHR057C 0.146339448 0.775346401 0.132935388 "CYP2 -- protein folding -- Cyclophilin (peptidylprolyl cis-trans isomerase or PPIase), ER or secreted isoform, plays a role in the stress response" YNL307C MCK1 2.2 24 3.4 0.6561 0.544229748 iYNL307C 0.270938314 0.709816441 0.167695219 "MCK1 -- meiosis -- Serine/threonine/tyrosine protein kinase, positive regulator of meiosis and spore formation" YBR023C CHS3 2.1 23 3.4 0.6561 0.459156866 iYBR023C 0.32998273 0.731005716 0.774252421 CHS3 -- cell wall biogenesis -- Chitin synthase IIIresponsible for chitin ring at base of bud and chitin in the lateral cell walls and spores YHR146W YHR146W 2 22 3.4 0.6561 0.31984926 iYHRCdelta10 YHRCdelta11 0.434300107 0.676096339 0.660577997 0.478598651 0.679286296 YHR146W -- unknown -- similarity to pheromone adaptation protein Mdg1p YPL170W YPL170W 2 22 3.4 0.6561 0.68081685 iYPL171C 0.844024615 0.169755076 0.453232243 YPL170W -- unknown -- similarity to steroid membrane receptors YBR282W MRPL27 1.9 21 3.4 0.6561 0.601842382 iYBR281C 0.520424245 0.818875893 0.814929358 MRPL27 -- protein synthesis -- Mitochondrial ribosomal large subunit YMR200W ROT1 1.9 21 3.4 0.6561 0.409843921 iYMR199W 0.2063617 0.855181936 0.532378837 ROT1 -- cytoskeleton -- Suppressor of tor2 mutation YPL087W YDC1 1.8 20 3.4 0.6561 0.311615323 iYPL088W 0.39644013 0.457500206 0.526536658 YDC1 -- sphingolipid metabolism -- Alkaline dihydroceramidase YGR220C MRPL9 1.6 17 3.4 0.6561 0.182024844 iYGR220C 0.575815337 0.671110014 0.570151636 MRPL9 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL9E. coli L3human MRL3) YOR150W MRPL23 1.6 17 3.4 0.6561 0.271350891 iYOR149C 0.246080875 0.865465317 0.75337952 MRPL23 -- protein synthesis -- Mitochondrial ribosomal large subunit YPR094W YPR094W 1.6 17 3.4 0.6561 0.539744212 iYPR093C 0.517750232 0.459226771 YPR094W -- unknown -- unknown function YKL207W YKL207W 1.5 16 3.4 0.6561 0.436423198 iYKL208W 0.338663732 0.698723065 0.233186887 YKL207W -- unknown -- unknown function YMR150C IMP1 1.5 16 3.4 0.6561 0.26805243 0.611438251 "IMP1 -- protein processing -- Catalytic subunit of mitochondrial inner membrane protease Imp, responsible for removal of signal peptides from some proteins of intermembrane space" YNL003C PET8 1.5 16 3.4 0.6561 0.631879028 iYNL003C 0.777041948 0.552149714 0.346654275 "PET8 -- mitochondrial protein targeting -- mitochondrial carrier (MCF) family, has similarity to Mrs4p and Mrs3p" YPL059W GRX5 1.5 17 3.4 0.6561 0.380329858 YPLCTy4-1E iYPLCtau2 0.386551815 0.36415616 0.6896249 0.582560297 0.530212697 "GRX5 -- oxidative stres response -- Glutaredoxin, involved in protection against protein oxidative damage" YPL149W APG5 1.5 16 3.4 0.6561 0.605162397 iYPL150W 0.327920251 0.941840768 0.728598882 APG5 -- autophagy -- autophagy and nutrient starvation YBR002C RER2 1.3 15 3.4 0.6561 0.585775757 iYBR002C 0.67035393 0.839360587 0.838531514 "RER2 -- protein glycosylation -- Cis-prenyltransferase, involved in dolichol synthesis" YER026C CHO1 1.3 14 3.4 0.6561 0.597134252 iYER026C 0.433738848 0.774212129 0.610631604 "CHO1 -- phospholipid metabolism -- Phosphatidylserine synthase, CDP-diacylglycerol serine O-phosphatidyltransferase" YGR257C YGR257C 1.3 15 3.4 0.6561 0.792514458 iYGR257C 0.34824562 0.80214425 0.179419986 YGR257C -- unknown -- Member of mitochondrial carrier family (MCF) of membrane transporters YIL048W NEO1 1.3 15 3.4 0.6561 0.437625039 iYIL049W 0.293886953 0.797439224 0.411224821 NEO1 -- neomycin resistance -- ATPase that leads to neomycin-resistant protein when overexpressed YMR319C FET4 1.3 15 3.4 0.6561 0.34014874 iYMR319C-0 iYMR319C-1 0.574810016 0.490153549 0.234345429 0.732033516 0.34094174 FET4 -- transport -- Low-affinity Fe(II) transport protein YGR101W YGR101W 1.2 14 3.4 0.6561 0.2777173 iYGR100W 0.365731254 0.323261858 0.32717593 "YGR101W -- unknown -- unknown function, possibly involved in respiration" YPR114W YPR114W 1.2 13 3.4 0.6561 0.2898461 iYPR113W 0.146592197 0.32659204 0.046820405 YPR114W -- unknown -- unknown function YBR265W TSC10 1.1 12 3.4 0.6561 0.186259505 iYBR264C 0.458036438 0.774754985 0.58869572 "TSC10 -- sphingolipid biosynthesis -- 3-Ketosphinganine reductase, catalyzes the second step in the synthesis of phytosphingosine" YNR012W URK1 1.1 12 3.4 0.6561 0.310671983 iYNR011C 0.2283917 0.610774142 0.426275332 "URK1 -- pyrimidine metabolism -- Uridine kinase, converts ATP and uridine to ADP and UMP" YOR291W YOR291W 1.1 11 3.4 0.6561 0.443018765 iYOR290C 0.555173707 0.190951917 0.17168954 YOR291W -- unknown -- Member of cation translocating P-type ATPase superfamily YBL018C POP8 1 11 3.4 0.6561 0.819931683 iYBL018C 0.223106276 0.935406895 0.365835596 "POP8 -- tRNA processing -- Subunit of both RNase P and RNase MRP, which are needed for tRNA processing and 5.8S rRNA processing, respectively" YFL001W DEG1 1 11 3.4 0.6561 0.514762874 iYFL002C 0.488667638 0.493535515 0.292292849 DEG1 -- tRNA processing -- Pseudouridine synthase that catalyzes the formation of pseudouridine-38 and -39 in cytoplasmic and mitochondrial tRNAs YFR028C CDC14 1 11 3.4 0.6561 0.608599184 iYFR028C itY(GUA)F2 0.489935441 0.769258233 0.85948668 0.197124756 0.475786735 CDC14 -- mitosis -- Dual specificity protein phosphatase (PTPase) that performs a function late in the cell cycle YJR118C ILM1 1 11 3.4 0.6561 0.755511305 iYJR118C 0.583569294 0.723171125 0.545520464 "ILM1 -- mitochondrial genome maintenance (putative) -- unknown function, possibly involved in mitochondrial DNA maintenance" YKL166C TPK3 1 11 3.4 0.6561 0.436232943 iYKL166C-0 iYKL166C-1 0.245007635 0.408771643 0.609732517 0.103351955 0.679438574 "TPK3 -- signaling, nutrient control of cell growth -- cAMP-dependent protein kinase 3 or protein kinase A (PKA) catalytic subunit" YMR102C YMR102C 1 12 3.4 0.6561 0.51018225 iYMR102C 0.342820103 0.537872066 0.215275431 "YMR102C -- unknown -- unknown function, contains WD (WD-40) repeats" YNL038W YNL038W 1 11 3.4 0.6561 0.145620852 iYNL039W 0.224503197 0.594795539 0.064644852 YNL038W -- unknown -- unknown function YNL188W KAR1 1 10 3.4 0.6561 0.152403769 iYNL189W 0.681908628 0.15075818 0.784382768 KAR1 -- cytoskeleton -- spindle pole body duplication and karyogamy YNL292W PUS4 1 11 3.4 0.6561 0.23693896 iYNL293W 0.592189657 0.363213924 0.110055866 PUS4 -- tRNA processing -- Pseudouridine synthase that creates pseudouridine-55 in cytoplasmic and mitochondrial tRNAs YNR038W DBP6 1 11 3.4 0.6561 0.593375673 iYNR037C 0.065828161 0.52434158 0.341961143 DBP6 -- rRNA processing -- Putative RNA helicase required for ribosomal RNA processing and biogenesis of 60S ribosomal subunit YCR097W A1 0.9 10 3.4 0.6561 0.991608915 iYCR096C YCR097W-A 0.988131424 0.971347271 0.647326417 0.256664006 0.57442348 "A1 -- transcription -- Homeodomain regulatory proteinwith Alpha2p, represses transcription of haploid-specific genes in diploid cells" YIL079C YIL079C 0.9 10 3.4 0.6561 0.551744012 iYIL079C 0.26756644 0.723445143 0.51908707 YIL079C -- unknown -- similarity to gag polyprotein YKL225W YKL225W 0.9 10 3.4 0.6561 0.995812371 0.112955205 YKL225W -- unknown -- unknown function YLR409C YLR409C 0.9 9 3.4 0.6561 0.505255619 iYLR409C 0.672771617 0.56632083 0.545136284 "YLR409C -- unknown -- unknown function, has WD (WD-40) repeats" YPR120C CLB5 0.9 9 3.4 0.6561 0.296645941 itC(GCA)P2 iYPR120C 0.362774997 0.269847765 0.282014682 0.333145116 0.435427926 "CLB5 -- cell cycle -- B-type cyclin appearing late in G1, involved in initiation of DNA synthesis" YPR146C YPR146C 0.9 10 3.4 0.6561 0.482425911 0.605426975 YPR146C -- unknown -- unknown function YEL055C POL5 0.8 9 3.4 0.6561 0.764265906 iYEL055C 0.893724121 0.470109571 0.822033482 POL5 -- DNA replication -- DNA polymerase V that has motifs typical of DNA polymerase family YKL175W YKL175W 1.8 20 3.3 0.6458 1 0.939155006 iYKL176C 0.983139099 0.708414555 0.093216281 YKL175W -- unknown -- Vacuolar membrane the regulation of zinc storage YHR001W-A QCR10 2.6 28 3.3 0.6458 0.595473705 iYHR001W 0.343448015 0.519916143 0.26232206 QCR10 -- oxidative phosphorylation -- Ubiquinol cytochrome-c reductase subunit (8.5 kDa protein)component of ubiquinol cytochrome-c reductase complex YOR326W MYO2 2.4 27 3.3 0.6458 0.315505029 iYOR325W 0.557269444 0.364163713 0.536896723 "MYO2 -- cytoskeleton -- Myosin heavy chain, class V, involved in polarized growth and secretion" YKL104C GFA1 2.2 26 3.3 0.6458 0.642703685 iYKL104C 0.380582958 0.942401053 0.398996133 "GFA1 -- cell wall biogenesis -- Glucosamine--fructose-6-phosphate aminotransferase, isomerizing (hexosephosphate aminotransferase), first step in chitin biosynthesis pathway" YDL053C YDL053C 2 23 3.3 0.6458 0.277634808 iYDL053C 0.577538435 0.215104462 0.517706303 YDL053C -- unknown -- Protein possibly involved in proteasome function YGR167W CLC1 2 23 3.3 0.6458 0.552137876 iYGR166W 0.521604969 0.468076616 0.291844801 "CLC1 -- endocytosis and secretion -- Clathrin light chain, involved in the internalization step of endocytosis" YBR210W YBR210W 1.9 21 3.3 0.6458 0.709517353 iYBR209W itC(GCA)B 0.756498061 0.190865028 0.785027952 0.233019852 0.161879013 "YBR210W -- unknown -- unknown function, has similarity to Erv14p, a ER-derived vesicles" YCL054W SPB1 1.8 20 3.3 0.6458 0.335383918 iYCL055W-0 iYCL055W-1 0.563733949 0.711333167 0.395234877 0.473904977 0.701901386 SPB1 -- ribosome biogenesis -- Putative S-adenosyl-methionine-dependent methyltransferase required for synthesis of 60S ribosomal subunit YOR215C YOR215C 1.8 20 3.3 0.6458 0.376499778 iYOR215C 0.097857322 0.315178859 0.063003545 YOR215C -- unknown -- unknown function YML007W YAP1 1.7 18 3.3 0.6458 0.570859697 iYML008C 0.303277182 0.498911027 0.365203512 "YAP1 -- oxidative stress -- Transcriptional activator of basic leucine zipper (bZIP) family, involved in oxidative stress response" YDL047W SIT4 1.6 17 3.3 0.6458 0.199265594 iYDL048C-0 iYDL048C-1 0.424348861 0.342138379 0.412524366 0.354509178 0.255474624 "SIT4 -- cell cycle -- Protein serine/threonine phosphatase involved in cell cycle regulation, member of PPP family of protein phosphatases and related to PP2A phosphatase" YER100W UBC6 1.6 17 3.3 0.6458 0.406316035 iYER099C 0.428307329 0.576510721 0.632472385 "UBC6 -- protein degradation, ubiquitin-mediated -- Ubiquitin-conjugating enzymeanchored in the ER membrane with the catalytically active domain in cytoplasm" YER155C BEM2 1.6 17 3.3 0.6458 0.453300025 iYER155C 0.24485866 0.522665603 0.129268493 BEM2 -- bud emergence -- GTPase-activating (GAP) regulates Rho1p and has a role in bud emergence and cell cycle-related cytoskeletal reorganization YLR066W SPC3 1.6 18 3.3 0.6458 0.419373459 iYLR065C 0.48670498 0.49792498 0.557748172 SPC3 -- secretion -- Subunit of signal peptidase complex YPR020W ATP20 1.6 18 3.3 0.6458 0.506082736 iYPR019W 0.605156582 0.532274417 0.558488394 ATP20 -- ATP synthesis -- F1F0-ATP synthase complex F0 membrane domain g subunit Q0080 1.5 17 3.3 0.6458 YDL103C QRI1 1.5 16 3.3 0.6458 0.654745171 iYDL103C 0.177942149 0.776803119 0.120674357 QRI1 -- UDP-N-acetylglucosamine biosynthesis -- UDP-N-acetylglucosamine pyrophosphorylase YDR237W MRPL7 1.5 16 3.3 0.6458 0.186038321 iYDR236C 0.133376406 0.375380196 0.478202095 "MRPL7 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL5/YmL7), belongs to the L5 family of prokaryotic ribosomal proteins" YIL033C SRA1 1.5 17 3.3 0.6458 0.65990046 iYIL033C 0.320470148 0.717436024 0.179806006 SRA1 -- signaling? -- Regulatory subunit of cAMP-dependent protein kinases YIR004W DJP1 1.5 16 3.3 0.6458 0.495270671 iYIR003W 0.691848276 0.632733726 0.287947148 DJP1 -- peroxisome biogenesis -- peroxisomal biogenesishas similarity to E. coli DnaJ and other DnaJ-like proteins YOL027C YOL027C 1.5 16 3.3 0.6458 0.276454357 iYOL027C 0.664990715 0.51077519 0.75591416 YOL027C -- unknown -- unknown function YOR196C LIP5 1.5 17 3.3 0.6458 0.072947001 iYOR196C 0.226320001 0.109102027 0.184728051 "LIP5 -- fatty acid metabolism -- Lipoic acid synthase, mutants cannot synthesize lipoic acid, but can attach lipoic acid to protein" YPL024W NCE4 1.5 16 3.3 0.6458 0.191194483 iYPL025C 0.122477117 0.133902675 0.241720176 NCE4 -- cell separation -- Negative regulator of CTS1 expression YAL021C CCR4 1.3 15 3.3 0.6458 0.429605242 iYAL021C 0.482393486 0.63534978 0.276357183 CCR4 -- catabolite repression -- Component of CCR4 transcriptional complexhas positive and negative effects on transcription YBL005W-A 1.3 16 3.3 0.6458 0.349465391 iYBL005W YBLWdelta8 0.725733875 0.604635622 0.475498479 0.492717847 0.541666667 YCL055W KAR4 1.3 16 3.3 0.6458 0.490720706 iYCL056C 0.165835203 0.631284916 0.041814373 KAR4 -- karyogamy -- Regulatory pheromone induction of karyogamy genes YKR084C HBS1 1.3 15 3.3 0.6458 0.303021524 iYKR084C 0.512543639 0.814787199 0.612486892 HBS1 -- unknown -- Protein related to translation elongation factor EF-1alpha and to Sup35p YLR195C NMT1 1.3 16 3.3 0.6458 0.608971782 iYLR195C 0.432717076 0.852052991 0.36054256 "NMT1 -- protein processing -- N-myristoyltransferase, catalyzes cotranslational transfer of myristate from myristoyl-CoA to N-terminal glycine of certain nascent proteins" YPR009W YPR009W 1.3 15 3.3 0.6458 0.438323695 iYPR008W 0.909180638 0.635916855 0.577218728 YPR009W -- unknown -- unknown function YGR246C BRF1 1.2 14 3.3 0.6458 0.317067288 iYGR246C 0.49060464 0.677905945 0.633200319 "BRF1 -- transcription -- Component of RNA polymerase III transcription initiation factor B, 70K subunit" YNL168C YNL168C 1.2 14 3.3 0.6458 0.873082684 iYNL168C 0.535723464 0.981308411 0.545777204 YNL168C -- unknown -- similarity to E. coli hpcE gene product which is involved in degradation of aromatic compounds YOR094W ARF3 1.2 14 3.3 0.6458 0.448586322 iYOR093C 0.589891508 0.365671028 0.610587002 ARF3 -- secretion -- similarity to members of arf family (ras superfamily) of GTP-binding proteins YPR169W YPR169W 1.2 14 3.3 0.6458 0.118172556 iYPR168W 0.661323197 0.135594586 0.459385335 YPR169W -- unknown -- unknown function YBR075W YBR075W 1.1 13 3.3 0.6458 0.708510291 iYBR074W 0.479535711 0.890103751 0.461372706 YBR075W -- unknown -- unknown function YDL155W CLB3 1.1 12 3.3 0.6458 0.319269132 iYDL156W 0.646326159 0.725911298 0.70689167 CLB3 -- cell cycle -- G2/M-phase-specific cyclin YDR038C ENA5 1.1 13 3.3 0.6458 0.536377522 iYDR038C 0.482591419 0.354385045 0.878094775 ENA5 -- transport -- P-type ATPase involved in Na+ efflux YFL066C YFL066C 1.1 13 3.3 0.6458 0.940779629 iYFL066C 0.924448497 0.635569532 0.686671987 "YFL066C -- unknown -- near identity to other subtelomerically-encoded proteins including Yil177p, Yhl050p, and Yer190p" YGL210W YPT32 1.1 13 3.3 0.6458 0.514879433 iYGL211W 0.308748998 0.839181287 0.452151732 "YPT32 -- secretion -- GTP-binding protein required in the secretory pathway at the stage of formation of trans-Golgi vesicles, member of rab family in the ras superfamily" YJL115W ASF1 1.1 13 3.3 0.6458 0.047138333 iYJL116C 0.215122068 0.08952522 0.303460515 "ASF1 -- transcription -- Component of replication-coupling assembly factor (RCAF), anti-silencing causes derepression of silent loci when overexpressed" YJR054W YJR054W 1.1 13 3.3 0.6458 0.610976323 iYJR053W 0.293123062 0.91790203 0.367508268 YJR054W -- unknown -- unknown function YMR148W YMR148W 1.1 12 3.3 0.6458 0.456664369 iYMR147W 0.474626619 0.587529571 0.62191358 YMR148W -- unknown -- unknown function YNL078W YNL078W 1.1 12 3.3 0.6458 0.535029576 iYNL079C 0.082929148 0.669996777 0.01161775 YNL078W -- unknown -- unknown function YPR144C YPR144C 1.1 12 3.3 0.6458 0.392852533 iYPR144C SNR45 0.585774404 0.811626906 0.55795757 0.51931919 0.455607669 "YPR144C -- unknown -- unknown function, has strong similarity to an S. pombe unknown function" YBR061C YBR061C 1 11 3.3 0.6458 0.786718926 iYBR061C 0.781543146 0.924336533 0.817392592 YBR061C -- unknown -- similarity to Ctr86p and E. coli ftsJ YJL063C MRPL8 1 12 3.3 0.6458 0.332332589 iYJL063C 0.263715131 0.735209413 0.52365671 MRPL8 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL8) YKL137W YKL137W 1 12 3.3 0.6458 0.432877197 iYKL138C 0.06210777 0.454384125 0.064937158 "YKL137W -- unknown -- respiratory growth, for normal distribution of actin patches, and for normal resistance to NaCl and H2O2" YLR426W YLR426W 1 11 3.3 0.6458 0.302671105 iYLR425W 0.204183534 0.711068891 0.058174936 "YLR426W -- unknown -- similarity to Fox2p, E. coli 3-oxoacyl-[acyl-carrier protein] reductase and insect-type alcohol dehydrogenase/ribitol dehydrogenase family" YMR304C-A 1 12 3.3 0.6458 0.689441588 0.536549708 YNL323W YNL323W 1 11 3.3 0.6458 0.626143903 iYNL324W 0.143486928 0.634904962 0.141340782 YNL323W -- unknown -- similarity to Ycx1p YPL101W YPL101W 1 11 3.3 0.6458 0.074580862 0.361619747 YPL101W -- unknown -- unknown function YKL069W YKL069W 0.9 11 3.3 0.6458 0.335254544 iYKL070W 0.521290617 0.856590396 0.837638077 YKL069W -- unknown -- unknown function YOR006C YOR006C 0.9 9 3.3 0.6458 0.103434571 iYOR006C 0.071151987 0.13059942 0.050769357 YOR006C -- unknown -- unknown function YLR401C YLR401C 1 12 3.2 0.6377 1 0.98731847 iYLR401C 0.984731152 0.648284118 0.352665968 YLR401C -- unknown -- weak similarity to R. capsulatus protein nifR3 YBR036C CSG2 2.7 31 3.2 0.6377 0.47604725 iYBR036C 0.089220444 0.625219473 0.243494424 CSG2 -- sphingolipid metabolism -- synthesis of mannosylated sphingolipids YDR214W YDR214W 2.4 27 3.2 0.6377 0.226348619 iYDR213W 0.614462705 0.791380686 0.547313282 YDR214W -- unknown -- unknown function YER023W PRO3 2.1 25 3.2 0.6377 0.450788515 iYER022W 0.141739411 0.657286267 0.050899411 PRO3 -- proline biosynthesis -- Delta-1-pyrroline-5-carboxylate reductase (P5C reductase)carries out last (third) step in proline biosynthesis pathway YDR152W YDR152W 1.9 23 3.2 0.6377 iYDR151C 0.48923339 0.750725105 YDR152W -- unknown -- unknown function YOL026C YOL026C 1.9 23 3.2 0.6377 0.698689605 iYOL026C itS(GCU)O 0.389840928 0.640086515 0.766599794 0.139469226 0.305913632 YOL026C -- unknown -- unknown function YAL053W YAL053W 1.8 20 3.2 0.6377 0.856395216 iYAL054C 0.675166795 0.612244898 0.594972067 YAL053W -- unknown -- unknown function YDR264C AKR1 1.8 21 3.2 0.6377 0.837196442 iYDR264C 0.806919898 0.860377054 0.655494683 "AKR1 -- signaling, pheromone pathway; endocytosis; cell shape control -- Ankyrin repeat-containing proteinhas an inhibitory effect on signaling in the pheromone pathway" YIR011C STS1 1.8 20 3.2 0.6377 0.318632175 iYIR011C 0.134793521 0.33033342 0.142615749 STS1 -- nuclear protein targeting -- when overexpressed restores protein transport and rRNA stability to a sec23 mutation YLL048C YBT1 1.8 21 3.2 0.6377 0.470746792 iYLL048C 0.633126429 0.57554247 0.293680297 "YBT1 -- transport -- similarity to mammalian ATP-dependent bile acid transporter, member of ATP-binding cassette (ABC) superfamily" YER112W LSM4 1.7 20 3.2 0.6377 0.284809853 iYER111C 0.415947846 0.595760234 0.683123509 LSM4 -- mRNA splicing -- U6 snRNA-associated Sm-like group YJR073C OPI3 1.7 20 3.2 0.6377 0.788358118 iYJR073C 0.719523941 0.753544956 0.45754717 "OPI3 -- phospholipid metabolism -- Phospholipid-N-methyltransferase, carries out the second and third methylation steps of phosphatidylcholine biosynthesis pathway" YML070W DAK1 1.7 20 3.2 0.6377 0.298732353 iYML071C tR(UCU)M2 0.894407765 0.563308948 0.540328099 0.848108413 0.225481142 DAK1 -- carbohydrate metabolism; stress response -- Putative dihydroxyacetone kinase YBR049C REB1 1.6 18 3.2 0.6377 0.576572101 iYBR049C 0.13271282 0.692997614 0.171562577 REB1 -- transcription -- Termination factor for RNA polymerase I and transcription factor for RNA polymerase II YDR284C DPP1 1.6 18 3.2 0.6377 0.260482543 iYDR284C 0.338133078 0.792136642 0.629967909 DPP1 -- phospholipid metabolism -- Diacylglycerol pyrophosphate phosphatase YIL030C SSM4 1.6 18 3.2 0.6377 0.508965783 iYIL030C itK(CUU)I 0.685529198 0.667625933 0.790742219 0.596654275 0.70865822 "SSM4 -- mRNA decay -- mRNA turnover, inactivation suppresses mRNA instability due to rna14-3 mutation" YIL145C YIL145C 1.6 18 3.2 0.6377 0.430367737 iYIL145C 0.320632837 0.860427188 0.357704403 YIL145C -- unknown -- similarity to E. coli pantoate beta-alanine ligase (pantothenate synthetase) YLR203C MSS51 1.6 18 3.2 0.6377 0.528689745 iYLR203C 0.403671151 0.892715094 0.382066277 "MSS51 -- mRNA splicing, COX1 and COB mRNA -- respiratory growthpossibly involved in translational activation of mitochondrial COX1 mRNA" YMR047C NUP116 1.6 18 3.2 0.6377 0.27657388 iYMR047C 0.168601696 0.327693536 0.105750487 NUP116 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) of GLFG familymay be involved in binding and translocation of nuclear proteins YNL313C YNL313C 1.5 17 3.2 0.6377 0.339210313 iYNL313C 0.397146539 0.541928721 0.448505523 "YNL313C -- unknown -- unknown function, has tetratricopeptide (TPR) repeats" YOR061W CKA2 1.5 17 3.2 0.6377 0.542542139 iYOR060C 0.39952033 0.630111524 0.227438112 "CKA2 -- cell cycle -- Casein kinase II (Protein kinase CK2), catalytic (alpha-prime) subunit" YOR085W OST3 1.5 17 3.2 0.6377 0.254167395 iYOR084W 0.583376768 0.526659676 0.41168004 OST3 -- protein glycosylation -- Oligosaccharyltransferase gamma subunitmember of a complex of 8 ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif YPL118W MRP51 1.5 17 3.2 0.6377 0.410060724 iYPL119C 0.250373451 0.513433592 0.148276146 MRP51 -- protein synthesis -- Mitochondrial ribosomal small subunit YGR281W YOR1 1.3 15 3.2 0.6377 0.403205573 iYGR280C 0.357014334 0.336338532 0.262465817 "YOR1 -- transport -- Oligomycin-resistance factor, member of ATP-binding cassette (ABC) superfamily" YHR039C YHR039C 1.3 15 3.2 0.6377 0.544863482 iYHR039C 0.74155482 0.453980802 0.287589753 YHR039C -- unknown -- strong similarity to aldehyde dehydrogenases YLR005W SSL1 1.3 16 3.2 0.6377 0.706285422 iYLR004C 0.857989891 0.558966862 0.334814449 SSL1 -- transcription -- Component of RNA polymerase II transcription initiation factor TFIIH YMR005W MPT1 1.3 16 3.2 0.6377 0.384014532 iYMR004W 0.120025726 0.225299282 0.161076171 MPT1 -- protein synthesis -- Component of RNA polymerase II general transcription factor TFIID YNR039C ZRG17 1.3 16 3.2 0.6377 0.332259131 iYNR039C 0.140885804 0.546332551 0.374450015 ZRG17 -- unknown -- weak similarity to Anopheles mitochondrial NADH dehydrogenase subunit 2 YBR220C YBR220C 1.2 14 3.2 0.6377 0.624156651 iYBR220C 0.243764408 0.929503706 0.41245012 "YBR220C -- unknown -- similarity to human acetyl coenzyme A transporter, E. coli ampG protein, and other acetyl-CoA transporter proteins" YBR291C CTP1 1.2 14 3.2 0.6377 0.229924086 iYBR291C 0.569666776 0.287869114 0.50459233 "CTP1 -- transport -- Mitochondrial inner membrane citrate transport protein, member of mitochondrial carrier family (MCF) protein family" YIL020C HIS6 1.2 14 3.2 0.6377 0.741041441 iYIL020C 0.853729617 0.416440543 0.259336936 HIS6 -- histidine biosynthesis -- Phosphoribosyl imidazolecarboxamide isomerase YLR220W CCC1 1.2 15 3.2 0.6377 0.096607963 iYLR219W 0.270366278 0.223942538 0.005800838 "CCC1 -- ion homeostasis, Ca2+ and Mn2+ -- potential role in calcium regulation, overproduction suppresses the calcium-sensitive phenotype of csg1 strains" YMR195W YMR195W 1.2 14 3.2 0.6377 0.442204954 YMR194C-A iYMR194C-A 0.13518241 0.217459418 0.689252336 0.082291315 0.299353599 YMR195W -- unknown -- unknown function YBR125C PTC4 1.1 14 3.2 0.6377 0.181718758 iYBR125C 0.429169499 0.747099581 0.212700908 PTC4 -- unknown -- Serine/threonine protein phosphatase of PP2C family YBR166C TYR1 1.1 14 3.2 0.6377 0.66208712 iYBR166C 0.559263946 0.839235299 0.55510796 "TYR1 -- tyrosine biosynthesis -- Prephenate dehydrogenase (NADP+), step of tyrosine biosynthesis pathway" YLR049C YLR049C 1.1 13 3.2 0.6377 0.719291081 iYLR049C 0.151100512 0.820945177 0.160611693 YLR049C -- unknown -- unknown function YMR125W STO1 1.1 12 3.2 0.6377 0.693903769 iYMR124W 0.182637718 0.833595388 0.199463221 STO1 -- glycolysis -- Large subunit of nuclear cap-binding protein complex YPR119W CLB2 1.1 13 3.2 0.6377 0.454572945 iYPR118W tK(UUU)P 0.612566796 0.780386895 0.289719626 