Comparing the Complete S. cerevisiae and C. elegans Proteomes: Orthology and Divergence
Goals of this study
Organization of this study
Definitions
Genome Scorecards
Core biology is carried out by similar numbers of proteins
Building a Biological Rosetta Stone
Distribution of core biological functions conserved in both yeast and worm
Core Biological Functions
Core Biological Functions (contíd)
Constructing Sequence Similarity Groups
Similarity Groups: MCM DNA replication initiator complex
Similarity Groups: Tubulin
Multiple Sequence Alignments
Domain Analysis
Worm-Only Domains
Yeast-Only Domains
Shared Domains (Yeast & Worm)
Frequency of occurrence of common domains
Conclusions
Future Directions
Genome-wide protein similarity view
PPT Slide
Acknowledgements
Acknowledgements (contíd)
Extra slides
Single-linkage clustering and multi-domain proteins
Whole genomic DNA microarray DeRisi et al.(1997) Science 278: 680
Email: sac@neomorphic.com
Home Page: http://genome-www.stanford.edu/~sac
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