Figure 2. Cell-lineage specific gene expression in scleroderma skin biopsies. Cell lines were used to define the cell-lineage specific gene expression observed in the skin biopsies. Gene expression data for systemic scleroderma (SSc) and normal (Nor) skin biopsies were collapsed by UniGene cluster ID. A. The dendrogram for fibroblast cell lines are labeled green, muscle cell line orange, lymphoid tissue and cell lines blue, epithelial cells purple and endothelial cells brown. B. Overview of the 1123 genes that change more then 2-fold on at least three arrays in the skin biopsy data; the colored bars to the right identify the location of the inserts displayed in Figure 2C - 2G. C. B-lymphocyte gene expression cluster, D. endothelial gene expression cluster, E. epithelial gene expression cluster, F. fibroblasts gene expression cluster, G. normal gene expression cluster.