0.417422602 0.800516254 CLB2 -- cell cycle -- G2/M-phase-specific cyclin YMR289W YMR289W 1 12 3.2 0.6377 0.139096353 iYMR288W 0.104766118 0.505677848 0.041201434 YMR289W -- unknown -- unknown function YOR240W YOR240W 1 12 3.2 0.6377 0.020510456 0.092592593 YOR240W -- unknown -- Putative methyltransferase unknown role YFR018C YFR018C 0.8 9 3.2 0.6377 0.817228291 iYFR018C 0.333740209 0.790928134 0.110136452 YFR018C -- unknown -- similarity to human glutaminyl-peptide cyclotransferase YOL059W GPD2 1.2 14 3.1 0.6294 1 0.882457431 iYOL060C 0.995398953 0.773716699 0.633863031 GPD2 -- glycerol metabolism -- Glycerol-3-phosphate dehydrogenase (NAD+)involved in glycerol production converting glycerol-3-phosphate and NAD+ to dihydroxyacetone phosphate and NADH YLR403W SFP1 1.1 13 3.1 0.6294 1 0.812303583 iYLR402W 0.970000438 0.84660814 0.538356054 "SFP1 -- unknown -- Zinc finger nuclear protein localization, three dispersed C2H2-type zinc fingers" YBR207W FTH1 2.8 34 3.1 0.6294 0.319292194 iYBR206W 0.342173553 0.401149037 0.569649378 FTH1 -- unknown -- Vacuolar iron transporter with similarity to Ftr1p YCL031C RRP7 2.5 29 3.1 0.6294 0.550176809 iYCL031C 0.129203827 0.4194282 0.067251462 RRP7 -- rRNA processing -- pre-rRNA processing and ribosome assembly YGL191W COX13 2.2 27 3.1 0.6294 0.799121052 iYGL192W 0.250496199 0.977924589 0.3778826 COX13 -- oxidative phosphorylation -- Cytochrome-c oxidase chain VIa YIL035C CKA1 2.2 27 3.1 0.6294 0.747705374 iYIL035C 0.125173024 0.833439745 0.159281341 "CKA1 -- cell cycle (putative) -- Casein kinase II (protein kinase CK2), catalytic (alpha) subunit" YDR434W YDR434W 2.1 25 3.1 0.6294 0.792069437 iYDR433W 0.647702365 0.945601249 0.400660651 YDR434W -- unknown -- unknown function YKL212W SAC1 1.9 22 3.1 0.6294 0.647162379 iYKL213C 0.108148529 0.929824561 0.108799185 "SAC1 -- secretion -- Polyphosphoinositide phosphatase, required for transport of ATP into ER which plays a role in Golgi function and actin cytoskeletal organization" YBL056W PTC3 1.8 22 3.1 0.6294 0.414793762 iYBL057C 0.69810621 0.793615984 0.941739824 PTC3 -- osmotic stress response (putative) -- Protein serine/threonine phosphatase of PP2C family YHR142W CHS7 1.7 21 3.1 0.6294 0.963763406 iYHR141C 0.601883986 0.781708595 0.063426911 CHS7 -- cell wall biogenesis -- the regulated transport of chitin synthase III (Chs3p) from the ER YLR262C YPT6 1.7 20 3.1 0.6294 0.29627173 iYLR262C YLR262C-A 0.394842432 0.057400113 0.436844864 0.435365753 0.002739285 "YPT6 -- secretion -- GTP-binding the secretory pathway, member of rab family in the ras superfamily" YDR335W MSN5 1.6 18 3.1 0.6294 0.326035444 iYDR334W 0.102718224 0.657497782 0.323476914 MSN5 -- signaling -- Importin-beta family member required for nuclear export of Pho4p and involved in pheromone response pathway YKL003C MRP17 1.6 19 3.1 0.6294 0.571608377 iYKL003C 0.164667547 0.728079374 0.248630358 MRP17 -- protein synthesis -- Mitochondrial ribosomal small subunit YOR241W MET7 1.6 19 3.1 0.6294 0.307614308 iYOR240W 0.641033346 0.679337232 0.763190077 "MET7 -- unknown -- Folylpolyglutamate synthetase, involved in methionine biosynthesis and maintenance of mitochondrial genome" YGR077C PEX8 1.5 18 3.1 0.6294 0.309797233 iYGR077C 0.531068433 0.632774284 0.333305171 PEX8 -- peroxisome biogenesis -- Peroxisomal protein (peroxin) involved in protein import into peroxisomes YNL284C MRPL10 1.5 17 3.1 0.6294 0.525381453 iYNL284C itT(AGU)N1 0.694099437 0.605169449 0.900056465 0.779301444 0.544145478 "MRPL10 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL10), member of L15 family of prokaryotic ribosomal proteins" YML010W SPT5 1.3 16 3.1 0.6294 0.389168502 iYML011C 0.277242432 0.591408632 0.166666667 SPT5 -- transcription -- chromatin structure that influences expression of many genes YMR080C NAM7 1.3 16 3.1 0.6294 0.438581489 iYMR080C 0.410139048 0.861608652 0.164832285 NAM7 -- mRNA decay -- involved with Nmd2p and Upf3p in decay of mRNA containing nonsense codons YIL074C SER33 1.2 14 3.1 0.6294 0.367654201 iYIL074C 0.522404123 0.812051077 0.516771488 SER33 -- serine biosynthesis -- 3-phosphoglycerate dehydrogenaseinvolved in synthesis of serine from 3-phosphoglycerate YLR089C YLR089C 1.2 15 3.1 0.6294 0.302605884 iYLR089C 0.026699819 0.833901884 0.14679503 YLR089C -- unknown -- Putative mitochondrial alanine aminotransferase YNL155W YNL155W 1.2 14 3.1 0.6294 0.775142263 iYNL156C 0.493966305 0.888253303 0.59587496 YNL155W -- unknown -- unknown function YNR020C YNR020C 1.2 15 3.1 0.6294 0.049333458 iYNR020C 0.489209578 0.310022559 0.41106818 YNR020C -- unknown -- unknown function YOR315W YOR315W 1.2 15 3.1 0.6294 0.510690511 iYOR314W 0.537594056 0.44217024 0.733645237 YOR315W -- unknown -- unknown function YPL274W SAM3 1.2 14 3.1 0.6294 0.088994292 iYPL275W-0 iYPL275W-1 0.668815738 0.521744806 0.172056282 0.510831586 0.709865877 "SAM3 -- transport, amino acid -- High affinity S-adenosylmethionine permease, has similarity to Gap1p and other amino acid permeases" YER016W BIM1 1.1 14 3.1 0.6294 0.42435528 iYER015W 0.453159412 0.373774924 0.68443735 "BIM1 -- cytoskeleton -- associated with microtubules, required for a cell cycle check point" YGL114W YGL114W 1.1 14 3.1 0.6294 0.623393289 iYGL115W 0.826048243 0.656864325 0.45004834 YGL114W -- unknown -- member of oligopeptide transporter (OPT) family of membrane transporters YMR300C ADE4 1.1 13 3.1 0.6294 0.681442416 iYMR300C 0.620148935 0.979017527 0.768670209 ADE4 -- purine biosynthesis -- Amidophosphoribosyltransferase (glutamine phosphoribosylpyrophosphate amidotransferase)catalyzes the first step in de novo purine biosynthesis YOR217W RFC1 1.1 14 3.1 0.6294 0.195547289 iYOR216C 0.451985529 0.203914861 0.088489151 RFC1 -- DNA replication -- DNA replication protein RFC large subunit YBL016W FUS3 1 12 3.1 0.6294 0.733702996 iYBL017C 0.413701706 0.925878182 0.443735036 FUS3 -- mating (cell cycle arrest) -- Serine/threonine protein kinase required for cell cycle arrest and for cell fusion during matingmember of MAP kinase family YDR248C YDR248C 1 12 3.1 0.6294 0.310607886 iYDR248C 0.261884708 0.241420591 0.463163231 YDR248C -- unknown -- similarity to E. coli gluconate kinase gntV YGR152C RSR1 1 12 3.1 0.6294 0.480886361 iYGR152C 0.083265828 0.533193515 0.1424703 "RSR1 -- bud site selection -- GTP-binding bud site selection, member of ras family in the ras superfamily" YKL205W LOS1 1 13 3.1 0.6294 0.315654356 iYKL206C 0.349756546 0.479858202 0.251512463 "LOS1 -- tRNA splicing -- Transport receptor for tRNA, member of karyopherin-beta family" YKR099W BAS1 1 12 3.1 0.6294 0.356852022 iYKR098C 0.361025784 0.367438324 0.268611022 "BAS1 -- histidine, adenine biosynthesis -- Transcription factor involved in regulation of basal and induced activity of histidine and adenine biosynthesis genes" YLR088W GAA1 1 12 3.1 0.6294 0.278671461 iYLR087C 0.439511424 0.579495039 0.609893651 "GAA1 -- protein processing -- Probable component, with Gpi8p, of a glycosylphosphatidylinositol (GPI) transamidase involved in the attachment of GPI anchors to proteins" YLR336C SGD1 1 12 3.1 0.6294 0.208476559 iYLR336C YLR337C 0.544703355 0.088850642 0.075043199 0.162124389 0.133447044 SGD1 -- signaling (putative) -- the Hog1p pathway YML108W YML108W 1 12 3.1 0.6294 0.421192777 iYML109W 0.586174366 0.556664006 0.551013277 YML108W -- unknown -- unknown function YPR131C NAT3 1 13 3.1 0.6294 0.97777482 iYPR131C 0.978777689 0.588374451 0.063725095 NAT3 -- protein processing -- N-acetyltransferase YER186C YER186C 0.9 11 3.1 0.6294 0.529425757 iYER186C YERComega1 0.393573506 0.709729267 0.829600387 0.605118078 0.385419238 YER186C -- unknown -- unknown function YNL181W YNL181W 0.9 11 3.1 0.6294 0.358311027 iYNL182C 0.441682709 0.427410901 0.491977923 YNL181W -- unknown -- unknown function YHR127W HSN1 0.8 10 3.1 0.6294 0.284433421 iYHR126C 0.233181345 0.417096358 0.167708685 HSN1 -- unknown -- High-copy allele-specific suppressor SEC4 YLR073C YLR073C 0.8 9 3.1 0.6294 0.651931856 iYLR073C 0.770769463 0.605140187 0.3946116 YLR073C -- unknown -- unknown function YOR073W YOR073W 0.8 9 3.1 0.6294 0.425194951 iYOR072W-0 iYOR072W-1 0.264266341 0.405852804 0.621628093 0.543828553 0.419723969 YOR073W -- unknown -- unknown function YCL025C AGP1 1.8 22 3 0.6195 1 0.710335204 iYCL025C 0.93869021 0.434317638 0.297406905 AGP1 -- transport -- Broad substrate range amino acid permease with high affinity for asparagine and glutamine YLR104W YLR104W 1.2 16 3 0.6195 1 0.961597792 iYLR103C 0.976071294 0.342994807 0.71124718 YLR104W -- unknown -- unknown function YBL020W RFT1 1 13 3 0.6195 1 0.894994051 iYBL021C 0.951460901 0.834879406 0.56473133 RFT1 -- cell cycle -- nuclear division YCR002C CDC10 2.7 34 3 0.6195 0.738489504 iYCR002C 0.598642436 0.960423256 0.68499601 "CDC10 -- cytokinesis -- Septin, component of 10 nm filaments of mother-bud neck, involved in cytokinesis" YLR261C YLR261C 2.2 27.5 3 0.6195 0.335385506 0.522044904 YLR261C -- unknown -- unknown function YNL099C YNL099C 2 24 3 0.6195 0.336404851 iYNL099C 0.27636565 0.427361458 0.160865157 YNL099C -- unknown -- similarity to protein tyrosine phosphatases (PTPs) YDR178W SDH4 1.9 24 3 0.6195 0.41755201 iYDR177W 0.216549244 0.947953593 0.193570929 "SDH4 -- TCA cycle, oxidative phosphorylation -- Membrane anchor subunit in the succinate dehydrogenase complex" YKL135C APL2 1.9 23 3 0.6195 0.590464466 iYKL135C 0.255040976 0.774062251 0.396671173 "APL2 -- secretion -- Beta-adaptin, large subunit of clathrin-associated protein (AP) complex" YPR133C YPR133C 1.9 23 3 0.6195 0.146293888 iYPR133C YPR133W-A 0.384154817 0.664162039 0.093695132 0.12159072 0.454489867 YPR133C -- unknown -- unknown function YBR279W PAF1 1.8 22 3 0.6195 0.099175143 iYBR278W 0.176057333 0.112632936 0.279180447 "PAF1 -- transcription -- associated with RNA polymerase II, involved in positive and negative regulation" YLR069C MEF1 1.8 22 3 0.6195 0.260109329 iYLR069C 0.683339716 0.610482802 0.30838106 "MEF1 -- protein synthesis -- Mitochondrial translation elongation factor G, promotes GTP-dependent translocation of nascent chain from A-site to P-site of ribosome" YPR072W NOT5 1.8 22 3 0.6195 0.44265573 iYPR071W tS(UGA)P 0.845194254 0.838982699 0.418326345 0.835102444 0.277458601 NOT5 -- transcription -- negatively regulates transcription of TATA-less promoters and has similarity to Not3p YGL022W STT3 1.7 22 3 0.6195 0.657673712 iYGL023C 0.050895039 0.588268156 0.105323788 "STT3 -- protein glycosylation -- Oligosaccharyltransferase subunit, member of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif" YKR065C YKR065C 1.7 20 3 0.6195 0.150987433 iYKR065C 0.217607458 0.356026426 0.136403969 YKR065C -- unknown -- unknown function YMR022W UBC7 1.7 22 3 0.6195 0.525765542 iYMR021C 0.481649125 0.850978337 0.601216627 "UBC7 -- protein degradation, ubiquitin-mediated -- Ubiquitin-conjugating enzymeassociates with Ubc6p on the cytoplasmic side of endoplasmic reticulum" YKR038C YKR038C 1.6 19 3 0.6195 0.378786018 iYKR038C itD(GUC)K 0.450800544 0.532839299 0.852763578 0.364201016 0.402483892 YKR038C -- unknown -- similarity to Qri7p and Pasteurella haemolytica glycoproteinase YOL158C ENB1 1.6 19 3 0.6195 0.534220995 iYOL158C 0.614695567 0.448806072 0.68419779 ENB1 -- unknown -- iron uptake via a siderophore enterobactinmember of yeast-specific putative multidrug-resistance family of major facilitator superfamily (MFS) YOR311C YOR311C 1.6 20 3 0.6195 0.132050708 iYOR311C 0.70778073 0.278508772 0.441266516 YOR311C -- unknown -- unknown function YDR105C YDR105C 1.5 17 3 0.6195 0.490111212 iYDR105C 0.173825663 0.823396713 0.19479385 YDR105C -- unknown -- unknown function YBL017C PEP1 1.3 16 3 0.6195 0.408128387 iYBL017C 0.413701706 0.416440385 0.443735036 PEP1 -- vacuolar protein targeting -- Receptor for vacuolar sorting of carboxypeptidase Y and soluble vacuolar proteins YGR074W SMD1 1.3 17 3 0.6195 0.405553004 0.61198381 "SMD1 -- mRNA splicing -- Spliceosomal snRNA-associated Sm core protein, also associated with telomerase TLC1 RNA" YJL140W RPB4 1.3 17 3 0.6195 0.203241008 iYJL141C 0.289284931 0.11845218 0.386303138 "RPB4 -- transcription -- RNA polymerase II, fourth-largest subunit (B32), non-essential subunit that confers stress tolerance" YNL090W RHO2 1.3 16 3 0.6195 0.499550057 iYNL091W 0.319710264 0.739692464 0.364324847 "RHO2 -- signaling -- GTP-binding protein, member of rho family in the ras superfamily" YGR276C RNH70 1.2 15 3 0.6195 0.293600182 iYGR276C 0.454766867 0.75445898 0.049387689 "RNH70 -- DNA replication (putative) -- Ribonuclease H (70 kDa), endonuclease that degrades RNA in RNA-DNA hybrids" YJR014W YJR014W 1.2 16 3 0.6195 0.304884869 iYJR013W 0.324848573 0.066520468 0.007340486 YJR014W -- unknown -- similarity to human DENR/DRP density-regulated protein YKL167C MRP49 1.2 15 3 0.6195 0.831470815 iYKL167C 0.088177816 0.8851335 0.159681611 "MRP49 -- protein synthesis -- Mitochondrial ribosomal large subunit," YKL174C YKL174C 1.2 16 3 0.6195 0.583145333 iYKL174C 0.216426942 0.259856345 0.080925778 YKL174C -- unknown -- similarity to Hnm1p and other permeases YKR002W PAP1 1.2 15 3 0.6195 0.226168315 iYKR001C 0.50700822 0.342755036 0.715920077 "PAP1 -- mRNA polyadenylation -- Poly(A) polymerase, required for mRNA 3' end formation, has a poorly conserved RNA recognition (RRM) domain" YKR056W TRM2 1.2 16 3 0.6195 0.884862472 iYKR055W 0.389944763 0.876424349 0.29737351 TRM2 -- unknown -- Uridine methyltransferase that catalyzes the formation of ribothymidine at position 54 in cytoplasmic and mitochondrial tRNA YLR459W CDC91 1.2 15 3 0.6195 0.541117874 iYLR458W 0.351285712 0.782407407 0.623619233 CDC91 -- unknown -- unknown function YOR002W ALG6 1.2 16 3 0.6195 0.270771069 iYOR001W 0.421979259 0.660742204 0.552794022 ALG6 -- protein glycosylation -- Glucosyltransferase involved in the synthesis of dolichol-linked oligosaccharide precursor YPL023C MET12 1.2 15 3 0.6195 0.269163837 iYPL023C 0.082992882 0.518449887 0.068240413 "MET12 -- methionine biosynthesis -- Methylenetetrahydrofolate reductase (MTHFR), involved in methionine biosynthesis" YPL210C SRP72 1.2 16 3 0.6195 0.443758107 iYPL210C 0.464348558 0.484916201 0.399371576 SRP72 -- secretion -- Signal recognition particle subunit YDR116C YDR116C 1.1 14 3 0.6195 0.172457044 iYDR116C 0.145983477 0.44942348 0.546130449 YDR116C -- unknown -- similarity to prokaryotic ribosomal protein L1 YDR275W YDR275W 1.1 13 3 0.6195 0.860695168 iYDR274C 0.440126783 0.770831653 0.306606962 YDR275W -- unknown -- unknown function YGL213C SKI8 1.1 14 3 0.6195 0.528102243 iYGL213C 0.412285552 0.870731507 0.318315788 "SKI8 -- meiosis, recombination -- meiotic recombination and in protection from double-stranded RNA (dsRNA) virusesmember of WD (WD-40) repeat family" YJL061W NUP82 1.1 13 3 0.6195 0.388864175 iYJL062W 0.823377044 0.522719948 0.218276137 NUP82 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin)required for export of poly(A)+ RNA YJR088C YJR088C 1.1 13 3 0.6195 0.887719336 iYJR088C 0.19652921 0.955155106 0.41833807 YJR088C -- unknown -- unknown function YNL291C MID1 1.1 14 3 0.6195 0.494942119 iYNL291C 0.413980677 0.529165324 0.225458899 MID1 -- transport -- Putative Ca2+ channel component YKL019W RAM2 1 12 3 0.6195 0.615321055 iYKL020C 0.078888847 0.794947617 0.282836864 "RAM2 -- protein processing -- farnesyltransferase, alpha subunit, shared between farnesyltransferase (FTase) and geranylgeranyltransferase type I (GGTase I)" YPL146C YPL146C 1 13 3 0.6195 0.144014261 iYPL146C 0.670104794 0.222634508 0.706761006 YPL146C -- unknown -- unknown function YJR112W NNF1 0.9 11 3 0.6195 0.145784687 iYJR111C 0.559054504 0.301321302 0.509708549 NNF1 -- mitosis -- nuclear envelope required for proper nuclear morphology and nuclear migration during mitosis YLL004W ORC3 0.9 11 3 0.6195 0.571657188 iYLL005C 0.274780931 0.7691402 0.42514363 "ORC3 -- DNA replication -- Origin recognition complex (ORC), 62 kDa subunit" YMR259C YMR259C 0.9 11 3 0.6195 0.174207775 iYMR259C 0.540749013 0.4663869 0.81556265 "YMR259C -- unknown -- unknown function, has a peroxisomal targeting signal" YMR312W YMR312W 0.9 12 3 0.6195 0.35762419 iYMR311C 0.378471088 0.540529565 0.386480825 YMR312W -- unknown -- unknown function YOL056W GPM3 0.9 11 3 0.6195 0.223895458 iYOL057W 0.640142125 0.207439896 0.483285417 GPM3 -- glycolysis -- Phosphoglycerate mutasehas similarity to Gpm1p and Gpm2p YPL172C COX10 0.9 11 3 0.6195 0.469128517 iYPL172C 0.63337525 0.727886119 0.681649206 COX10 -- respiration -- Farnesyl transferase required for heme A synthesis YAL046C YAL046C 0.8 10 3 0.6195 0.750040473 iYAL046C 0.496752983 0.792535706 0.54993241 YAL046C -- unknown -- unknown function YBL028C YBL028C 0.8 10 3 0.6195 0.956253361 iYBL028C 0.982135054 0.866493225 0.831935709 YBL028C -- unknown -- unknown function YEL032W MCM3 0.8 9 3 0.6195 0.646100575 itS(AGA)E 0.097325317 0.594135802 0.007824474 "MCM3 -- DNA replication -- Member of MCM/P1 family, part of MCM complex that assembles at ARS elements to initiate replication" YLR437C YLR437C 1.5 18 2.9 0.6083 1 0.919657581 iYLR437C 0.969247087 0.118250752 0.169567421 YLR437C -- unknown -- unknown function YNL216W RAP1 0.9 12 2.9 0.6083 1 0.921957156 iYNL217W 0.970484452 0.925925926 0.164849021 "RAP1 -- transcription -- DNA-binding repressor and activator activities, also involved in silencing at telomeres and silent mating type loci" YLR248W RCK2 2.8 35 2.9 0.6083 0.593171811 iYLR247C 0.104758594 0.742265549 0.229046975 RCK2 -- unknown -- Calcium/calmodulin-dependent serine/threonine protein kinase (CaM kinase) YDL235C YPD1 2 26 2.9 0.6083 0.605688718 iYDL235C 0.423779953 0.348471404 0.246430588 YPD1 -- signaling -- Phosphorelay proteinfunctions between Sln1p and Ssk1p in a two-component system in the high-osmolarity sensing MAP kinase pathway YGL238W CSE1 1.7 21 2.9 0.6083 0.646275727 0.718498228 "CSE1 -- mitosis, chromosome segregation -- Karyopherin-beta involved in the nuclear export of karyopherin-alpha, possible kinetochore interacts with centromeric element CDEII" YOR008C SLG1 1.7 22 2.9 0.6083 0.176063454 iYOR008C 0.462360716 0.219891909 0.473985642 "SLG1 -- signaling, stress response and cell wall integrity -- Plasma membrane maintenance of cell wall integrity and for the stress response during vegetative growth" YBR173C UMP1 1.6 20 2.9 0.6083 0.190841342 iYBR173C 0.210537106 0.415646149 0.057504873 "UMP1 -- protein degradation, ubiquitin-mediated -- Proteasome maturation factorchaperone involved in proteasome assembly" YDR135C YCF1 1.5 18 2.9 0.6083 0.524901086 iYDR135C 0.776735094 0.295248078 0.635040402 "YCF1 -- transport -- Vacuolar glutathione S-conjugate transporter, member of ATP-binding cassette (ABC) superfamily" YER064C YER064C 1.5 19 2.9 0.6083 0.784458339 iYER064C 0.676218817 0.645882068 0.841927167 "YER064C -- unknown -- similarity to members of a putative transporter family that includes Ybr089p, Yer064p, Yer119p, Yil088p, Ykl146p, and Ynl101p" YJL042W MHP1 1.5 18 2.9 0.6083 0.296584559 iYJL043W 0.67781985 0.437444543 0.196718648 "MHP1 -- cytoskeleton -- Microtubule-interacting protein, related functionally to Drosophila 250 kDa microtubule-associated protein" YPL204W HRR25 1.5 19 2.9 0.6083 0.337976493 0.197030778 HRR25 -- DNA repair -- Casein kinase I (serine/threonine/tyrosine protein kinase) involved in DNA repair and meiosis YBR133C HSL7 1.3 17 2.9 0.6083 0.307373212 0.786819207 HSL7 -- cell cycle -- Negative regulatory Swe1p protein kinase YDR016C DAD1 1.3 17 2.9 0.6083 0.199212155 iYDR016C 0.095423351 0.174029555 0.182004265 DAD1 -- unknown -- unknown function YDR507C GIN4 1.3 17 2.9 0.6083 0.420949723 iYDR507C 0.241873139 0.511971269 0.095310989 "GIN4 -- cell cycle (growth inhibitor) -- Serine/threonine-protein kinase required for septin organization at the bud neck, has similarity to Ycl024p" YER125W RSP5 1.3 17 2.9 0.6083 0.488971109 iYER124C 0.435684358 0.890461216 0.410598206 "RSP5 -- protein degradation, ubiquitin-mediated -- Ubiquitin-protein ligase" YGR009C SEC9 1.3 17 2.9 0.6083 0.415661832 iYGR009C 0.360322167 0.709797679 0.34660814 SEC9 -- secretion -- Component of a t-SNARE complex on the plasma membraneinvolved in vesicle docking and secretion YJR161C COS5 1.3 18 2.9 0.6083 0.932827277 iYJR161C 0.995868141 0.681245012 0.364116309 COS5 -- unknown -- Member of COS family of subtelomerically-encoded proteins YMR189W GCV2 1.3 17 2.9 0.6083 0.629236182 iYMR188C 0.142510098 0.829278118 0.229938272 "GCV2 -- amino acid metabolism -- Glycine decarboxylase pyridoxal phosphate containing P subunit (glycine cleavage P protein), functions in the pathway for glycine degradation" YMR303C ADH2 1.3 17 2.9 0.6083 0.677362934 iYMR303C 0.394199571 0.521036387 0.352582846 "ADH2 -- glycolysis -- Alcohol dehydrogenase II, oxidizes ethanol to acetaldehydeexpression is repressed by glucose" YOR226C ISU2 1.3 17 2.9 0.6083 0.315232103 iYOR226C 0.085332463 0.415610786 0.085670835 ISU2 -- iron homeostasis -- similarity to iron-sulfur cluster nitrogen fixation proteins YPL026C SHA3 1.3 17 2.9 0.6083 0.202640776 iYPL026C 0.223198207 0.067278532 0.254981044 SHA3 -- glucose transport (putative) -- Serine/threonine protein kinase that suppresses the growth defect of snf3 mutants on low glucose YEL047C YEL047C 1.2 16 2.9 0.6083 0.373979092 iYEL047C 0.825984537 0.680526736 0.567505914 YEL047C -- unknown -- Cytoplasmic soluble fumarate reductase YER020W GPA2 1.2 16 2.9 0.6083 0.511786399 iYER019C-A 0.30579423 0.846761199 0.717128585 GPA2 -- signaling -- Guanine nucleotide-binding protein alpha subunit involved in regulation of cAMP pathway YER063W THO1 1.2 17 2.9 0.6083 0.616126698 iYER062C 0.413223122 0.798568255 0.568240413 THO1 -- transcription (putative) -- suppresses hpr1 mutation YGR005C TFG2 1.2 17 2.9 0.6083 0.291342588 iYGR005C 0.475248393 0.35081068 0.904879454 "TFG2 -- transcription -- RNA polymerase II transcription initiation factor TFIIF (factor g)54 kDa subunit, component of RNA polymerase holoenzyme complex" YMR033W ARP9 1.2 16 2.9 0.6083 0.600319034 iYMR032W 0.547467838 0.817536501 0.564776023 "ARP9 -- cytoskeleton (putative) -- Component of SWI-SNF global transcription activator complex and RSC chromatin remodeling complex, acts to assist gene-specific activators through chromatin remodeling" YNL048W ALG11 1.2 16 2.9 0.6083 0.190788409 iYNL049C 0.304094532 0.483122426 0.434789764 ALG11 -- protein glycosylation -- N-linked oligosaccharide assembly YPR188C YPR188C 1.2 16 2.9 0.6083 0.152663753 iYPR188C 0.432707104 0.388268156 0.540050012 YPR188C -- unknown -- similarity to calmodulin and calmodulin-related proteins YCR057C 1.1 15 2.9 0.6083 0.514782751 iYCR057C 0.516900673 0.669378866 0.559856345 YDL002C NHP10 1.1 15 2.9 0.6083 0.096961692 iYDL002C 0.59180924 0.082259104 0.447608292 NHP10 -- chromatin structure -- Probable DNA-binding n HMG-box DNA-binding domain YER080W YER080W 1.1 15 2.9 0.6083 0.884197231 iYER079W 0.611512498 0.960716302 0.461778985 YER080W -- unknown -- unknown function YHR076W YHR076W 1.1 15 2.9 0.6083 0.370966335 iYHR075C 0.31943465 0.527194931 0.271269739 YHR076W -- unknown -- unknown function YHR187W IKI1 1.1 14 2.9 0.6083 0.322081917 iYHR186C 0.474843113 0.196902476 IKI1 -- killer toxin sensitivity -- sensitivity to pGKL killer toxin YJL041W NSP1 1.1 15 2.9 0.6083 0.481543556 iYJL042W 0.654259722 0.34839074 0.494173982 NSP1 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) with XFXFG motifs YLR090W XDJ1 1.1 15 2.9 0.6083 0.143165838 iYLR089C 0.026699819 0.308479532 0.14679503 XDJ1 -- unknown -- Homolog of E. coli DnaJ YLR241W YLR241W 1.1 14 2.9 0.6083 0.234881535 iYLR240W 0.283954627 0.757716049 0.259783368 YLR241W -- unknown -- unknown function YLR405W YLR405W 1.1 14 2.9 0.6083 0.749460664 iYLR404W 0.903404396 0.835596149 0.795037061 YLR405W -- unknown -- unknown function YGR001C YGR001C 1 12.5 2.9 0.6083 0.536157199 iYGR001C 0.173002585 0.862729449 0.215517241 YGR001C -- unknown -- unknown function YIL110W YIL110W 1 12 2.9 0.6083 0.411519399 iYIL111W 0.504532945 0.94243536 YIL110W -- unknown -- unknown function YJR057W CDC8 