SSc 1 41/M 1 yr 43/66 + lung MTX,
omeprazole
Speckled muscles Vioxx
SSc 2 54/M 4 yrs 30/66 - GI omeprazole
RP
SSc 3 62/F 1 yr 33/66 + 1:640 GI nisedipine
nucleolar
SSc 4 58/F 2 yrs 27/66 +1:640 lung nisedipine; prevacid
Speckled RP, GI
The clinical data for the four subjects from which skin biopsies were taken is shown (SSc1 – 4). In each case the age, sex, duration of disease as defined by onset of first non-Raynaud’s Phenomenon symptoms, Modified Rodnam Skin Scores on a 66 point scale, anti-nuclear antibody (ANA) titers, internal organ involvement and medication taken by each patient. The age and sex of normal controls are: Nor1 (39, male), Nor2 (58, female), Nor3 (58, female), Nor4 (41, female). Abbreviations are: SSc, Systemic Scleroderma; GI, gastrointestinal tract; RP, Raynaud’s Phenomenon; MTX, methotrexate.