Figure v. Genes that cluster with the MAP kinase SLT2.
Genes were chosen based on the genomic cluster shown in Figure 1, then genes in this set were reorganized by hierarchical clustering.

Many encoded protein kinases are autoregulated at the level of gene expression. Thus, the induction of an encoded signaling factor suggests the activity of the pathway it participates in, and also implicates the genes that it clusters with as targets of the pathway. Thus, the expression of genes that cluster with the MAP kinase SLT2 may be affected by activity of this pathway. The functions of many of the genes in this cluster are related to ER protein folding, secretion through the ER, and the structure of the cell wall. Previously-identified targets of the PKC pathway are indicated in purple (Jung and Levin, 1999; Mattison et al., 1999).