1 12 2.9 0.6083 0.913342595 iYJR056C itY(GUA)J2 0.084391002 0.628386515 0.704708699 0.034723936 0.417197709 CDC8 -- DNA replication -- Thymidylate kinase involved in dTTP biosynthesis pathway YJR100C YJR100C 1 13 2.9 0.6083 0.424050677 iYJR100C itL(UAG)J 0.694910399 0.565460757 0.598293042 0.649109015 0.506284241 "YJR100C -- unknown -- unknown function, has similarity to mouse TRA1/NOR1 proteins" YOL052C SPE2 1 13 2.9 0.6083 0.72581191 iYOL052C 0.724410666 0.666747888 0.5896249 "SPE2 -- polyamine metabolism -- S-adenosylmethionine decarboxylase, post-translationally cleaved into alpha and beta chains" YPR008W YPR008W 1 13 2.9 0.6083 0.604137442 iYPR007C YPRCdelta13 0.517242556 0.542050384 0.378589649 0.255147646 0.43485975 YPR008W -- unknown -- similarity to Cup2p and Candida albicans metal-activated transcription factor Amt1p YPR109W YPR109W 1 12 2.9 0.6083 0.786083543 iYPR108W tT(UGU)P 0.58354759 0.788126062 0.873700455 0.699000967 0.467039106 YPR109W -- unknown -- unknown function YDL063C YDL063C 0.9 12 2.9 0.6083 0.748848526 0.838365717 YDL063C -- unknown -- unknown function YDR517W GRH1 0.9 11 2.9 0.6083 0.715497622 iYDR516C 0.247189943 0.807363841 0.383963862 "GRH1 -- unknown -- Component of spindle checkpoint, has similarity to mammalian GRASP proteins" YGR047C TFC4 0.9 11 2.9 0.6083 0.279991647 iYGR047C 0.40001728 0.730821973 0.411456573 "TFC4 -- transcription -- RNA polymerase transcription III initiation factor TFIIIC (tau), 131 kDa subunit, has 11 tetratricopeptide (TPR) repeats" YKL014C YKL014C 0.9 12 2.9 0.6083 0.459408418 iYKL014C 0.40498234 0.539961328 0.780293265 YKL014C -- unknown -- unknown function YMR263W YMR263W 0.9 11 2.9 0.6083 0.236112228 iYMR262W 0.814850668 0.122685757 0.669403064 YMR263W -- unknown -- Component of Rpd3p-Sin3p histone deacetylase complex YBL107C YBL107C 0.8 10 2.9 0.6083 0.576378947 iYBL107C 0.753636949 0.731243663 0.331006183 YBL107C -- unknown -- unknown function YDL150W RPC53 0.8 10 2.9 0.6083 0.152907429 0.197206704 "RPC53 -- transcription -- RNA polymerase III, fourth-largest essential subunit (C53)" YGR251W YGR251W 0.8 10 2.9 0.6083 0.190955291 iYGR250C-0 iYGR250C-1 0.290386629 0.47485632 0.170802449 0.426554812 0.745011971 YGR251W -- unknown -- unknown function YHR062C RPP1 0.8 9 2.9 0.6083 0.555077444 iYHR062C 0.271283696 0.845365814 0.194732642 "RPP1 -- rRNA and tRNA processing -- Subunit of RNase P and RNase MRP ribonucleoprotein particles, which are needed for tRNA processing and 5.8S rRNA processing, respectively" YIL019W YIL019W 0.8 10 2.9 0.6083 0.989599035 iYIL020C 0.853729617 0.173068534 0.259336936 "YIL019W -- unknown -- unknown function, has potential coiled-coil region" YML061C PIF1 0.8 11 2.9 0.6083 0.597798654 iYML061C 0.772122532 0.440509801 0.77956816 "PIF1 -- DNA repair, mitochondrial -- Single-stranded DNA-dependent ATPase and 5'-3' DNA helicase required for maintenance and repair of mitochondrial DNA, also functions in nucleus to regulate telomere length" YPL066W YPL066W 0.8 11 2.9 0.6083 0.228957004 iYPL067C 0.474620106 0.026700008 0.53264166 YPL066W -- unknown -- unknown function YOR179C YOR179C 0.7 9 2.9 0.6083 0.359095483 iYOR179C-0 iYOR179C-1 0.773918963 0.952104741 0.245944576 0.681132532 0.168385433 YOR179C -- unknown -- similarity to Ysh1p YEL071W DLD3 1.6 21 2.8 0.5951 1 0.617478746 iYEL072W-0 iYEL072W-1 0.952496383 0.715987017 0.863926576 0.973586769 0.668627135 DLD3 -- unknown -- D-lactate dehydrogenase YOR043W WHI2 1.2 16 2.8 0.5951 1 0.860692893 iYOR042W SNR62 0.822757653 0.751633453 0.599174936 0.65408805 WHI2 -- cell size -- growth regulation YIL121W YIL121W 0.8 10 2.8 0.5951 1 0.893011028 iYIL122W 0.935970555 0.946922643 0.59187032 YIL121W -- unknown -- Member of multidrug-resistance 12-spanner family of major facilitator superfamily (MFS-MDR) YBR126C TPS1 2.8 38 2.8 0.5951 0.554554096 iYBR126C 0.235298098 0.713923829 0.256758078 "TPS1 -- trehalose metabolism -- Trehalose-6-phosphate synthase, component of trehalose-6-phosphate synthase/phosphatase complex" YJR117W STE24 2 27 2.8 0.5951 0.424843163 iYJR116W 0.379675605 0.690892958 0.177322472 STE24 -- protein processing -- Prenyl-dependent protease involved both in the first N-terminal proteolytic step and in C-terminal CAAX processing of a-factor YNL006W LST8 2 28 2.8 0.5951 0.626443512 iYNL007C 0.692632051 0.873437122 0.474415205 LST8 -- secretion -- transport of permeases from the Golgi to the plasma membrane YKR039W GAP1 1.9 25 2.8 0.5951 0.2528747 iYKR038C itD(GUC)K 0.450800544 0.532839299 0.746777312 0.364201016 0.402483892 "GAP1 -- transport -- General amino acid permease, proton symport transporter for all naturally-occuring L-amino acids, 4-aminobutyric acid (GABA), ornithine, citrulline, some D-amino acids, and some toxic analogs" YFL057C YFL057C 1.8 24 2.8 0.5951 0.739771543 0.742537909 "YFL057C -- unknown -- Putative aryl alcohol dehydrogenase, may participate in late steps of degradation of aromatic compounds that arise from the degradation of lignocellulose" YER090W TRP2 1.7 22 2.8 0.5951 0.589420492 iYER089C 0.553514023 0.79113541 0.663712536 TRP2 -- tryptophan biosynthesis -- Component I of anthranilate synthase YGR232W YGR232W 1.7 22 2.8 0.5951 0.879854569 iYGR231C 0.393658637 0.922735127 0.522465113 YGR232W -- unknown -- unknown function YPL053C KTR6 1.7 22 2.8 0.5951 0.280641271 iYPL053C 0.378822831 0.466564491 0.4562704 KTR6 -- protein glycosylation -- Mannosyltransferase of KRE2 family YNR076W PAU6 1.6 21 2.8 0.5951 0.928759267 iYNR075W 0.885073449 0.437118563 0.192548158 PAU6 -- unknown -- Member of seripauperin (PAU) family (YLL064C and PAU6 code for identical proteins) YKL007W CAP1 1.5 20 2.8 0.5951 0.702094142 iYKL008C 0.767560673 0.696422817 0.790191175 "CAP1 -- cytoskeleton -- Actin-capping protein, alpha subunit" YLR314C CDC3 1.5 19 2.8 0.5951 0.134092447 iYLR314C 0.543653259 0.127773344 0.495926434 "CDC3 -- cytokinesis -- Septin, component of 10 nm filaments of mother-bud neckinvolved in cytokinesis" YPL179W SAL6 1.5 19 2.8 0.5951 0.118852181 iYPL180W 0.548708509 0.133473096 0.404389465 SAL6 -- translational regulation -- Protein serine/threonine phosphatase involved in regulation of protein synthesismember of PPP family of protein phosphatases and related to PP1 phosphatases YPL232W SSO1 1.5 19 2.8 0.5951 0.441134826 iYPL233W 0.251966648 0.315251572 0.247718824 SSO1 -- secretion -- Syntaxin homolog (t-SNARE) involved in vesicle transport from Golgi to plasma membrane YBR198C TAF90 1.3 18 2.8 0.5951 0.414411216 iYBR198C 0.328981648 0.243502274 0.381243957 "TAF90 -- transcription -- Component of TAF(II) complex (TBP-associated protein complex) and SAGA complex (Spt-Ada-Gcn5-acetyltransferase)required for activated transcription by RNA polymerase II, member of WD (WD-40) repeat family" YDL074C YDL074C 1.3 17 2.8 0.5951 0.595834754 iYDL074C 0.417592839 0.508137286 0.772719948 "YDL074C -- unknown -- Putative coiled-coil protein, has similarity to human EEA1, an early endosome antigen" YFR037C RSC8 1.3 17 2.8 0.5951 0.297226783 iYFR037C 0.176896704 0.368448637 0.15412504 RSC8 -- chromatin structure -- Component of abundant chromatin remodeling complex (RSC) YGL252C RTG2 1.3 18 2.8 0.5951 0.419172644 iYGL252C 0.049700502 0.515470798 "RTG2 -- interorganelle communication -- inter-organelle communication between mitochondria, peroxisomes, and nucleus" YGR147C NAT2 1.3 18 2.8 0.5951 0.75094461 iYGR147C 0.702170767 0.732942233 0.524481729 NAT2 -- protein processing -- N-acetyltransferase for N-terminal methionine YHR103W SBE22 1.3 17 2.8 0.5951 0.351439706 iYHR102W 0.376906482 0.502427384 0.271348763 SBE22 -- bud growth -- bud growth YKR030W YKR030W 1.3 17 2.8 0.5951 0.457951259 iYKR029C 0.20933946 0.597047087 0.48262402 YKR030W -- unknown -- unknown function YML121W GTR1 1.3 17 2.8 0.5951 0.474192239 iYML122C 0.463110053 0.488932072 0.291814373 GTR1 -- phosphate transport -- GTP-binding the function of Pho84p phosphate transporter YAL008W YAL008W 1.2 16 2.8 0.5951 0.439636275 iYAL009W 0.258881422 0.448284118 0.251754457 YAL008W -- unknown -- unknown function YBR177C EHT1 1.2 16 2.8 0.5951 0.696137053 0.803258455 EHT1 -- unknown -- Alcohol acyl transferase YGL035C MIG1 1.2 16 2.8 0.5951 0.467090316 iYGL035C 0.156069949 0.549548824 0.314572534 "MIG1 -- glucose repression -- Zinc-finger transcriptional repressor involved in glucose-repression, has two tandem C2H2-type zinc fingers, has similarity to mammalian Sp1, Krox/Egr, and Wilms tumor proteins" YHR192W YHR192W 1.2 16 2.8 0.5951 0.465504496 iYHR191C 0.640907806 0.888320338 0.417278374 YHR192W -- unknown -- unknown function YKL110C KTI12 1.2 16 2.8 0.5951 0.381800025 iYKL110C-0 iYKL110C-1 0.291102111 0.279584621 0.862523303 0.805426975 0.236923327 KTI12 -- killer toxin resistance -- resistance to Kluyveromyces lactis killer toxin YKR001C VPS1 1.2 17 2.8 0.5951 0.541614213 iYKR001C 0.50700822 0.740734773 0.715920077 "VPS1 -- vacuolar protein targeting -- Vacuolar sorting protein, member of dynamin family of GTPases" YDL116W NUP84 1.1 15 2.8 0.5951 0.739463133 iYDL117W 0.707861206 0.324679831 0.613575933 NUP84 -- nuclear protein targeting -- Nuclear pore protein YDR121W DPB4 1.1 14 2.8 0.5951 0.213621312 iYDR120C 0.18605031 0.143256185 0.173866535 DPB4 -- DNA replication -- Protein subunit (29 kDa) of DNA Polymerase epsilon (Polymerase II) YDR140W YDR140W 1.1 14 2.8 0.5951 0.062475303 iYDR139C 0.149855978 0.147288735 0.235324948 YDR140W -- unknown -- motif characteristic of S-adenosylmethionine-dependent methyltransferases YDR281C PHM6 1.1 15 2.8 0.5951 0.687915668 iYDR281C 0.317192048 0.499930147 0.736226506 "PHM6 -- unknown -- unknown function, has a role in phosphate metabolism" YER005W YND1 1.1 14 2.8 0.5951 0.640787104 iYER004W 0.564865312 0.453109158 0.643883069 "YND1 -- protein glycosylation (putative) -- Membrane-bound apyrase (nucleotide diphosphatase) required for N-linked and O-linked glycosylation, has similarity to Gda1p" YER019W YER019W 1.1 14 2.8 0.5951 0.444006753 iYER018C 0.128924161 0.847269419 0.040566115 "YER019W -- unknown -- moderate similarity to mammalian neutral sphingomyelinases, has motifs typical of ATP/GTP-binding sites" YER099C PRS2 1.1 14 2.8 0.5951 0.805245265 iYER099C 0.428307329 0.884421702 0.632472385 "PRS2 -- purine biosynthesis -- Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase), synthesizes phosphoribosylpyrophosphate (PRPP) from ribose-5' phosphate and ATP" YGR165W YGR165W 1.1 15 2.8 0.5951 0.63467821 itR(UCU)G2 0.399599412 0.82020953 0.389852384 YGR165W -- unknown -- unknown function YHR001W YHR001W 1.1 15 2.8 0.5951 0.745724642 iYHL001W CEN8 0.638889896 0.656293594 0.829439252 0.409050577 0.40911709 YHR001W -- unknown -- similarity to Ykr003p and members of oxysterol-binding protein family YLR018C YLR018C 1.1 15 2.8 0.5951 0.475456136 iYLR018C 0.434846148 0.522616609 0.398004789 YLR018C -- unknown -- Component of nuclear pore complex (nucleoporin) YMR208W ERG12 1.1 15 2.8 0.5951 0.323624061 iYMR207C 0.264869031 0.787367912 0.654106117 "ERG12 -- sterol metabolism -- Mevalonate kinase, generates mevalonate-5-phosphate from mevalonate" YNL163C YNL163C 1.1 14 2.8 0.5951 0.531468825 iYNL163C 0.976840993 0.591927167 0.86632083 YNL163C -- protein synthesis -- Translation elongation factor EF4 YBR070C SAT2 1 13 2.8 0.5951 0.401317581 iYBR070C 0.264988322 0.487471074 0.193272566 SAT2 -- stress response -- osmotolerance YDR498C SEC20 1 13 2.8 0.5951 0.597294095 iYDR498C 0.33257907 0.782105441 0.110429943 "SEC20 -- secretion -- Secretory pathway transport of proteins from ER to Golgicontains C-terminal HDEL motif, unusual for a membrane protein" YER113C YER113C 1 14 2.8 0.5951 0.691044553 iYER113C 0.221784776 0.927374302 0.157992565 YER113C -- unknown -- similarity to Emp70p YFL009W CDC4 1 14 2.8 0.5951 0.495713414 iYFL010C 0.611762802 0.779569034 0.669221492 "CDC4 -- cell cycle -- F-box protein and component of SCF-Cdc4p complex (Skp1p-Cdc53p-Cdc34p-Cdc4p) which targets Sic1p, Far1p, Cdc6p, Ctf13p and Gcn4p for ubiquitin-dependent degradation, has WD (WD-40) repeats" YGL111W YGL111W 1 13 2.8 0.5951 0.441372351 iYGL112C 0.161083016 0.481562703 0.154769578 YGL111W -- unknown -- unknown function YJL184W YJL184W 1 13 2.8 0.5951 0.141454068 iYJL185C 0.369670928 0.226283301 0.504548408 YJL184W -- unknown -- unknown function YKL074C MUD2 1 14 2.8 0.5951 0.153039576 iYKL074C 0.190215616 0.310908798 0.099903319 "MUD2 -- mRNA splicing -- involved early in pre-mRNA splicing, has one degenerate RNA recognition (RRM) domain" YNR022C YNR022C 1 13 2.8 0.5951 0.284904757 iYNR022C 0.472748721 0.728074773 0.259115035 YNR022C -- unknown -- unknown function YPL195W APL5 1 14 2.8 0.5951 0.521069976 iYPL196W 0.530756873 0.652835965 0.245246536 "APL5 -- vacuolar protein targeting -- Delta-adaptin, large subunit of clathrin-associated protein (AP) complex" YGL139W YGL139W 0.9 12 2.8 0.5951 0.358474767 iYGL140C 0.545811635 0.371513207 0.261612131 YGL139W -- unknown -- unknown function YIL104C YIL104C 0.9 12 2.8 0.5951 0.205937547 iYIL104C 0.554071556 0.558659218 0.568012842 YIL104C -- unknown -- unknown function YIL152W YIL152W 0.9 12 2.8 0.5951 0.276269806 iYIL153W 0.641212022 0.377554458 0.237307661 YIL152W -- unknown -- unknown function YJL098W SAP185 0.9 12 2.8 0.5951 0.530563037 iYJL099W 0.496184864 0.838382211 0.348211408 SAP185 -- cell cycle -- associates with and contributes to function of protein phosphatase Sit4p YJL128C PBS2 0.9 12 2.8 0.5951 0.792596265 iYJL128C-0 iYJL128C-1 0.28909649 0.370038461 0.880013286 0.465975479 0.486327337 PBS2 -- signaling -- MAP kinase kinase (MEK) activated by high osmolarity through the Sln1p-Ypd1p-Ssk1p two-component osmosensor and the Sho1p osmosensor YJL208C NUC1 0.9 12 2.8 0.5951 0.22322045 iYJL208C 0.067498707 0.499712005 0.085423893 "NUC1 -- mitochondrial recombination -- Nuclease with both DNase and RNase activity, major nuclease of mitochondria" YLR290C YLR290C 0.9 12 2.8 0.5951 0.617504093 iYLR290C 0.865114883 0.65325434 0.786838251 YLR290C -- unknown -- unknown function YLR348C DIC1 0.9 12 2.8 0.5951 0.639736572 0.776536313 "DIC1 -- transport -- Mitochondrial dicarboxylate transport protein, member of mitochondrial carrier family" YOL007C CSI2 0.9 12 2.8 0.5951 0.288848914 iYOL007C 0.231786998 0.321438621 0.119303057 CSI2 -- cell wall biogenesis -- chitin synthesis YDR097C MSH6 0.8 11 2.8 0.5951 0.211504893 iYDR097C 0.527453675 0.627170246 0.635434956 MSH6 -- DNA repair -- Component with Msh2p of DNA mismatch binding factorinvolved in repair of single base mismatches YGR017W YGR017W 0.8 11 2.8 0.5951 0.444574407 iYGR016W 0.727722649 0.516919111 0.824016853 YGR017W -- unknown -- unknown function YKL214C YKL214C 0.8 11 2.8 0.5951 0.977060814 iYKL214C 0.430424582 0.407853666 YKL214C -- unknown -- unknown function YOR081C YOR081C 0.8 10 2.8 0.5951 0.191937234 iYOR081C 0.136965044 0.432968095 0.204119183 YOR081C -- unknown -- unknown function YOR288C MPD1 0.8 11 2.8 0.5951 0.410093037 iYOR288C 0.572447103 0.538385584 0.525137826 MPD1 -- protein folding (putative) -- Potential protein disulfide isomerase YJL050W MTR4 0.7 9 2.8 0.5951 0.607040059 iYJL051W 0.433351622 0.42952913 0.072752175 "MTR4 -- mRNA export -- mRNA export from nucleus, member of DEAD-box RNA helicase family" YLR126C YLR126C 0.7 9 2.8 0.5951 0.122108978 iYLR126C 0.792522266 0.255626496 0.576916829 YLR126C -- unknown -- weak similarity to Pseudomonas aeroginosa anthranilate synthase component II YLR256W HAP1 1.1 15 2.7 0.5822 1 0.799147743 iYLR255C 0.923474956 0.526426039 0.12901318 "HAP1 -- transcription -- Transcription factor with heme-dependent DNA-binding activity, responsible for heme-dependent activation of many genes" YOR161C YOR161C 1.1 15 2.7 0.5822 1 0.448973732 iYOR161C 0.973227566 0.435197702 0.308966862 YOR161C -- unknown -- unknown function YCR082W YCR082W 3.6 49 2.7 0.5822 0.511030764 iYCR081W 0.418815099 0.836338532 0.612051077 YCR082W -- unknown -- similarity to Rbk1p YGR137W YGR137W 2.1 29 2.7 0.5822 0.406855172 0.625299282 YGR137W -- unknown -- similarity to tomato extensin PIR YGL195W GCN1 1.9 26 2.7 0.5822 0.55078842 iYGL196W 0.671777585 0.808263452 0.832812304 GCN1 -- protein synthesis -- Component of a protein complex required for activation of Gcn2p protein kinase in response to starvation for amino acids or purines YCR037C PHO87 1.8 24 2.7 0.5822 0.686271832 iYCR037C 0.128437114 0.7378398 0.123590883 PHO87 -- transport -- Member of phosphate permease family of membrane transporters YLL020C YLL020C 1.7 24 2.7 0.5822 0.449874625 0.225457772 YLL020C -- unknown -- unknown function YEL013W VAC8 1.6 21 2.7 0.5822 0.742998219 iYEL014C 0.674067952 0.799600958 0.56691135 VAC8 -- vacuolar protein targeting -- Vacuolar vacuolar inheritance and protein targeting from the cytoplasm to vacuole YIL116W HIS5 1.5 20 2.7 0.5822 0.588602926 iYIL117C 0.359909238 0.98219465 0.423702868 "HIS5 -- histidine biosynthesis -- Histidinol-phosphate aminotransferase (imidazole acetol phosphate aminotransferase), eighth step in histidine biosynthesis pathway" YJL053W PEP8 1.5 20 2.7 0.5822 0.618695947 iYJL054W 0.684485887 0.862004548 0.379285311 PEP8 -- vacuolar protein targeting -- vacuolar targeting YDR477W SNF1 1.3 18 2.7 0.5822 0.514635125 iYDR476C 0.226848083 0.691779729 0.597959352 SNF1 -- glucose derepression -- Serine/threonine protein kinase essential for derepression of glucose-repressed genesacts with Snf4p YIR034C LYS1 1.3 19 2.7 0.5822 0.449098637 iYIR034C 0.498395807 0.55888564 0.203673864 "LYS1 -- lysine biosynthesis -- Saccharopine dehydrogenase (NAD+, L-lysine forming)eighth and last step in lysine biosynthesis pathway" YLL012W YLL012W 1.3 19 2.7 0.5822 0.434252491 iYLL013C 0.224673608 0.711051031 0.171763966 YLL012W -- unknown -- similarity to human triacylglycerol lipase YLL023C YLL023C 1.3 18 2.7 0.5822 0.576712864 iYLL023C 0.493291697 0.742998612 0.668291098 YLL023C -- unknown -- unknown function YOL122C SMF1 1.3 18 2.7 0.5822 0.62069474 iYOL122C 0.71231305 0.701143751 0.899860117 SMF1 -- transport -- High-affinity manganese transporter YDR464W SPP41 1.2 16 2.7 0.5822 0.376376712 iYDR463W 0.591800521 0.243554625 0.354532164 "SPP41 -- splicing -- Suppressor of temperature-sensitive prp3, temperature-sensitive prp4, and prp11, probably a negative regulator of PRP3 and PRP4 gene expression" YHL020C OPI1 1.2 17 2.7 0.5822 0.097088095 iYHL020C 0.248317566 0.414798571 0.274993829 OPI1 -- phospholipid metabolism -- Negative regulator of phospholipid biosynthesis pathway YKL185W ASH1 1.2 17 2.7 0.5822 0.633920082 iYKL186C 0.441512475 0.592338388 0.3896249 "ASH1 -- mating type switching -- GATA-type transcription factor, negative regulator of HO expression localized preferentially in daughter cells" YML081W YML081W 1.2 17 2.7 0.5822 0.30348091 YML081C-A iYML081C-A 0.176107737 0.206755685 0.299629391 0.246938447 0.549788824 "YML081W -- unknown -- similarity to Zms1p and Adr1p, has two tandem C2H2-type zinc fingers" YML101C YML101C 1.2 17 2.7 0.5822 0.358461287 iYML101C 0.352351623 0.422403582 0.365936191 YML101C -- unknown -- unknown function YMR046C 1.2 17 2.7 0.5822 0.876755703 YMR046W-A 0.604311565 0.518637373 0.504389465 YPL105C YPL105C 1.2 16 2.7 0.5822 0.23067562 iYPL105C 0.525070017 0.161512928 0.77047087 YPL105C -- unknown -- similarity to Smy2p YBL079W NUP170 1.1 16 2.7 0.5822 0.597636017 iYBL080C 0.375361259 0.652012584 0.502643533 NUP170 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) with similarity to mammalian Nup155p YCR008W SAT4 1.1 15 2.7 0.5822 0.393400147 iYCR007C tN(GUU)C 0.813106626 0.48500876 0.514764565 0.927712801 0.175819534 SAT4 -- salt tolerance -- Serine/threonine protein kinase involved in sensitivity to salt YDL117W YDL117W 1.1 16 2.7 0.5822 0.679779828 iYDL118W 0.440630415 0.795051875 YDL117W -- unknown -- unknown function YDL164C CDC9 1.1 16 2.7 0.5822 0.318013182 0.355083857 "CDC9 -- DNA replication and repair -- DNA ligase, functions in DNA replication and repair in both the nucleus and mitochondrion" YDR251W PAM1 1.1 15 2.7 0.5822 0.722193174 iYDR250C 0.320325545 0.832540131 0.461582196 "PAM1 -- unknown -- Coiled-coil protein and multicopy suppressor of loss of PP2A (genes PPH21, PPH22, and PPH3)" YDR390C UBA2 1.1 15 2.7 0.5822 0.6462272 iYDR390C tG(CCC)D 0.297868528 0.587893189 0.78098521 0.228970471 0.157780108 "UBA2 -- protein degradation, ubiquitin-mediated -- Subunit of a heterodimeric enzyme consisting of Uba2p and Aos1p, activates the ubiquitin-like Smt3p for conjugation to other proteins" YER082C YER082C 1.1 15 2.7 0.5822 0.45455985 iYER082C 0.478348098 0.479996506 0.239909077 "YER082C -- unknown -- unknown function, has two tandem C2H2-type zinc fingers, has one WD (WD-40) domain" YHR206W SKN7 1.1 15 2.7 0.5822 0.445058308 iYHR205W 0.559389462 0.388414438 0.638114046 "SKN7 -- oxidative stress -- Transcription factor involved in oxidative stress response and G1 cell cycle control, has similarity to response regulator proteins of bacterial two-component systems" YKL062W MSN4 1.1 15 2.7 0.5822 0.42217502 iYKL063C-0 iYKL063C-1 0.450425784 0.905779505 0.706815985 0.213450292 "MSN4 -- transcription -- Zinc-finger transcriptional activator for genes regulated through Snf1p, has strong similarity to Msn2p, has two tandem C2H2-type zinc fingers" YKL076C YKL076C 1.1 15 2.7 0.5822 0.287904932 0.651402501 YKL076C -- unknown -- unknown function YMR093W YMR093W 1.1 16 2.7 0.5822 0.834063866 iYMR092C 0.898791799 0.731444533 0.098850963 "YMR093W -- unknown -- unknown function, has WD (WD-40) repeats" YNL137C NAM9 1.1 15 2.7 0.5822 0.376537752 iYNL137C 0.293057773 0.625935983 0.300748997 NAM9 -- protein synthesis -- Mitochondrial ribosomal small subunitmember of E. coli S4 superfamily YOL014W YOL014W 1.1 15 2.7 0.5822 0.644525126 iYOL015W 0.551540814 0.724451275 0.449403803 YOL014W -- unknown -- unknown function YPL020C ULP1 1.1 15 2.7 0.5822 0.422531225 iYPL020C 0.698381751 0.194173982 0.414205906 "ULP1 -- protein degradation -- Smt3p-specific protease, degrades conjugated ubiquitin-like protein Smt3p" YPL221W BOP1 1.1 16 2.7 0.5822 0.916203855 iYPL222W 0.475029241 0.536534506 0.142845633 BOP1 -- unknown -- unknown function YBR264C YPT10 1 14 2.7 0.5822 0.201257281 iYBR264C 0.458036438 0.60700559 0.58869572 YPT10 -- unknown -- member of rab family in the ras superfamily of small GTP-binding proteins YBR274W CHK1 1 14 2.7 0.5822 0.659779725 iYBR273C 0.401904817 0.943059327 0.643220134 "CHK1 -- cell cycle -- Checkpoint kinase, required for metaphase DNA-damage checkpoint" YER115C SPR6 1 14 2.7 0.5822 0.863867079 iYER115C 0.835146031 0.927148847 0.342491138 SPR6 -- sporulation -- Sporulation-specific protein YGL023C PIB2 1 14 2.7 0.5822 0.321006512 iYGL023C 0.050895039 0.581618843 0.105323788 "PIB2 -- signaling (putative) -- unknown function, has similarity to Fab1p and Vps27p" YGL056C SDS23 1 13 2.7 0.5822 0.306534026 iYGL056C 0.166284433 0.869071753 0.408395102 "SDS23 -- unknown -- Spindle pole body protein, has similarity to S. pombe sds23/moc1" YGL101W YGL101W 1 14 2.7 0.5822 0.745852058 iYGL102C 0.706060111 0.741627582 0.236397432 YGL101W -- unknown -- unknown function YHR191C CTF8 1 14 2.7 0.5822 0.166108361 iYHR191C 0.640907806 0.106743536 0.417278374 CTF8 -- mitosis (putative) -- unknown function YKL138C MRPL31 1 14 2.7 0.5822 0.327867546 iYKL138C 0.06210777 0.544187225 0.064937158 MRPL31 -- protein synthesis -- Mitochondrial ribosomal large subunit YLR036C YLR036C 1 13 2.7 0.5822 0.471500925 iYLR036C 0.273352083 0.480925778 0.448678698 YLR036C -- unknown -- unknown function YLR118C YLR118C 1 14 2.7 0.5822 0.105847183 iYLR118C 0.741149933 0.185916179 0.433814633 YLR118C -- unknown -- similarity to esterases YNL122C YNL122C 1 14 2.7 0.5822 0.699526299 iYNL122C 0.410918526 0.790998107 0.343988182 YNL122C -- unknown -- unknown function YOR048C RAT1 1 14 2.7 0.5822 0.345770401 iYOR048C 0.225596171 0.547601415 0.701150479 "RAT1 -- transcription -- 5'-3' exoribonuclease (exonuclease II), required for efficient nucleocytoplasmic RNA trafficking and for ribosomal RNA processing" YPR097W YPR097W 1 