GeneExplorer is a web application written by
that allows the exploration of large bodies of gene expression data
generated by DNA microarray experiments using a web browser
as its interface. Gene Explorer is based on the Windows program
written by Michael Eisen.
A hierarchical clustering algorithm (Eisen et al.
(1998)) was used to group genes based on their similarity in the
expression patters. The data are shown in a tabular format in
row of colored boxes represents the variation in transcript levels for
a given gene across all of the array experiments, and
each column represents the measured transcript levels for all genes in a
single sample. The variation in transcript levels for
represented by a color scale, in which red indicates an increase in
and green indicates a decrease in transcript levels, relative to the
unstressed sample. The saturation of the color corresponds to the magnitude
transcript variation. A black color indicates an undetectable change in
expression, while a gray box indicates missing data.
An overview of the data is shown on the left pane as a "thumbnail" image,
and a blown-up view of the data is shown on the right pain in a
"zoom" image. By clicking on a region of interest in the "thumbnail" view,
a regional enlargement will be displayed in the "zoom" field, and the ORF
and gene names will be visible. A detailed header of the array experiments can be
viewed through the link near the top of the page.