14 2.7 0.5822 0.250223617 iYPR096C 0.314670834 0.139461811 0.127369525 YPR097W -- unknown -- unknown function YAL022C YAL022C 0.9 12 2.7 0.5822 0.620736501 iYAL022C 0.034604874 0.940863033 0.073082197 "YAL022C -- unknown -- similarity to human equilibrative nucleoside transporters, has 11 potential transmembrane domains" YBR083W TEC1 0.9 13 2.7 0.5822 0.270730119 iYBR082C-0 iYBR082C-1 0.691274081 0.237478897 0.444946358 0.624203818 0.865054797 "TEC1 -- pseudohyphal growth -- Transcriptional activator, involved with Ste12p in pseudohyphal formation" YBR243C ALG7 0.9 13 2.7 0.5822 0.433946734 iYBR243C 0.593411041 0.729044834 0.796648045 ALG7 -- protein glycosylation -- UDP-N-acetyl-glucosamine-1-P transferase (GPT)ER transfers GlcNac-P from UDP-GlcNac to Dol-P YDR322W MRPL35 0.9 12 2.7 0.5822 0.42780491 iYDR321W 0.485003143 0.84302935 0.647988151 MRPL35 -- protein synthesis -- Mitochondrial ribosomal large subunit YGR093W YGR093W 0.9 12 2.7 0.5822 iYGR092W 0.820525533 0.633040702 YGR093W -- unknown -- unknown function YKL106W AAT1 0.9 12 2.7 0.5822 0.580577883 iYKL107W 0.73821965 0.955678587 0.657222666 "AAT1 -- aspartate metabolism? -- Putative aspartate aminotransferase, mitochondrial" YPR048W TAH18 0.9 13 2.7 0.5822 0.398332945 iYPR047W 0.473090612 0.76680655 0.292919905 TAH18 -- unknown -- similarity to NAPDH-cytochrome P450 reductase YBR112C SSN6 0.8 11 2.7 0.5822 0.401823621 0.390356291 SSN6 -- transcription -- General repressor of RNA polymerase II transcription that is brought to target promoters by sequence-specific DNA-binding proteinshas tetratricopeptide (TPR) repeats and exists in a complex with Tup1p YIL126W STH1 0.8 11 2.7 0.5822 0.793906354 iYIL127C 0.157529047 0.528756957 0.041300315 "STH1 -- chromatin structure -- Component of abundant chromatin remodeling complex (RSC), DNA helicase of Snf2p family, has a bromodomain" YLL021W SPA2 0.8 11 2.7 0.5822 0.085096872 iYLL022C 0.078223236 0.08424406 0.340063847 SPA2 -- cytoskeleton -- cell polarity and cell fusion during mating YMR157C YMR157C 0.8 12 2.7 0.5822 0.31674004 iYMR157C 0.58225271 0.699653277 0.488989272 YMR157C -- unknown -- unknown function YNR029C YNR029C 0.8 11 2.7 0.5822 0.848460487 iYNR029C 0.219911411 0.236303577 0.399720475 YNR029C -- unknown -- weak similarity to Rhodococcus sp. nitrile hydratase beta chain YOR239W YOR239W 0.8 11 2.7 0.5822 0.018930368 iYOR238W 0.161567104 0.074488337 0.057040531 YOR239W -- unknown -- unknown function YOR346W REV1 0.8 10 2.7 0.5822 0.736293023 0.278671215 REV1 -- DNA repair -- Deoxycytidyl transferaseinvolved in mutagenic translesion DNA synthesis YLR218C YLR218C 0.7 10 2.7 0.5822 0.062900705 iYLR218C 0.501014858 0.137753319 0.173268087 YLR218C -- unknown -- unknown function YMR225C MRPL44 1 14 2.6 0.5698 1 0.940911649 iYMR225C 0.801845556 0.520045514 0.662470172 MRPL44 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmR44) YMR266W YMR266W 1 14 2.6 0.5698 1 0.528759751 iYMR265C 0.927593903 0.306014976 0.688798495 YMR266W -- unknown -- Possible membrane transporter involved in tunicamycin sensitivity YFL023W YFL023W 0.8 12 2.6 0.5698 1 0.719362705 iYFL024C 0.922211429 0.262487915 0.001949318 YFL023W -- unknown -- unknown function YMR121C RPL15B 1.6 23 2.6 0.5698 1 0.904306399 iYMR121C 0.220306073 0.829768555 0.318302815 "RPL15B -- protein synthesis -- Ribosomal protein L15 (yeast L13YL10rp15Rrat L15), nearly identical to Rpl15Ap" YML110C COQ5 2.5 35 2.6 0.5698 0.223330424 iYML110C 0.591982517 0.618675475 0.607082359 COQ5 -- ubiquinone biosynthesis -- Mitochondrial C-methyltransferase of ubiquinone biosynthetic pathway YKR071C YKR071C 2.4 34 2.6 0.5698 0.353520778 iYKR071C 0.310877026 0.809486373 0.240622506 YKR071C -- unknown -- unknown function YCR043C YCR043C 2 29 2.6 0.5698 0.309723788 iYCR043C 0.790120792 0.437865497 0.568977469 YCR043C -- unknown -- unknown function YCR077C PAT1 2 28 2.6 0.5698 0.557994693 iYCR077C 0.349354551 0.848614244 0.381564246 PAT1 -- mitosis; chromosome transmission -- faithful chromosome transmission and normal translation initiation YGR136W YGR136W 1.9 27 2.6 0.5698 0.488235104 iYGR135W 0.369361025 0.755829672 0.318570929 "YGR136W -- unknown -- weak similarity to chicken growth factor receptor-binding protein, has an SH3 domain" YFR052W RPN12 1.8 25 2.6 0.5698 0.615602225 iYFR051C 0.164495071 0.933176101 0.337984996 RPN12 -- protein degradation -- Non-ATPase component of 26S proteasome complexrequired for activation of Cdc28p protein kinase YGL167C PMR1 1.8 25 2.6 0.5698 0.411866399 iYGL167C 0.378854295 0.786077277 0.693063678 PMR1 -- transport -- Ca2+-transporting P-type ATPase of Golgi membrane involved in Ca2+ import into Golgi YKL013C ARC19 1.8 26 2.6 0.5698 0.219533508 iYKL013C 0.22366874 0.514523163 0.182681564 ARC19 -- cytoskeleton -- Component of ARP2/3 actin-organizing complexinvolved in actin assembly and function YNL192W CHS1 1.8 26 2.6 0.5698 0.383606185 iYNL193W 0.686654947 0.582681564 0.502336449 "CHS1 -- cytokinesis -- Chitin synthase I, has a repair function during cell separation" YOR257W CDC31 1.8 25 2.6 0.5698 0.047674237 iYOR256C 0.250858092 0.054302288 0.178887546 "CDC31 -- cytoskeleton -- Centrin, calmodulin-like calcium-binding spindle pole body, involved in first phase of spindle pole body duplication" YPL176C YPL176C 1.8 26 2.6 0.5698 0.392146696 iYPL176C 0.741214169 0.587614059 0.732597486 YPL176C -- unknown -- similarity to Ssp134p YPR191W QCR2 1.8 26 2.6 0.5698 0.212897665 iYPR190C 0.513001277 0.300999033 0.344359417 "QCR2 -- oxidative phosphorylation -- Ubiquinol cytochrome-c reductase core protein 2, component of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex)" YFR010W UBP6 1.7 24 2.6 0.5698 0.397231561 iYFR009W 0.422978203 0.514063592 0.179569034 "UBP6 -- protein degradation, ubiquitin-mediated -- Putative ubiquitin-specific protease, ubiquitin C-terminal hydrolase" YCL028W RNQ1 1.5 21 2.6 0.5698 0.371175084 iYCL029C 0.4459963 0.273677281 0.389040343 "RNQ1 -- unknown -- unknown function, may be required for resistance to certain drugs" YJL223C PAU1 1.5 21 2.6 0.5698 0.94173104 iYJL223C-0 iYJL223C-1 0.895785691 0.376250511 0.769768781 0.413791666 0.190164221 PAU1 -- unknown -- Member of seripauperin (PAU) family (PAU1 and YIL176C code for identical proteins) YER163C YER163C 1.3 18 2.6 0.5698 0.280867191 iYER163C-0 iYER163C-1 0.356008532 0.245960241 0.614251625 0.274582408 0.342168869 YER163C -- unknown -- unknown function YIL088C YIL088C 1.3 19 2.6 0.5698 0.327696275 iYIL088C 0.417712993 0.62037037 0.315066239 YIL088C -- unknown -- Putative membrane transporter of amino acid/auzin permease (AAAP) family YIL111W COX5B 1.3 18 2.6 0.5698 0.383632389 iYIL112W 0.448106761 0.489928525 0.684267479 "COX5B -- oxidative phosphorylation -- Cytochrome-c oxidase chain Vb, expressed under anaerobic conditions" YLR268W SEC22 1.3 19 2.6 0.5698 0.417892674 iYLR267W 0.463530969 0.597709552 0.279341952 SEC22 -- secretion -- Synaptobrevin (v-SNARE) homolog involved in fusion of ER-to-Golgi transport vesiclesrecognized by putative target t-SNARE (Sed5p) YML097C VPS9 1.3 20 2.6 0.5698 0.40976066 iYML097C 0.556336564 0.72501747 0.583271623 VPS9 -- vacuolar protein targeting -- vacuolar sorting YDR006C SOK1 1.2 17 2.6 0.5698 0.429938098 iYDR006C 0.55090115 0.364485235 0.346454787 SOK1 -- unknown -- can when overexpressed suppress mutants of cAMP-dependent protein kinase YDR031W YDR031W 1.2 18 2.6 0.5698 0.501973518 iYDR030C 0.284867273 0.395527603 0.194044702 YDR031W -- unknown -- unknown function YDR168W CDC37 1.2 17 2.6 0.5698 0.483036952 iYDR167W 0.288748567 0.793342537 0.313220941 CDC37 -- cell cycle -- Cell cycle spindle pole body duplication and passage through STARTinteracts with multiple protein kinase systems possibly as a targeting subunit YDR308C SRB7 1.2 17 2.6 0.5698 0.745798982 iYDR308C 0.437647951 0.983080607 0.440878795 SRB7 -- transcription -- Component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YFR049W YMR31 1.2 17 2.6 0.5698 0.488241604 iYFR048W 0.41552961 0.590048196 0.163827861 YMR31 -- protein synthesis -- Mitochondrial ribosomal protein YHL017W YHL017W 1.2 18 2.6 0.5698 0.675344126 iYHL018W 0.256629616 0.952073211 0.115659519 YHL017W -- unknown -- strong similarity to Ptm1p YNR013C YNR013C 1.2 17 2.6 0.5698 0.144323795 iYNR013C 0.022490934 0.471667997 0.017300195 "YNR013C -- unknown -- similarity to Pho87p and Yjl198p, member of phosphate permease family of membrane transporters" YOL098C YOL098C 1.2 17 2.6 0.5698 0.312734378 iYOL098C SNR58 0.465521403 0.74345169 0.407823589 0.275099761 0.575129955 YOL098C -- unknown -- unknown function YOR262W YOR262W 1.2 17 2.6 0.5698 0.072577385 iYOR261C 0.176334806 0.058250081 0.351133339 YOR262W -- unknown -- unknown function YAL040C CLN3 1.1 16 2.6 0.5698 0.674289448 iYAL040C 0.893915714 0.419989478 0.181429071 CLN3 -- cell cycle -- G1/S-specific cyclin that interacts with Cdc28p protein kinase to control events at START YBL090W MRP21 1.1 16 2.6 0.5698 0.339519684 iYBL091C 0.8525615 0.699162101 0.691269645 MRP21 -- protein synthesis -- Mitochondrial ribosomal small subunit YCR046C IMG1 1.1 16 2.6 0.5698 0.458638029 iYCR046C 0.656851882 0.755908688 0.71541502 "IMG1 -- protein synthesis -- Putative mitochondrial ribosomal protein, essential for respiration and integrity of mitochondrial genome" YEL063C CAN1 1.1 16 2.6 0.5698 0.675099813 iYEL063C 0.605509133 0.356454883 0.527231711 "CAN1 -- transport -- Permease for basic amino acids, arginine, lysine, and histidine" YHR083W YHR083W 1.1 16 2.6 0.5698 0.664921478 iYHR082C 0.145986769 0.87563366 0.034677982 YHR083W -- unknown -- unknown function YIL098C FMC1 1.1 17 2.6 0.5698 0.095179635 iYIL098C 0.421690669 0.390901024 0.476526966 FMC1 -- respiration (putative) -- production or assembly of mitochondrial cytochromes YJR076C CDC11 1.1 16 2.6 0.5698 0.349605986 iYJR076C 0.35614315 0.535355148 0.441902049 "CDC11 -- cytokinesis -- Septin, component of 10 nm filaments of mother-bud neck, involved in cytokinesis" YKL213C DOA1 1.1 16 2.6 0.5698 0.189451941 iYKL213C 0.108148529 0.319674115 0.108799185 "DOA1 -- protein degradation, ubiquitin-mediated -- Protein required in ubiquitin proteolysis and found complexed with Cdc48p, has WD (WD-40) repeats" YBL011W SCT1 1 14 2.6 0.5698 0.555683752 0.843577717 SCT1 -- unknown -- Suppressor of a choline transport mutant YBR192W RIM2 1 14 2.6 0.5698 0.490705666 iYBR191W 0.79876915 0.561253802 0.811652035 RIM2 -- transport -- mitochondrial carrier (MCF) family that is required for respiration YLL036C PRP19 1 14 2.6 0.5698 0.668121774 iYLL036C 0.302500206 0.775259909 0.597384665 "PRP19 -- mRNA splicing; DNA repair -- Non-snRNP spliceosome component, also involved in mitotic recombination and gene conversion" YOL041C NOP12 1 14 2.6 0.5698 0.57412207 iYOL041C 0.553007041 0.386792453 0.258610908 NOP12 -- unknown -- unknown function YGL159W YGL159W 0.9 13 2.6 0.5698 0.58793063 iYGL160W 0.520801682 0.902513696 0.65638114 YGL159W -- unknown -- unknown function YGL196W YGL196W 0.9 12 2.6 0.5698 0.572521458 iYGL197W 0.463437262 0.946762116 0.849640862 YGL196W -- unknown -- unknown function YGR138C YGR138C 0.9 13 2.6 0.5698 0.375462693 iYGR138C 0.35767977 0.493494424 0.089814089 YGR138C -- unknown -- Member of multidrug-resistance 12-spanner family of major facilitator superfamily (MFS-MDR) YIL091C YIL091C 0.9 12 2.6 0.5698 0.303842306 iYIL091C 0.024172759 0.185868514 0.038015305 YIL091C -- unknown -- unknown function YMR001C CDC5 0.9 13 2.6 0.5698 0.360266103 iYMR001C 0.246608765 0.318851312 0.414924182 "CDC5 -- cell cycle -- Serine/threonine protein kinase required for exit from mitosismay be involved in operation of mitotic spindle, member of polo family of protein kinases" YMR044W IOC4 0.9 13 2.6 0.5698 0.07486426 iYMR043W 0.185063108 0.066601689 0.354279261 "IOC4 -- unknown -- unknown function, has glu-rich domains" YNL129W YNL129W 0.9 13 2.6 0.5698 0.076103123 iYNL130C 0.079974097 0.193308875 0.332487195 YNL129W -- unknown -- unknown function YNL169C PSD1 0.9 13 2.6 0.5698 0.350362604 iYNL169C 0.737266722 0.710655804 0.892907058 "PSD1 -- phospholipid metabolism -- Phosphatidylserine decarboxylase, mitochondrial isozyme, converts phosphatidyl-L-serine to phosphatidylethanolamine" YNR027W YNR027W 0.9 13 2.6 0.5698 0.224273345 iYNR026C 0.23286995 0.440545764 0.215782359 YNR027W -- unknown -- unknown function YOR160W MTR10 0.9 13 2.6 0.5698 0.508648184 iYOR159C 0.283022579 0.849822752 0.165108629 "MTR10 -- mRNA export -- Karyopherin-beta, involved in nuclear protein import and indirectly in mRNA transport from nucleus to cytoplasm" YPL112C YPL112C 0.9 13 2.6 0.5698 0.429544824 iYPL112C tM(CAU)P 0.577330501 0.688328293 0.221971374 0.150331936 0.365241636 YPL112C -- unknown -- unknown function YDR400W URH1 0.8 11 2.6 0.5698 0.824117614 iYDR399W 0.653855414 0.961205253 0.649610136 URH1 -- unknown -- Uridine ribohydrolase YDR539W YDR539W 0.8 12 2.6 0.5698 0.494337013 iYDR538W 0.330963557 0.898790422 0.252992817 YDR539W -- unknown -- unknown function YHR003C YHR003C 0.8 11 2.6 0.5698 0.624792693 iYHR003C 0.457362419 0.614116309 0.424022346 YHR003C -- unknown -- strong similarity to Ykl027p and weak similarity to E. coli thiF and moeB and to wheat ubiquitin-activating enzyme YOL110W SHR5 0.8 12 2.6 0.5698 0.982937016 iYOL111C 0.491089484 0.794783181 0.12244898 "SHR5 -- protein processing -- ras function, mutants can block attachment and palmitoylation of ras proteins" YOR280C YOR280C 0.8 11 2.6 0.5698 0.089433857 iYOR280C 0.363504058 0.202044025 0.417478882 YOR280C -- unknown -- similarity to N-terminal region of S. pombe dihydrofolate reductase YNL102W POL1 0.7 10 2.6 0.5698 0.817831015 iYNL103W 0.416758542 0.426146581 0.133419272 POL1 -- DNA replication -- DNA polymerase I alpha 180 kDa subunit YOR236W DFR1 0.7 10 2.6 0.5698 0.641188717 iYOR235W YOR235W 0.969447299 0.987736951 0.44161879 0.406920078 0.250625151 DFR1 -- folate biosynthesis -- Dihydrofolate reductase YLR399C BDF1 1.1 16 2.5 0.5597 1 0.946993909 iYLR399C 0.999391224 0.844134078 0.951762523 "BDF1 -- meiosis -- sporulation, has two bromodomain motifs and one ET domain" YDR186C YDR186C 1 16 2.5 0.5597 1 0.861345206 iYDR186C 0.966076436 0.613924036 0.005619232 YDR186C -- unknown -- unknown function YML130C ERO1 2 30 2.5 0.5597 0.493468324 iYML130C 0.457751556 0.572510474 0.280753633 ERO1 -- protein folding -- protein disulfide bond formation in the endoplasmic reticulum YBL038W MRPL16 1.9 28 2.5 0.5597 0.573369521 iYBL039C 0.370798854 0.718378756 0.241137609 "MRPL16 -- protein synthesis -- Mitochondrial ribosomal large subunit (YmL47E. coli L16), belongs to the L16 family of prokaryotic ribosomal proteins" YAL068C YAL068C 1.7 25 2.5 0.5597 0.916863296 iYAL068C-0 iYAL068C-1 0.911393119 0.708837723 0.283788174 0.255387071 0.651032667 YAL068C -- unknown -- Member of seripauperin (PAU) family YHR138C YHR138C 1.6 24 2.5 0.5597 0.35269091 iYHR138C 0.072464897 0.612622508 0.116495098 "YHR138C -- unknown -- vacuolar fusion, has sequence similarity to Pbi2p" YKR082W NUP133 1.6 24 2.5 0.5597 0.534687811 iYKR081C 0.716013722 0.75257815 0.617587295 NUP133 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) without peptide repeat elementsinvolved in export of poly(A)+ mRNA YNL058C YNL058C 1.6 24 2.5 0.5597 0.080378825 YNL058C -- unknown -- unknown function YLR429W CRN1 1.5 23 2.5 0.5597 0.201221963 0.311093376 "CRN1 -- cytoskeleton -- Coronin, actin-binding protein, contains WD (WD-40) repeats" YNL239W LAP3 1.3 21 2.5 0.5597 0.414375549 iYNL240C 0.157910853 0.71396648 0.182814799 "LAP3 -- protein degradation -- Aminopeptidase of cysteine protease family, homologous to rabbit bleomycin hydrolase" YBR135W CKS1 1.2 18 2.5 0.5597 0.279555541 iYBR134W 0.720521495 0.459788659 0.758942958 "CKS1 -- cell cycle -- associated with Cdc28p kinase, homolog of S. pombe suc1" YBR288C APM3 1.2 17 2.5 0.5597 0.61328706 iYBR288C 0.423925634 0.740475603 0.35497408 "APM3 -- vacuolar protein targeting -- Clathrin-associated protein (AP) complex, medium subunit" YIL066C RNR3 1.2 18 2.5 0.5597 0.56373251 iYIL066C 0.406835933 0.801332034 0.565459385 RNR3 -- DNA repair -- Ribonucleotide reductase (ribonucleoside-diphosphate reductase) large regulatory subunitconverts deoxyribonucleoside diphosphate to ribonucleoside diphosphate YLR120C YPS1 1.2 18 2.5 0.5597 0.65612942 iYLR120C 0.567755323 0.820125042 0.173702868 "YPS1 -- protein processing -- Yapsin 1, GPI-anchored aspartyl protease that cleaves C-terminal to paired basic residues (Aspergillopepsin I)" YMR010W YMR010W 1.2 19 2.5 0.5597 0.659569854 iYMR009W 0.407013486 0.819391788 0.401958364 YMR010W -- unknown -- unknown function YPR176C BET2 1.2 17 2.5 0.5597 0.122961648 iYPR176C 0.306406319 0.348874728 0.326719999 "BET2 -- protein processing -- Geranylgeranyltransferase Type II beta subunit, forms a complex with Bet4p" YDL076C YDL076C 1.1 17 2.5 0.5597 0.899639342 iYDL076C 0.973746268 0.203431764 0.106832098 YDL076C -- unknown -- unknown function YHL027W RIM101 1.1 16 2.5 0.5597 0.352675684 iYHL028W 0.322933682 0.529699511 0.170391061 "RIM101 -- meiosis -- Transcription factor involved in induction of IME1, IME2, DIT1, and DIT2 transcription" YNL330C 1.1 17 2.5 0.5597 0.690626518 iYNL330C 0.677820244 0.538526529 YAR003W YAR003W 1 15 2.5 0.5597 0.508895815 iYAR002C-A 0.286208291 0.68654951 0.666964234 "YAR003W -- unknown -- unknown function, contains a WD (WD-40) repeat" YCR044C YCR044C 1 16 2.5 0.5597 0.478597727 iYCR044C 0.624178253 0.550925926 0.570970131 "YCR044C -- unknown -- Suppressor of cdc1-1 temperature-sensitive growth defect, involved in Mn2+ homeostasis" YDR389W SAC7 1 15 2.5 0.5597 0.559351279 iYDR388W 0.140843646 0.696727853 0.219142765 SAC7 -- signaling -- GTPase-activating protein for Rho1p YEL015W YEL015W 1 15 2.5 0.5597 0.51972792 iYEL016C 0.452469332 0.610215483 0.661376088 YEL015W -- unknown -- unknown function YMR153W NUP53 1 15 2.5 0.5597 0.318297303 iYMR152W 0.451522403 0.402180814 0.487869114 NUP53 -- nuclear protein targeting -- Component of karyopherin docking complex of nuclear pore complexhas similarity to Asm4p YNL026W YNL026W 1 15 2.5 0.5597 0.356278967 iYNL027W 0.507839422 0.691280838 0.393893007 YNL026W -- unknown -- unknown function YNL039W TFC5 1 14 2.5 0.5597 0.207747262 iYNL040W 0.491249854 0.281189084 0.603060973 "TFC5 -- transcription -- Component of RNA polymerase III transcription factor TFIIIB, called B'' or TFIIIB90" YNL211C YNL211C 1 15 2.5 0.5597 0.316775311 iYNL211C 0.431966882 0.304699382 0.490496174 YNL211C -- unknown -- unknown function YOL088C MPD2 1 14 2.5 0.5597 0.144369552 iYOL088C 0.5694489 0.338946181 0.331856268 MPD2 -- unknown -- disulfide isomerase-related protein YDL042C SIR2 0.9 13 2.5 0.5597 0.560854094 0.546728972 "SIR2 -- silencing -- NAD-dependent histone deacetylase, involved in maintenance of silencing of HMR, HML and telomeres" YDR472W TRS31 0.9 13 2.5 0.5597 0.747621208 iYDR471W SNR13 0.84295058 0.7187819 0.849949307 0.760516494 0.182221505 TRS31 -- secretion (putative) -- TRAPP (Transport Protein Particle) complex involved in vesicular transport from endoplasmic reticulum to Golgi YGR262C YGR262C 0.9 13 2.5 0.5597 0.379773283 iYGR262C 0.480238095 0.938190383 0.709730957 YGR262C -- unknown -- similarity to apple tree calcium/calmodulin-binding protein kinase YHR115C YHR115C 0.9 14 2.5 0.5597 0.302686933 iYHR115C 0.197197223 0.511967156 0.286595902 YHR115C -- unknown -- unknown function YIL103W YIL103W 0.9 13 2.5 0.5597 0.394447143 iYIL104C 0.554071556 0.771994844 0.568012842 YIL103W -- unknown -- similarity to diptheria toxin resistance protein YPL128C TBF1 0.9 12 2.5 0.5597 0.150588524 iYPL128C 0.126342753 0.204489867 0.161213089 TBF1 -- telomere length regulation -- Teleomere binding proteinbinds to TTAGGG repeats YPR182W SMX3 0.9 13 2.5 0.5597 0.422002581 iYPR181C 0.595905382 0.222921034 0.198261858 "SMX3 -- mRNA splicing -- Spliceosomal snRNA-associated Sm core protein, also likely associated with telomerase TLC1 RNA" YBL111C YBL111C 0.8 12.5 2.5 0.5597 0.954121627 iYBL111C 0.997475409 0.854356949 0.376616121 YBL111C -- unknown -- unknown functionsubtelomerically encoded YHR218W YHR218W 0.8 22 2.5 0.5597 0.956723926 iYHR217C 0.995206987 0.774376585 0.159259885 "YHR218W -- unknown -- near identity to subtelomerically-encoded proteins including Yhr219p and Yfl065p, possible pseudogene" YKL073W LHS1 0.8 12 2.5 0.5597 0.614324305 iYKL074C 0.190215616 0.836976129 0.099903319 LHS1 -- secretion -- Hsp70 superfamily member required for efficient translocation of protein precursors across the ER membrane YLR077W YLR077W 0.8 12 2.5 0.5597 0.321734342 iYLR076C 0.412130886 YLR077W -- unknown -- unknown function YLR328W YLR328W 0.8 11 2.5 0.5597 0.634950168 iYLR327C tS(GCU)L 0.479010143 0.535666745 0.725104737 0.396401118 0.013239116 YLR328W -- unknown -- Nicotinamide mononucleotide (NMN) adenylyltransferase YMR233W YMR233W 0.8 11 2.5 0.5597 0.060703564 iYMR232W 0.590626149 0.111263294 0.344689029 YMR233W -- unknown -- similarity to Bud7p YOL006C TOP1 0.8 11 2.5 0.5597 0.081916788 iYOL006C 0.49632473 0.421130585 "TOP1 -- DNA replication -- DNA topoisomerase I, relaxes supercoiled DNA by making single-stranded breaks" YOL125W YOL125W 0.8 12 2.5 0.5597 0.709063277 iYOL126C 0.546030005 0.948195295 0.262753319 YOL125W -- unknown -- unknown function YOR264W YOR264W 0.8 11 2.5 0.5597 0.306340727 0.153988868 YOR264W -- unknown -- unknown function YFR036W CDC26 0.7 9 2.5 0.5597 0.287612658 iYFR035C itK(CUU)F 0.797412873 0.23155265 0.081062194 0.392120894 0.217172782 "CDC26 -- cell cycle -- Component of anaphase-promoting complex (APC), required for Clb2p degradation and for the metaphase-anaphase transition" YLR231C YLR231C 0.7 9 2.5 0.5597 0.183214085 0.388157895 YLR231C -- unknown -- weak similarity to rat kynureninase (PIR YML021C UNG1 0.7 10 2.5 0.5597 0.459711001 iYML021C 0.166907566 0.599143541 0.064047753 UNG1 -- DNA repair -- Uracil-DNA glycolyaseremoves uracil from DNA YML036W YML036W 0.7 10 2.5 0.5597 0.634047335 iYML037C 0.226989422 0.853851112 0.405826018 YML036W -- unknown -- unknown function YMR130W YMR130W 0.7 11 2.5 0.5597 0.770686682 iYMR129W 0.660080745 0.855543023 0.643167902 YMR130W -- unknown -- unknown function YDR310C SUM1 0.6 9 2.5 0.5597 0.413626732 iYDR310C 0.34114508 0.353074773 0.377355386 "SUM1 -- silencing -- middle sporulation element-mediated repression of SMK1, SPR3 and NDT80 during vegetative growth, suppressor of mar1-1 (sir2)" YHR040W YHR040W 0.6 9 2.5 0.5597 0.412512598 iYHR039C-B 0.412507617 0.374640007 0.22571475 "YHR040W -- unknown -- weak similarity to Hit1p, expressed under nitrogen-starvation conditions" YOR124C UBP2 1.3 20 2.4 0.5488 1 0.624929216 iYOR124C 0.982807296 0.377766807 0.775856045 "UBP2 -- protein degradation, ubiquitin-mediated -- Ubiquitin-specific protease (ubiquitin C-terminal hydrolase), cleaves at the C-terminus of ubiquitin" YLR452C SST2 0.9 14 2.4 0.5488 1 0.924525419 iYLR452C 0.990278156 0.832169495 0.927613727 SST2 -- mating -- desensitization to alpha-factor pheromone YGL058W RAD6 2 30 2.4 0.5488 0.381302944 iYGL059W 0.393397174 0.644577166 0.664744934 "RAD6 -- protein degradation, ubiquitin-mediated -- Ubiquitin conjugating enzyme involved in an error-prone DNA-damage recovery pathway" YER052C HOM3 1.9 29 2.4 0.5488 0.200259025 iYER052C 0.244771029 0.358183165 HOM3 -- Met. and Thr. biosynthesis -- Aspartate kinase (L-aspartate 4-P-transferase)first step in the common pathway for methionine and threonine biosynthesis YCL033C YCL033C 1.8 27 2.4 0.5488 0.145062302 iYCL033C 0.159255283 0.206465237 0.118093087 "YCL033C -- unknown -- similarity to Neisseria pilin B, putative transcription regulator" YOL111C YOL111C 1.5 24 2.4 0.5488 0.38332507 iYOL111C 0.491089484 0.157142857 0.12244898 YOL111C -- unknown -- similarity to human ubiquitin-like protein GDX YJR049C UTR1 1.3 21 2.4 0.5488 0.461501118 iYJR049C 0.450950999 0.841819633 0.241260974 UTR1 -- unknown -- may be associated with ferric reductase activity YOR357C GRD19 1.3 21 2.4 0.5488 0.839693798 iYOR357C 0.453573438 0.963744763 0.28158234 GRD19 -- secretion -- retrieval of late Golgi membrane proteins from the prevacuolar compartment YHR030C SLT2 1.2 19 2.4 0.5488 0.521386976 iYHR030C 0.4969882 0.632424878 0.504484489 "SLT2 -- signaling, PKC1 pathway -- Serine/threonine protein kinase of MAP kinase family involved in the cell wall integrity (low-osmolarity) pathway" YMR183C SSO2 1.2 19 2.4 0.5488 0.335332738 iYMR183C 0.417494197 0.672146848 0.428375765 SSO2 -- secretion -- Syntaxin homolog (t-SNARE) involved in vesicle transport from Golgi to plasma membrane YNL081C YNL081C 1.2 18 2.4 0.5488 0.307789174 iYNL081C 0.2532203 0.680555556 0.117575122 "YNL081C -- unknown -- Putative mitochondrial ribosomal small subunit, has similarity to ribosomal protein S13 of prokaryotes and plant mitochondria" YBR253W SRB6 1.1 17 2.4 0.5488 0.378493959 iYBR252W 0.344155121 0.279825764 0.676362683 SRB6 -- transcription -- Component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YDR354W TRP4 1.1 17 2.4 0.5488 0.548212386 iYDR353W 0.65260896 0.943632229 0.570716458 "TRP4 -- tryptophan biosynthesis -- Anthranilate phosphoribosyltransferase, second step in tryptophan biosynthesis pathway" YHR108W GGA2 1.1 17 2.4 0.5488 0.127339185 iYHR107C 0.128650586 0.521833709 0.221978558 GGA2 -- unknown -- trafficking of proteins between the trans-Golgi network and the vacuole YLL029W YLL029W 1.1 17 2.4 0.5488 0.465134738 iYLL030C 0.292979564 0.448462614 0.412672241 YLL029W -- unknown -- similarity to X-prolyl aminopeptidase P YNL097C PHO23 1.1 17 2.4 0.5488 0.023925931 iYNL097C tL(CAA)N 0.122045943 0.588682359 0.026559454 0.070023862 0.261998871 "PHO23 -- phosphate signaling -- chromatin remodeling and possibly transcription regulation, involved in expression of PHO5" YBL083C YBL083C 1 15.5 2.4 0.5488 0.596045184 0.553843672 YBL083C -- unknown -- unknown functionquestionable ORF YBR257W POP4 1 15 2.4 0.5488 0.109446448 iYBR256C 0.395114573 0.438574837 0.768616802 "POP4 -- rRNA and tRNA processing -- component of both RNase MRP and RNase P, involved in both rRNA and tRNA processing" YDR153C YDR153C 1 15 2.4 0.5488 iYDR153C 0.631236182 0.371348763 YDR153C -- unknown -- unknown function YDR459C YDR459C 1 15 2.4 0.5488 0.52228556 iYDR459C 0.545021341 0.748619233 0.621843995 "YDR459C -- unknown -- unknown function, has similarity to Erf2p" YDR494W YDR494W 1 16 2.4 0.5488 0.299949852 iYDR493W 0.279740461 0.331708902 0.131091618 YDR494W -- unknown -- unknown function YGR261C APL6 1 16 2.4 0.5488 0.420929285 iYGR261C 0.195560994 0.519393456 0.265615748 "APL6 -- vacuolar protein targeting -- Beta-adaptin, large subunit of clathrin-associated protein (AP) complex" YHR205W SCH9 1 15 2.4 0.5488 0.637806889 iYHR204W 0.571106859 "SCH9 -- signaling -- Serine/threonine protein kinase involved in nutrient-sensing signaling pathway, probably parallel to cAMP pathway" YJL030W MAD2 1 15 2.4 0.5488 0.825440335 iYJL031C 0.297070863 0.508279824 0.298268778 MAD2 -- mitosis -- Spindle-assembly checkpoint protein YJL126W NIT2 1 15 2.4 0.5488 0.064153067 iYJL127C 0.128573192 0.329342967 0.259417601 NIT2 -- unknown -- Nitrilase YLR158C ASP3C 1 15 2.4 0.5488 0.40835159 iYLR158C-0 iYLR158C-1 0.108462854 0.156847204 0.746067597 0.329759584 0.185838368 "ASP3C -- asparagine utilization -- L-asparaginase II, extracellular" YML079W YML079W 1 16 2.4 0.5488 0.186747164 iYML080W 0.643611439 0.564222078 0.705089941 YML079W -- unknown -- unknown function YNL262W POL2 1 15 2.4 0.5488 0.881534256 iYNL263C 0.16353584 0.450129955 0.669052909 "POL2 -- DNA replication -- DNA polymerase epsilon large subunit, catalytic subunit essential for DNA replication and involved in DNA repair" YOL070C YOL070C 1 15 2.4 0.5488 0.145915314 iYOL070C 0.545533763 0.495433226 0.321947326 YOL070C -- unknown -- unknown function YAL019W YAL019W 0.9 15 2.4 0.5488 0.545063208 iYAL020C 0.085744049 0.363872645 0.09901708 "YAL019W -- unknown -- Snf2p family with a DNA-dependent ATPase domain, involved in resistance to UV radiation" YEL006W YEL006W 0.9 13 2.4 0.5488 0.630116735 iYEL007W 0.375427965 0.690220923 0.246511253 YEL006W -- unknown -- Member of mitochondrial carrier (MCF) family of membrane transporters YFL027C YFL027C 0.9 14 2.4 0.5488 0.468619157 iYFL027C 0.458348397 0.817215287 0.563482268 YFL027C -- unknown -- unknown function YGL112C TAF60 0.9 15 2.4 0.5488 0.634122196 iYGL112C 0.161083016 0.85945857 0.154769578 TAF60 -- transcription -- Component of TAF(II) complex (TBP-associated protein complex) and SAGA complex (Spt-Ada-Gcn5-acetyltransferase)required for activated transcription by RNA polymerase II YIL059C YIL059C 0.9 14 2.4 0.5488 0.477027493 0.61867518 YIL059C -- unknown -- unknown function YML046W PRP39 0.9 13 2.4 0.5488 0.690425382 iYML047C 0.389429252 0.780995402 0.327516299 PRP39 -- mRNA splicing -- U1 snRNA-associated commitment of pre-mRNA to splicing pathway YOR174W MED4 0.9 14 2.4 0.5488 0.351134986 iYOR173W 0.571107002 0.452384789 0.743273934 MED4 -- transcription -- Component of RNA polymerase II holoenzyme and mediator subcomplex YOR189W YOR189W 0.9 13 2.4 0.5488 0.172142076 iYOR188W 0.332041884 0.31292897 0.431086974 YOR189W -- unknown -- unknown function YPL122C TFB2 0.9 14 2.4 0.5488 0.388677525 iYPL122C 0.291304701 0.421871143 0.492039587 "TFB2 -- transcription -- Component of RNA polymerase II transcription initiation TFIIH (factor b), 55 kDa subunit" YDR036C YDR036C 0.8 12 2.4 0.5488 0.896273771 iYDR036C 0.98692732 0.553577183 0.255800726 YDR036C -- unknown -- Member of enoyl-coA hydratase/isomerase protein family YEL059C-A SOM1 0.8 12 2.4 0.5488 0.122002642 0.06091585 "SOM1 -- protein processing -- Possible subunit of Imp peptidase complex, required for mitochondrial inner peptidase function" YGR263C YGR263C 0.8 12 2.4 0.5488 0.530632734 iYGR263C 0.342622622 0.87565842 0.555811435 YGR263C -- unknown -- unknown function YJR074W MOG1 0.8 12 2.4 0.5488 0.829367047 iYJR073C 0.719523941 0.780766161 0.45754717 "MOG1 -- unknown -- nuclear import, interacts with Gsp1p" YLR436C ECM30 0.8 12 2.4 0.5488 0.456117561 iYLR436C 0.743092539 0.405172414 0.12803423 ECM30 -- cell wall biogenesis -- Protein possibly involved in cell wall structure or biosynthesis YML011C YML011C 0.8 13 2.4 0.5488 0.334536568 iYML011C 0.277242432 0.734289397 0.166666667 YML011C -- unknown -- unknown function YNL024C YNL024C 0.8 13 2.4 0.5488 0.824965587 iYNL024C 0.82707865 0.41268681 0.329600387 YNL024C -- unknown -- unknown function YNL080C YNL080C 0.8 13 2.4 0.5488 0.734155505 iYNL080C 0.50237491 0.66745283 0.537562742 YNL080C -- unknown -- unknown function YNL289W PCL1 0.8 12 2.4 0.5488 0.610902373 iYNL290W 0.289213295 0.580974843 0.21867518 PCL1 -- cell cycle -- G1/S-specific cyclin that can interact with the Cdc28p-like kinase Pho85p YPL038W MET31 0.8 13 2.4 0.5488 0.226756706 iYPL039W 0.279320484 0.075129955 0.21093813 "MET31 -- sulfur amino acid metbolism -- Zinc-finger transcriptional regulation of methionine metabolism, has two tandem C2H2-type zinc fingers" YIL014W MNT3 0.7 11 2.4 0.5488 0.57406508 iYIL015C-A itT(AGU)I2 0.682531813 0.756333031 0.903151485 0.737589785 0.590103751 MNT3 -- protein glycosylation -- Mannosyltransferase that adds the final mannose to O-linked oligosaccharide chainssimilar to Mnn1p YLR143W YLR143W 0.7 11 2.4 0.5488 0.541412392 iYLR142W itD(GUC)L1 0.662438273 0.524143618 0.796052632 0.585625555 0.186802974 YLR143W -- unknown -- weak similarity to Mmd1p YMR076C PDS5 0.7 10 2.4 0.5488 0.171404333 iYMR076C itV(AAC)M2 0.460522452 0.711653475 0.324650089 0.410250162 0.440604934 "PDS5 -- mitosis, sister chromatid cohesion -- unknown functionloss can lead to precocious separation of sister chromatids" YMR138W CIN4 0.7 10 2.4 0.5488 0.518771605 iYMR137C 0.396282689 0.548916841 0.162930474 "CIN4 -- mitosis, chromosome segregation -- GTP-binding chromosome segregation, mutants arrest at mitosis with loss of microtubule structure" YOR233W KIN4 0.7 10 2.4 0.5488 0.33171352 iYOR232W 0.430118461 0.482758621 0.393087335 "KIN4 -- unknown -- Serine/threonine protein kinase related to Kin1p and Kin2p, catalytic domain is highly related to Snf1p" YJL081C ARP4 0.6 10 2.4 0.5488 0.088362621 iYJL081C 0.031676537 0.425797615 0.008579058 "ARP4 -- cytoskeleton -- interacts with core histones, member of NuA4 histone acetyltransferase complex" YML096W YML096W 0.6 10 2.4 0.5488 0.372507303 iYML097C 0.556336564 0.865293432 0.583271623 YML096W -- unknown -- similarity to asparagine synthetases Asn1p and Asn2p YBL061C SKT5 1.5 23 2.3 0.5362 1 0.826273495 iYBL061C 0.97432819 0.54301676 0.851998066 "SKT5 -- cell wall biogenesis -- Protoplast regeneration and killer toxin resistance protein, required for chitin synthase III activity" YGR178C PBP1 2.1 34 2.3 0.5362 0.590311524 iYGR178C 0.19051136 0.557017544 0.078489355 PBP1 -- mRNA processing -- interacts with Poly(A)-binding protein Pab1p YFL048C EMP47 2 31 2.3 0.5362 0.700380102 iYFL048C 0.252454291 0.833306478 0.320885434 EMP47 -- secretion -- Golgi and endoplasmic reticulum membrane C-terminal dilysine (KKXX or KXKXX) motif YMR298W YMR298W 1.9 32 2.3 0.5362 0.411399131 iYMR297W 0.690653587 0.751956118 0.601301115 YMR298W -- unknown -- unknown function YDR504C YDR504C 1.8 29 2.3 0.5362 0.517485976 0.308088946 YDR504C -- unknown -- unknown function YJR065C ARP3 1.8 29 2.3 0.5362 0.699693994 iYJR065C 0.239807647 0.889376218 0.160202655 "ARP3 -- cytoskeleton -- Actin-related ARP2/3 complex, involved in cell polarity and endocytosis" YAL030W SNC1 1.6 24 2.3 0.5362 0.80071854 iYAL031C 0.382883171 0.803013213 0.284277733 SNC1 -- secretion -- Synaptobrevin (v-SNARE) homolog present on post-Golgi vesicles YGL244W RTF1 1.5 23 2.3 0.5362 0.178300499 iYGL245W 0.390362264 0.128581412 0.577908476 RTF1 -- transcription -- important for TATA site selection by the TATA binding Spt15p YBR236C ABD1 1.3 21 2.3 0.5362 0.44105609 iYBR236C 0.421316036 0.694253791 0.539106145 ABD1 -- mRNA capping -- mRNA cap methyltransferase that methylates the terminal guanine residue of mRNA cap YDR145W TAF61 1.3 22 2.3 0.5362 0.153577131 iYDR144C 0.510090063 0.18973574 0.633203379 TAF61 -- transcription -- Component of TAF(II) complex (TBP-associated protein complex)and SAGA complex (Spt-Ada-Gcn5-acetyltransferase)required for activated transcription by RNA polymerase II YER183C YER183C 1.3 21 2.3 0.5362 0.789294684 iYER183C-0 iYER183C-1 0.217927318 0.168899401 0.431437319 0.12226656 0.362159329 YER183C -- unknown -- unknown function YLL064C YLL064C 1.3 22 2.3 0.5362 0.921115604 iYLL064C 0.941072489 0.468567251 0.555747552 YLL064C -- unknown -- Member of seripauperin (PAU) family (YLL064C and PAU6 code for identical proteins) YML129C COX14 1.3 22 2.3 0.5362 0.260647583 iYML129C 0.71632873 0.506574171 0.871071308 COX14 -- respiration -- assembly of cytochrome oxidase YPL265W DIP5 1.3 23 2.3 0.5362 0.587878327 iYPL266W 0.216831066 0.682300667 0.569771189 DIP5 -- transport -- Dicarboxylic amino acid permease YHR024C MAS2 1.2 20 2.3 0.5362 0.307495771 iYHR024C 0.509788834 0.564634247 0.389622946 MAS2 -- protein processing -- Catalytic (alpha) subunit of mitochondrial processing peptidase YKL012W PRP40 1.2 21 2.3 0.5362 0.572232776 iYKL013C 0.22366874 0.727392413 0.182681564 PRP40 -- mRNA splicing -- U1 snRNA-associated pre-mRNA splicing YLR275W SMD2 1.2 21 2.3 0.5362 0.500040196 iYLR274W 0.137311991 0.601274502 0.267462638 "SMD2 -- mRNA splicing -- Spliceosomal snRNA-associated Sm core protein, also likely associated with telomerase TLC1 RNA" YPR073C LTP1 1.2 20 2.3 0.5362 0.37368809 iYPR073C 0.66514211 0.449002394 0.774009024 LTP1 -- unknown -- Protein tyrosine phosphatase (PTPase) with similarity to a phosphatase from bovine heart and human placenta YDL099W YDL099W 1.1 18 2.3 0.5362 0.066456209 iYDL100C 0.119276172 0.055865922 0.140788283 YDL099W -- unknown -- unknown function YDL230W PTP1 1.1 19 2.3 0.5362 0.80586612 iYDL231C 0.334223353 0.59917722 0.305347167 PTP1 -- unknown -- Protein tyrosine phosphatase YGL002W ERP6 1.1 19 2.3 0.5362 0.288871404 iYGL003C 0.35550903 0.525157233 0.372428813 ERP6 -- membrane trafficking; secretion (putative) -- similarity to COPII-coated vesicle proteins Emp24p and Erv25p YGL082W YGL082W 1.1 18 2.3 0.5362 0.499502432 iYGL083W 0.231814896 0.912185886 0.026496409 YGL082W -- unknown -- unknown function YHR056C YHR056C 1.1 17 2.3 0.5362 0.462489569 iYHR056C 0.260676639 0.646998404 0.425573932 "YHR056C -- unknown -- unknown function, encoded from the CUP1A and CUP1B repeat region" YHR195W NVJ1 1.1 18 2.3 0.5362 0.401813765 iYHR194W 0.467159197 0.519952115 0.156892797 NVJ1 -- vacuolar protein targeting (putative) -- Vac8p-binding protein YMR214W SCJ1 1.1 19 2.3 0.5362 0.262577589 iYMR213W 0.620173113 0.348034438 0.196019981 "SCJ1 -- unknown -- Homolog of E. coli DnaJ, functions in the endoplasmic reticulum by interaction with Kar2p" YNL320W YNL320W 1.1 18 2.3 0.5362 0.444490678 iYNL321W 0.472065631 0.862068966 0.216654324 YNL320W -- unknown -- similarity to S. pombe bem1/bud5 suppressor YBL055C YBL055C 1 16 2.3 0.5362 0.793156482 iYBL055C 0.628223746 0.975803634 0.78754988 YBL055C -- unknown -- unknown function YBR066C NRG2 1 16 2.3 0.5362 0.335314857 iYBR066C 0.41741522 0.357864919 0.54795515 "NRG2 -- unknown -- Suppressor of snf mutations, predicted transcription factor with two tandem C2H2-type zinc fingers" YBR139W YBR139W 1 16 2.3 0.5362 0.376522044 iYBR138C 0.703276186 0.901588085 0.661053472 YBR139W -- unknown -- similarity to serine-type carboxypeptidases YDL093W PMT5 1 15 2.3 0.5362 0.645676096 0.465408805 "PMT5 -- protein glycosylation -- similarity to O-mannosyltransferases Pmt1p, Pmt2p, Pmt3p, Pmt4p, and Pmt6p" YGL079W YGL079W 1 15 2.3 0.5362 0.851060385 iYGL080W 0.498645153 0.638148444 YGL079W -- unknown -- unknown function YGR119C NUP57 1 16 2.3 0.5362 0.687957726 iYGR119C 0.557083688 0.903563941 0.403671215 "NUP57 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) of GLFG family, acts in a complex with Nic96p, Nup49p, and Nsp1p" YHR175W CTR2 1 17 2.3 0.5362 0.784692574 iYHR174W 0.910703277 0.897227022 0.4437357 CTR2 -- transport -- Putative low-affinity copper transport protein YMR212C EFR3 1 17 2.3 0.5362 0.608101707 iYMR212C 0.209125343 0.869070825 0.431266903 "EFR3 -- unknown -- similarity to Drosophila cmp44E, conserved, ubiquitous membrane protein requiired for cell viability" YAR007C RFA1 0.9 15 2.3 0.5362 0.639948249 iYAR007C 0.087857507 0.690380277 0.155360168 "RFA1 -- DNA replication -- DNA replication factor A, 69K subunit, binds single-stranded DNA" YDR094W 0.9 14 2.3 0.5362 0.250691936 0.254139912 YDR266C YDR266C 0.9 14 2.3 0.5362 0.716631261 iYDR266C 0.518647141 0.864163713 0.61688472 "YDR266C -- unknown -- unknown function, contains a RING finger domain" YDR514C YDR514C 0.9 15 2.3 0.5362 0.332412434 iYDR514C 0.540930352 0.654524808 0.684676776 YDR514C -- unknown -- unknown function YGR174C CBP4 0.9 14 2.3 0.5362 0.18084622 iYGR174C 0.559072104 0.200957702 0.560273184 CBP4 -- respiration -- Ubiquinol-cytochrome c reductase assembly factoressential for assembly and stability of ubiquinol-cytochrome c reductase YGR193C PDX1 0.9 16 2.3 0.5362 0.724286245 iYGR193C 0.186688364 0.734371219 0.143784001 PDX1 -- glycolysis -- Pyruvate dehydrogenase complex protein Xbinding protein for Lpd1p YGR241C YAP1802 0.9 14 2.3 0.5362 0.23241822 0.228651237 YAP1802 -- endocytosis and secretion -- homologous to clathrin assembly polypeptide AP180interacts with Pan1p YHR110W ERP5 0.9 15 2.3 0.5362 0.342476179 iYHR109W 0.407121841 0.919952115 0.456723401 ERP5 -- membrane trafficking; secretion (putative) -- similarity to COPII-coated vesicle proteins Emp24p and Erv25p YIL115C NUP159 0.9 15 2.3 0.5362 0.585443575 iYIL115C 0.575383616 0.793291098 0.701026277 NUP159 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) with XFXFG repeats YDR208W MSS4 0.8 13 2.3 0.5362 0.450422586 iYDR207C 0.26210841 0.4647291 0.223483913 MSS4 -- actin organization -- Phosphatidylinositol-4-phosphate 5-kinaserequired for proper organization of actin cytoskeleton YDR257C RMS1 0.8 13 2.3 0.5362 0.86532179 iYDR257C 0.695380369 0.907594833 0.791585445 RMS1 -- transcription -- Putative transcriptional regulator YDR478W SNM1 0.8 12 2.3 0.5362 0.178018637 iYDR477W 0.559340321 0.27773344 0.602402699 SNM1 -- rRNA processing -- RNA-binding RNase MRP YGL039W YGL039W 0.8 14 2.3 0.5362 0.805474794 iYGL040C-0 iYGL040C-1 0.361018348 0.619067798 0.895150389 0.404044473 0.673630717 YGL039W -- unknown -- unknown function YHL026C YHL026C 0.8 13 2.3 0.5362 0.493867768 iYHL026C 0.100743248 0.875926523 0.015634 "YHL026C -- unknown -- unknown function, has potential signal sequence and 2 potential transmembrane domains" YHR131C YHR131C 0.8 12 2.3 0.5362 0.163968278 iYHR131C 0.385485722 0.481743536 0.599015891 YHR131C -- unknown -- unknown function YMR221C YMR221C 0.8 13 2.3 0.5362 0.404656185 iYMR221C 0.570059881 0.618834796 0.793425717 YMR221C -- unknown -- unknown function YOR163W DDP1 0.8 13 2.3 0.5362 0.396782958 iYOR162C 0.239211156 0.355425601 0.301240735 DDP1 -- unknown -- Diadenosine hexaphosphate (Ap6A) hydrolase YOR319W HSH49 0.8 12 2.3 0.5362 0.586294466 iYOR318C 0.388225874 0.832782125 0.133580705 "HSH49 -- mRNA splicing -- U2 snRNP protein and pre-mRNA splicing factor with similarity to human SAP49, has 2 RNA recognition (RRM) domains" YDR176W NGG1 0.7 11 2.3 0.5362 0.396947931 iYDR175C 0.178403756 0.746942697 0.217048018 NGG1 -- chromatin structure -- Component of two nucleosomal histone acetyltransferase complexes YDR493W YDR493W 0.7 11 2.3 0.5362 0.342257478 iYDR492W 0.516679627 0.697181451 0.433209797 YDR493W -- unknown -- unknown function YGR031W YGR031W 0.7 11 2.3 0.5362 0.816494618 iYGR030C 0.712805569 0.930726257 0.716617934 YGR031W -- unknown -- unknown function YLR287C YLR287C 0.7 12 2.3 0.5362 0.977085798 iYLR287C 0.941144248 0.948801292 0.864724661 YLR287C -- unknown -- unknown function YLR364W YLR364W 0.7 11 2.3 0.5362 0.179256684 iYLR363C 0.320005267 0.204333439 0.364766082 YLR364W -- unknown -- weak similarity to yeast glutaredoxin-like protein YMR062C ARG7 0.7 11 2.3 0.5362 0.486974539 iYMR062C 0.336338519 0.825310623 0.609813084 "ARG7 -- arginine biosynthesis -- Ornithine acetyltransferasecatalyzes the fifth step in ornithine and arginine biosynthesis, also has acetylglutamate synthase activity" YMR277W FCP1 0.7 10 2.3 0.5362 0.138134258 iYMR276W 0.265710167 0.496502921 0.144147778 FCP1 -- transcription -- TFIIF-interacting component of C-terminal domain phosphatase YOL054W YOL054W 0.7 10 2.3 0.5362 0.154025534 iYOL055C YOLWdelta6 0.540391776 0.723782812 0.138097927 0.294324023 0.532707973 "YOL054W -- unknown -- normal resistance to NaCl and for normal mating efficiency of MATa cells, contains a C3HC4-type zinc finger" YOL140W ARG8 0.7 10 2.3 0.5362 0.751143417 iYOL141W 0.20130074 0.969223489 0.370532814 ARG8 -- arginine biosynthesis -- Acetylornithine aminotransferasecatalyzes the fourth step in ornithine and arginine biosynthesis YOR130C ORT1 0.6 10 2.3 0.5362 0.104523002 iYOR130C tD(GUC)O 0.465289748 0.633413262 0.359170575 0.632337526 0.373982442 "ORT1 -- arginine biosynthesis -- Ornithine transport mitochondria involved in arginine metabolism, member of mitochondrial carrier (MCF) family" YOR287C YOR287C 0.6 9 2.3 0.5362 0.052764613 iYOR287C 0.343207603 0.01500399 0.398322851 "YOR287C -- unknown -- unknown function, possible coiled-coil protein" YPL157W YPL157W 0.6 10 2.3 0.5362 0.332378804 iYPL158C 0.67321588 0.244533121 0.529236668 YPL157W -- unknown -- Putative methyltransferase unknown role YEL022W GEA2 0.9 16 2.2 0.5247 1 0.711407145 iYEL023C 0.986360315 0.150050693 0.809018356 GEA2 -- secretion -- Component of complex with guanine-nucleotide-exchange activity for ARF YEL060C PRB1 1.5 25 2.2 0.5247 0.39913427 iYEL060C 0.338104479 0.410790549 0.167278532 "PRB1 -- protein degradation -- Protease B (yscB/PrB/cerevisin), serine protease of subtilisin family with broad proteolytic specificity" YMR188C YMR188C 1.5 24 2.2 0.5247 0.432758745 iYMR188C 0.142510098 0.576998051 0.229938272 "YMR188C -- unknown -- Possible mitochondrial ribosomal protein, has weak similarity to prokaryotic 30S ribosomal protein S17" YGR275W RTT102 1.3 23 2.2 0.5247 0.037017622 iYGR274C 0.54591963 0.156809733 0.398868137 RTT102 -- transposition (putative) -- Regulator of Ty1 Transposition YLL027W ISA1 1.3 22 2.2 0.5247 0.329977721 iYLL028W 0.373122818 0.444095038 0.27497583 ISA1 -- unknown -- Mitochondrial normal iron metabolism YML119W YML119W 1.3 22 2.2 0.5247 0.372885552 iYML120C 0.306104818 0.631497726 0.756767876 YML119W -- unknown -- unknown function YDR068W DOS2 1.2 22 2.2 0.5247 0.081096747 iYDR067C 0.365215859 0.031237274 0.519933911 DOS2 -- unknown -- unknown function YER134C YER134C 1.2 21 2.2 0.5247 0.565255699 iYER134C 0.177474681 0.639063592 0.157823589 YER134C -- unknown -- unknown function YGR057C LST7 1.2 20 2.2 0.5247 0.355170265 iYGR057C 0.257155289 0.755745184 0.242491566 LST7 -- secretion -- regulated transport of nitrogen-regulated permeases from the Golgi to the plasma membrane YJR042W NUP85 1.2 20 2.2 0.5247 0.424585906 iYJR041C 0.11837298 0.324074074 0.284805027 NUP85 -- nuclear protein targeting -- Nuclear pore protein YKL184W SPE1 1.2 21 2.2 0.5247 0.681398773 iYKL185W 0.628142275 0.840321454 0.615211086 "SPE1 -- polyamine biosynthesis -- Ornithine decarboxylase, rate limiting step of polyamine biosynthesis pathway" YLL043W FPS1 1.2 21 2.2 0.5247 0.431655629 iYLL044W 0.97889893 0.29171995 0.503054839 "FPS1 -- transport -- Glycerol channel protein, member of major intrinsic protein (MIP) family of transmembrane channel proteins" YMR311C GLC8 1.2 21 2.2 0.5247 0.118953616 iYMR311C 0.378471088 0.389863548 0.386480825 "GLC8 -- mitosis, chromosome segregation -- Modulator of protein serine/threonine phosphatase Glc7p, involved in control of vacuole fusion" YOR244W ESA1 1.2 21 2.2 0.5247 0.255861542 iYOR243C 0.430019062 0.748922586 0.498515024 "ESA1 -- chromatin structure -- Histone acetyltransferase of MYST family, catalytic subunit of NuA4 histone acetylase complex" YGL062W PYC1 1.1 19 2.2 0.5247 0.510913631 iYGL063W 0.470590661 0.722346369 0.419820885 "PYC1 -- TCA cycle -- Pyruvate carboxylase 1, catalyzes convertion of pyruvate to oxaloacetate in the gluconeogenesis pathway" YHR106W TRR2 1.1 18 2.2 0.5247 0.110394377 iYHR105W 0.4679429 0.396169194 0.242481641 "TRR2 -- pyrimidine biosynthesis -- Mitochondrial thioredoxin reductase, has strong similarity to cytoplasmic thioredoxin reductase Trr1p" YLR330W CHS5 1.1 18 2.2 0.5247 0.55481951 iYLR329W 0.636862662 0.496293909 0.744643999 CHS5 -- cell wall biogenesis -- chitin synthase III activity YPR115W YPR115W 1.1 19 2.2 0.5247 0.451655084 iYPR114W 0.287164082 0.2445753 0.113872645 YPR115W -- unknown -- unknown function YDR090C YDR090C 1 18 2.2 0.5247 0.232227985 iYDR090C 0.178975163 0.1989204 0.311582809 YDR090C -- unknown -- similarity to Yro2p YDR175C YDR175C 1 17 2.2 0.5247 0.622173581 iYDR175C 0.178403756 0.944373504 0.217048018 YDR175C -- unknown -- unknown function YER092W YER092W 1 17 2.2 0.5247 0.856233244 YER091C-A iYER091C-A 0.28527004 0.121509865 0.189870032 0.125120851 0.119234801 YER092W -- unknown -- unknown function YGL044C RNA15 1 18 2.2 0.5247 0.377210378 iYGL044C 0.031433759 0.43066871 0.060183693 "RNA15 -- mRNA 3'-end processing -- Component of pre-mRNA cleavage and polyadenylation factor I (CFI), involved in poly(A) site choice, interacts with Rna14p, Pap1p, and Pcf11p, contains one RNA recognition (RRM) domain" YJL101C GSH1 1 17 2.2 0.5247 0.537768133 iYJL101C 0.271819437 0.742346117 0.381543922 "GSH1 -- glutathione biosynthesis -- Gamma-glutamylcysteine synthetase, catalyzes rate-limiting step in glutathione synthesis" YKL179C YKL179C 1 17 2.2 0.5247 0.711797419 iYKL179C 0.551364521 0.571588188 0.65911306 YKL179C -- unknown -- similarity to kinesin and human kinesin-related protein CENP-E YNL166C BNI5 1 16 2.2 0.5247 0.424847607 iYNL166C 0.892326866 0.344034847 0.550596197 BNI5 -- unknown -- can suppress some cdc3 cdc10 double mutant strains YPL011C TAF47 1 17 2.2 0.5247 0.356396212 iYPL011C 0.517983275 0.550682261 0.443832984 TAF47 -- transcription -- Component of TAF(II) complex YPR129W SCD6 1 17 2.2 0.5247 0.570796726 iYPR128C 0.120319174 0.031862547 0.025672673 SCD6 -- secretion (putative) -- Multicopy suppressor of inviable strains of clathrin heavy chain deficient yeast YBR175W YBR175W 0.9 14 2.2 0.5247 0.5643616 0.913608131 "YBR175W -- unknown -- unknown function, has several WD (WD-40) repeats" YGL100W SEH1 0.9 15 2.2 0.5247 0.382461292 iYGL101W 0.326621742 0.788511118 0.594173982 "SEH1 -- nuclear protein targeting -- found in complex with nuclear pore proteins, member of WD (WD-40) repeat family" YGL127C SOH1 0.9 14 2.2 0.5247 0.127054093 iYGL127C 0.459000327 0.244988473 0.198759265 SOH1 -- unknown -- allows hpr1 null mutant to grow at 37 deg YJL065C YJL065C 0.9 15 2.2 0.5247 0.399315452 0.638341651 YJL065C -- unknown -- similarity to DNA polymerase epsilon subunit c YNL045W YNL045W 0.9 16 2.2 0.5247 0.387705348 iYNL046W 0.41628892 0.734693878 0.163991288 YNL045W -- unknown -- Bifunctional leukotriene A4 hydrolase and anion-activated leucyl aminopeptidase YOR026W BUB3 0.9 15 2.2 0.5247 0.403620189 iYOR025W 0.117470349 0.531693918 0.052114924 "BUB3 -- cell cycle, checkpoint -- Checkpoint cell cycle arrest in response to loss of microtubule function" YOR203W YOR203W 0.9 16 2.2 0.5247 0.636555328 0.849749033 YOR203W -- unknown -- unknown function YGL092W NUP145 0.8 13 2.2 0.5247 0.575403079 iYGL093W 0.475942841 0.649002394 0.268356075 "NUP145 -- nuclear protein targeting -- Nuclear pore protein (nucleoporin) with GLFG repeat motif, required for nuclear envelope structure" YGR252W GCN5 0.8 14 2.2 0.5247 0.352602095 iYGR251W 0.311759017 0.227958377 0.273822825 GCN5 -- chromatin structure -- Component of two nucleosomal histone acetyltransferase complexes YHR046C YHR046C 0.8 14 2.2 0.5247 0.239583328 iYHR046C 0.158778479 0.44385448 0.393304425 "YHR046C -- unknown -- similarity to inositol monophosphatase of E. coli, Aspergillus nidulans, and Neurospora crassa" YIL009W FAA3 0.8 13 2.2 0.5247 0.603103143 iYIL009C-A itD(GUC)I2 0.592555583 0.759562329 0.474740091 0.629229778 0.919792498 FAA3 -- fatty acid metabolism -- Acyl-CoA synthase (long-chain fatty acid CoA ligase)activates endogenous but not imported fatty acids YLR114C EFR4 0.8 12 2.2 0.5247 0.090166278 iYLR114C 0.404842951 0.201678598 0.586975362 EFR4 -- unknown -- weak similarity in the C-terminus to Drosophila melanogaster bicaudal-D protein YNL023C FAP1 0.8 12 2.2 0.5247 0.477173385 iYNL023C 0.453715613 0.664852458 0.349339349 FAP1 -- transcription (putative) -- similarity to human DNA-binding protein tenascin and Drosophila melanogaster shuttle craft protein YNR026C SEC12 0.8 12 2.2 0.5247 0.384154381 iYNR026C 0.23286995 0.778294225 0.215782359 "SEC12 -- secretion -- Guanine-nucleotide exchange factor for Sar1p, required for vesicle formation but is not incorporated into the vesicle" YOR143C THI80 0.8 13 2.2 0.5247 0.676478924 iYOR143C 0.273921966 0.943131403 0.175019952 "THI80 -- thiamine metabolism -- Thiamine pyrophosphokinase, converts thiamine to the coenzyme thiamine pyrophosphate" YPL115C BEM3 0.8 14 2.2 0.5247 0.405155021 iYPL115C 0.248894734 0.303403878 0.235540857 "BEM3 -- bud emergence -- GTPase-activating protein (GAP) for Cdc42p and Rho1p, contains a PH (pleckstrin) domain" YPL139C UME1 0.8 14 2.2 0.5247 0.334351575 iYPL139C 0.572576877 0.810774142 0.66634178 UME1 -- meiosis -- Negative regulator of meiosis YPR190C RPC82 0.8 13 2.2 0.5247 0.109600053 iYPR190C 0.513001277 0.108203736 0.344359417 "RPC82 -- transcription -- RNA polymerase III, third-largest subunit" YBL052C SAS3 0.7 12 2.2 0.5247 0.241667101 iYBL052C 0.19196047 0.333709314 0.080601555 "SAS3 -- silencing -- histone acetyltransferase activity, influences silencing at HMR locus, has a single C2H2-type zinc finger -36308" YDR527W YDR527W 0.7 11 2.2 0.5247 0.54006355 0.522693338 YDR527W -- unknown -- unknown function YGR014W MSB2 0.7 11 2.2 0.5247 0.489033939 iYGR013W 0.2884534 0.749516597 0.205929745 MSB2 -- bud emergence -- for which overproduction suppresses bud emergence defect of cdc24 mutant YJL210W PEX2 0.7 12 2.2 0.5247 0.203851786 0.389132554 PEX2 -- peroxisome biogenesis -- Peroxisomal biogenesis protein (peroxin) required for peroxisomal import of some proteins YKR079C YKR079C 0.7 12 2.2 0.5247 0.375741344 iYKR079C 0.588401422 0.644532214 0.828391879 YKR079C -- unknown -- unknown function YLR316C TAD3 0.7 12 2.2 0.5247 0.281501678 0.594659998 TAD3 -- tRNA processing -- Subunit of tRNA-specific adenosine-34 deaminase YML060W OGG1 0.7 11 2.2 0.5247 0.444044503 iYML061C 0.772122532 0.793724525 0.77956816 "OGG1 -- DNA repair -- DNA glycosylase, excises 7,8-dihydro-8-oxoguanine (8-OxoG) and formamidopyrimidine (Fapy) residues from DNA" YNL256W FOL1 0.7 12 2.2 0.5247 0.473045168 iYNL257C 0.471601746 0.923021478 0.376058724 "FOL1 -- folate biosynthesis -- Dihydroneopterin aldolase, dihydro-6-hydroxymethylpterin pyrophosphokinase, dihydropteroate synthetase" YOR321W PMT3 0.7 11 2.2 0.5247 0.159955779 iYOR320C 0.453284537 0.284031839 0.372903564 PMT3 -- protein glycosylation -- Mannosyltransferase (dolichyl phosphate-D-mannose YPL132W COX11 0.7 12 2.2 0.5247 0.964298001 iYPL133C 0.840626776 0.921896466 0.712992677 COX11 -- respiration -- heme A synthesis YPR128C YPR128C 0.7 12 2.2 0.5247 0.395063733 iYPR128C 0.120319174 0.729857633 0.025672673 "YPR128C -- unknown -- similarity to ADP/ATP carrier proteins, member of mitochondrial carrier family (MCF)localized to peroxisomes" YGL204C YGL204C 0.6 10 2.2 0.5247 0.702813607 iYGL204C 0.345265495 0.881890808 0.32316661 YGL204C -- unknown -- unknown function YMR070W MOT3 0.6 10 2.2 0.5247 0.133418925 iYMR069W 0.659126286 0.538661468 0.607257467 "MOT3 -- mating -- High-copy suppressor of MOT1-SPT3 synthetic lethality, has two tandem C2H2-type zinc fingers" YIR016W YIR016W 1.2 22 2.1 0.5121 1 0.911587768 iYIR015W 0.954281725 0.806865828 0.127853513 YIR016W -- unknown -- unknown function YGL084C GUP1 0.9 16 2.1 0.5121 1 0.902071485 iYGL084C 0.945305622 0.923243921 0.532003192 "GUP1 -- unknown -- unknown function, putative glycerol transporter with similarity to Gup2p" YBL021C HAP3 0.7 12 2.1 0.5121 1 0.987050693 iYBL021C 0.951460901 0.928687459 0.56473133 "HAP3 -- transcription -- Component (with Hap2p, Hap4p, and Hap5p) of heterotrimeric CCAAT-binding factor" YGR294W YGR294W 3.1 55 2.1 0.5121 0.92203405 0.607384251 YGR294W -- unknown -- Member of seripauperin (PAU) family YCL009C ILV6 2.9 50 2.1 0.5121 0.496001518 iYCL009C 0.6774126 0.761067928 0.331773816 ILV6 -- isoleucine and valine biosynthesis -- Acetolactate synthase regulatory subunit YNL305C YNL305C 2 35 2.1 0.5121 0.305221457 iYNL305C 0.063767623 0.528758331 0.070517568 YNL305C -- unknown -- similarity to Aspergillus nidulans negative-acting regulatory protein qutR and Drosophila melanogaster N-methyl-D-aspartate receptor-associated protein YJL171C YJL171C 1.7 29 2.1 0.5121 0.785427092 iYJL171C 0.462246852 0.954759584 0.266241022 YJL171C -- unknown -- unknown function YLR064W YLR064W 1.7 30 2.1 0.5121 0.363242942 iYLR063W 0.406359206 0.55581761 0.159831454 YLR064W -- unknown -- unknown function YLR146C SPE4 1.5 24 2.1 0.5121 0.383461562 iYLR146C 0.712932262 0.77325163 0.576318604 SPE4 -- spermine biosynthesis -- Spermine synthase (spermidine aminopropyltransferase) catalyzes the final step in of polyamine biosynthesis YOR131C YOR131C 1.5 26 2.1 0.5121 0.147719753 iYOR131C 0.233918894 0.502394254 0.170626843 YOR131C -- unknown -- similarity to E. coli protein yhfE of dam operon YOR142W LSC1 1.3 25 2.1 0.5121 0.502632442 iYOR141C 0.209208835 0.713407821 0.245899909 "LSC1 -- TCA cycle -- Alpha subunit of succinyl-CoA synthetase (succinyl-CoA ligase, succinate thiokinase)" YLR023C YLR023C 1.2 22 2.1 0.5121 0.474257328 iYLR023C 0.36159112 0.52690167 0.028810854 YLR023C -- unknown -- unknown function YLR387C YLR387C 1.2 22 2.1 0.5121 0.957092169 iYLR387C 0.976171593 0.706464485 0.731923384 "YLR387C -- unknown -- Protein possibly involved in proteasome function, has three dispersed C2H2-type zinc fingers" YMR302C RNA12 1.2 21 2.1 0.5121 0.53090189 iYMR302C 0.481771572 0.757541899 0.39516698 RNA12 -- rRNA processing -- role in early maturation of pre-rRNA and mitochondrial maintenance YPL031C PHO85 1.2 22 2.1 0.5121 0.255013396 iYPL031C 0.156765013 0.269980507 0.201926326 "PHO85 -- phosphate metabolism; cell cycle; glycogen metabolism -- Cyclin-dependent protein kinase that interacts with cyclin Pho80p to regulate phosphate pathway, also interacts with other Pho80p-like cyclins" YAL014C YAL014C 1.1 20 2.1 0.5121 0.331757773 iYAL014C 0.324781648 0.770750988 0.072530864 YAL014C -- unknown -- unknown functionhas potential C-terminal geranylgeranylation YBR172C SMY2 1.1 20 2.1 0.5121 0.413667795 iYBR172C 0.637492896 0.507075472 0.569735868 SMY2 -- unknown -- suppresses myo2-66 mutant when overexpressed YGR270W YTA7 1.1 20 2.1 0.5121 0.135395409 iYGR269W 0.272339565 0.5039085 0.105506823 YTA7 -- protein degradation -- Member of AAA ATPase protein family YKL140W TGL1 1.1 20 2.1 0.5121 0.266475058 iYKL141W 0.238688047 0.617283951 0.523755747 TGL1 -- glycerolipid metabolism -- Triglyceride lipase YLR347C KAP95 1.1 21 2.1 0.5121 0.838384076 iYLR347C 0.546786466 0.957846004 0.286751796 "KAP95 -- nuclear protein targeting -- Karyopherin-beta, targets proteins with nuclear localization (NLS) sequences to the nuclear pore complex" YMR061W RNA14 1.1 19 2.1 0.5121 0.192094087 iYMR060C 0.406373599 0.329577219 0.300439338 "RNA14 -- mRNA 3'-end processing -- Component of pre-mRNA cleavage and polyadenylation factor I (CFI) involved in poly(A) site choice, interacts with Rna15p, Fip1p, Pap1p, and Pcf11p" YAL029C MYO4 1 18 2.1 0.5121 0.682952261 iYAL029C 0.522747814 0.607808341 0.543586851 "MYO4 -- cell polarity -- Myosin heavy chain, class V" YBR153W RIB7 1 17 2.1 0.5121 0.707637518 iYBR152W 0.358297414 0.808250081 0.375926523 "RIB7 -- flavin biosynthesis -- HTP reductase, second step in the riboflavin biosynthesis pathway" YDR337W MRPS28 1 17 2.1 0.5121 0.378693576 iYDR336W 0.302918241 0.692833045 0.638702912 MRPS28 -- protein synthesis -- Mitochondrial ribosomal small subunit (E. coli S15) YDL189W YDL189W 0.9 16 2.1 0.5121 0.340982574 iYDL190C 0.555874255 0.341500399 0.897011046 YDL189W -- unknown -- unknown function YDR476C YDR476C 0.9 15 2.1 0.5121 0.184439074 iYDR476C 0.226848083 0.644474485 0.597959352 YDR476C -- unknown -- unknown function YGL246C RAI1 0.9 16 2.1 0.5121 0.579245588 iYGL246C 0.233313939 0.834119497 0.228810854 RAI1 -- unknown -- binds and enhances function of nuclear exonuclease Rat1p YJL016W YJL016W 0.9 16 2.1 0.5121 0.688977029 iYJL017W 0.622944229 0.875523687 0.802713488 "YJL016W -- unknown -- unknown function, overlaps with YJL015C" YJL154C VPS35 0.9 15 2.1 0.5121 0.480588141 iYJL154C 0.257558621 0.677199046 0.123416956 "VPS35 -- vacuolar protein targeting -- vacuolar sorting, mutant has vacuoles of normal morphology" YJR111C YJR111C 0.9 15 2.1 0.5121 0.307022704 iYJR111C 0.559054504 0.415967855 0.509708549 YJR111C -- unknown -- unknown function YKR072C SIS2 0.9 16 2.1 0.5121 0.29911655 iYKR072C 0.642806738 0.470213138 0.523864821 "SIS2 -- cell cycle and ion homeostasis -- ion homeostasis, plays a role in resistance to elevated NaCl or LiCl" YLR134W PDC5 0.9 16 2.1 0.5121 0.738893901 iYLR133W 0.605169067 0.895169917 0.794087667 PDC5 -- glycolysis -- Pyruvate decarboxylase isozyme 2 YML043C RRN11 0.9 16 2.1 0.5121 0.285320295 iYML043C 0.244048894 0.357382283 0.572458167 RRN11 -- transcription -- Component of RNA polymerase I core transcription factor (CF) along with Rrn6p and Rrn7p YMR177W MMT1 0.9 16 2.1 0.5121 0.352744201 iYMR176W 0.14440617 0.677593782 0.227987421 MMT1 -- mitochondrial iron transport -- mitochondrial iron accumulation YNL246W YNL246W 0.9 16 2.1 0.5121 0.375110539 iYNL247W 0.251721176 0.43944129 0.082742507 YNL246W -- unknown -- similarity to Drosophila melanogaster SET protein YNL252C MRPL17 0.9 16 2.1 0.5121 0.316808233 iYNL252C 0.646585512 0.60030229 0.416522669 MRPL17 -- protein synthesis -- Mitochondrial ribosomal large subunit YER089C PTC2 0.8 13 2.1 0.5121 0.603140835 iYER089C 0.553514023 0.624756335 0.663712536 "PTC2 -- unknown -- Protein serine/threonine phosphatase of PP2C family, negative regulator of unfolded protein response (UPR) pathway" YFR034C PHO4 0.8 13 2.1 0.5121 0.403388759 iYFR034C 0.550696046 0.142201096 "PHO4 -- phosphate signaling -- Basic helix-loop-helix (bHLH) transcription factor required for expression of phosphate pathway, inactivated by hyperphosphorylation by Pho80p-Pho85p cyclin-dependent protein kinase" YHR130C YHR130C 0.8 15 2.1 0.5121 0.295625692 0.113922011 YHR130C -- unknown -- unknown function YIL130W YIL130W 0.8 15 2.1 0.5121 0.458354484 iYIL131C 0.195731739 0.516201117 0.171849823 YIL130W -- unknown -- similarity to transcription factorshas Zn[2]-Cys[6] fungal-type binuclear cluster domain in the N-terminal region YJL006C CTK2 0.8 14 2.1 0.5121 0.8729966 iYJL006C itL(UAA)J 0.600795283 0.611327473 0.934666338 0.398725498 0.496256068 "CTK2 -- transcription -- C-terminal domain (RNA polymerase II CTD) kinase beta subunit, cyclin-related protein component that interacts with the cyclin-dependent protein kinase Ctk1p" YJL091C YJL091C 0.8 13 2.1 0.5121 0.680673179 iYJL091C 0.679580421 0.858403215 0.617202729 YJL091C -- unknown -- unknown function YLR460C YLR460C 0.8 14 2.1 0.5121 0.310058348 iYLR460C-0 iYLR460C-1 0.720026135 0.941672582 0.744145917 0.798651722 0.641580208 YLR460C -- unknown -- strong similarity to Ycr102p YMR039C TSP1 0.8 14 2.1 0.5121 0.067931506 iYMR039C 0.088594506 0.063164679 0.038695505 TSP1 -- transcription -- Transcriptional coactivatormay be involved in the release of TFIIB from the transcription complex during RNA polymerase II transcription initiation YPR140W YPR140W 0.8 15 2.1 0.5121 0.428198286 iYPR139C 0.17880289 0.620283019 0.050173429 YPR140W -- unknown -- Putative acyltransferase with similarity to human Barth syndrome gene tafazzin YBR271W YBR271W 0.7 11 2.1 0.5121 0.133539353 iYBR270C 0.335562457 0.299514523 0.676974144 YBR271W -- unknown -- Putative SAM-dependent methyltransferase YEL018W YEL018W 0.7 13 2.1 0.5121 0.36547337 iYEL019C 0.117619882 0.361777628 0.069681771 YEL018W -- unknown -- unknown function YGR028W MSP1 0.7 12 2.1 0.5121 0.915025324 iYGRWdelta14 itE(UUC)G3 0.666934641 0.69558588 0.98499601 0.449140921 0.66677409 "MSP1 -- mitochondrial protein targeting -- Intra-mitochondrial sorting protein, member of AAA family of ATPases" YGR227W DIE2 0.7 11 2.1 0.5121 0.082162692 iYGR226C 0.216694051 0.104288499 0.178639019 DIE2 -- glucosylation? -- Glucosyltransferase involved in the terminal glucosylation step of lipid-linked oligosaccharide YJL193W YJL193W 0.7 13 2.1 0.5121 0.91841175 iYJL194W 0.684307729 0.817158819 0.602565137 "YJL193W -- unknown -- similarity to Sly41p, member of triose phosphate translocator family of membrane transporters" YKL045W PRI2 0.7 13 2.1 0.5121 0.298054175 iYKL046C 0.379005976 0.66576154 0.391872309 "PRI2 -- DNA replication -- DNA primase large subunit (DNA polymerase alpha 58 kDa subunit), involved in synthesis of RNA primers for Okazaki fragments" YKL149C DBR1 0.7 11 2.1 0.5121 0.575250407 iYKL149C 0.107250142 0.783054713 0.21973058 DBR1 -- mRNA splicing -- Lariat RNA debranching enzyme involved in turnover of excised spliceosomal introns YNL001W DOM34 0.7 13 2.1 0.5121 0.686128859 iYNL002C 0.553694885 0.824132284 0.268587361 DOM34 -- protein synthesis (putative) -- translation YNL119W YNL119W 0.7 13 2.1 0.5121 0.659949497 0.848592401 YNL119W -- unknown -- Protein possibly involved in cytoplasmic ribosome function YOR084W YOR084W 0.7 12 2.1 0.5121 iYOR083W 0.671454247 0.847499155 YOR084W -- unknown -- unknown function YHR029C YHR029C 0.6 11 2.1 0.5121 0.615182591 iYHR029C 0.463930358 0.783568666 0.296058586 YHR029C -- unknown -- similarity to Pseudomonas aureofaciens phzC involved in phenazine antibiotic synthesistranscription induced by the drug FK506 in a GCN4-dependent manner YIL016W SNL1 0.6 11 2.1 0.5121 0.448033026 YIL017C iYIL017C 0.368180333 0.308125964 0.912696454 0.240219408 0.740582399 SNL1 -- nuclear protein targeting -- interacts genetically with nuclear pore complex proteins YJL087C TRL1 0.6 10 2.1 0.5121 0.274476999 0.813889784 "TRL1 -- tRNA splicing -- tRNA ligase required for tRNA splicing, has 3 activities in one polypeptide" YMR267W PPA2 0.6 11 2.1 0.5121 0.128021847 iYMR266W 0.360188419 0.265790111 0.358473824 "PPA2 -- oxidative phosphorylation -- Inorganic pyrophosphatase, mitochondrial" YOL093W YOL093W 0.6 9 2.1 0.5121 0.084244943 iYOL094C 0.548142064 0.300008228 0.174790356 YOL093W -- unknown -- unknown function YPL254W HFI1 0.6 10 2.1 0.5121 0.477861554 iYPL255W 0.340678831 0.675306509 0.620981831 "HFI1 -- transcription -- Component of ADA complex, interacts functionally with histone H2Ai" YDR440W DOT1 0.4 9 2.1 0.5121 0.333871492 iYDR439W-0 iYDR439W-1 0.326924109 0.340097965 0.269114126 0.357031186 0.578849722 "DOT1 -- meiosis, checkpoint; transcriptional silencing -- cell cycle arrest at the pachytene stage of meiosis in a zip1 mutant" YJL033W HCA4 0.4 8 2.1 0.5121 0.471179355 iYJL034W 0.54241507 0.468783043 0.199910929 "HCA4 -- rRNA processing -- Probable RNA helicase CA4, involved in ribosomal RNA processing" YJR055W HIT1 0.4 9 2.1 0.5121 0.597696084 iYJR054W YJLWdelta16 0.345043814 0.851484963 0.800957702 0.189816307 0.789540385 HIT1 -- unknown -- growth at high temperature YKL176C YKL176C 1.1 21 2 0.4969 1 0.92419664 iYKL176C 0.983139099 0.798983625 0.093216281 YKL176C -- unknown -- unknown function YOR354C YOR354C 0.9 16 2 0.4969 1 0.576437806 iYOR354C-0 iYOR354C-1 0.925420027 0.965657265 0.395176252 0.610055866 0.242568228 YOR354C -- unknown -- unknown function YPL082C MOT1 0.9 17 2 0.4969 1 0.607770428 iYPL082C IntYPL081W 0.953480189 0.963957202 0.302852079 0.128651237 0.821085747 "MOT1 -- transcription -- Transcriptional Accessory Protein (TAF) involved in RNA polymerase II transcriptional repression through interaction with TATA-binding protein (TBP), member of Snf2p family of DNA helicases" YER046W YER046W 0.7 13 2 0.4969 1 0.735869296 iYER045C-0 iYER045C-1 0.939890272 0.95689995 0.612945493 0.762335248 0.764644852 YER046W -- unknown -- unknown function YGR258C RAD2 0.7 13 2 0.4969 1 0.546212594 iYGR258C-0 iYGR258C-1 0.962064635 0.356930106 0.275056397 0.522303783 0.294641216 "RAD2 -- DNA repair, nucleotide excision -- Structure-specific single-stranded DNA endonuclease of nucleotide excision repairosome" YDL215C GDH2 1.9 34 2 0.4969 0.292116812 iYDL215C 0.134446708 0.517060579 0.604297694 "GDH2 -- glutamate metabolism -- Glutamate dehydrogenase (NAD), primary pathway for generating ammonia from glutamate" YKL150W MCR1 1.8 34 2 0.4969 0.733795666 iYKL151C 0.893278506 0.605220754 0.363860775 MCR1 -- electron carrier -- NADH-cytochrome b5 reductase YBL050W SEC17 1.7 32 2 0.4969 0.638227005 iYBL051C 0.258890752 0.955538085 0.189406969 SEC17 -- secretion -- fusion of vesicles to target membranes as well as for vacuolar fusionhomolog of mammalian alpha-SNAP YDR457W TOM1 1.6 29 2 0.4969 0.615984031 iYDR456W 0.587879778 0.443954082 0.479228846 "TOM1 -- cell cycle, G2/M -- the G2/M transition, has similarity to Rsp5p, a ubiquitin-protein ligase" YPL169C MEX67 1.6 28 2 0.4969 0.487976291 iYPL169C 0.642040715 0.453351595 0.692976856 MEX67 -- mRNA export -- the export of mRNA from the nucleus to the cytoplasm YIL154C YIL154C 1.3 24 2 0.4969 0.196175118 iYIL154C 0.197914728 0.399920192 0.225890985 YIL154C -- stress response -- control of mitochondrial sugar utilization YMR184W YMR184W 1.3 26 2 0.4969 0.414278776 iYMR183C 0.417494197 0.428375765 YMR184W -- unknown -- unknown function YBR077C YBR077C 1.2 23 2 0.4969 0.563296308 iYBR077C 0.274647185 0.703396545 0.157032978 YBR077C -- unknown -- unknown function YBR091C MRS5 1.2 23 2 0.4969 0.711197294 iYBR091C 0.217626699 0.811647173 0.292312698 "MRS5 -- mitochondrial protein targeting -- Essential component of mitochondrial import machinery, required for transfer of hydrophobic inner membrane carrier proteins across the intermembrane space" YIL023C YIL023C 1.2 22 2 0.4969 0.37631965 iYIL023C 0.600933543 0.875432194 0.521628093 YIL023C -- unknown -- similarity to Atx2 YBR004C YBR004C 1.1 21 2 0.4969 0.663916165 iYBR004C 0.634299954 0.863607342 0.696986787 YBR004C -- unknown -- expressed between 3 and 6 hours after transfer to sporulation medium YDR516C YDR516C 1.1 20 2 0.4969 0.638987428 iYDR516C 0.247189943 0.804492718 0.383963862 YDR516C -- unknown -- similarity to Glk1p YER167W BCK2 1.1 20 2 0.4969 0.472228457 iYER166W 0.528316508 0.37858524 0.321069433 BCK2 -- signaling -- the SIT4 pathway for CLN activation and in suppression of lethality due to mutations in the kinase C pathway YJR113C YJR113C 1.1 22 2 0.4969 0.674545794 0.896848603 "YJR113C -- protein synthesis -- Probable mitochondrial ribosomal protein S7 of small subunit, homolog of E. coli ribosomal protein S7" YLR099C ICT1 1.1 21 2 0.4969 0.54261646 iYLR099C 0.308696027 0.744938292 0.39896874 ICT1 -- copper ion homeostasis (putative) -- normal sensitivity to copper YNR033W ABZ1 1.1 20 2 0.4969 0.412366345 YNR032C-A iYNR032C-A 0.323755764 0.067344241 0.680047885 0.376732195 0.092101149 ABZ1 -- PABA biosynthesis -- Para-aminobenzoate synthase YOR197W YOR197W 1.1 21 2 0.4969 0.250198331 iYOR196C 0.226320001 0.435024603 0.184728051 YOR197W -- unknown -- unknown function YBR038W CHS2 1 19 2 0.4969 0.398018098 iYBR037C 0.179275612 0.44287786 0.290854451 "CHS2 -- cell wall biogenesis -- Chitin synthase II, responsible for primary septum disk" YDR357C YDR357C 1 19 2 0.4969 0.74106253 iYDR357C 0.500165262 0.963458901 0.37998848 YDR357C -- unknown -- unknown function YGR255C COQ6 1 19 2 0.4969 0.701068203 iYGR255C itT(UGU)G2 0.739055864 0.427839586 0.828794715 0.623700455 0.496115319 COQ6 -- ubiquinone biosynthesis -- Monooxygenase required for coenzyme Q (ubiquinone) biosynthesis YHR107C CDC12 1 19 2 0.4969 0.371195916 iYHR107C 0.128650586 0.652513966 0.221978558 "CDC12 -- cytokinesis -- Septin, component of 10 nm filaments of mother-bud neckinvolved in cytokinesis" YJR086W STE18 1 19 2 0.4969 0.762724084 iYJR085C 0.076939899 0.856509829 0.442413905 "STE18 -- signaling, pheromone pathway -- Gamma subunit of guanine nucleotide-binding mediates signal transduction by pheromones during mating" YKL203C TOR2 1 18 2 0.4969 0.419075977 iYKL203C 0.233027596 0.244219534 0.269566737 "TOR2 -- signaling, cell cycle, meiosis and actin cytoskeleton organization -- Phosphatidylinositol-4 kinase (PI-4 kinase), involved in cell growth and sensitivity to the immunosuppressant rapamycin, has similarity to Tor1p" YBR273C YBR273C 0.9 18 2 0.4969 0.159460813 iYBR273C 0.401904817 0.338517239 0.643220134 YBR273C -- unknown -- unknown function YER130C YER130C 0.9 17 2 0.4969 0.894534184 iYER130C 0.974083212 0.986609664 0.494533635 "YER130C -- unknown -- unknown function, has two tandem zinc finger domains" YJL093C TOK1 0.9 18 2 0.4969 0.387682883 iYJL093C 0.245531904 0.826656026 0.216987981 TOK1 -- transport -- Two-domain outwardly-rectifying voltage-gated potassium channel YNL177C YNL177C 0.9 16 2 0.4969 0.702834466 iYNL177C 0.802971487 0.729692668 0.810347628 YNL177C -- unknown -- unknown function YNL321W YNL321W 0.9 16 2 0.4969 0.16672256 iYNL322C 0.25315304 0.203351595 0.230145319 YNL321W -- unknown -- Member of calcium permease family of membrane transporters YOR329C SCD5 0.9 16 2 0.4969 0.104637116 iYOR329C 0.256928862 0.125893437 0.415120112 SCD5 -- secretion -- Multicopy suppressor of clathrin deficiency YBR085W AAC3 0.8 15 2 0.4969 0.950305482 iYBR084C-A 0.985655862 0.668063165 0.377094972 "AAC3 -- transport -- ADP/ATP transporter protein, member of mitochondrial carrier (MCF) family" YDL018C ERP3 0.8 15 2 0.4969 0.566377755 iYDL018C 0.436640347 0.839349017 0.564804469 ERP3 -- membrane trafficking; secretion (putative) -- similarity to COPII-coated vesicle proteins Emp24p and Erv25p YDL179W PCL9 0.8 15 2 0.4969 0.299338776 iYDL180W 0.703820625 0.70302467 0.836206897 PCL9 -- cell cycle -- Cyclin that associates with Pho85p YDL246C YDL246C 0.8 15 2 0.4969 0.392415661 iYDL246C-0 iYDL246C-1 0.276325308 0.430814924 0.335308993 0.362490024 0.610062893 YDL246C -- unknown -- similarity to Sor1p YDR364C CDC40 0.8 15 2 0.4969 0.381558699 iYDR364C 0.58525605 0.834956105 0.30196584 "CDC40 -- cell cycle and mRNA splicing -- the second catalytic step of mRNA splicing, member of WD (WD-40) repeat family" YER010C YER010C 0.8 15 2 0.4969 0.182523311 iYER010C-0 iYER010C-1 0.527797579 0.251308313 0.543128655 0.680606544 0.275584795 YER010C -- unknown -- unknown function YER164W CHD1 0.8 16 2 0.4969 0.516580865 iYER163C-0 iYER163C-1 0.356008532 0.245960241 0.604470157 0.274582408 0.342168869 CHD1 -- transcription -- similarity to mouse CHD (Chromodomain-Helicase-DNA-binding) protein YFL046W YFL046W 0.8 15 2 0.4969 0.029157662 iYFL047W 0.22315457 0.052274541 0.012751787 YFL046W -- unknown -- weak similarity to myosin heavy chain A YHR113W YHR113W 0.8 15 2 0.4969 0.524585973 iYHR112C 0.091854379 0.84382457 0.254695262 YHR113W -- unknown -- similarity to vacuolar aminopeptidase Lap4p/Ape1p YHR123W EPT1 0.8 13.5 2 0.4969 0.687963301 iYHR122W 0.89508803 0.556652678 0.815202587 "EPT1 -- phospholipid metabolism -- sn-1,2-Diacylglycerol ethanolaminephosphotransferase" YJL062W LAS21 0.8 14 2 0.4969 0.103812557 iYJL063C 0.263715131 0.259014278 0.52365671 LAS21 -- unknown -- addition of a side chain to the glycosylphospatidylinositol (GPI) core structure YJR003C YJR003C 0.8 14 2 0.4969 0.719514237 iYJR003C 0.408269549 0.960312979 0.321206744 YJR003C -- unknown -- weak similarity to human collagen alpha 3 (VI) chain precursor YJR041C YJR041C 0.8 14 2 0.4969 0.399527144 iYJR041C 0.11837298 0.904522698 0.284805027 YJR041C -- unknown -- similarity to Podospora anserina NADH dehydrogenase chain 4 YJR103W URA8 0.8 16 2 0.4969 0.462201301 iYJR102C 0.550273905 0.839751853 0.703182268 "URA8 -- pyrimidine biosynthesis -- CTP synthase, last step in pyrimidine biosynthesis pathway" YKL078W JA2 0.8 14 2 0.4969 0.064395088 iYKL079W 0.214677889 0.174860335 0.20815863 "JA2 -- unknown -- RNA helicase of DEAH box family, possible pre-mRNA splicing factor" YML027W YOX1 0.8 14 2 0.4969 0.697644505 iYML028W 0.600473122 0.697786414 0.307825228 YOX1 -- unknown -- homeodomain that binds tRNA-Leu gene YOL029C YOL029C 0.8 14 2 0.4969 0.32670063 iYOL029C 0.620225459 0.620258372 0.604871225 YOL029C -- unknown -- unknown function YOR017W PET127 0.8 15 2 0.4969 0.444692202 iYOR016C 0.045248503 0.665765461 0.035275339 PET127 -- protein synthesis -- Mitochondrial membrane-associated stability and processing of mitochondrial mRNAs YAL020C ATS1 0.7 13 2 0.4969 0.354206138 iYAL020C 0.085744049 0.66475991 0.09901708 "ATS1 -- cytoskeleton (putative) -- similarity to human RCC1 protein, suppressor of mutations in alpha tubulin" YBR238C YBR238C 0.7 12 2 0.4969 0.296238126 iYBR238C 0.270411272 0.472475932 0.482521947 YBR238C -- unknown -- unknown function YDL098C SNU23 0.7 12 2 0.4969 0.534259022 iYDL098C 0.379016246 0.680266111 0.277486489 SNU23 -- mRNA splicing (putative) -- Component of U4/U6.U5 snRNP YDR348C YDR348C 0.7 12 2 0.4969 0.298649601 iYDR348C 0.277321094 0.585723493 0.416356877 YDR348C -- unknown -- unknown function YDR518W EUG1 0.7 13 2 0.4969 0.487662685 iYDR517W 0.293587431 0.916201117 0.311322287 "EUG1 -- protein folding -- disulfide isomerase, required only in the absence of Pdi1p" YFR005C SAD1 0.7 13 2 0.4969 0.638629536 iYFR005C 0.053423992 0.89584996 0.093729695 "SAD1 -- mRNA splicing, snRNP assembly -- snRNP assembly factor required for pre-mRNA splicing" YGR117C YGR117C 0.7 11 2 0.4969 0.985458171 iYGR117C 0.959779417 0.976855547 0.00489229 YGR117C -- unknown -- unknown function YHR084W STE12 0.7 12 2 0.4969 0.277843943 iYHR083W 0.764964804 0.713416695 0.943063678 "STE12 -- mating and pseudohyphal growth -- Transcription factor that binds to pheromone response element (PRE) to regulate genes required for mating, also functions with Tec1p to regulate genes required for filamentous growth" YJL172W CPS1 0.7 13 2 0.4969 0.529001939 iYJL173C 0.367959432 0.682043097 0.4896249 "CPS1 -- protein degradation -- Gly-X carboxypeptidase yscS, involved in nitrogen metabolism" YJR141W YJR141W 0.7 13 2 0.4969 0.783778658 iYJR140C 0.56016081 0.974429297 0.301401869 YJR141W -- unknown -- Essential unknown function YMR129W POM152 0.7 13 2 0.4969 0.472794299 iYMR128W 0.201083738 0.625524562 0.441351308 POM152 -- nuclear protein targeting -- Nuclear pore membrane glycoproteintype II integral membrane N-terminal region on pore side and C-terminal region in the cisternae YNL021W HDA1 0.7 13 2 0.4969 0.338109114 iYNL022C 0.590932705 0.683450303 0.232342007 "HDA1 -- chromatin structure -- Component of histone deacetylase A, 75 kDa subunit" YOL115W TRF4 0.7 13 2 0.4969 0.215776879 iYOL116W 0.365485136 0.309141776 0.525466963 "TRF4 -- mitosis, chromosome condensation -- Protein required in the absence of Top1p" YOR144C EFD1 0.7 12 2 0.4969 0.324736068 iYOR144C 0.585856919 0.68780573 0.590234102 EFD1 -- recombination (putative) -- stability of direct DNA repeats YDR260C SWM1 0.6 11 2 0.4969 0.834284553 iYDR260C 0.503522704 0.639590223 0.191699559 SWM1 -- sporulation -- spore wall assembly YGL155W CDC43 0.6 11 2 0.4969 0.563142135 iYGL156W 0.191003912 0.851173671 0.246958432 "CDC43 -- protein processing -- Geranylgeranyltransferase type I beta subunit, recognizes a C-terminal CXXL motif" YHR149C YHR149C 0.6 11 2 0.4969 iYHR149C 0.231423021 0.406227313 YHR149C -- unknown -- unknown function YJL010C YJL010C 0.6 10 2 0.4969 0.414603318 iYJL010C 0.485388053 0.438573849 0.485674939 YJL010C -- unknown -- unknown function YJR043C POL32 0.6 12 2 0.4969 0.251263418 iYJR043C itM(CAU)J3 0.240930716 0.544899108 0.365915444 0.214844374 0.535934848 POL32 -- DNA replication -- Small (55 kDa) subunit of DNA polymerase delta YKR003W YKR003W 0.6 11 2 0.4969 0.49037737 iYKR002W 0.768351273 0.881243957 0.720542578 "YKR003W -- unknown -- similarity to human oxysterol-binding protein (OSBP),member of KES1/HES1/OSH1/YKR003W family of oxysterol-binding protein" YMR088C YMR088C 0.6 10 2 0.4969 0.388995759 iYMR088C 0.414192694 0.726957783 0.211470419 YMR088C -- unknown -- Member of multidrug-resistance 14-spanner family of major facilitator superfamily (MFS-MDR) YNL282W POP3 0.6 11 2 0.4969 0.5245391 iYNL283C 0.533663139 0.941033138 0.266422082 "POP3 -- rRNA and tRNA processing -- Component of both RNase MRP and RNase P, involved in processing of both rRNA and tRNA precursors" YNR048W YNR048W 0.6 11 2 0.4969 0.322399935 iYNR047W 0.426861031 0.23817168 0.570415727 YNR048W -- unknown -- unknown function YOR138C YOR138C 0.6 10 2 0.4969 0.408966781 iYOR138C 0.37116245 0.621243885 0.233585232 YOR138C -- unknown -- unknown function YDR428C YDR428C 0.4 9 2 0.4969 0.488163653 iYDR428C 0.27707593 0.582292235 0.141406758 YDR428C -- unknown -- unknown function YPR029C APL4 1.1 21 1.9 0.4819 1 0.743767935 iYPR029C 0.972814298 0.600789558 0.657417117 "APL4 -- secretion -- Gamma-adaptin, large subunit of clathrin-associated protein (AP) complex" YNL101W YNL101W 1 20 1.9 0.4819 1 0.900978161 iYNL102W 0.97040561 0.720649895 0.782934255 YNL101W -- unknown -- Putative membrane transporter of amino acid/auxin permease (AAAP) family YDR189W SLY1 0.9 17 1.9 0.4819 1 0.66881738 iYDR188W 0.67368349 0.38706218 0.282189929 "SLY1 -- secretion -- vesicle trafficking between endoplasmic reticulum and Golgi, member of Sec1p family" YHR091C MSR1 0.8 15 1.9 0.4819 1 0.7250558 iYHR091C 0.958591963 0.899691358 0.121018611 MSR1 -- protein synthesis -- Arginyl-tRNA synthetase of mitochondria YBR199W KTR4 2.2 45 1.9 0.4819 0.552615339 iYBR198C 0.328981648 0.642617717 0.381243957 "KTR4 -- protein glycosylation -- Alpha-1,2-mannosyltransferase of KRE2 family" YOR317W FAA1 1.9 37 1.9 0.4819 0.618787566 iYOR316C-0 iYOR316C-1 0.705008664 0.917170267 0.514099259 0.429768555 0.557940942 FAA1 -- fatty acid metabolism -- Long-chain fatty acid CoA ligase (fatty acid activator 1)can incorporate exogenous myristate into myristoyl-CoA and other fatty acids to the CoA derivatives YOR382W YOR382W 1.9 38 1.9 0.4819 0.345218814 iYOR381W-0 iYOR381W-1 0.34695742 0.313789008 0.122292103 0.418469077 0.10046902 YOR382W -- unknown -- unknown function YDR309C GIC2 1.8 36 1.9 0.4819 0.43899549 iYDR309C 0.14644484 0.502154828 0.293054771 "GIC2 -- bud emergence -- Putative effector of Cdc42p, important for bud emergence" YCR073W-A 1.7 34 1.9 0.4819 0.221246269 iYCR073C 0.522376288 0.326576217 0.66733806 YCL045C YCL045C 1.6 31 1.9 0.4819 0.293328173 0.626347404 YCL045C -- unknown -- unknown function YBR234C ARC40 1.5 28 1.9 0.4819 0.469168525 iYBR234C 0.146099442 0.531260561 0.151407599 "ARC40 -- cytoskeleton -- Component of ARP2/3 actin-organizing complex, involved in actin assembly and function" YEL065W SIT1 1.5 29 1.9 0.4819 0.570277845 iYEL066W 0.553119036 0.620826195 0.658659218 "SIT1 -- transport -- Ferrioxamine B permease, member of yeast-specific multidrug-resistance (MFS-MDR) family of major facilitator superfamily (MFS)" YLR250W SSP120 1.5 29 1.9 0.4819 0.398411788 iYLR249W 0.53231936 0.673550052 0.492142616 SSP120 -- secretion -- Putative secretory protein YML100W TSL1 1.3 27 1.9 0.4819 0.365735626 iYML101C 0.352351623 0.450828882 0.365936191 TSL1 -- trehalose metabolism -- Component of trehalose-6-phosphate synthase/phosphatase complexalternate third subunit with Tps3p YCR048W ARE1 1.2 24 1.9 0.4819 0.47167651 0.525503574 ARE1 -- sterol metabolism -- Acyl-CoA YDR182W CDC1 1.2 23 1.9 0.4819 0.288432966 iYDR181C 0.574142742 0.673245614 0.348183089 "CDC1 -- Mn2+ ion homeostasis -- ion homeostatisaffects bud emergence, mating, macromolecular synthesis, intrachromosomal recombination, and nuclear division" YKL087C CYT2 1.2 24 1.9 0.4819 0.275094974 iYKL087C 0.586220757 0.397920832 0.674760023 CYT2 -- cytochrome c1 biosynthesis -- Holocytochrome-c1 synthase YDR294C DPL1 1.1 23 1.9 0.4819 0.483271265 iYDR294C 0.30994773 0.785593289 0.768734371 DPL1 -- phospholipid metabolism -- Dihydrosphingosine-1-phosphate lyase YFL041W FET5 1.1 21 1.9 0.4819 0.771680832 iYFL042C 0.115843439 0.965921788 0.283133016 FET5 -- transport -- Multicopper oxidase involved in ferrous iron transport YOR267C YOR267C 1.1 22 1.9 0.4819 0.087466272 iYOR267C 0.099866123 0.051643571 0.032865833 YOR267C -- unknown -- Serine/threonine protein kinase with similarity to members of NPR1 subfamily YBR080C SEC18 1 20 1.9 0.4819 0.358893445 iYBR080C 0.601104571 0.704868316 0.580301686 "SEC18 -- secretion -- fusion of vesicles to target membranes as well as for vacuolar fusion, homolog of mammalian NSF protein, member of AAA family of ATPases" YBR246W YBR246W 1 18 1.9 0.4819 0.33918654 0.841228419 YBR246W -- unknown -- unknown function YFR031C SMC2 1 19 1.9 0.4819 0.441619256 iYFR031C 0.786199315 0.335320657 0.589810747 "SMC2 -- mitosis, chromosome condensation and segregation -- Subunit of condensin protein complex required for chromosome condensation and segregation, coiled-coil SMC family" YIL046W MET30 1 19 1.9 0.4819 0.603593128 iYIL047C 0.101755046 0.858998145 0.002842755 "MET30 -- sulfur amino acid metbolism -- F-box targets proteins for ubiquitination by interacting with the SCF complex (Skp1p-Cdc53p-Cdc34p), regulates sulfur assimilation genes in response to S-adenosylmethionine levels, contains five WD (WD-40) repeats" YMR261C TPS3 1 19 1.9 0.4819 0.379917585 iYMR261C 0.488454505 0.258137286 0.602694584 "TPS3 -- trehalose utilization -- Component of trehalose-6-phosphate synthase/phosphatase complex, alternative third subunit with Tls1p" YPL173W MRPL40 1 18 1.9 0.4819 0.191492259 iYPL174C 0.481889484 0.318948133 0.621986341 MRPL40 -- protein synthesis -- Mitochondrial ribosomal large subunit YPR067W ISA2 1 21 1.9 0.4819 0.161646505 iYPR066W 0.535922721 0.260255387 0.627492396 ISA2 -- unknown -- Mitochondrial iron metabolism YCL010C YCL010C 0.9 17 1.9 0.4819 0.335180226 iYCL010C 0.412832993 0.204229848 0.51754386 YCL010C -- unknown -- unknown function YEL043W YEL043W 0.9 18 1.9 0.4819 0.563936023 iYEL044W 0.805427218 0.359006007 0.450341479 YEL043W -- unknown -- unknown function YGL013C PDR1 0.9 17 1.9 0.4819 0.407634791 iYGL013C 0.642780309 0.61500399 0.611373166 PDR1 -- transport -- Transcription factor related to Pdr3p YGR019W UGA1 0.9 16 1.9 0.4819 0.540987766 iYGR018C 0.681369969 0.803965232 0.624234612 "UGA1 -- GABA metabolism -- 4-Aminobutyrate aminotransferase (GABA transaminase), produces gamma-aminobutyric acid" YHR009C YHR009C 0.9 17 1.9 0.4819 0.929428446 iYHR009C IntYHR010W 0.985386052 0.925097389 0.443815478 0.235412299 0.250719987 YHR009C -- unknown -- unknown function YJL129C TRK1 0.9 17 1.9 0.4819 0.235497978 iYJL129C 0.31098387 0.455626496 0.510957138 "TRK1 -- transport -- Potassium transporter of plasma membrane, high affinity, member of potassium transporter (TRK) family of membrane transporters" YJL164C TPK1 0.9 18 1.9 0.4819 0.302967983 iYJL164C 0.324722969 0.455206676 0.18955276 "TPK1 -- signaling -- cAMP-dependent protein kinase 1, catalytic chainprotein kinase A" YKR088C YKR088C 0.9 17 1.9 0.4819 0.506370467 iYKR088C 0.48211271 0.892019154 0.412586799 YKR088C -- unknown -- unknown function YNL152W YNL152W 0.9 18 1.9 0.4819 0.423209516 iYNL153C 0.811096033 0.24764565 0.112739138 YNL152W -- unknown -- unknown function YNL158W YNL158W 0.9 17 1.9 0.4819 0.388122519 iYNL159C 0.202857208 0.572705507 0.278820305 YNL158W -- unknown -- unknown function YNR040W YNR040W 0.9 17 1.9 0.4819 0.626781773 iYNR039C 0.140885804 0.555227454 0.374450015 YNR040W -- unknown -- unknown function YPL064C YPL064C 0.9 17 1.9 0.4819 0.093944517 iYPL064C 0.547384783 0.065789474 0.61797209 YPL064C -- unknown -- unknown function YPR024W YME1 0.9 17 1.9 0.4819 0.13020376 iYPR023C 0.216326888 0.207438493 0.331531822 "YME1 -- mitochondrial protein processing -- Mitochondrial zinc-dependent protease and member of AAA family of ATPases, responsible for degradation of improperly folded proteins in the intermembrane space" YAL056W YAL056W 0.8 15 1.9 0.4819 0.44702659 iYAL058C-A 0.511098201 0.421769256 0.639863548 YAL056W -- unknown -- unknown function YBR003W COQ1 0.8 15 1.9 0.4819 iYBR002C 0.67035393 0.838531514 "COQ1 -- ubiquinone biosynthesis -- Hexaprenyl pyrophosphate synthetase, catalyzes the first step in coenzyme Q (ubiquinone) biosynthesis pathway" YBR017C KAP104 0.8 16 1.9 0.4819 0.574058271 iYBR017C 0.320037679 0.813597491 0.362250599 "KAP104 -- nuclear protein targeting -- Transportin, beta-karyopherin involved in nuclear transport of mRNA-binding proteins" YBR021W FUR4 0.8 16 1.9 0.4819 0.446747957 iYBR020W 0.389804763 0.650837989 0.695877561 "FUR4 -- transport -- Uracil permease, member of uracil/allantoin permease family of membrane transporters" YCL020W 0.8 15 1.9 0.4819 0.584226981 iYCL022C tE(UUC)C 0.700121395 0.793162827 0.445492662 0.546458739 0.541089268 YCL047C YCL047C 0.8 16 1.9 0.4819 0.288054937 iYCL047C 0.425317233 0.641687505 0.296656064 YCL047C -- unknown -- unknown function YDL217C TIM22 0.8 14 1.9 0.4819 iYDL217C 0.621085835 0.752198112 TIM22 -- mitochondrial protein targeting -- Essential mitochondrial inner membrane import of mitochondrial inner membrane proteins YIL044C AGE2 0.8 16 1.9 0.4819 0.298876138 iYIL044C 0.128143576 0.737190742 0.057605543 "AGE2 -- unknown -- similarity to Gcs1p, member of Gcs1p/Glo3p/Sps18p family" YJL179W PFD1 0.8 15 1.9 0.4819 0.723627592 iYJL180C 0.190133943 0.530782976 0.069231414 "PFD1 -- protein folding -- Component of Gim protein complex that promotes formation of functional alpha- and gamma-tubulin and actin, has similarity to bovine prefoldin subunit 1" YJR116W YJR116W 0.8 15 1.9 0.4819 0.58599395 iYJR115W 0.422037536 0.498308089 0.290767 YJR116W -- unknown -- unknown function YLR097C YLR097C 0.8 15 1.9 0.4819 0.556684845 iYLR097C 0.375249978 0.850547857 0.528264626 "YLR097C -- unknown -- unknown function, contains an F-box" YLR237W THI7 0.8 16 1.9 0.4819 0.165076979 iYLR236C 0.303846762 0.394964206 0.180284703 THI7 -- transport -- Thiamine transport protein YNL290W RFC3 0.8 16 1.9 0.4819 0.385828083 iYNL291C 0.413980677 0.891859537 0.225458899 "RFC3 -- DNA replication -- Replication factor C, 40 kDa subunit, member of DEAD box family of putative helicase proteins" YOL031C YOL031C 0.8 15 1.9 0.4819 0.366301862 iYOL031C 0.224688506 0.806056118 0.343342878 YOL031C -- unknown -- weak similarity to Yarrowia lipolytica Sls1 protein precursor YOL112W MSB4 0.8 16 1.9 0.4819 0.193633623 iYOL113W 0.557522124 0.191588785 0.374756328 MSB4 -- unknown -- Multicopy suppressor of bud emergence mutants YOL148C SPT20 0.8 16 1.9 0.4819 0.219439729 iYOL148C 0.047715226 0.826462602 0.195500325 "SPT20 -- chromatin structure -- Component of nucleosomal histone acetyltransferase (Spt-Ada-Gcn5-Acetyltransferase or SAGA) complex, member of TBP class of SPT proteins" YOR338W YOR338W 0.8 14 1.9 0.4819 0.725679518 iYOR337W 0.722923485 0.341020266 0.076083159 YOR338W -- unknown -- unknown function YDL019C YDL019C 0.7 14 1.9 0.4819 0.416036207 iYDL019C 0.683729 0.333812099 0.919389888 YDL019C -- unknown -- similarity to Osh1p YDR093W YDR093W 0.7 12 1.9 0.4819 0.399085449 iYDR092W 0.340248285 0.314212053 0.220214568 YDR093W -- unknown -- Member of Drs2p family of P-type ATPase superfamily YJL054W TIM54 0.7 14 1.9 0.4819 0.422154738 iYJL055W 0.488871048 0.597605746 0.239847303 "TIM54 -- mitochondrial protein targeting -- Essential mitochondrial inner membrane import of mitochondrial inner membrane proteins, part of translocation channel" YLR105C SEN2 0.7 13 1.9 0.4819 0.889811753 iYLR105C 0.845035073 0.383983242 0.732031943 "SEN2 -- tRNA splicing -- tRNA splicing endonuclease, beta subunit, has active site for 5' splice site cleavage" YLR211C YLR211C 0.7 12 1.9 0.4819 0.212555332 iYLR211C 0.386413177 0.379329609 0.427760307 YLR211C -- unknown -- unknown function YLR305C STT4 0.7 13 1.9 0.4819 0.467588745 iYLR305C 0.766007841 0.30077729 0.519249513 "STT4 -- signaling, PKC1 pathway -- Phosphatidylinositol-4-kinase" YLR397C AFG2 0.7 13 1.9 0.4819 0.500175917 iYLR397C 0.885046347 0.774860335 0.513700321 "AFG2 -- unknown -- AAA family of ATPases, has similarity to mammalian valosin-containing protein (VCP)" YMR119W-A 0.7 13 1.9 0.4819 0.533300281 0.200201072 YMR244C-A 0.7 14 1.9 0.4819 0.36616701 0.086287464 YPL015C HST2 0.7 13 1.9 0.4819 0.338190541 iYPL015C 0.272013806 0.48084597 0.280615533 HST2 -- unknown -- similarity to Sir2p YPL158C YPL158C 0.7 14 1.9 0.4819 0.197411342 iYPL158C 0.67321588 0.166928721 0.529236668 YPL158C -- unknown -- unknown function YAL009W SPO7 0.6 12 1.9 0.4819 0.482313107 iYAL010C 0.365233864 0.550617085 0.510715437 SPO7 -- meiosis -- meiosis YBR145W ADH5 0.6 12 1.9 0.4819 0.319766476 iYBR144C 0.655678305 0.764884278 0.63619466 "ADH5 -- glycolysis -- Alcohol dehydrogenase, zinc-dependent, also called formaldehyde dehydrogenase" YBR176W ECM31 0.6 12 1.9 0.4819 0.925350771 iYBR175W 0.639116668 0.97157245 0.863035772 ECM31 -- cell wall biogenesis -- Putative ketopantoate hydroxymethyltransferase (3-methyl-2-oxobutanoate hydroxymethyltransferase) required for coenzyme A synthesis YGR062C COX18 0.6 11 1.9 0.4819 0.457588241 iYGR062C 0.398258128 0.69881202 0.515405114 COX18 -- respiration -- activity of mitochondrial cytochrome oxidase YJR099W YUH1 0.6 12 1.9 0.4819 0.142753871 iYJR098C 0.245683753 0.346923259 0.306145251 "YUH1 -- protein degradation, ubiquitin-mediated -- Ubiquitin-specific protease" YKL018W YKL018W 0.6 11 1.9 0.4819 0.631722807 iYKL019W 0.141899328 0.810295291 0.039880761 YKL018W -- unknown -- unknown function YKL027W YKL027W 0.6 11 1.9 0.4819 0.5653019 iYKL028W 0.634936053 0.608453658 0.407598613 YKL027W -- unknown -- similarity to E. coli molybdopterin-converting factor YKR010C TOF2 0.6 11 1.9 0.4819 0.404925033 iYKR010C 0.694558645 0.560861499 0.741218176 TOF2 -- DNA replication (putative) -- interacts with DNA topoisomerase I YGR284C YGR284C 3.4 67 1.8 0.4649 1 0.943936635 iYGR284C 0.611544336 0.842784545 0.412529928 YGR284C -- unknown -- similarity to mouse Surf-4 protein YER169W RPH1 0.8 16 1.8 0.4649 1 0.617762436 iYER168C 0.941527414 0.384386078 0.062031137 "RPH1 -- DNA repair -- DNA damage-responsive repressor of PHR1, has two C2H2-type zinc finger domains" YJR132W NMD5 0.8 16 1.8 0.4649 1 0.684075057 iYJR131W 0.929675008 0.569038337 0.358053809 NMD5 -- unknown -- Member of karyopherin-beta familyinvolved in nuclear transport YLR103C CDC45 0.7 13 1.8 0.4649 1 0.870188304 iYLR103C 0.976071294 0.590800625 0.71124718 CDC45 -- DNA replication -- initiation of chromosomal DNA replication YMR014W YMR014W 0.7 14 1.8 0.4649 1 0.963966986 iYMR013C-0 iYMR013C-1 0.987984505 0.987123058 0.29202666 0.107891179 0.264872871 "YMR014W -- unknown -- unknown function, has possible coiled-coil domain" YDR441C APT2 1.8 37 1.8 0.4649 0.736152424 iYDR441C 0.600396592 0.857384851 0.441601689 "APT2 -- purine metabolism -- Adenine phosphoribosyltransferase (APRT), may be a heterodimer with Apt1p" YCR017C YCR017C 1.7 34 1.8 0.4649 0.599501069 iYCR017C 0.326287596 0.334206848 0.613196906 YCR017C -- unknown -- sensitivity to certain drugs YGL087C MMS2 1.7 35 1.8 0.4649 0.877965446 iYGL087C 0.474160086 0.578212291 0.267241379 "MMS2 -- DNA repair, postreplication -- Ubiquitin-conjugating enzyme variant (UEV) resistance to DNA damaging agents" YML117W-A 1.7 34 1.8 0.4649 0.491160884 0.374381484 YIL124W AYR1 1.6 33 1.8 0.4649 0.485999834 iYIL125W 0.568166793 0.938210857 0.39751853 AYR1 -- lipid metabolism -- 1-Acyl dihydroxyacetone phosphate reductase YAR027W YAR027W 1.3 28 1.8 0.4649 0.684549498 iYAR023C itL(CAA)A 0.228411829 0.70893782 0.248010284 0.721303541 0.789725974 "YAR027W -- unknown -- strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p, and Ycr007p" YDR372C YDR372C 1.3 27 1.8 0.4649 0.361437217 iYDR372C 0.447827723 0.87773344 0.633258137 YDR372C -- unknown -- unknown function YDR394W RPT3 1.2 26 1.8 0.4649 0.878427399 iYDR393W 0.844271812 0.961304895 0.647347077 "RPT3 -- protein degradation -- ATPase component of 26S proteasome complex, member of AAA family of ATPases" YJR125C ENT3 1.2 26 1.8 0.4649 0.328854013 iYJR125C 0.183003203 0.488347965 0.154000699 ENT3 -- endocytosis (putative) -- unknown function YGL091C NBP35 1.1 24 1.8 0.4649 0.72124942 iYGL091C 0.440600717 0.880526736 0.32334308 "NBP35 -- unknown -- Putative nucleotide-binding protein, has similarity to bacterial partitioning ATPases" YGR097W ASK10 1.1 23 1.8 0.4649 0.49596644 iYGR096W 0.346554911 0.531257562 0.506281621 ASK10 -- stress response -- Potential transcription factor involved in Skn7p-mediated two-component regulatory system YGR102C YGR102C 1.1 23 1.8 0.4649 0.365083661 iYGR102C 0.388843515 0.598244214 0.620281131 YGR102C -- unknown -- unknown function YMR220W ERG8 1.1 23 1.8 0.4649 0.211883325 iYMR219W 0.13648405 0.324980048 0.02956816 "ERG8 -- sterol metabolism -- Phosphomevalonate kinase, converts mevalonate-5-phosphate to mevalonate pyrophosphate, involved in isoprene and ergosterol biosynthesis pathways" YOR202W HIS3 1.1 22 1.8 0.4649 0.378617582 iYOR201C 0.309070519 0.433280128 0.095710355 "HIS3 -- histidine biosynthesis -- Imidazoleglycerolphosphate (IGP) dehydratase, seventh step in histidine biosynthesis pathway" YDL065C PEX19 1 22 1.8 0.4649 0.397756833 iYDL065C 0.641216796 0.290527404 0.547326417 PEX19 -- peroxisome biogenesis -- Farnesylated peroxisome biogenesis (peroxin) YDR228C PCF11 1 22 1.8 0.4649 0.387447322 iYDR228C 0.397937963 0.198164405 0.627154444 "PCF11 -- mRNA 3'-end processing -- Component of pre-mRNA cleavage and polyadenylation factor I, interacts with Rna14p and Rna15p" YER017C AFG3 1 22 1.8 0.4649 0.589274141 iYER017C 0.604433494 0.717398244 0.734832202 "AFG3 -- protein degradation -- Mitochondrial protein involved with Yta12p in proteolytic and chaperonin activities at the inner membrane, responsible for assembly of respiratory chain complexes, member of AAA family of ATPases" YIL010W DOT5 1 20 1.8 0.4649 0.540761944 iYIL011W 0.690847644 0.707348552 0.505283536 "DOT5 -- transcription -- Nuclear thiol peroxidase, involved in telomeric silencing" YJR126C YJR126C 1 21 1.8 0.4649 0.314225823 iYJR126C 0.490144957 0.425748165 0.362215091 "YJR126C -- unknown -- unknown function, has similarity to transferrin receptor" YKR028W SAP190 1 21 1.8 0.4649 0.165764756 iYKR027W 0.742632497 0.476754711 0.748648867 SAP190 -- cell cycle -- associates with and contributes to function of protein phosphatase Sit4p YKR087C YKR087C 1 21 1.8 0.4649 0.462508168 iYKR087C 0.632661598 0.778267399 0.724530128 YKR087C -- unknown -- putative zinc-binding motif of neutral zinc metallopeptidases YMR135C YMR135C 1 20 1.8 0.4649 0.498088567 0.571109338 YMR135C -- unknown -- unknown function YNL125C ESBP6 1 21 1.8 0.4649 0.198149066 iYNL125C 0.062573782 0.319881202 0.131901588 "ESBP6 -- unknown -- similarity to mammalian monocarboxylate transporters MCT1 and MCT2, member of monocarboxylate porter (MCP) family of major facilitator superfamily (MFS)" YNL238W KEX2 1 21 1.8 0.4649 0.212920614 iYNL239W 0.675707725 0.505631655 0.747798897 "KEX2 -- secretion -- Endoprotease (yscF) of late Golgi compartment involved in processing of alpha-factor, cleaves C-terminal to a dibasic sequence" YNR074C YNR074C 1 20 1.8 0.4649 0.40766059 iYNR074C 0.326374293 0.298420478 0.224415205 YNR074C -- unknown -- similarity to various reductases YPL002C SNF8 1 20 1.8 0.4649 0.239344113 iYPL002C 0.489405214 0.212487327 0.509092405 SNF8 -- glucose derepression -- glucose derepression YAR014C YAR014C 0.9 18 1.8 0.4649 0.491812553 iYAR014C 0.312322622 0.503992902 0.326519916 "YAR014C -- unknown -- unknown function, contains a predicted SH3 domain" YBR241C YBR241C 0.9 18 1.8 0.4649 0.158389668 iYBR241C 0.64440667 0.432881085 0.666290232 YBR241C -- unknown -- Member of hexose transporter family of major facilitator superfamily (MFS) YCL001W RER1 0.9 18 1.8 0.4649 0.741521423 iYCL002C 0.194936938 0.475329503 0.418826627 RER1 -- secretion; protein targeting -- retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment YDL102W CDC2 0.9 17 1.8 0.4649 0.505534737 iYDL103C 0.177942149 0.431260425 0.120674357 CDC2 -- DNA replication -- DNA polymerase delta large subunit YJL180C ATP12 0.9 19 1.8 0.4649 0.835710853 iYJL180C 0.190133943 0.68957115 0.069231414 ATP12 -- ATP synthesis -- F1-ATP synthase assembly protein YKL059C YKL059C 0.9 20 1.8 0.4649 0.467763945 iYKL059C 0.243142617 0.258862391 0.415941317 YKL059C -- unknown -- similarity to members of chaperonin-containing T-complex YLR016C YLR016C 0.9 19 1.8 0.4649 0.44559649 iYLR016C 0.436914802 0.55795877 0.448410347 YLR016C -- unknown -- unknown function YNL161W CBK1 0.9 18 1.8 0.4649 0.307554866 iYNL162W 0.737199441 0.332927225 0.447930951 CBK1 -- cell wall biosynthesis (putative) -- Serine/threonine protein kinase required for sporulation YOR097C YOR097C 0.9 19 1.8 0.4649 0.415494749 iYOR097C 0.608704363 0.604868316 0.585714286 YOR097C -- unknown -- unknown function YPL089C RLM1 0.9 19 1.8 0.4649 0.745044124 iYPL089C 0.415662771 0.161277051 0.17450854 "RLM1 -- cell wall organization -- Transcription factor of MADS (Mcm1p, Agamous, Deficiens, SRF) box family" YPL203W PKA3 0.9 17 1.8 0.4649 0.28724174 iYPL204W 0.24832386 0.328873585 0.4094539 "PKA3 -- signaling, nutrient control of cell growth -- cAMP-dependent protein kinase 2, catalytic chain of protein kinase A" YDR511W YDR511W 0.8 15 1.8 0.4649 0.34058443 iYDR510W 0.299329438 0.790029846 0.345038435 YDR511W -- unknown -- unknown function YGR125W YGR125W 0.8 16 1.8 0.4649 0.323402809 iYGR124W 0.463908517 0.879567637 0.560574621 YGR125W -- unknown -- Member of sulfate permease family of membrane transporters YHL029C YHL029C 0.8 15 1.8 0.4649 0.560495217 iYHL029C 0.08757653 0.756185156 0.056707268 YHL029C -- unknown -- unknown function YJL104W YJL104W 0.8 16 1.8 0.4649 0.855396407 iYJL105W 0.49681229 0.933001398 0.647172703 YJL104W -- unknown -- unknown function YLL042C APG10 0.8 15 1.8 0.4649 0.794083951 iYLL042C 0.725918731 0.814041906 0.358914123 APG10 -- autophagy -- Protein-conjugating enzyme essential for autophagy YML051W GAL80 0.8 16 1.8 0.4649 0.551595846 iYML052W 0.037382426 0.721785465 0.094725284 "GAL80 -- galactose regulation -- Negative regulator for expression of galactose-induced genes, forms a 1" YMR152W YIM1 0.8 16 1.8 0.4649 0.455781458 iYMR151W 0.093433518 0.717303143 0.085769981 "YIM1 -- protein processing -- Mitochondrial inner membrane protease, has sequence similarity to E. coli leader peptidase" YNL165W YNL165W 0.8 15 1.8 0.4649 0.865084446 iYNL166C 0.892326866 0.948261858 0.550596197 YNL165W -- unknown -- unknown function YOR148C SPP2 0.8 15 1.8 0.4649 0.034096512 iYOR148C 0.247713166 0.06767489 0.215961692 "SPP2 -- mRNA splicing -- pre-mRNA processing, high-copy suppressor of temperature-sensitive prp2 mutations" YOR213C SAS5 0.8 16 1.8 0.4649 0.572866316 iYOR213C 0.240680031 0.726635514 0.468992903 SAS5 -- silencing -- silencing at telomeres and the silent mating type loci YPL214C THI6 0.8 17 1.8 0.4649 0.388190134 iYPL214C 0.476888578 0.57402872 0.502021857 "THI6 -- thiamine biosynthesis -- Bifunctional thiamine-phosphate pyrophosphorylase (TMP-PPase)/hydroxyethylthiazole kinase (Th-kinase), enzyme of thiamine biosynthetic pathway" YPR057W BRR1 0.8 16 1.8 0.4649 0.793518346 iYPR056W 0.909880653 0.770105671 0.34128232 BRR1 -- mRNA splicing -- snRNP biogenesis YBR163W DEM1 0.7 14 1.8 0.4649 0.267028266 iYBR162W-A 0.450190793 0.739606832 0.800676764 "DEM1 -- cell morphology (putative) -- unknown function, has a role in multiple processes including cell cycle, stress resistance, mitochondrial morphology and respiration" YDL058W USO1 0.7 15 1.8 0.4649 0.52765905 iYDL059C 0.27118792 0.426067638 0.575179569 "USO1 -- secretion -- Coiled-coil similarity to mammalian integrin, required for protein transport from ER to Golgi" YDL207W GLE1 0.7 15 1.8 0.4649 0.707382224 iYDL208W 0.677687341 0.4743083 GLE1 -- mRNA export -- RNA export mediator YGL050W YGL050W 0.7 13 1.8 0.4649 0.612947305 iYGL051W itR(UCU)G1 0.112004829 0.402090631 0.645665485 0.502196688 0.160115304 YGL050W -- unknown -- unknown function YGL094C PAN2 0.7 15 1.8 0.4649 0.460644313 iYGL094C 0.42421502 0.703315318 0.552585604 PAN2 -- mRNA processing -- Component of Pab1p-stimulated poly(A) ribonuclease YGL164C YGL164C 0.7 14 1.8 0.4649 0.492967034 iYGL164C 0.549042406 0.008203379 0.406711301 YGL164C -- unknown -- unknown function YGR228W YGR228W 0.7 14 1.8 0.4649 0.234332982 iYGR227W 0.789102557 0.148374545 0.284940601 YGR228W -- unknown -- unknown function YIL068C SEC6 0.7 13 1.8 0.4649 0.809003493 iYIL068C 0.387571203 0.705905826 0.185366678 SEC6 -- secretion -- Component of exocyst complex required for exocytosis YIR008C PRI1 0.7 13 1.8 0.4649 0.49292493 iYIR008C 0.637448366 0.800837899 0.369766879 PRI1 -- DNA replication -- DNA primase small subunit (DNA polymerase alpha 48 kDa subunit) involved in the synthesis of RNA primers for Okazaki fragments YJR080C YJR080C 0.7 13 1.8 0.4649 0.558792116 iYJR080C 0.18497226 0.918435754 0.383447044 YJR080C -- unknown -- unknown function YJR084W YJR084W 0.7 15 1.8 0.4649 0.39098964 iYJR083C 0.350194734 0.870982677 0.070143256 YJR084W -- unknown -- unknown function YJR159W SOR1 0.7 13 1.8 0.4649 0.369914884 iYJR158W-0 iYJR158W-1 0.279705834 0.295900033 0.536871508 0.284441242 0.424102155 "SOR1 -- sorbitol metabolism -- Sorbitol dehydrogenase, converts L-sorbitol and NAD(+) to L-sorbose and NADH" YKL057C NUP120 0.7 13 1.8 0.4649 0.461546356 iYKL057C 0.653830694 0.762442526 0.455981751 NUP120 -- nuclear protein targeting -- Nuclear pore protein YKL130C SHE2 0.7 13 1.8 0.4649 0.432874354 iYKL130C 0.547513104 0.97905253 0.583041468 SHE2 -- cell polarity -- mother cell-specific expression of HO YKL168C KKQ8 0.7 13 1.8 0.4649 0.599551049 iYKL168C 0.395793418 0.752255881 0.661794525 KKQ8 -- unknown -- Serine/threonine protein kinase of unknown function YLR427W YLR427W 0.7 13 1.8 0.4649 0.102492057 iYLR426W 0.25489975 0.228765024 0.598128579 YLR427W -- unknown -- unknown function YNL094W YNL094W 0.7 15 1.8 0.4649 0.601616644 iYNL095C 0.160741191 0.680393112 0.316759777 YNL094W -- unknown -- unknown function YNL164C YNL164C 0.7 14 1.8 0.4649 0.212252231 iYNL164C 0.438856052 0.60726257 0.280485674 YNL164C -- unknown -- unknown function YPL057C SUR1 0.7 14 1.8 0.4649 0.592643812 iYPL057C 0.521112354 0.572226656 0.174626381 SUR1 -- sphingolipid metabolism -- the synthesis of mannosylated sphingolipids YBL069W AST1 0.6 11 1.8 0.4649 0.864240752 0.84649512 AST1 -- plasma membrane protein targeting -- targeting of plasma membrane H(+)-ATPase Pma1p YBR141C YBR141C 0.6 11 1.8 0.4649 0.379466835 iYBR141C 0.169228227 0.762264457 0.030168589 YBR141C -- unknown -- unknown function YDL001W YDL001W 0.6 12 1.8 0.4649 0.082333699 iYDL002C 0.59180924 0.116309292 0.447608292 YDL001W -- unknown -- similarity to Yfr048p YDR107C YDR107C 0.6 12 1.8 0.4649 0.176836044 iYDR107C 0.339912062 0.447631325 0.171820405 YDR107C -- unknown -- strong similarity to Emp70p YHR154W ESC4 0.6 12 1.8 0.4649 0.8589754 iYHR153C 0.124452672 0.540027813 0.141179453 ESC4 -- silencing -- chromatin silencing YHR202W YHR202W 0.6 11 1.8 0.4649 0.682771927 iYHR201C 0.413266282 0.773797921 0.429337232 YHR202W -- unknown -- unknown function YOR188W MSB1 0.6 10 1.8 0.4649 0.159180007 iYOR187W 0.384199306 0.449063087 0.263482781 MSB1 -- polarized growth -- may play a role in polarity establishment and bud formation YPL208W YPL208W 0.6 12 1.8 0.4649 0.337604526 iYPL209C 0.588736813 0.348671772 0.405098008 YPL208W -- unknown -- unknown function YEL066W HPA3 0.4 10 1.8 0.4649 0.710016187 0.735903848 HPA3 -- chromatin structure -- Histone and other protein acetyltransferase YFR038W YFR038W 0.4 9 1.8 0.4649 0.423896128 iYFR037C 0.176896704 0.543764785 0.15412504 YFR038W -- unknown -- Member of Snf2/Rad54 subfamily of NTP-dependent DNA helicases YJL218W YJL218W 0.4 10 1.8 0.4649 0.170692768 iYJL219W 0.510049492 0.388906624 0.398529909 YJL218W -- unknown -- similarity to E. coli galactoside O-acetyltransferase YOR092W ECM3 0.4 11 1.8 0.4649 0.189886506 iYOR091W 0.683655727 0.359696728 0.777471815 ECM3 -- cell wall biogenesis -- Protein possibly involved in cell wall structure or biosynthesis YOR071C YOR071C 0.3 8 1.8 0.4649 0.268385934 iYOR071C 0.720590196 0.606598371 0.729322298 YOR071C -- transport -- Probable low affinity thiamine transporter YPL095C YPL095C 0.9 19 1.7 0.4491 1 0.703586411 iYPL095C 0.943159177 0.743495611 0.717556607 YPL095C -- unknown -- similarity to Ybr177p YCL037C SRO9 0.7 15 1.7 0.4491 1 0.926198309 iYCL037C 0.960346205 0.051674484 0.151642208 "SRO9 -- cytoskeleton -- associated with ribosomes, has a potential role in translational accuracy, member of a subfamily of La motif proteins" YDR448W ADA2 0.7 14 1.7 0.4491 1 0.984446701 iYDR447C 0.981874847 0.956708902 0.633419272 ADA2 -- chromatin structure -- Component of two nucleosomal histone acetyltransferase complexes YFL024C EPL1 0.7 16 1.7 0.4491 1 0.518354192 iYFL024C 0.922211429 0.430965682 0.001949318 "EPL1 -- unknown -- Member of NuA4 histone acetyltransferase complex, has similarity to Drosophila E(Pc) (Enhancer of Polycomb) protein" YNL326C YNL326C 0.6 12 1.7 0.4491 1 0.982782833 iYNL326C 0.52948983 0.066387367 0.286062378 YNL326C -- unknown -- similarity to Akr1p and Ydr126p YGL207W SPT16 2 44 1.7 0.4491 0.544662889 iYGL208W 0.16019464 0.536570679 0.073180637 SPT16 -- chromatin structure -- General chromatin factor required for adequate expression of CLN and other genes YIL129C TAO3 2 43 1.7 0.4491 0.882347947 iYIL129C 0.148920465 0.840383081 0.144221021 TAO3 -- transcription (putative) -- Transcriptional Activator of OCH1 YBR287W YBR287W 1.2 26 1.7 0.4491 0.169309323 iYBR286W 0.799418976 0.439337614 0.804418454 YBR287W -- unknown -- unknown function YLR106C YLR106C 1.2 26 1.7 0.4491 0.548647597 iYLR106C 0.726183777 0.418196329 0.5132723 YLR106C -- unknown -- weak similarity near the N-terminus to Dyn1p and with weak similarity in the C-terminus to End3p YOR185C GSP2 1.2 27 1.7 0.4491 0.478341228 iYOR185C 0.416727269 0.640303272 0.492202729 "GSP2 -- nuclear organization -- Ran, a GTP-binding protein member of ras superfamily involved in trafficking through nuclear pores" YBR201W DER1 1.1 23 1.7 0.4491 0.625204182 iYBR200W 0.264559335 0.495553845 0.401793796 "DER1 -- protein degradation, ER -- degradation of misfolded soluble proteins in the endoplasmic reticulum" YDR349C YPS7 1.1 25 1.7 0.4491 0.409502995 iYDR349C iYDRWdelta26 0.657790708 0.869900571 0.878277003 0.880760554 0.802090826 "YPS7 -- protein degradation -- Yapsin 7, GPI-anchored aspartyl protease" YHR087W YHR087W 1.1 24 1.7 0.4491 0.816596024 iYHR086W 0.078747157 0.843274755 0.285012518 YHR087W -- unknown -- unknown function YIL138C TPM2 1.1 24 1.7 0.4491 0.053258441 iYIL138C 0.448984533 0.075984973 0.452044025 "TPM2 -- cytoskeleton -- Tropomyosin isoform 2, coiled-coil protein" YLR093C NYV1 1.1 23 1.7 0.4491 0.456549517 iYLR093C 0.617577525 0.833867348 0.492619182 NYV1 -- vacuolar protein targeting -- Synaptobrevin (v-SNARE) homolog involved in vacuolar vesicle fusion YDR079W PET100 1 20 1.7 0.4491 0.572166112 iYDR078C 0.458068288 0.415042235 0.247181766 PET100 -- respiration -- assembly of cytochrome c oxidase YGL228W SHE10 1 22 1.7 0.4491 0.775938754 iYGL229C 0.081517807 0.950876327 0.109286009 SHE10 -- unknown -- causes lethality when overexpressed YLR461W PAU4 1 22 1.7 0.4491 0.936289359 iYLR460C-0 iYLR460C-1 0.720026135 0.941672582 0.745825603 0.798651722 0.641580208 PAU4 -- unknown -- Member of seripauperin (PAU) family YBL015W ACH1 0.9 20 1.7 0.4491 0.597637022 iYBL016W 0.653642621 0.917802694 0.847396925 "ACH1 -- acetyl-CoA metabolism -- Acetyl-CoA hydrolase, hydrolyzes longer acyl CoA chains slowly" YEL039C CYC7 0.9 19 1.7 0.4491 0.398399216 iYEL039C 0.41910428 0.499349253 0.432215234 "CYC7 -- respiration -- Cytochrome-c isoform 2, predominant isoform during anaerobic growth" YGL248W PDE1 0.9 20 1.7 0.4491 0.542762815 iYGL249W 0.114500032 0.964137519 0.360136452 "PDE1 -- purine metabolism -- 3',5'-Cyclic-nucleotide phosphodiesterase, low affinity" YKL066W YKL066W 0.9 19 1.7 0.4491 0.74734008 0.834802382 YKL066W -- unknown -- unknown function YMR009W YMR009W 0.9 19 1.7 0.4491 0.669828764 iYMR008C 0.482848742 0.930167598 0.195133742 YMR009W -- unknown -- similarity to MMSAB operon regulatory protein YMR285C YMR285C 0.9 19 1.7 0.4491 0.150333022 iYMR285C 0.653610973 0.697104138 0.529992594 YMR285C -- unknown -- unknown function YOR245C YOR245C 0.9 18 1.7 0.4491 0.12678133 iYOR245C 0.20115789 0.390822027 0.18488344 YOR245C -- unknown -- unknown function YAL055W PEX22 0.8 16 1.7 0.4491 0.400850017 iYAL056W 0.529770689 0.362955205 0.348684211 PEX22 -- unknown -- unknown function YBR022W YBR022W 0.8 18 1.7 0.4491 0.324833217 iYBR021W 0.428418186 0.621037348 0.277544639 "YBR022W -- unknown -- Adenosine diphosphate-ribose 1""-phosphate (Appr-1""-p)-processing enzyme" YDL006W PTC1 0.8 16 1.7 0.4491 0.799215211 iYDL007W 0.592925368 0.304866258 0.325185998 "PTC1 -- tRNA splicing -- Protein serine/threonine phosphatase of PP2C family, involved in the dephosphorylation of multiple MAP kinases and involved in tRNA splicing" YDL231C YDL231C 0.8 16 1.7 0.4491 0.52979593 iYDL231C 0.334223353 0.469114126 0.305347167 "YDL231C -- unknown -- unknown function, has a putative zinc finger domain" YDR005C MAF1 0.8 17 1.7 0.4491 0.5648373 iYDR005C 0.550582036 0.798096314 0.582024594 MAF1 -- protein targeting (putative) -- sorting of Mod5p YDR146C SWI5 0.8 17 1.7 0.4491 0.252062233 iYDR146C 0.523000305 0.27296165 0.842679944 "SWI5 -- cell cycle -- Transcription factor that controls cell cycle-specific transcription of HO, has three tandem C2H2-type zinc fingers" YDR293C SSD1 0.8 18 1.7 0.4491 0.560363725 iYDR293C 0.134092552 0.731237817 0.273203352 "SSD1 -- drug resistance -- Single-copy suppressor of many different mutations, associated with cytoplasmic RNA" YDR296W MHR1 0.8 18 1.7 0.4491 0.329283574 iYDR295C 0.269601437 0.533032185 0.226022425 "MHR1 -- recombination, mitochondrial -- repair, recombination and maintenance of mitochondrial DNAalso copurifies with RNA polymerase II" YGL129C YGL129C 0.8 17 1.7 0.4491 0.373076949 iYGL129C 0.575050123 0.41452514 0.194573025 "YGL129C -- unknown -- Putative mitochondrial carrier protein, required for respiration and mitochondrial maintenance" YHL047C TAF1 0.8 19 1.7 0.4491 0.498440806 iYHL047C-0 iYHL047C-1 0.303141904 0.45790837 0.472386273 0.13585123 "TAF1 -- unknown -- Triacetylfusarinine C transporter, member of yeast-specific putative multidrug-resistance family of major facilitator superfamily (MFS)" YLR095C IOC2 0.8 18 1.7 0.4491 0.270038008 iYLR095C 0.396597729 0.322388376 0.365012754 IOC2 -- unknown -- unknown function YOR034C AKR2 0.8 16 1.7 0.4491 0.477929581 iYOR034C 0.678205776 0.610860458 0.692801622 AKR2 -- endocytosis of Ste3p -- constitutive endocytosis of Ste3p YPL034W YPL034W 0.8 17 1.7 0.4491 0.455571507 0.368794892 YPL034W -- unknown -- unknown function YBR058C UBP14 0.7 16 1.7 0.4491 0.404836231 iYBR058C 0.546017094 0.677236198 0.507815018 "UBP14 -- protein degradation, ubiquitin-mediated -- Ubiquitin-specific protease, ubiquitin C-terminal hydrolase" YDL080C THI3 0.7 16 1.7 0.4491 0.281230872 iYDL080C 0.645596649 0.338289963 0.722352182 THI3 -- thiamine metabolism -- Major alpha-ketoisocaproate carboxylase YDL108W KIN28 0.7 15 1.7 0.4491 0.352074617 iYDL109C 0.522053016 0.49707967 0.547595841 "KIN28 -- transcription -- Cyclin-dependent serine/threonine protein kinase, component of transcription initiation factor TFIIH, phosphorylates C-terminal domain (CTD) of Rpo21p" YDL141W BPL1 0.7 15 1.7 0.4491 0.484925351 iYDL142C 0.218272513 0.849255328 0.388172736 "BPL1 -- protein processing -- Biotin protein ligase, catalyzes covalent attachment of biotin to biotin domain of acceptor proteins in an ATP-dependent reaction" YDR180W SCC2 0.7 14 1.7 0.4491 0.53979462 iYDR179W-A 0.736556785 0.925203653 0.845411014 "SCC2 -- mitosis, sister chromatid cohesion -- Cohesin, mitotic sister chromatid cohesion" YDR435C PPM1 0.7 14 1.7 0.4491 0.865813552 iYDR435C 0.217921256 0.984517159 0.39377494 "PPM1 -- unknown -- Carboxy methyltransferase for protein phosphatase 2A catalytic subunit, has similarity to human LCMT" YEL052W AFG1 0.7 14 1.7 0.4491 0.439977815 iYEL053C 0.846048718 0.297704271 0.776818502 AFG1 -- unknown -- weak similarity to members of AAA family of ATPases YFL004W PHM1 0.7 15 1.7 0.4491 0.76584907 iYFL005W 0.530482519 0.871985158 0.626414598 PHM1 -- unknown -- Putative polyphosphate synthetase YGL226W YGL226W 0.7 15 1.7 0.4491 0.083469225 iYGL226C-A 0.329992862 0.317251462 0.098894894 YGL226W -- unknown -- weak similarity to Neurospora cytochrome-c oxidase chain V precursor YHR207C YHR207C 0.7 14 1.7 0.4491 0.640283756 iYHR207C 0.331297962 0.874969301 0.723884811 "YHR207C -- unknown -- unknown function, has two C2H2-type zinc fingers" YIL022W TIM44 0.7 13 1.7 0.4491 0.511033002 iYIL023C 0.600933543 0.557969226 0.521628093 TIM44 -- mitochondrial protein targeting -- Mitochondrial inner membrane protein required in transport across the inner membrane YLL010C PSR1 0.7 15 1.7 0.4491 0.292235436 iYLL010C 0.426871591 0.449074074 0.632189583 PSR1 -- unknown -- unknown function YLR021W YLR021W 0.7 14 1.7 0.4491 0.141581424 iYLR020C 0.316167798 0.216759777 0.184221493 YLR021W -- unknown -- unknown function YNL185C MRPL19 0.7 16 1.7 0.4491 0.563956371 0.631281762 MRPL19 -- protein synthesis -- Mitochondrial ribosomal large subunit YNL258C YNL258C 0.7 16 1.7 0.4491 0.385984972 iYNL258C 0.718866949 0.554972977 0.85698324 YNL258C -- unknown -- Essential unknown function YNL264C PDR17 0.7 15 1.7 0.4491 0.200305262 iYNL264C 0.277824415 0.531338227 0.06026426 PDR17 -- drug resistance -- lipid biosynthesis and in resistance to drugs and to NaCl YOR316C COT1 0.7 15 1.7 0.4491 0.350184911 iYOR316C-0 iYOR316C-1 0.705008664 0.917170267 0.390461216 0.429768555 0.557940942 COT1 -- Co2+ ion homeostasis -- cobalt accumulation YPL047W YPL047W 0.7 15 1.7 0.4491 0.857615254 iYPL048W 0.263071614 0.594785575 0.416754018 YPL047W -- unknown -- unknown function YPL134C YPL134C 0.7 15 1.7 0.4491 0.423921742 iYPL134C 0.698123436 0.343794714 0.503756115 "YPL134C -- unknown -- similarity to mitochondrial ADP/ATP carrier proteins, member of mitochondrial carrier (MCF) family of membrane transporters" YPR021C YPR021C 0.7 16 1.7 0.4491 0.400357625 iYPR021C 0.425563237 0.381963301 0.685794094 YPR021C -- unknown -- Member of mitochondrial carrier (MCF) family of membrane transporters YPR034W ARP7 0.7 15 1.7 0.4491 0.23187425 iYPR033C 0.134331049 0.147904483 0.068460462 ARP7 -- cytoskeleton (putative) -- Component of SWI-SNF global transcription activator complex and RSC chromatin remodeling complexacts to assist gene-specific activators through chromatin remodeling YPR199C ARR1 0.7 14 1.7 0.4491 0.458827926 iYPR199C 0.566696436 0.455466879 0.183930988 "ARR1 -- transcription -- Transcription factor of basic leucine zipper (bZIP) family involved in arsenic resistance, member of a fungal-specific family of bZIP proteins" YAL013W DEP1 0.6 13 1.7 0.4491 0.032705756 iYAL014C 0.324781648 0.211730583 0.072530864 DEP1 -- phospholipid metabolism -- Regulator of phospholipid metabolism YAL058W CNE1 0.6 13 1.7 0.4491 0.729598152 iYAL059W 0.586682069 0.541652585 0.482131254 "CNE1 -- secretion -- similarity to mammalian calnexin and calreticulin, may be involved in a quality control process for secretory pathway proteins" YDL167C NRP1 0.6 11 1.7 0.4491 0.483620761 iYDL167C 0.318980116 0.6207502 0.445969673 NRP1 -- unknown -- Asparagine-rich one RNA recognition (RRM) domain YDR075W PPH3 0.6 13 1.7 0.4491 0.634174453 iYDR074W 0.383644032 0.771672575 0.27337259 "PPH3 -- cell cycle -- Protein serine/threonine phosphatase, member of PPP family of protein phosphatases and related to PP2A phosphatases" YDR108W GSG1 0.6 12 1.7 0.4491 0.443569371 iYDR107C 0.339912062 0.469668807 0.171820405 GSG1 -- meiosis -- High molecular weight subunit of Transport Protein Particle (TRAPP) complex that is involved in the vesicular transport from the endoplasmic reticulum to the Golgi YGL243W TAD1 0.6 12 1.7 0.4491 0.280883159 iYGL244W 0.101912323 0.630518853 0.022545873 TAD1 -- tRNA processing -- tRNA[Ala]-specific adenosine deaminase YGR049W SCM4 0.6 12 1.7 0.4491 0.27515266 iYGR048W 0.518271676 0.409437947 0.56675002 SCM4 -- cell cycle -- suppresses temperature-sensitive allele of CDC4 when overexpressed YJR031C GEA1 0.6 13 1.7 0.4491 0.418140567 iYJR031C 0.392373739 0.380438286 0.170159194 GEA1 -- secretion -- Component of complex with guanine-nucleotide-exchange activity for ARF YKL006C-A 0.6 13 1.7 0.4491 0.564046749 iYKL006C-A 0.979317633 0.246027265 0.713733235 YKL215C YKL215C 0.6 14 1.7 0.4491 0.376568944 iYKL215C 0.156775331 0.496007098 0.219017975 YKL215C -- unknown -- similarity to Pseudomonas hydantoinases hyuA-hyuB YLR200W YKE2 0.6 13 1.7 0.4491 0.548402939 iYLR199C 0.613079711 0.688427773 0.518884226 "YKE2 -- cytoskeleton -- Prefoldin subunit 6, component of Gim protein complex that promotes formation of functional alpha- and gamma-tubulin, and actin" YLR239C YLR239C 0.6 13 1.7 0.4491 0.140822011 iYLR239C 0.409548472 0.573606518 0.395498911 YLR239C -- unknown -- similarity to E. coli LipB protein which is involved in lipoate biosynthesis YMR035W IMP2 0.6 12 1.7 0.4491 0.880892465 iYMR034C 0.588371718 0.649628578 0.811322307 "IMP2 -- protein processing -- Catalytic subunit of mitochondrial inner membrane protease Imp, acts in complex with Imp1p but has different substrate specificity for removal of signal peptides" YOR154W YOR154W 0.6 12 1.7 0.4491 0.388742953 iYOR153W 0.72011955 0.720271349 0.769238487 YOR154W -- unknown -- unknown function YPL007C TFC8 0.6 12 1.7 0.4491 0.772600644 iYPL007C 0.176434339 0.83471668 0.245457722 "TFC8 -- unknown -- RNA Polymerase III transcription initiation factor TFIIIC (tau), 60 k